David Sinclair | Cracking & reversing the aging clock | Frontiers Forum 2019
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- Опубликовано: 10 июн 2024
- Renowned longevity researcher David Sinclair believes aging is not inevitable but a treatable condition. In his talk at the Frontiers Forum 2019, he explained why we age - and how we can reverse aging to extend human healthspan and lifespan.
David Sinclair is Professor in the Department of Genetics, Blavatnik Institute and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard Medical School. The Frontiers Forum is held in Montreux, Switzerland. See all speakers: forum.frontiersin.org 
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Wow, someone under 60 that actually sees value in older people. Amazing!!
He just wants their money to fund his research
He is actually only 9 years under 60, but his method works :)
@@jimmyfortef3674 maybe- but he does research and gives many people suffering from illness hope
I will be 50 on my next birthday, but many people still think I am still 30+. Very overwhelming but all thanks to NMN by vitruvin. Along with balanced diet and regular exercise, it's definitely possible to improve the quality of living and slow the aging process.
If aging could be reversed safely and effectively, then this would be a galactic event. We can travel the stars
This is great information. I am a student of health and fitness. At 71 I feel great.
If you watch his older videos (10 years ago) on the internet, you don’t see him get old at all.
this guy is close to 51 what ever he takes i want it.
same here..
Daily: 1 gram of NMN, 500mg Resveratrol, metformin, intermittent fasting, weights twice per week. (All explained on Rogan podcast).
you can get the full list from the Joe Rogan Podcast comment section.
@@kevn99 NMN is the issue at the moment because it's really expensive. NMN increases NAD. Another supplement that also increases and is cheaper is Nicotinamide Riboside. An even cheaper way is to supplement with vitamin B3. This won't produce as much NAD but it will produce more than you're currently getting. Of course continue with resveratrol, metformin, fasting and weight training.
You can also get NAD supplements.
I am 65 - I run 5k almost every day, I do a weight routine, martial arts and this year I have returned to playing baseball
Be careful check your arteries for stenosis first and reverse it with a plant based diet if you have it. I have seen many with stroke or a heart attack doing this with a injured vascular system. A friend of mine last December at 39 had a heart attack running after he received a Garmin Watch because one of his artery was clogged. Be careful and check your heart and arteries before this kind of exercise.
Listened to the whole thing because he looked young at 50.
I was shocked when he said he is 50...damn
Check him out on the Joe Rogan podcast: ruclips.net/video/rhNFhdTFym4/видео.html
@@Random-rs9bl , he can pass for 45.
Not a gray hair.
Excellent! Thank you for all of your hard work in this area!
I've gotten excellent results with Nicotinamide riboside 450 mg per day,300 mg in the morning, no breakfast.150 mg with lunch, my energy level and stamina are 100% better,my eyesight has improved dramatically, mental focus is 100%. I'm 51 ,construction worker,and can only verify what has worked for me.I hope everyone gets the results I have,the difference is amazing.
Philip King read BK. I had the same Experience if not better and something is happening to the two of us
Philip King where are you buying?
Hi Phillip. I'm in South Africa. Where can I get these to start myself? Have my reasons and it's not just to look younger promise you so would love to try it for a different experiment. If you can give me a link maybe or something?
Magic word for me, eyesight. Will give it a shot..
Hey Philip nice information thanks for sharing. I would like to stay in touch thanks.
MY EXPERIENCE
I was doubtful but desperate and this is what happened to me and totally unexpected. I stared doing intermittent fasting by skipping breakfast. I got on PQQ20mg, resveratrol, NR 250mg, Cycloastragenol 25mg on a empty stomach first thing in the morning.
After about six weeks I noticed I could not sleep for more than 7 hours and thought this was interfering with sleeping BUT I realized my body no longer required to sleep longer and I could work all day into the evening without any fatigue Like I used to when I was younger. Loose skin under my neck started to tighten and also on my face which was a surprise. My eyes started focusing much better on small print. When I go for a light jog I know I can push much farther than before where I usually run and walk intermittently. My balance has improved where I can walk on a beam instead of falling off. I started dreaming almost every night very intensely. My male body is doing weird things that I haven’t experienced since I was 18. All I can say is something is happening that has never happened before with anything else and I have not changed anything. I eat very healthy organic non-treated food and I don’t eat junk but the change has to be because of this because that’s all I have done different and if this is only the beginning I am looking forward to 3 months supply I can’t what to see what happens but this is my experience which I am did not expect or plan for because nothing else has done anything but my energy was gone and I was getting weaker and felt wobbly and health slipping away. I was good till I hit 60 and then started noticing a change downhill and that’s happened to everyone in my family. I saw that early so I made changes at a very young age and it still came on no matter what I did until I tried this.
Things that matter. Get the pesticides/roundup and chemicals out of your food, get the weight down by replacing junk food with natural food your body can recognize, drink pure clean water filtered, Lower high carbs and sugars, do a light jog every day.
When you get desperate enough and scared you will be willing to try this like I did and hope your results will be the same before it gets too late.
I don’t know if it’s the combination I’m taking and the way I’m taking it or what but it may have something to do with increasing the speed and effect I am having.
I do everything you do except take those drugs. Except for some arthritis in my knees (with it, I still walk 1.5/2 mi, 4 days a wk, do a 20 min pilates workout 3 days a wk with little or no pain) I have energy throughout the day. I'm 68 yo. I have been eating 2 meals a day for a mo, have virtually eliminated sugar and bad carbs for yrs on & off but now, mostly off. I firmly believe this keeps aging at bay, at least. I also feel very good and rarely get sick. Can you tell me what it is you are ingesting? Thanks.
BK, thanks for the great information, will definitely try it, thanks. All my best to you.
Where do u get it?
BK can you recommend where to buy these ingredients from a reliable source. Thank you
BK what's NR250mg?
Great video, thank you for the information and the hope
I am waiting for this.i hope it comes in my lifetime.
Dr. Sinclair, Sir, please, let's get this show on the road. I'm 75 and I damned sure do not want to be the last human to ever die. In the future mankind will look back on the time when we all had to die at some time. I'm running out of time. I have a good life and I want it to continue. Also, I am busy, I don't have time for death. So sir, please let's get this thing going.
Fascinating! I am following Prof. Sinclairs advancements closely 👌
Causes of aging:
1. Mitochondrial dysfunction.
2. Telomere shortening
3. Epigenetic changes
4. Mutations.
5. Aggregation of proteins.
6. Glycation.
7. Oxidative stress.
8. Enviromental factors.
chemtrails!!!
Thank you! was wondering what were the others...
activated human endogen viruses!!
Car Accidents, Politics, Wives, Kids.
9. Buzzfeed articles.
This guy looks incredible for 50.
@@VirtualPhoton I genuinely thought he was about 40-41
@@VirtualPhoton doesn't look close to 50 actually.
@Ayura I also wo ukd guessed around 38 or 39
Im 53 and look equally young. I never say my real age for ageism nasty comments.Healthy life and doing the right things work
Na.. He looks like a healthy, 50 But, he still looks 50.
Great speech. What an inspiration he is and all those involved in this work.
From childhood I always said I would Live forever, or die trying. Now I see vindication over the horizon to all who were laughing at me. I did take the quote form somewhere though I can't remember where.
I do intermittent fasting. It's cheaper than medications.
If you're just doing time-restricted eating, it seems to me you won't be getting the same benefits as fasting for 5-7 days every now and then. From all the evidence shaking out of this stuff, it seems to me the body has evolved for times of abundance and lean times, and replicating that turns on a lot of autophagy that we miss out on if we just have a chronically calorie-restricted diet. We still need so much more evidence to elucidate all this stuff properly, though.
The supplements work in ways that fasting does not. It isn't known what the equivalence would be so it isn't a question of either one or the other (yet).
@Zio Oren sounds very scientific of you.
@Ayura intermittent fasting seems to make a difference according to his studies.
Eat also Plant based it will save you from buying all the expensive supplements all self proclaimed gurus will want you to buy to stay healthy....
Excellent as always!
Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number.
This is awesome! The downside is there are some corrupt people who society would not do well to have around that long.
Thanks doctor you’re doing a great humanitarian job for the improvement of mankind and history will remember you and generations to come will be greatly for your efforts
Yes because every one love a pill to solve all their problems.... There are eating patterns out there if you research that already make people live well past 100. Research the Hunzas.
Very intriguing
astonished how can people dislike it! anyways very thoughtful indeed. need to skip a meal, especially at night and definitely would try to fast at least two days a week.
that's brilliant, equating concepts of communication theory to biology. Wow.
I thought he was early 30s not 51. Something is working
He's not 51, he's 50 🤸♂️
Tom Kruze It is...the stuff that he does really works.
and he start late if you are late 20 and you abou these stuff. You gonna be happy
He doesn't look 30. LoL
botox
This guy is coming out with a book in 2020..Definitely going to read it.
September 10th 2019 actually
It's out now ("Lifespan").
salute doctor i need This
I have been taking NMN and Pterostilbene for 5 months and feel great. Arthritis almost gone. More energy quicker recovery sharper mind. Family and friends also the same. I’m 54. My 83 year old dad now does 50-60 pushups a day and can work outside 6-9 hours. Huge improvement. And both out cholesterol have improved.
which product did you chose? how much do you take and how often?
what nmn do you recommend ??
@@ifyouknowyouknow6964 Good question. It's not cheap so important to know...
Might want to keep a close eye on LDL levels if taking Pterostilbene over the longer term .. if you can still get it! ;-)
www.nutritionaloutlook.com/heart-health/chromadex-ceases-new-pterostilbene-orders-based-research-demonstrating-increase-ldl-cholesterol
Followed Sinxlair for years...he never told anyone what he was taking until recently...he must be on the cusp of a breakthrough that will make what he has been doing moot
I noticed that to the last months
Not true. Sinclair said in 2007 that he was taking 300 mg a day of resveratrol then a year later said over 500 mg. He said in 2015 that he raised in to 1,000 mg of resveratrol "and a NAD booster." From 2016 he said he takes resveratrol (down to 500 mg a day), NMN (500 mg then later 1,000 mg a day) plus 1,000 mg of metformin.
He advises what he takes at the back of his book which was released yesterday.
@@karadevereux1049 what's the name of his book?
He was born in Australia 🇦🇺 1969 ...
Love this guy ,. I'm trying to figure out why I still look how I did twenty years ago ..I just turned 41
I have been taking nmn,1 gram a day for about 3 months now. Also taking reservatol. Can’t really say I see a difference but will probably give it another 3 months. At about $130 a month I hope to see a difference to continue.
روووعة هذه ستكون ثوره في تاريخ البشريه
I would love to reach 120 why not if God allows me to live the long
My grandpa is 100 years old and he still here with us
What really work to turn back time...david...
I’d like to meet his dad!
this combined with Neuralnet and there may be some hope for the human race
what's Neuralnet?
Neuralink?
Elon Musk's venture.
@@xtian384 The Brain-AI interface Elon Musk's company is working on.
Wow. Perhaps I speak for many when say I'm not nearly so afraid of dying as of the possible ravages of old age leading to death.
That is what he is hoping to achieve by reversing aging, also helping people to stay disease free longer.... 🙏
Rick Murie nobody is afraid of dying but anyone is afraid of the shitty low level chronic inflammation diseases you have as you age >45-50..i'd rather dye than go back to my 45yo crappy aging body, now at 50yo i live same as when i was 30yo and can swim almost the same
A plant based diet is the only answer to that. Aging filled with energy and good health. Watch the documentary What the Health on Netflix.
David, i am really thankful for all your time and effort. Thanks again .. I would like to know if my husband can be helped he is going blind and it is so sad to see because he is such an active man . He is a diabetic and it has attached his eyes he has gone blind in the right eye and has about 30% vision in the left ..I would like to surprise him with a possible cure
Anna Redelinghuys Try switching his diet to the whole plant based (vegan) diet. Dr. Michael Greger explains how it helps in his book “How not to die.”
"MR BOY" - James Patrick Kelly's short story from 1997.
i guess this might sound naive to people, but this man gives me hope. also, i think what he's talking about is not fanciful--it's only fanciful in the context of a history without the knowledge that we have today. aging is inevitable, but the deterioration of the body may be fungible, or even negotiable. the challenge would be to figure out how to structure society if and when that happens.
i am going to live forever, i already figured how to keep young looking inside and outside the natural way.
Tell me please
what happens when you take NMN for a year and then you interrupt the intake for 2 months or so? Does anyone know this?
It's all down to collagen too and sugar reduces collagen so take collagen capsules, cut out sugar and derma rollers are amazing for bringing new cells to the skin reducing wrinkles, lines and sagging skin!
We can all make life so much better
Why should we accept anything as the "way of things"?
There is no reason for that.
Accepting disease as something normal is just a poor excuse for not wanting to work to solve that problem
You don't have to work
Just keep a positive mind and show some gratitude for those who make lives better
Good morning
Wow he looks so young....amazing....looks like he's only in his mid 30's!
What are examples for NAD Boosters?
So how can we take in Yamanaka factors?
ترجمه العربية متى تنزل؟؟
Great work David on your work ,Please can you focus on, affordability and access . why educate when these subs are for the privileged few
Go see John Rose
anyone over 40 reversed gray hair with any treatments? please share.
Anyone ever told U that U look like Christian Slater?
Thanks for sharing.
I would love it if U would post the words & names of things since I can't spell very well.
Thanks again.
Resveratrol
NMN: Nicotinamide Mononucleotide
NAD+: Nicotinamide Adenine Dinucleotide
Metformin
so what do you do
So does pine bark extract and grape seed extract- same thing.
This is the thing... they never told you where the f... they extract those things from. Because they are not stupid. if everyone knew they only need some pine extract and grape seed extract, everyone would just buy those and they are cheap. Those people don't want to help, they are into this for the money potential it holds. But to conceal what people need to do, they just create complicated names to blur the reality. Reality is EAT BLUEBERRIES, NUTS AND GRAPES. Add some pine bark extract to all that.
I'm not interested in dying, but for everyone who wants to die I wont try to stop you. Hopefully this anti-aging research will expand lifespans dramatically, and I am optimistic that we can simultaneously deal with the environmental and social consequences that will arise from this development :)
If Nmn can improve life of yeast, i would assume that it can improve the function or life of bacteria as well. iI that’s the case what are the long term effects of helping bacteria like helicobacter pylori (H. pylori)?
or other Bacteria that can cause things like, Coronary artery disease?
Our water in Florida, has this flesh eating bacteria called Vibrio.
Most people can fight it off, but if I’m taking this…..Am i helping any of those bacteria to further spread?.
He speaks on this on Joe Rogan - he says certain things can cause cancer cells to increase or the major drawbacks if certain things or steps are not done a certain way. There is the problem of ethics too- where the wealthier or more powerful in society could use this info in a corrupt way- but, as with any truly valuable new amazing cutting edge knowledge - that has always been the case and risk- usually, it goes mainstream after the rich have a hand in it. . We hope that it is goes the right way ethically - try to enforce laws that help and take our chances-as with many health advances in the past. .
Anyone came from Joe Rogan?
Yusuke Muramatsu no i came from Martin cabello aka dr foo
Yeah...then I watched Ben Greenfield...he was a wealth of info
That’s how I heard of David Sinclair!👍
Yes, saw him on Rogan. Greenfield,Rhonda Patrick, Peter Attia . All great !!
JRE
I have listened to a number of his talks, and in the final analysis there is NO breakthrough. Only ‘maybe’ medicines coming. Only practical advice given for NOW, is not new: fasting , eat well, no smoking, exercise. Or can someone assist me in some other practical anti / reverse ageing strategies? What information can be recovered and how?
I understand that over a very long period of time you brain will become overloaded with information. So that would make living for eternity impossible. But I also have these “theories” where you can come up with some method to have self induced amnesia on memories that are deemed unnecessary such as a former relationship that didn’t work out.
Or even death of family members so you don’t need to have the pain of the loss.
Maybe far enough in the future we gain the capability to transfer are consciousness into some software and then gain the capability to store memories that we don’t need at the moment, so we can draw upon the memory’s when we need them.
Then again these are just some things I thought up after listening to this video. This video had me thinking for a good half an hour over possible futures.
it doesnt overload. you just forget.
Pugger 653 Do you remember every single thing that happened since you were little? Brain will erase every single thoughts and memories that it thinks is unnecessary.
0:34 Is he asking "How many of you would like to return to 20?" The damn audio skipped.
I recall he said " How many of you would like to live to 120..."
my question would be..at what cost? can normal working..or retired people afford such a thing? or will it be so costly that only Bill Murray or someone like him can benefit?
Maybe $100/month. Seems low compared to hospital visits, pharmaceuticals, time, misery etc.
Me: we all getting old
David: im about to rewind this mans career
Also look at Carolyn Hartz who is now 71 And she looks 46 years old.
He looks younger than he was 7 years ago ... check his older video
Wow ! He talks the walk ! If he really is 50 but looks 30 then I am a believer
they make good hair dye these days.
Yeah only on looks? What about the inside? Let him post his cholesterol level, bones density mass, Arterial stiffening test and age test via a PWV test. Looks means nothing. I have seen 50 years old look like in their 20s and they died on their sleep of heart attack because their arteries were clogged by years of ingesting wrong foods filled with fats and cholesterol. He and you needs to switch to a Plant Based diet asap. Do not be superficial.
Is it possible to learn this power?
Research plant based diet. Watch the documentary "What the health". That is power.
Since I was young I have fasted and eat one larger meal a day usually and have always thought it helped my body's metabolism remain slower than others and now it's becoming accepted as healthy. My ego is being overfed now :)
How old are you now Chris
actually its better to have faster metabolism. eating once a day doesnt really change the metabolism it just drains your glucose stores and helps body to repair itself.
What type of meal did you eat though? Probably to satisfy your ego you should also take an arterial scan and test to see they are not filled with stenosis if you have been eating animal foods and oils all along? Switch to a plant based diet and you will see miracles.
Wow ! David Sinclair looks the same, if not younger, than that video he did on mitochondria some years ago.....Was it just Resveratrol,....what about Pomegranates...?
... dingleberries methinks.
great guy!
where can we find NMN and at least try it
www.revgenetics.com/advanced-nmn-nicotinamide-mononucleotide/
but I have no experience with the substance
최고
메트포르멘을 제외하곤 한번 시도해볼만 하네요.
I want some of the molecule.
of course a magic pill cure it all loool... Lazy. Do you believe in miracles? Have you ever see one? I have... is called Plant based diet.
There is German technology that introduces frequencies, vibration and resonance because it’s the language and key to longevity.
How are you suppose to take supplements while fasting? I would be sick.
With broth or something with a little fat in it. Intermittent means you don't have to go completely off food, just keep it in a 6-8 hour window, minimum 12. He takes his with yogurt.
Sounds like Lazarus Long from Robert Heinlein....he did exactly that... lived a life then revuvenated.
Excellent!
"Time Enough for Love"
NANO BIO TECH THTS A GREAT AREA FOR STAYING YOUNGER .
Help everyone to see climate change take us all out. That said, I like this just in case. Lifespan, fascinating read.
No way he is 50. I need what he is taking please. Where i can find it
Also see Dr Berg and Dr Mindy Pelz....Dr Berg's 53!
Lyla N botox
U also need to eat what he is eating and exercise
Amazon
@Wuotans Krieger smug cynicism at its worst
how will that have effect on women's fertility?
I mean how will the NMN make someone so young and affect an individuals reproduction. you stated that mice sharp their physical conditions like vision and muscle response. And what about cognitive conditions?
Do you know where I can purchase NMN at an affordable price? It runs about $100 a month for a gram a day. Not sustainable for most of us who have kids in college.
Angela Asadi I take it and rationalize it as elongating my life span so I can enjoy my kids and my kids kids that much longer. That’s well worth $100/month for me.
it is much chipper the $100 per month. look on Amazon.
i took that for almost a yeas. i do not see a difference. more i got side effect - leg muscle pain. stop and everything and my pain stop.
I in general look younger being 50 (family gines - all members aging pretty good). MND beside Sinclair research you do not see much from other researchers.
As I stop MND I look on Fiseting. I look like much more research wa done by many more people. I feel much better on Fiseting.
Best company I have found is Alive by Nature. US company and quality products. I take 250mg NMN daily and it really gives me a boost... Costs about $2 per day so quite affordable too 😊
You can buy it in bulk from China, minimum order is 1 Kilo; $800 (food grade, that is what the capsules are on Amazon) - split the cost with a friend and get a 2 year supply for $400.
Corner store in our town sells it for a buck, its called M&M.
he doesn't look older since his first ted talk
Maybe his dad is experiencing a placebo effect. The mind is very powerful. We under estimate our brains.
His son, this doctor, isn't giving his father sugar pills though. And I don't think a doctor who has spent the last 20-30 years of their life studying will bet the farm on sugar pills to grant his own father a better life.
How tf is this not trending why is this not being distributed worldwide. What is the world waiting for???? WE CAN BECOME IMMORTALS..... AND WHAT NOBODY CARES????
Expect major pushback from big pharma. They don't want to funnel solutions. It's all about options and money.
well, maybe pharmaceutical industry is connected with him, so he would also make a lot of money- no?
Big pharma wouldn't care less...don't kid yourself
Timothy Tassone Well, they’ll sell a lot of Metformin, so that should shut them up for a while.😂
Metformin is cheap.
he has enough money to market his medication him self so i wouldn't worry too much
Make eternal youth happen to both humans and animals!
upload to the cloud
only if it's a quality life
We all now know it works. Online even every pharmaceutical company in China won't sell the powder for less than $3,000/kilo. It goes up to $5,000 depending on where you check. I can buy a kilo of cocaine in Quito for $2,000. When will the price come down to reasonable levels?
I wish to reverse my age and look 18 again. How do i do this?
Hmmm. I want to know this too.
Majella read my comments. I it works
I think a lot of this science focusses on internal systems mostly, though the outside benefits as a matter of course. Still age a bit outside, just energetic and healthy. Look up old pics of Dave Asprey then and now. He is definitely aging backward. But David's NMN and resveratrol have prevented gray hair.
Eat healthy, don't snack, try to only eat dinner, restrict calories, sleep healthy (no distractions), workout whole body hard (including get heart rate above 150 for 15 mins weekly, at least). He's suggested all these tips
Can't wait to start his book Lifespan! Thank you Dr Sinclair. Yes I want to live on this Earth a purposeful healthy productive life as long as God has chosen for me. I didn't get to decide when I was born nor when I'll die. No epigenetics can protect me from the angel of death and my final breath. Personally I would not wish to stretch over 90/100 even in the healthiest state, that is more than enough of this very ephemeral life lol so unfortunately the science doesn't take into account spiritual dimension. Achieve 200 or more years for what purpose exactly? And will Earth be a better place to live in?
Shem Believer Oy
Please hurry with reversing the ageing process.
Only thing is that the average age of death is the same as it was more than two thousand years ago. 3 score and 10 (70). Upon searching Google it gave 71.5.
Hmmm. How are we really living longer?
Less children die, so it looks like we are living longer.
☝️☝️☝️❤️❤️❤️❤️thank you for your information
How many mg of Resveratrol does he recommend daily?
Im 31 soon to be 32, i want to start an anti aging program and Reverse my biological clock, any suggestion on What i should begin with?
1. Time restricted eating. 2. NAD booster like NR or NMN. 3. sirtuin stimulating resveratrol. 4. exercise 5 cold thermogenisis 5. metformin if you can find a doctor to prescribe it. 6 I personally believe in taking some vitamins and minerals
Заклетник Yeah well thats not enough, i want the full package here
HIIT, lifting weights, fasting a day in the week, balanced diet
Research a plant based diet. Watch the documentary "What the health" on Netflix. Also "The Game Changers". Diet is the first single cause of longevity or death it depends on what is ingested three meals a day for years and years. The source of fuel it is the most important... supplements comes later.
Is this new product launched in may any better TIME+ by NUCHIDO it’s supposed to boost NAD+ 4 time more than nr or nmn any thoughts
All these old people living forever. We will run out of Oatmeal!
... and diapers
fladave99 Mills 😂 they will eat fresh corn insted of oatmeal hehe
We don't eat grains..we've all gone Keto!
Lol
Aye laddie, and the finest oats, from Scotland. From one Mills to another!
Eat clean healthy food. Exercise, rest.
Aka Plant based diet.