This was a fantastic episode. Just sharing my notes here. Main takeaways: 1- Eat less often. 2- Avoid sugary drinks and foods. 3- Reduce meat intake for longevity. 4- Its never too late for dietary changes. 5- Find veggies that have been stressed out (organic, colorful veggies) 6-Never start a meal with sugars, if you do eat them at last (desert). EAT LESS OFTEN -There is a genetic pathway that gets triggered by low energy. These genes (sirtuins) respond to low energy (low glucose levels-caloric restriction), high heat, low amino acids, high salt (stressors). -----They take care of the DNA repair and the stabilization of the epigenome. -When the body is hungry, the body makes NAD (fuel for the sirtuins). -Two ways to activate sirtuins synthetically: 1) Use some molecules 2) NAD booster. Longevity genes: Mtor: protein that registers amino acids. Allows the cell to build things. Not a recipe for longevity. Activates autophagy. Ampk: goes up when hungry. Makes more mitochondria (important for making energy) Sirtuins Fasting: - Metformin: mimics fasting. - Time Restricted Feeding: At least 16 hours. - Liver compensates for the lack of food. Glucose neo-genesis. It overcomes the feeling of hunger. The liver starts making glucose at a steady level. Sugar: big killer. It spikes glucose. Glucose shut down sirtuins and ampk. Defenses against diseases and aging shut down. Protein: we should avoid high protein red meat diet for longevity. It inhibits mtor. Amino acids: three important. Leucine, isoleucine, and valine: BCAAs. Are used to sense protein intake. The sensor is mtor. The mtor activates when you get them. Mtor repairs and build muscle. In the short run, this is good for building muscle etc. But in the long run, mtor is the responsible for autophagy, which is key to longevity. Plant based diets: the more vegetarian you are, the longer you live. The best, Okinawa diet, is plant base diet with fish - (probably because of Essential fatty acids) Humans grew COLD and HUNGRY. Now we live at warm houses with food available all the time. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich
He says he eats one meal a day and he shed his weight and got his 20-year-old body back. This is what happened to me. I am 70. I was getting obese. I heard of intermittent fasting and said: what the heck. so coffee for breakfast and then I ate whatever I wanted once a day. It could be ice cream, pizza, whatever. And if I was starving I had a handful of raisins or a cup of tea with honey. Not only did the weight come off, but my whole figure returned. I had no flab. I did no do exercise. I happened to go to the doctor for something and he said he never saw anyone my age so healthy. So this is all true. Shocking. I've gained some weight due to being a bit depressed over world events, but when Spring comes I'll start again. I do have a dog, so I do walk a lot, and climb stairs. Try it. It is fantastic.
It’s understandable to be worried about world events,I can relate and if you are not concerned I would question that 😃 but yes we do need to find a way to mitigate that worry/stress for ourselves.
@@cindyhathaway6571 good question. Athletic Green does not increase insulin, so it does not break a fast. I take lemon water, apple cider vinegar and green tea when i m on fast. Just careful you dont add sugar of any kind.
@@maurameadesperry1715 no, you absolutely are unhealthy worrying about world events. It has nothing to do with you and you are creating stress on the body for absolutely no reason. What is the point of worrying about something you can do nothing about? Do you thinks monks, yogis, Amish etc...people living in the outskirts of the media crap have the stress levels you have? I guarantee they don't.
I got introduced to David Sinclair through the Lex Fridman podcast and was impressed with his insights on health and nutrition. Looked up this podcast, listened to this episode, and immediately started a 20/4 fasting regimen which became an 18/6 regimen after about two weeks. After about a month and a half of consistently eating this way, I have dropped 3 inches in my waist and now fit into a pair of jeans I wasn’t able to wear since before the pandemic. My skin has cleared up from all the extra water intake, my energy levels have evened out, my ability to focus has skyrocketed, my severe bloating issues have disappeared, my keratosis pilaris has gone away, there are no more puffy bags under my eyes, and my mood has significantly lifted because of the increased confidence from all of the above. I just turned 40 and feel and look like I did in my 20’s. You truly saved my life, Dr. Sinclair! I will never stop eating this way.
Is it easier for the body to reach the fasting mode when de food is plant-based? Is it the same 12 hs of fasting for a Plant-based diet as the 16 hs for a meat-based diet?
yes it is easier and i experienced it once. Fruits and veggies, nuts and seeds(raw of course) have living energy on them and your body is electrical so they feed it with enzymes, vitamins, minerals and you need less food and meat is a dead food(death) so it only harm you because it has no living energy on it and you are taking the stress hormones of the animal and toxins@@Martin-bk3sp
I am a biology teacher. I have used many of these protocols on myself. It blows my mind to listen to the scientific research that is going on in this regard. I would definitely share this info with my students. Great work Dr Sinclair. Hats off
One of the best podcasts about living a long healthy life I’ve seen. I'm 84 and wish food scientist's had found this fasting protocol years ago. I do a 24 hour fast once a week and I feel wonderful. Anyway I can see a future where obesity will be a thing of the past but sadly not in my lifetime. Good luck to all you wonderful healthy people.
People been fasting since the biguining of time ..his protocol is what early man used to consume and not consume . I mean even all religions of the world advice human beings to fast and abstain from eating too much ..
This podcast makes me know that there are people that genuinely care about humanity and want to see us all living, we’re fortunate to be able to watch this for free, I will definitely support the sponsors of this podcast, blessings in all your work 🙏🏻
Key takeaways: • Cut-off artificial sugars (processed carbohydrates) • Cut-off meat or atleast start reducing it from your diet. Meat lovers can switch to Mediterranean or Okinawan diet models. • Practice intermittent fasting. Start with skipping breakfast and try to avoid snaking in between. Tip 1- if its harder for you to practice I.F. then start drinking warm water, black coffee or green tea. Tip 2- if its still hard then consume a handful of nuts (as they contain proteins and healthy fats) and wait for 20 minutes. Tip 3- You can try natural sweeteners like stevia. • Consume more colored vegetables and fruits. Go for organic if possible. • Meal order- Consume proteins and vegetables first. • Start doing strength training and walking • For longevity, vegetarian and vegan diets are the best.
Yes, just eat sheet and nuts all day , look like a Haggard white man, never enjoy anything, cover in fear....and live to 86 instead of 85 1/2. Meanwhile in Italy in Europe...a glass of wine a day, meats, pizza ...deserts...105 or above...easy and widespread....what is it with you white Americans cowering in guilt and fear...?
@@levondarratt787 I am vegan 20 years and fit as fuck and look many times younger than my age. I love my diet. Your microbiome changes gradually as you eat more plants. You won't even miss the trans fats, cholesterol and other toxic garbage in animal products after a few months of eating properly!
OMG to me it's so much less about the longevity. I like how I feel *now* . And this way of dieting is really *not hard* . Be honest: when was the last time you were hungry ...
I keep discovering that I had it right all along! Honestly this is how I have been eating and I was called a bad mom for not having sweet food laying around for my children and most days we would fast. We have never been sick. Now my children are all grownup man between the ages of 26-30 and once they left at age 18 to college they gained weight and ate terribly which affected their immune system but thankfully they are now getting back to what they learned while living at home. Our diet was basically like this: Monday-Friday we will have no breakfast, no snacks and eat a healthy lunch and a big heathy dinner and during the weekends we will have a big breakfast and a dinner and skip lunch. Great information in this channel! Love it
Bad mom for not teaching your kids terrible eating habits and not making them addicted to sugar like every other kid. Sweets aren't a treat, they're an addictive unhealthy drug that is ubiquitous and universally accepted.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
@@leandrog2785 I am a bad mom too. I remember my young son complaining about the healthy mean I had prepared... " why can't we eat normal food like everyone else?" Now he is a very healthy eating adult. My other son chose to eat all the food he was denied, mostly sugar. He is not in good health.
I live on coffee and sugar and have never been sick in the last 50 years. I had gained weight and started intermittent fasting and its like he said, the weight poured off and my 20 year old figure returned and I am 70. My doctor told me he never saw anyone so healthy. Go figure. I am the worst eater you could ever see. Glad to finally hear this. I don't eat meat, don't like food, eat junk. But do love fruit and salad and mostly eat those. :) just sharing.
esp if it's all plant sludge humans don't have the physical digestive system for plants esp if they claim it's healthy sounds like acquired mentaI iIIness...
This was absolutely EXCELLENT!! At almost 62 and watching co-workers & friends who are around my age, pass away from various causes (often age related illnesses) has really alerted me to my own health and mortality. I don't want to succumb to illnesses or to die young. Nor do I want to age and be sick throughout those last years....for myself or for my family to watch me suffer. Dr Sinclair...bless you for sharing your knowledge, your insights, your recommendations and for showing us, that regardless of our stage/age in life, we can help ourselves. 😊 💞
My story in a nutshell: People told me to eat more (3 times), you’re malnourished, but I’m not hungry! So I did, weight and cholesterol went through the roof. 2 years ago I went back to my old ways reinforced by the ideas presented here. Steak and veggies OMAD, every day. All my blood tests checked out and I feel great again. Best part, I lost 45 pounds in those two years. I’m winning at soccer games easily too 😁.
First time listening to and watching Dr. Sinclair, and I really like his down to earth, not dogmatic, approach to all this stuff. Love how he is willing to admit that he still loves meat and is not all that motivated. Very refreshing.
@@BloomByCC you can have your cake and steak whenever you want; just eat a lot of fiber and an anti-inflammatory brew or smoothie before you eat them to lessen their bad effects
I have begun to skip breakfast and dinner: one meal about three p.m. or later. That's fantastic. In the morning only 1 spoon of olive oil and vitamins C, D3, B and k2 mk7. Thank you dr. Sinclair.
Wonderful presentation! I have been following a low carb Mediterranean style diet in combination with time restricted eating (limit my feeding window to 2-3 hours each day and will do a 72 hour fast on average around once a month). While it is a challenge to consume all my food in this window, I have worked it into a routine where I prepare and consume a large, very varied multi-colored vegetable salad supplemented with some nuts and seeds and a small amount of goat or sheep cheese in combination with whatever vegetables and proteins that my wife has prepared for dinner. I do apply a large amount of EVOO/vinegar with a combination of herbs and spices high in polyphenol content to my kickoff salad. I use a very high quality aged balsamic and a homemade apple cider vinegar. Some people find it repulsive, but I ferment my own apple cider vinegar mainly for the scoby and mother content (I do consume the minced up scoby in my salads). I will also include a can of anchovies or sardines 2 or 3 times a week. I realize that I am a cohort of 1, but my results in the past 18 months have been miraculous. I’ve lost almost 80 pounds, brought my A1C down from 8.9 to 5.4, eliminated what I had been describing as the aches and pains of getting older. To state it as short as I can - I feel younger now than I did 20 years ago. This is very doable. I’m not a zealot and do fall off while on vacation or dining out at or with friends. In those situations, I will consume whatever is placed before me. I do avoid sweets most of the time, but will enjoy celebratory confections (birthday, anniversary, wedding, …) out or superstition and/or respect. I never want to be put in a position where those around me get the feeling that I’m trying to shame anyone. I find that people become very interested in my journey and just maybe might be encouraged to experiment on their own. Case in point - beside close family and friends, I’ve gotten the attention of my GP, oncologist, surgeon, eye doctor, and the guy who has cut my hair for the past 40 years. They all spend most of our visits asking what changes I’ve made because of the dramatic health improvements I am experiencing. I am off all previous meds (diabetes, thyroid, hypertension), my hair is filling in, and my GP commented during my last visit that I should write a book if I manage to maintain my progress over the long haul. I simply chuckled at him and said “There are already hundreds of these books out there - we just have to get people to read them!” 😊😊😊
I started my daily time-restricted eating journey about 2 years ago. Dropped from high 80 kg to stabilise mid 60 kg currently. I'm dirt poor and can't afford supplements, but at 76 I now feel much more healthy. The only downside is I now have way too much skin and need cosmetic surgery. My wife hates 'the new me' from looks alone and is constantly doing her best to 'feed me up'. I try not to offended her by refusing, but always end up feeling uncomfortable afterwards, but it hasn't significantly affected my weight coz I just resume my regime when she's not there, which fortunately is often as she's a nurse. If I had enough money, I'd be doing everything Sinclair recommends.
I've always bounced in and out of exercising and eating well, taking my relatively healthy body for granted. Dr Sinclair's very easy to understand advice has given me the motivation to make permanent healthier habits for nutrition and lifestyle. Delaying aging by 8 or 10 years was the motivation I needed!
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I have been doing what this guy says for the past 3 years + without even knowing about his existence, found him out in Andrew Hubberman's podcast. I eat once a day (giving at least 16 hrs of fast) and fast once a week 24 hrs and sometimes for longer. I used to be always sick and tired all the time since kid. It's been 3 years + I don't get sick, I did a full blood and hormonal pack exam test and all my stats are on the optimal spectrum, my testosterone is at its peak and I feel great, full of energy and mind clear. I'm basically watching his videos and learning more + confirming what I discovered by trial and error by myself and I trust 100% this man is correct. I'll die fasting, restricting calories and avoid processed shit. There are entire industries draining people's mental and physical health but thankfully I got out of this and we have blessed people like this guy to come out and publicly provide the population with this life changing knowledge. Success for you Dr. David.
My journey is about a year now & after my blood tests have been done abroad & my cardiologist confirmed my 2 BP tablets and wanted to write them down for 2 weeks & to post to him what's up, when I came back home to London. An amazing thing happened last One month ago, I stopped taking my tablets to cause my Blood Pressure reading was 111 68 90 but I have my beta blogger tablet to take twice a day to lower my heartbeats🤗🤗 That's my new blood pressure reading. I've watched my Blood Pressure during the day & was always less than the recommended Numbers eg :120 75 85 heart rate. I don't know what had helped me 🤗 NMN AM & Resveratrol PM around 3 pm with the meal, I don't know. I take low dose NMN & RSVTL now.& plus X3 times week quercetin. But 3x NMN 500 mg &Resveratrol x3 times 500 mg. Rest is 250 mg daily all the supplements. 🤗🌅🌸💊 Thanks to our💊💊Doctor & Hope All goes well. I will keep sharing changes in my body from here or from other social media Lots of love from London🌅💕
This was the most amazing post ever for me personally ….because it also mimicked exactly what I also have been doing through my journey of trial & error & it helped recognize that …that in fact I have been on the right track ( when I was thinking I was not measuring up to some PERFECT journey of Intermittent fasting) Sinclair makes it simple ,clear, that is o.k. To not have to be rigid but always reaching for the closest goal of plant based & fasting as possible & not to beat yourself up if that is only 98% of the time. I have lost 50 lbs so far got stuck for along time in a plateau but lately have been successfully moving the scales again & this video has reinforced I am being successful. Found this video just at the right time.I am going to watch many more of Sinclair.
So are you basically eating the same amount of calories you used to eat just crammed into 1 meal? I really want to give this a real attempt but the episode didn't really give any guidance on how many calories to eat or if there is a significant difference if we cut down to just 2 meals a day within a say 4 hour window vs doing just 1 meal. I'm doing 4 hours of Zone 2 cardio a week, 1 hit session, and 2 weight sessions.
Love listening to David...so wise and not arrogant. This is such a wealth of information, thank you! Fasting while maintaining nutrition is really the best way to improve many things, I have experienced first hand for myself! My red wine consumption isn't moderate like it should be but working on that :-)
I'm 54. I'm type 2 diabetic. I've been on a "journey" since January 2022. Today is October 28, 2022. I am on a "keto-vore" diet - and OMAD since March. I have done a lot of fasting over my lifetime - 10 day, 2 week, 3 week fasts at various times of my life. But, I haven't done much fasting in the last few 5 years or so. In June, I decided I wanted to try a 30 day, water-only fast. The longest I'd ever done prior to that time was 22 days. I did the math and realized that if I wanted to finish a 30 day water-only fast before the holidays, I needed to build up to it and had to start right away. In July, I completed a 2 week water-only fast. Then I ate for one week. In August, I completed a 3 week water-only fast. Then I ate for two weeks. In September I started my 30 day water-only fast. I completed it on October 5. I ate for 10 days - then did another 5 day water-only fast. I have been eating since October 21. I am debating another 5 day fast next week. Then I'll have two weeks of various "thanksgiving feasts" - and after the official Thanksgiving, I want to fast for 28 days before Christmas. I never experienced the "pain" of hunger in my fasting experience because I always built up slowly. 3 days, 5, days, 1 week, 10 days, 2 weeks, 3 weeks, etc. - with healthy eating in between. However, on my 30 day fast, I noticed that at day 24, I started feeling *strong* hunger. I actually started feeling the "pain" of hunger for the first time. I was dropping a pound a day at that point. (Yes, I took some supplementation and allowed some salt and pickle juice.) It is definitely a mental game to fast. The first 3 days are always the hardest. After 3 days, the physical hunger goes away - but then the mental push to eat seems to strengthen. At 5 days, that diminishes. But, the brain keeps pushing to eat. It's a big mental game. You'll have thoughts like, "No doctor told you that you had to do this, why not have something light to eat?" Or "How bad could a little broth be?" Or, "Why not fry up an egg, no need to deprive yourself." Yes, actual thoughts, in my head, pushing me to eat. At this point, I feel *better* when I'm fasted. I sleep better. My body feels better. I have more energy (though it's shorter lived and I have to learn how to pace myself). I think much more clearly. Everyone who knows me comments about how much younger I look since I've been on this journey. My blood sugars while fasting (I was off my diabetic meds) were consistently between 86 and 100. I stopped my Metformin because I was crashing into blood sugars of as low as 49. However, I've started a lower dosage now and I'll be taking it in my future fasts (at this lower dosage). In February, having been sugar-free for a month, I asked another friend who has been on a similar journey, "When can I have sugar again?" He asked when my birthday was. It's in November. He said, "On your birthday, you can have sugar - and *only* on your birthday." I couldn't imagine living 9 more months without sugar. Here I am, two weeks from my birthday and *I DO NOT WANT ANY SUGAR* - I'm actually a little afraid of having any. I have struggled beyond my sugar-addiction for 10 months. I do not want to fight those battles again. I have no plans to eat any sugar. I want to encourage everyone that you can do this. You can get healthier. You can live longer. You can manage long-term fasting, OMAD, Intermittent Fasting, caloric restriction and time-restricted eating (there's some really interesting research on ETRF - early time-restricted feeding). You can do this! :)
This is a piece of gold, thanks for your work. The only problem is the way the interview is driven, interrupting all the time and moving to the next subject without giving time to the doctor to elaborate the answer. It's stressful and it fragments the information 😩
It seems that in order to improve our health and longevity we need to put our body at the mercy of adversity regularly. Thanks for your outstanding insights!!!!
Following Dr Sinclairs work for a few years now and I really enjoy that he shares more about it on his youtube channel and obviously on Hubermans podcast. Thank you 🙏🏼
Thank you for finally making things clear as the title is, for the average non scientist humans. What list can we take to the vitamin store and what list to the grocery store and the times to take them. Which vitamins have to be taken with other vitamins and/or fatty food etc. Thank you so much to both of you. Thank you David for bringing Mathew LaPlante onboard to ask the questions that normal people ask and doesn't back down until he has an answer that the normal person can take to the store with them or just use at home. Thanks guys.
Matthew is not only irritating, he is distracting! David has to say often “Getting back to…” because of interruptions by Matthew. I say dump Matthew!; take a cue from Andrew Huberman, organize your material and present it. David’s talks are much easier to understand, and in less time.
Matthew is on for media growth. The average human are like Matthew, I also found him irritating but also find his simplistic thoughts to match what the average person could understand and be connected with the information coming in. Without Matthew the podcast would have way less rating. Sinclair I presume got the idea from joe rogans podcast average viewer
The list for the vitamin store is vitamine D + k2, omega 3 DHA 250mg EPA 125mg from algea instead of fish, B12 1000/2000 mg twice a week which now mostly comes with a 600 mg folate boost (5-methylfolate NOT! folic acid). And if you like some creatine. That is it for vitamines. Check your bloodwork wether zink or magnesium might be relevant to you.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Do you know what is the natural food to us humans? Lol, only this so called geniuses greedy people made human being live a shorter life. Just ask a doctor any doctor if our food is safe to eat Lol.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
@@lipstick318 Wouldn’t worry about it because once the Holographic Med Beds come out everyone on planet earth will live beyond 100 in very good health. Don’t go to google to look this up as they are corrupt and Big Tech, Big Pharma, Bankers, All Royals around the world, Vatican etc is being taken out
Love your information. I have been eating 2 meals a day for 6 months, no snacks, no sugar, minimal startchy carbs. Love it. I work hard to keep my children at an absolute minimal sugar intake and junk and processed food. Can you speak more about what would be good for our children in regards to fasting or just in general what kind of food timing and regiment would be healthier for them? Would love an episode on childrens nutrition.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
What he's saying about Xeno-Hormesis is 100% true! My father always told me that the grapes from dryer climates always produced better wine. And, when we would plant the family garden, my father would tell me not to water the plants too frequently or they would taste worse. And he's right!
Really enjoying the science. I've been fasting since 1978. I'm 62; folks would swear I'm in my 40's. I feel great, seldom tire and never,ever get sick. When we came in and said, "I'm hungry" Momma would say, "Well jump up and catch a Kungry " .😅🤣 I grew up on my family hundred acre farm in South Carolina. We played in the sunshine all day and ate wild plums, berries, sour grass and pecans. Meals were veggies from our garden, rice and meat from our farm. Evening snacks were boiled or roasted peanuts or baked sweet potatoes. Desert was not every meal, peach cobbler in season, cake or pie on Sunday, from scratch. We ran to the other side of the property to see grandma so many times a day, without a 2nd thought.
@@cluman1 Actually, I live closer to Mayberry now than I did then, haha. Not just where but when? This was the mid-1960's in the backcountry of the low-country, small town, rural South Carolina, many miles south of Mayberry! However, we raised our kids similarly in rural PA on a homestead, as far as the level of healthy, fresh foods go. And though my daughter's don't grow their own food, and one lives in the city of Stockholm and the other Quanajuato, they still feed their children this way. I come from an unbroken chain of rural folk; still live in the country and eat the food I grow.
Good sound sensible advice and information thanks Dr Sinclair. My wife and I intuitively decided to cut back to 2 meals per day about 2 weeks ago and we have both lost weight but not been hungry. Cut out all bread, pastries, cakes and processed food. Increased salads, vegetables, fish and a little chicken. Cut out all red meat. We both have more energy and look better. No puffiness or fluid retention. And a bonus is my wife's arthritis in her knee has lost the swelling and she is walking easier.
@@theantiveganchannel3596 why would it? Humans can digest plants just fine. Humans evolved from herbivores. Our ancestors were definitely plant eaters.
It's so valuable to be learning this on the side of doing a molecular biology degree. All this knowledge and insight is greatly beneficial to my focus. Thank you!
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I just want to thank you gentleman. As a parent who is newly looking to transform the health of myself and my daughter, I am overwhelmed with gratitude for the information shared here. Definitely subscribed and look forward to what else I learn her. Truly, thank you so much!
I listened to this a second time and took notes, so I can understand the mechanisms better, and so I can create for myself a more visual representation of it all. Thank you for this podcast!
You can also go to the video and the three little dots to the bottom right of the video click on that and read or download the transcript by copying and pasting it into a document.:-)
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Beautiful. I’m inspired to make further adjustments, based on my own needs and measurements. How awesome. I’ve moved through a number of dietary changes in my life-I’m 51 now. In my 20’s I was almost vegan except for butter and some cheese. Went Westin A Price at age 30. Paleo at age 40. IF and keto at age 45. Ate meat and eggs almost daily while doing keto. Dropped the keto 2 or 3 years ago, and my eating window not as wide. Now the gears are moving in my head about how best to move forward.
As a biochemist, I am amazed of this channel. I've been following Dr. Sinclair for quite a while now and can for sure say he is top notch. IF mixed witha medit. diet is the way to go. Greetings from Germany!
Keto is proven the way to go. A complete vegetarian diet is bad advice we need protein and not to mention a lot of vegetable have lectins esp night shade.
I’ve done 7 day fasts with just liquids- water, tea, Chinese herbs cooked down- and I do exercise like swimming and biking- the first 3 days are challenging but after my body gets used to it and my hunger comes and goes quickly without being as severe plus my thoughts get very clear and I feel like I have more energy.
For all the cynics out there. You guys need to define fasting or intermittent fasting a bit more. Couple of spoonfuls of yogurt first thing in the morning or Athletic Greens in the morning is technically breaking the fast. Love everything you guys are doing!
Sooo happy you finally launched your podcast/RUclips channel. Read your book “Lifespan” and it changed my life. This medium is ideal for getting millennials/GenZ on board. Hats off!
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Dear Dr Sinclair, this is one of the best channel about science and health. I am a cardiologist foccused in longevity and anti aging and you so thanks for all you trials and experience!
Thank you for your research and your time in bringing us this valuable information! At 65, I've done a lot of things wrong over the years, even though I knew better! But, I'm excited to know that it's never too late to reestablish better lifestyle and dietary habits that may help make a difference, in my lifespan, going forward!
Fascinating talk, I wanted to share one farmer I know in the Bay Area who specializes in dry farmed tomatoes. He literally doesn’t water his tomatoes, he grows them in Davenport CA where it’s quite foggy and it results in a more stressed plant (as mentioned around 57:30 is a thing to revere). If you’re in the Bay Area, try out Two Dog Farms, they really are phenomenal.
Excellent podcast. I have a background in neuroscience and have always been passionate about nutrition and exercise. This is the best accessible information I’ve come across in 15 years!
It’s full of fallacy and he is a great salesmen. He’s got so many things twisted around to support his products. Example Reveratol - proven to add to toxin load. He sells it. Also check out PUFA oils. So much science coming out , they are the problem not fruit or rice.
David - I would love to see you talk about the ancient traditions and their take on longevity - the Daoist alchemists, Yogic ascetics and so on. It's a fascinating thing because so much of what they said thousands of years ago is mapping perfectly onto cutting edge research today. (I'm not advocating an esoteric approach here because hey...they did also advocate some insane practices like mercury ingestion, just pointing out how interesting it is)
@Evolving_Soul yes.. but increaseed sensitivity is not recomended for the normal garbage/stress self centered lives modern people live today. to make yourseelf more sensitive and then put yourself into this society would most likely make you worse rather than better from the exposure to toxic stress and toxic people that you will feel to a greater extent. the part that people are missing is that the yogis also simplified thir lives to a bare min.. did not try to eat nothing then do all the garbage the modern person does.
18:39 I really appreciated this statement because it's clear Dr. Sinclair isn't trying to persuade anyone to do anything...he's just providing the information and we are advised to make our own decisions. Great episode.
David, thank you so much! I read you book last August and it changed my life style in a big way, I started watching video from other scientists about nutrition, eating, metaboli… I gave up sugar almost completed, I’ve been taking cold shower since, I eat once or twice a day now, working out about five days a week… I have one question for you, for your plant based diet, what is your main protein source, do you eat a lot of beans to get protein? Thank you!
Ron, even tho you didn't ask me to answer your question, I'll recommend that you vary your protein sources. I eat raw, organic nuts, and nut butters. Lentils are great, chickpeas, and quinoa as well as beans. The nuts also contain healthy, beneficial fats. Remember to store all nuts in the refrigerator, and eat them while their oils are fresh. I also love a nice piece of mahi mahi. Best to you!!
I’ve been following this protocol for almost 30 years. I look and feel decades younger. I’m perfectly healthy. Thank you for sharing this incredible information. Would love to learn more about adding the right supplements to my life.
Fantastic! I'm aggressive about living longer and am so glad I found your book and the podcasts! I feel hope for the first time. Also, love that you are bringing the information directly to us! Please never stop!
Great tips! I actually love intermittent fasting, before starting I remember I had a few days when I ate very low in sugar, then I started eating only once or twice a day, usually between 3pm-8pm. There are very few days when I actually feel hunger. Also, focusing on anything is so much easier.
Coffee in the morning. Chewing tobacco all day. Drink clean water with lemon. Huge salad at 10 pm. Eat fish or steak with salad. I dropped 60bs in 5 weeks, and it's not the first time I did it. I also use ON protein in the past. I love this new knowledge the Dr. has. Starvation, pain and suffering = clarity, peacefulness and knowing who you are and where your going!
Thank you so much for these videos! I really appreciate educators, scientists, and doctors that make their knowledge accessible to the general population. The science you present has changed my life.
Thank you so much for sharing all of this information on what a proper, healthy, life saving diet should consist of. I eat up (no pun intended haha) all the info. I can on diet and nutrition, however there is so much contradiction between the different popular diets out there and what’s trending this week that it’s super confusing and frustrating and easy to just give up. I’m grateful for your knowledge and expertise. I’m intrigued with all you’ve shared and excited for what the future holds for each one of us.
Very interesting. Thank you for making this available on RUclips. There is one thing that remains hazy to me, it's the recommended daily calorie intake. Your body has to "feel" hungry , but you still have to provide it with the necessary calories (whenever you choose to take them) to go through 24 hours and meet your energy needs. Surely you don't want to go below your BMR. So, how do you calculate this intake? Also, by reducing the number of meals to only one, you make it more difficult to cram into this unique meal all the variety of vitamins, minerals etc... you body requires, and you have to take supplements - as you do, in the mornings. You become highly dependent on these supplements. What happens if you suddenly don't have access to them, for a prolonged period of time? Do you revert to more meals per day , and does you body remember how to "extract" those elements from actual food? Take care
So happy you have created a youtube channel David!! Such an amazing gift to share. I went plant based about three years ago, then I kind of fell into IF. I found it easy to go to 16/8 but now I am 20/4. Thank god, working from home now, its kept pandemic weight off. Im almost 60. I lost my meno weight, leaned out and maintain my muscle mass by doing regular Ashtanga. still doing dropbacks and handstands. brain fog gone, IBS gone. also no more jet lag from long flights. I really get an instant feedback loop on what causes inflammation in my body, and when I avoid those foods, I feel immortal most days, like I used to in my twenties. its all amazing except my sleep. that is still a crap shoot.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
This is such a useful and pleasant format! I am enjoying getting to see how Matthew La Plant thinks, organizes and interacts with David. I hope. you decide to continue this series for another 30 or more episodes. If you would like some questions and feedback on your first two intros presenting your donors, just ask. A few modifications might work better. I had a radio show and know how difficult it is to read ads. If I knew I would live another 50 good years, I would start my neurology, biology, etc. courses. This is so very thrilling!
Great episode. I've understood all the things you can do to live longer. I am interested if the studies are focusing mainly on how to live longer or on how to live longer and have a good quality of life by doing things important to you? Probably it is easier to live longer if you have a simple relaxed life and just walk around and enjoy yourself, but what if you have to have a very active life : doing intellectual work in the mornings, doing intensive sports in the afternoons , social life...etc ...then how can you put all food in one meal, and all the other things focusing mainly on living longer??? So , is the research taking into consideration the diversity of professions and their needs to function at their best ?
David this knowledge and wisdom from your research that you’re giving away for free is an absolute blessing I hope people realize that because many people that truly understand life realize like you that the way things were given and blessed to you you bless others with can’t wait to hear this podcast
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I back you up 100% I started doing intermittent fasting because an interview you did, whaat you shared made some much sense that I started right away, I skip breakfast and lunch and I have my first meal around 6 pm, now I can tell you that I have never felt better in my entire life, I used to suffer from irritable bowel syndrome and gastritis, and I’m 100% cured with not medication whatsoever, just fasting and exercise, it is amazing to have the science behind it, thanks David for sharing your research ❤️
I suffer from irretable bowel syndrome and gastritis, I'm very skinny. Always sick, I would like to do intermittent fasting to feel better but don't want to loose weight
Hi David! Great episode! I've been doing 16/8 fasting since 2009 but is doing 18/6 since I started following you. I am also a glaucoma suspect and your research has given me so much hope and less worrying. I have two questions: 1. Meat is just slightly higher in BCAA per 100 gram of protein than, fish, chicken, low-fat cottage cheese and whey. Even soy, lentils and quinoa are almost as high in BCAA. Would eating a more plant-based diet still be beneficial if BCAA is still high? I need to get my protein from somewhere. I am an amateur weightlifter but also care about longevity. 2. You mentioned limit fructose. What about whole fruits? I eat a lot of both fruit and green leafy veggies. Thanks!
From my standpoint I believe that the issue of meat is not only the high amount of bcaa (which activates mTOR) but also the substances that are toxic for us and causes cardiovascular diseases... But are just my thoughts about it..
Would love a little more info on fasting times for women of reproductive age. I'm 34 and have been doing 14 hour fasts sometimes can stretch to 15 but it's pretty difficult. I am breastfeeding a 2 year old although it's really for comfort not food so I'm not too worried about that, but also have a short menstruation cycle ~21-23 days and would like to try get pregnant again in the next year. I always wake up hungry and I'm waiting to eat at 9am instead of 6/7... If I make dinner any earlier I'll be eating at 430 and might get too hungry to sleep. I've seen lots of articles but not peer reviewed about how fasts have been studied more on men and give men energy bc they evolved to get energy from starvation to be motivated to hunt. For women I read we just hold onto fat to preserve pregnancy/milk production/periods etc. This is such an awesome podcast but like some others it would be so awesome to hear a little more about actual biological sex differences.
If you look up doctor Mindy Pelz she has an entire channel dedicated to women and fasting. Essentially the best way to fast is working with your cycle. So I fast for as long as I can on days 1-20 of my cycle (starting the day after I begin my period), low carb, higher fat. After we hit the luteal phase (10 days before your period until you get your period, but especially the week leading up to your period), don’t fast as hard and up your carbs. This way you can maintain the benefits of fasting but still keep your hormones happy and functional. So if I’m fasting normally I might do 18-6 or even 20-4, but on the days leading up to my period I try not to fast more than 16-8 and sometimes even have breakfast if I’m ultras hungry that day. I used to fast way too hard/without breaks/no carbs and my hormones tanked really quickly (lost period, major anxiety, extreme insomnia, irritability, panic attacks), and doing it this way really seems to fix that.
I had been working graveyard shifts for 5 years so I ate differently then went back to a day schedule that was sedentary due to an injury. To say the least my body gained so much weight due to sleep eating and not being able to exercise like I used to. Thank you for the info. It's been hard trying to get back to a beneficial eating pattern!
You may know already but night or shift work long-term is very detrimental to your long-term health. So much that it's classified as a carcinogen by the WHO. Dr Rhonda Patrick and numerous others have discussed it as well. Just FYI that it's not the day schedule part of your change that specifically made you more unhealthy.
I’ve read articles summarizing research that suggests increased NAD levels (from NMN supplements) may fuel tumor growth - specifically brain cancer. What say you, Dr. Sinclair? Also, in an interview with Lewis Howes, Dr. Longo expressed concern about the possibility of intermittent fasting negatively affecting the heart/circulatory system. He also referenced research indicating a link between breakfast and positive health outcomes - with the inverse being true for people who don’t eat breakfast. Do you and Dr Longo have conflicting points of view about this? I’d love to hear your perspective, Dr. Sinclair!
We need more of these podcasts. Maybe Q&A. It would be very interesting to find out if Dr. David Sinclair has done any research on some of "longevity foods" like: dark chocolate, honey (it is thought that bee keepers always live long), nuts, beans, mushrooms, garlic. turmeric, cinnamon. Also how to bridge between "eat less often" and well known "eat 5 servings of fruits or vegetables a day"? Witing for new podcast Q&A_001 🙂
Please cover when to workout during the Fasting window and when to feed following exercise. For your upcoming Sauna, Cold, exercise, show, please cover when is it best to exercise before cold, or heat or after? Any relationship with Heat Shock proteins, fasting, exercise, feeding and timing? Thank you! Great talk and questions!
Work out after eating if you want better athletic performance. Fasted workouts are just plain harder and you don't get as much improvement. But fasted exercise MIGHT be better for weight loss (if you can burn as many calories, which I never can....I can't even work out before breakfast without feeling beaten with a 2x4).
Also, sauna AFTER exercise is great. But you can do it whenever. No cold until your body as totally cooled off or you'll throw away effects of exercise. If you want to do contrast, don't do it right after exercise.
Perfect investment. Great dialogue. Question: for competitive athletes (I'm 62, train 10 hours a week, have a BMI under 20, a RHR of 48, and I do struggle a little with moderate systolic BP/in the 135-140 range) how do we eat? I'm burning tons of calories, and need energy to train, so where's the balance? What's a good reco? Do we just eat more and hydrate more than a person who doesn't? Curious
My #1 rule for health is "NEVER eat after sundown." Per Dr. Satchin Panda that causes massive inflammation that doesn't get resolved until the next day. He also said that given a choice between eating bad /unhealthy food during the day or nutritious food in the evening, it is better to eat during the day because "eating late turns even nutritious food into junk." I told this to a stranger on a golf course a year ago. A month later he saw me at the golf course and told me that he had stopped eating after sundown (he overhead me talking about this with others). he said he was 73 and a LONG time Type 2 diabetic andoften taking insulin. He said he decided to change "just one thing". he confessed that he was, as before, still cheating on the diabetes diet even drinking some beer and wine on occasion. He then said that his AM glucose that morning was 78 and he "hadn't seen such a low number in a very long time." He saw a downturn of his am glucose reading within the first week. And that's all he had changed. Another man that I know of, was morbidly obese (nearly 300 lbs) and out of desperation he decided to never eat after 6PM. he didn't know of the above but was frustrated that he had no self-control. He also decided to drink more water and he started to crave it. He lost almost one-third of his body weight in 12 months with just these two changes. And he confessed that he was still eating his favorite snack: donuts. True story from an old man who turned his health around with time-restricted eating, intermittent fasting, a few multi-day fasts and "NEver eating after sundown."
This is supported by the Vedas. In Ayerveda we are asked to fast after sundown and try to go to bed by 10pm ( for body & mind to detox and regenerate) . Upon waking at sun up - scrape the tongue to remove trash 🙏
I follow the 16-8 protocol for years now and I'm trying the extended version of it)(20-4)more or less like suggested by doc sinclair currently... It's is quite tough to get into it - I can definetly agree to the fact that sufficient drinking is key to magae hunger until the evening! I'm currently evaluating whether the effects (caloric deficit, focus, and longterm health befits) are worth and doable the effort. Love this kind of scientic and life hacking content! 😁
This was so great. Thank you so much, I have learned quite a lot of helpful information! Both the Host and the Doctor are highly intelligent and have a sense of humor. I will return next week. Joy, Peace!!!
I thought David would've gone into more depth than he has in his previous podcast episodes with other hosts, but it seems to be the safe information. Would've been nice for more detail on, for example, cooked vs raw vegetables, what he specifically eats to get enough calories in such a small window, etc. I know people have been asking him these things for a while and he continues to dodge for whatever reason.
I totally agree with you. Its not clear to me how fructose and glucose are so bad if vegan is the way to go. At least half of the food vegans are eating are high in both of them. Did he thought on refined sugars?
I would've appreciated a deeper look at this topic, too. I mean it's great he does this podcast :) but what he says in this episode was stated by him (and others) quite often. Would've been great if he talks more about studies and what makes them good/bad etc. and discuss some of the conflicting informations regarding healthy eating (e.g. walter longo states that skipping breakfast might be detrimental).
@@juliusmotocikli Frankly you need to understand the difference between glucose and a carbohydrate. The latter is not just a glucose molecule but bound to other element where it takes much longer to release. Also the latter mostly contains fiber slowing down digestion and absorption. This is why the glycemic index needs to be combined with glycemic load to see the real impact on your blood glucose levels. For frustose he means refined fructose in the sense of fructose corn syrup. Where fructose found in fruit actually does not overload the liver shown in studies and does not cause fatty liver disease. This again is due to slower and constant release and the combination with fiber. Where the liver can offload excess of fructose to fiber in the gut. But if you do not eat fiber it will have to process all of the frutose digested. So it is really refined versus naturally occuring. Refined is bad guy, the natural occuring has mechanisms in our system to regulated and slow down absorption or prevent over excessive absorption. Same for Iron where heme-iron is absorpted fully where non-heme iron is only absorbed to the amount we need. Downside need to eat non-heme iron rich food regularly, upside no oxidative stress from the heme-iron overflow.
@@juliusmotocikli I agree, - overall content doesn't gel, or make much sense to me, either.🙄 but maybe he'll improve with age haha... no pun intended.😅 (meaning, he's fairly new to the podcast scene, so maybe his narrative will improve as he goes). So far, IMO, he doesn't seem to be communicating like the serious and accomplished scientist I know he is. Still, however, he is very well-intentioned. I'm definitely subscribing, precisely because he is not confirming my protein (animal) bias at all, and its infuriating 😅. I want to make sure I don't try to stay comfortably within my own biases when choosing who or what I l listen to - no growth there!
My great grandfather lived 110 years with no diseases and he was active till the last day of his life. He followed an Arab lifestyle, eating mainly dates, olive oil, with milk, and lamb meat from time to time, their bread was from unrefined Barely, and they were usually mixing dates with olive oil. But the most important he eats less always, as a lifestyle.
@@pinkiepinkster8395 I said from time to time. Maybe a few times a year. People need to consume that amount from time to time or they will die and get ill.
@@pinkiepinkster8395 The point of the comment was to describe his great granddad's lifestyle. I don't think he was trying to restrict calories purposefully. There weren't much information on dieting and living longer back then, so he probably just ate what was available to him. I don't understand the judgement of an old person you don't even know about.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I only eat on Saturday and Sunday now the rest of the week I fast water only . Life is so amazing I don’t have to worry about deciding what to eat during the week which frees me up to do so much more . I’m 62 and now can run better than I did 30 years ago and I look 20 years younger
You can retrain your brain. I literally forget to eat and only know I’m hungry when my chest starts rumbling and or roof of my mouth feels sore/dry even when drinking water
When I started intermittent fasting, three weeks ago. I decided I'd be able to do the 8:16 approach, and a bunch of friends and I all started trying this at the same time(mutual support). Unlike my friends, I assumed I was in for a rough three or four days as I got used to the hunger periods. I was right. I got headaches, had very low energy, and honestly felt a little sick at times the first day. Fortunately I started at the beginning of 2 days off from work, so I wrote off that first day. By the second day, I felt a good bit better, though still was bothered by the hunger pangs. By the third day, I felt "normal" and have felt less and less hungry, even though I was not eating as many calories. I have also been eating better without really trying. Don't know if that's a benefit of fasting or I'm just paying more attention than I used to. Now I am eating far less than I used to and not feeling at all hungry until just before feeding time.
hunger goeas as your stomach shrinks, what this guy is selling on here is simply dangerous as people blindly follow withought consulting naturopath nor herbalist with a naive thinking dr sinclair said it online so it must be truth.. your bravurous behavior may have life threatening consequences long term which you will never link later with your actions on fasting.. he is not in position to advise people and is not doing that . he is just sharing his own experience and his research that has nothing zero nada to do with individual person in front of the computer !apart from bringing himself lucrative profits into his bank account selling pharmaceutical drugs as lollypops....to me he is another puppet of Jesuits
It's simply keto sickness withdrawal from sugar and carbohydrates literally like coming off heroin happened to me wen I went zero carb and only eat meat got sick puking , diarrhea,sweats,headaches it was horrible I couldn't believe sugar and carbs were similar to narcotics and can only wonder what they were doing to my body now I fast 20 hours a day and only eat animal products,gray hair went away ,my wrinkles are diminishing,more energy than a teenager and a libido like one , today like is getting better and better as time goes on and I always thought it got worse
You mentioned drinking AG in the morning. Is there no insulin response from doing that? I'm wondering because I am doing 20:4 but maybe I should drink it during the 4 hour eating window???? Your thoughts please?
Great episode! A couple of questions: 1. Any recommendations on types of fish (low toxic bioaccunulation, good fatty acid profile)? 2. Are lectins, phytates, and oxalates as bad as some claim? Steer clear of legumes, etc?
1. If you opt for fish choose the kind low in fat. Fat is where contaminanta are stored in fish so Tuna can contain alot of what we dump in the ocean. Rather opt for white fish with low fat content. 2. Only if you are hyper sensitive to lectines are these a problem. But you cannot eat legumes and beans raw anyway. Cooking them removes lectines from them. Even the biggest proponent of lectines Steven Gundry did a 180 on thus subject and now even advices them as long as you properly cook you grains and legumes. But like Sinclair says, opt for the protein sources that have less mTOR activating proteins in them. Which are from plants. Bonus content: don't like fish or contaminated food? Just opt for a tablespoon od broken flax seed a day with a dha 250 + epa 125 algea supplement and you will be clear in the omega 3 part.
Love this episode. It is a great follow-up to the first one. Thank you, Dr. Sinclair!!! Your willingness to share the work that you have done over the last couple of decades is helping mankind in ways that we will all benefit from. Thank you!!
I am watching this while eating Chick - fil - A, I am enjoying eating fast food/junk food once a month. Depriving yourself of foods you enjoy is a bad idea, something that this episode highlights, and I agree.
What qualifies as too much protein? Is it proportional to body weight? Is it proportional to the amount of other macronutrients you eat? You mention red meat in particular, does that mean white meats are fine? Asking because I want to build muscle but I also want to think about the long run!
0.8g of protein per kg of body weight is pretty standard. If you're working out more, you could increase it to 1.1g/kg. Building muscle is more dependent on the way in which you exercise - less aerobic and more high intensity training with weights. White meat isn't much healthier, at least not at the levels consumed by most people.
Hi Dr. Sinclair. I purchased the Athletic greens. I practice Intermittent fasting - is it okay to drink the daily dose of Athletic greens in the morning when I'm fasting? I typically skip breakfast and eat my first meal at 11.30 am. Thanks!
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? The Body already Does it, why can't we do it, TODAY, NOW????? I Want to Live to be 351 Years Old, Period... Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones??? Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I watch all the videos that I can with dr. David Sinclair. He is a legend. I love to see how younger he looks compared to some older videos. I have only one question: did dr. Sinclair have some cosmetic procedures done? Botox? Face lifting? Or his appearance is 100% due to his lifestyle and supplements? I don’t care if he had cosmetic procedures done but I would like to have an honest answer.
Such interesting content! I have a question… When sick with a cold or flu for example, my parents would always try to encourage me to eat in order to keep up my strength and help me fight the illness, but listening to the podcast leads me to believe that the lack of appetite when sick is an intended side affect to assist the body in healing itself during a ‘fast’ Can you shed some light on this? Should we force feed ourselves when sick or is it just fluids which are important?
@@Boriskbjj COVAIDS is just a regular Corona Virus...Polymer Chain Reaction Tests were NEVER intended to detect illness. Fauci misused it back in the Late 1980's for AIDS just like he is now. To answer your original question, "Feed a Fever but STARVE a Cold" is what my 101 year old grandfather told me HIS Grandmother told him. 😁
A lot of this sounds very familiar to those of us who follow the HFLC (KETO) diet. But getting enough protein and fat to be able to avoid( or keep very low) in Carbohydrates is very difficult with a vegetarian regimen! Some would say near impossible if you want to keep to 20 - 30 gms of Carbs to stay in ketosis, which is very beneficial for type 2 diabetics or pre diabetics. And is it the low carb diet that extends life or the protein avoidance? I do not think that has been clearly determined yet as far as I can see.
He was saying to keep your blood sugar steady (no big ups and downs), not (limit) your carbs. Simply fasting, and monitoring what foods/carbs significantly spike your blood sugar when you eat is all you need. Also, high amounts of lipids can also cause or at least promote (pre) diabetes, so it’s not just sugar :( BUT he still recommended Mediterranean so you can have a bit of your fatty fish if you want :D
David Sinclair is such a great communicator, slightly difficult to catch all he is saying because the interviewer talks before he finishes his sentences. DC - always hugely informative, clear, and succinct. Thank you.
How can we follow a low-carb diet (as gluten and starch are proven to be some of the strongest triggers of inflammation and disease) while avoiding meat and still getting enough high-quality protein?
I thought this Aswell because I’m on my strength training journey & I keep being told repeatedly I need 140g of protein per day to grow muscle but I started studying blue-zones and they just don’t eat alot of meat period. So I guess since this podcast is specifically about longevity and not necessarily strength or being crazy fit then I think minimal amounts of protein is what’s consumed. So I’m guessing from plants and beans is where protein is taken from
This was a fantastic episode. Just sharing my notes here.
Main takeaways:
1- Eat less often.
2- Avoid sugary drinks and foods.
3- Reduce meat intake for longevity.
4- Its never too late for dietary changes.
5- Find veggies that have been stressed out (organic, colorful veggies)
6-Never start a meal with sugars, if you do eat them at last (desert).
EAT LESS OFTEN
-There is a genetic pathway that gets triggered by low energy. These genes (sirtuins) respond to low energy (low glucose levels-caloric restriction), high heat, low amino acids, high salt (stressors). -----They take care of the DNA repair and the stabilization of the epigenome.
-When the body is hungry, the body makes NAD (fuel for the sirtuins).
-Two ways to activate sirtuins synthetically:
1) Use some molecules
2) NAD booster.
Longevity genes:
Mtor: protein that registers amino acids. Allows the cell to build things. Not a recipe for longevity. Activates autophagy.
Ampk: goes up when hungry. Makes more mitochondria (important for making energy)
Sirtuins
Fasting:
- Metformin: mimics fasting.
- Time Restricted Feeding: At least 16 hours.
- Liver compensates for the lack of food. Glucose neo-genesis. It overcomes the feeling of hunger. The liver starts making glucose at a steady level.
Sugar: big killer. It spikes glucose. Glucose shut down sirtuins and ampk. Defenses against diseases and aging shut down.
Protein: we should avoid high protein red meat diet for longevity. It inhibits mtor.
Amino acids: three important. Leucine, isoleucine, and valine: BCAAs. Are used to sense protein intake. The sensor is mtor. The mtor activates when you get them. Mtor repairs and build muscle. In the short run, this is good for building muscle etc. But in the long run, mtor is the responsible for autophagy, which is key to longevity.
Plant based diets: the more vegetarian you are, the longer you live. The best, Okinawa diet, is plant base diet with fish - (probably because of Essential fatty acids)
Humans grew COLD and HUNGRY. Now we live at warm houses with food available all the time.
Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich
Thank you
Bro you awesome
Great summary ! Awesome!
Awesome breakdown! Thank you!
I think you’ve missed out the part that why stressed out plant is better. 😄
He says he eats one meal a day and he shed his weight and got his 20-year-old body back. This is what happened to me. I am 70. I was getting obese. I heard of intermittent fasting and said: what the heck. so coffee for breakfast and then I ate whatever I wanted once a day. It could be ice cream, pizza, whatever. And if I was starving I had a handful of raisins or a cup of tea with honey. Not only did the weight come off, but my whole figure returned. I had no flab. I did no do exercise. I happened to go to the doctor for something and he said he never saw anyone my age so healthy. So this is all true. Shocking. I've gained some weight due to being a bit depressed over world events, but when Spring comes I'll start again. I do have a dog, so I do walk a lot, and climb stairs. Try it. It is fantastic.
Don't worry about things you cannot control, like world events. It's unhealthy.
It’s understandable to be worried about world events,I can relate and if you are not concerned I would question that 😃 but yes we do need to find a way to mitigate that worry/stress for ourselves.
Just curious about drinking the athletic greens in the morning- wouldn’t that be considered a meal?
@@cindyhathaway6571 good question. Athletic Green does not increase insulin, so it does not break a fast. I take lemon water, apple cider vinegar and green tea when i m on fast. Just careful you dont add sugar of any kind.
@@maurameadesperry1715 no, you absolutely are unhealthy worrying about world events. It has nothing to do with you and you are creating stress on the body for absolutely no reason. What is the point of worrying about something you can do nothing about? Do you thinks monks, yogis, Amish etc...people living in the outskirts of the media crap have the stress levels you have? I guarantee they don't.
I got introduced to David Sinclair through the Lex Fridman podcast and was impressed with his insights on health and nutrition. Looked up this podcast, listened to this episode, and immediately started a 20/4 fasting regimen which became an 18/6 regimen after about two weeks. After about a month and a half of consistently eating this way, I have dropped 3 inches in my waist and now fit into a pair of jeans I wasn’t able to wear since before the pandemic. My skin has cleared up from all the extra water intake, my energy levels have evened out, my ability to focus has skyrocketed, my severe bloating issues have disappeared, my keratosis pilaris has gone away, there are no more puffy bags under my eyes, and my mood has significantly lifted because of the increased confidence from all of the above. I just turned 40 and feel and look like I did in my 20’s. You truly saved my life, Dr. Sinclair! I will never stop eating this way.
Is it easier for the body to reach the fasting mode when de food is plant-based? Is it the same 12 hs of fasting for a Plant-based diet as the 16 hs for a meat-based diet?
Ok, ok...
yes it is easier and i experienced it once. Fruits and veggies, nuts and seeds(raw of course) have living energy on them and your body is electrical so they feed it with enzymes, vitamins, minerals and you need less food and meat is a dead food(death) so it only harm you because it has no living energy on it and you are taking the stress hormones of the animal and toxins@@Martin-bk3sp
3
@@LindaLee-su1pd16:39
I am a biology teacher. I have used many of these protocols on myself. It blows my mind to listen to the scientific research that is going on in this regard. I would definitely share this info with my students. Great work Dr Sinclair. Hats off
Llp0
what protocols..i havnt heard one
@@jadezee6316 May be routines was a better word ... but things like having less food in your tummy .... no sugars in the diet ..... fasting .... etc
Don't worry wasim I'm with you
@@amartyasharma2963 l
One of the best podcasts about living a long healthy life I’ve seen.
I'm 84 and wish food scientist's had found this fasting protocol years ago. I do a 24 hour fast once a week and I feel wonderful.
Anyway I can see a future where obesity will be a thing of the past but sadly not in my lifetime.
Good luck to all you wonderful
healthy people.
My God gives you more many years to come. you have a beautiful soul.
may you live long and healthy sire! God bless!
People been fasting since the biguining of time ..his protocol is what early man used to consume and not consume .
I mean even all religions of the world advice human beings to fast and abstain from eating too much ..
YOU ARE AWESOME!!
lol it's call starving my self for 24 hours fasting is what obese peopIe say
This podcast makes me know that there are people that genuinely care about humanity and want to see us all living, we’re fortunate to be able to watch this for free, I will definitely support the sponsors of this podcast, blessings in all your work 🙏🏻
Key takeaways:
• Cut-off artificial sugars (processed carbohydrates)
• Cut-off meat or atleast start reducing it from your diet. Meat lovers can switch to Mediterranean or Okinawan diet models.
• Practice intermittent fasting. Start with skipping breakfast and try to avoid snaking in between.
Tip 1- if its harder for you to practice I.F. then start drinking warm water, black coffee or green tea.
Tip 2- if its still hard then consume a handful of nuts (as they contain proteins and healthy fats) and wait for 20 minutes.
Tip 3- You can try natural sweeteners like stevia.
• Consume more colored vegetables and fruits. Go for organic if possible.
• Meal order- Consume proteins and vegetables first.
• Start doing strength training and walking
• For longevity, vegetarian and vegan diets are the best.
Thank you!!
Yes, just eat sheet and nuts all day , look like a Haggard white man, never enjoy anything, cover in fear....and live to 86 instead of 85 1/2. Meanwhile in Italy in Europe...a glass of wine a day, meats, pizza ...deserts...105 or above...easy and widespread....what is it with you white Americans cowering in guilt and fear...?
@@levondarratt787 Can these 105 year olds sprint? 😁
@@levondarratt787 I am vegan 20 years and fit as fuck and look many times younger than my age. I love my diet. Your microbiome changes gradually as you eat more plants. You won't even miss the trans fats, cholesterol and other toxic garbage in animal products after a few months of eating properly!
OMG to me it's so much less about the longevity. I like how I feel *now* . And this way of dieting is really *not hard* . Be honest: when was the last time you were hungry ...
"This podcast is about what the science says, not what's socially acceptable" - Sinclair
I love it, wish everything was like that
Agreed!😊
Thank you Dr. Sinclair. Appreciate your efforts.
I keep discovering that I had it right all along! Honestly this is how I have been eating and I was called a bad mom for not having sweet food laying around for my children and most days we would fast. We have never been sick. Now my children are all grownup man between the ages of 26-30 and once they left at age 18 to college they gained weight and ate terribly which affected their immune system but thankfully they are now getting back to what they learned while living at home. Our diet was basically like this: Monday-Friday we will have no breakfast, no snacks and eat a healthy lunch and a big heathy dinner and during the weekends we will have a big breakfast and a dinner and skip lunch. Great information in this channel! Love it
Bad mom for not teaching your kids terrible eating habits and not making them addicted to sugar like every other kid. Sweets aren't a treat, they're an addictive unhealthy drug that is ubiquitous and universally accepted.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
@@leandrog2785 I am a bad mom too. I remember my young son complaining about the healthy mean I had prepared... " why can't we eat normal food like everyone else?" Now he is a very healthy eating adult. My other son chose to eat all the food he was denied, mostly sugar. He is not in good health.
I live on coffee and sugar and have never been sick in the last 50 years. I had gained weight and started intermittent fasting and its like he said, the weight poured off and my 20 year old figure returned and I am 70. My doctor told me he never saw anyone so healthy. Go figure. I am the worst eater you could ever see. Glad to finally hear this. I don't eat meat, don't like food, eat junk. But do love fruit and salad and mostly eat those. :)
just sharing.
esp if it's all plant sludge humans don't have the physical digestive system for plants
esp if they claim it's healthy
sounds like acquired mentaI iIIness...
This was absolutely EXCELLENT!! At almost 62 and watching co-workers & friends who are around my age, pass away from various causes (often age related illnesses) has really alerted me to my own health and mortality.
I don't want to succumb to illnesses or to die young. Nor do I want to age and be sick throughout those last years....for myself or for my family to watch me suffer.
Dr Sinclair...bless you for sharing your knowledge, your insights, your recommendations and for showing us, that regardless of our stage/age in life, we can help ourselves. 😊 💞
yeah they're eating a plant based diet aka SADiet which is no different then the vegan plant sludge diet
@@theantiveganchannel3596 rude and wrong :(
My story in a nutshell: People told me to eat more (3 times), you’re malnourished, but I’m not hungry! So I did, weight and cholesterol went through the roof. 2 years ago I went back to my old ways reinforced by the ideas presented here. Steak and veggies OMAD, every day. All my blood tests checked out and I feel great again. Best part, I lost 45 pounds in those two years. I’m winning at soccer games easily too 😁.
First time listening to and watching Dr. Sinclair, and I really like his down to earth, not dogmatic, approach to all this stuff. Love how he is willing to admit that he still loves meat and is not all that motivated. Very refreshing.
Is being human
yeah because it's a Ieftist mentaI iIIness to love plants citing humans Don't have a physical digestive system for plants
@@theantiveganchannel3596 😂 haha OK buddy, I'm sure you know more than the leading expert who has spent his life studying this
Ditto, so nonjudgmental. We’re all human, of course we all want cake and a steak… but…
@@BloomByCC you can have your cake and steak whenever you want; just eat a lot of fiber and an anti-inflammatory brew or smoothie before you eat them to lessen their bad effects
I have begun to skip breakfast and dinner: one meal about three p.m. or later. That's fantastic.
In the morning only 1 spoon of olive oil and vitamins C, D3, B and k2 mk7.
Thank you dr. Sinclair.
Wonderful presentation! I have been following a low carb Mediterranean style diet in combination with time restricted eating (limit my feeding window to 2-3 hours each day and will do a 72 hour fast on average around once a month). While it is a challenge to consume all my food in this window, I have worked it into a routine where I prepare and consume a large, very varied multi-colored vegetable salad supplemented with some nuts and seeds and a small amount of goat or sheep cheese in combination with whatever vegetables and proteins that my wife has prepared for dinner. I do apply a large amount of EVOO/vinegar with a combination of herbs and spices high in polyphenol content to my kickoff salad. I use a very high quality aged balsamic and a homemade apple cider vinegar. Some people find it repulsive, but I ferment my own apple cider vinegar mainly for the scoby and mother content (I do consume the minced up scoby in my salads). I will also include a can of anchovies or sardines 2 or 3 times a week. I realize that I am a cohort of 1, but my results in the past 18 months have been miraculous. I’ve lost almost 80 pounds, brought my A1C down from 8.9 to 5.4, eliminated what I had been describing as the aches and pains of getting older. To state it as short as I can - I feel younger now than I did 20 years ago. This is very doable. I’m not a zealot and do fall off while on vacation or dining out at or with friends. In those situations, I will consume whatever is placed before me. I do avoid sweets most of the time, but will enjoy celebratory confections (birthday, anniversary, wedding, …) out or superstition and/or respect. I never want to be put in a position where those around me get the feeling that I’m trying to shame anyone. I find that people become very interested in my journey and just maybe might be encouraged to experiment on their own. Case in point - beside close family and friends, I’ve gotten the attention of my GP, oncologist, surgeon, eye doctor, and the guy who has cut my hair for the past 40 years. They all spend most of our visits asking what changes I’ve made because of the dramatic health improvements I am experiencing. I am off all previous meds (diabetes, thyroid, hypertension), my hair is filling in, and my GP commented during my last visit that I should write a book if I manage to maintain my progress over the long haul. I simply chuckled at him and said “There are already hundreds of these books out there - we just have to get people to read them!” 😊😊😊
Absolutely brilliant progress, happy for you to manage to go through the initial phase of chnaging your lifestyle 👏👏👏👏👌👌👌👌😄😄😄😄😄😄
I started my daily time-restricted eating journey about 2 years ago. Dropped from high 80 kg to stabilise mid 60 kg currently.
I'm dirt poor and can't afford supplements, but at 76 I now feel much more healthy.
The only downside is I now have way too much skin and need cosmetic surgery. My wife hates 'the new me' from looks alone and is constantly doing her best to 'feed me up'. I try not to offended her by refusing, but always end up feeling uncomfortable afterwards, but it hasn't significantly affected my weight coz I just resume my regime when she's not there, which fortunately is often as she's a nurse.
If I had enough money, I'd be doing everything Sinclair recommends.
I've always bounced in and out of exercising and eating well, taking my relatively healthy body for granted. Dr Sinclair's very easy to understand advice has given me the motivation to make permanent healthier habits for nutrition and lifestyle. Delaying aging by 8 or 10 years was the motivation I needed!
I think we are extremely lucky to have podcasts like this.
Thank you for your work 🙏
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I have been doing what this guy says for the past 3 years + without even knowing about his existence, found him out in Andrew Hubberman's podcast. I eat once a day (giving at least 16 hrs of fast) and fast once a week 24 hrs and sometimes for longer.
I used to be always sick and tired all the time since kid. It's been 3 years + I don't get sick, I did a full blood and hormonal pack exam test and all my stats are on the optimal spectrum, my testosterone is at its peak and I feel great, full of energy and mind clear.
I'm basically watching his videos and learning more + confirming what I discovered by trial and error by myself and I trust 100% this man is correct. I'll die fasting, restricting calories and avoid processed shit.
There are entire industries draining people's mental and physical health but thankfully I got out of this and we have blessed people like this guy to come out and publicly provide the population with this life changing knowledge. Success for you Dr. David.
My journey is about a year now & after my blood tests have been done abroad & my cardiologist confirmed my 2 BP tablets and wanted to write them down for 2 weeks & to post to him what's up, when I came back home to London.
An amazing thing happened last One month ago, I stopped taking my tablets to cause my Blood Pressure reading was 111 68 90 but I have my beta blogger tablet to take twice a day to lower my heartbeats🤗🤗
That's my new blood pressure reading. I've watched my Blood Pressure during the day & was always less than the recommended Numbers eg :120 75 85 heart rate. I don't know what had helped me 🤗
NMN AM & Resveratrol PM around 3 pm with the meal,
I don't know. I take low dose NMN & RSVTL now.& plus X3 times week quercetin.
But 3x NMN 500 mg &Resveratrol x3 times 500 mg.
Rest is 250 mg daily all the supplements.
🤗🌅🌸💊
Thanks to our💊💊Doctor
& Hope All goes well.
I will keep sharing changes in my body from here or from other social media
Lots of love from London🌅💕
From What's up.. correction..🙏🙏
This was the most amazing post ever for me personally ….because it also mimicked exactly what I also have been doing through my journey of trial & error & it helped recognize that …that in fact I have been on the right track ( when I was thinking I was not measuring up to some PERFECT journey of Intermittent fasting) Sinclair makes it simple ,clear, that is o.k. To not have to be rigid but always reaching for the closest goal of plant based & fasting as possible & not to beat yourself up if that is only 98% of the time. I have lost 50 lbs so far got stuck for along time in a plateau but lately have been successfully moving the scales again & this video has reinforced I am being successful. Found this video just at the right time.I am going to watch many more of Sinclair.
@@duaneannekensleyhoffman2377 Same here. I've loved combining IF, plant nutrition and smart supplements to get some incredible and lasting results.
So are you basically eating the same amount of calories you used to eat just crammed into 1 meal? I really want to give this a real attempt but the episode didn't really give any guidance on how many calories to eat or if there is a significant difference if we cut down to just 2 meals a day within a say 4 hour window vs doing just 1 meal.
I'm doing 4 hours of Zone 2 cardio a week, 1 hit session, and 2 weight sessions.
The co-host LaPlante is truly outstanding. He controls the flow of the conversation and is also very knowledgeable. This makes the videos outstanding.
I’ve never seen anyone have the same last name as me
@@connorlaplante9318 come spend a week in Montreal , you will meet a new Laplante every day :-)
Love listening to David...so wise and not arrogant. This is such a wealth of information, thank you! Fasting while maintaining nutrition is really the best way to improve many things, I have experienced first hand for myself! My red wine consumption isn't moderate like it should be but working on that :-)
I'm 54. I'm type 2 diabetic. I've been on a "journey" since January 2022. Today is October 28, 2022.
I am on a "keto-vore" diet - and OMAD since March.
I have done a lot of fasting over my lifetime - 10 day, 2 week, 3 week fasts at various times of my life. But, I haven't done much fasting in the last few 5 years or so.
In June, I decided I wanted to try a 30 day, water-only fast. The longest I'd ever done prior to that time was 22 days. I did the math and realized that if I wanted to finish a 30 day water-only fast before the holidays, I needed to build up to it and had to start right away.
In July, I completed a 2 week water-only fast. Then I ate for one week.
In August, I completed a 3 week water-only fast. Then I ate for two weeks.
In September I started my 30 day water-only fast. I completed it on October 5. I ate for 10 days - then did another 5 day water-only fast.
I have been eating since October 21. I am debating another 5 day fast next week.
Then I'll have two weeks of various "thanksgiving feasts" - and after the official Thanksgiving, I want to fast for 28 days before Christmas.
I never experienced the "pain" of hunger in my fasting experience because I always built up slowly. 3 days, 5, days, 1 week, 10 days, 2 weeks, 3 weeks, etc. - with healthy eating in between.
However, on my 30 day fast, I noticed that at day 24, I started feeling *strong* hunger. I actually started feeling the "pain" of hunger for the first time. I was dropping a pound a day at that point. (Yes, I took some supplementation and allowed some salt and pickle juice.)
It is definitely a mental game to fast. The first 3 days are always the hardest. After 3 days, the physical hunger goes away - but then the mental push to eat seems to strengthen. At 5 days, that diminishes. But, the brain keeps pushing to eat. It's a big mental game. You'll have thoughts like, "No doctor told you that you had to do this, why not have something light to eat?" Or "How bad could a little broth be?" Or, "Why not fry up an egg, no need to deprive yourself." Yes, actual thoughts, in my head, pushing me to eat.
At this point, I feel *better* when I'm fasted. I sleep better. My body feels better. I have more energy (though it's shorter lived and I have to learn how to pace myself). I think much more clearly.
Everyone who knows me comments about how much younger I look since I've been on this journey. My blood sugars while fasting (I was off my diabetic meds) were consistently between 86 and 100. I stopped my Metformin because I was crashing into blood sugars of as low as 49. However, I've started a lower dosage now and I'll be taking it in my future fasts (at this lower dosage).
In February, having been sugar-free for a month, I asked another friend who has been on a similar journey, "When can I have sugar again?" He asked when my birthday was. It's in November. He said, "On your birthday, you can have sugar - and *only* on your birthday." I couldn't imagine living 9 more months without sugar.
Here I am, two weeks from my birthday and *I DO NOT WANT ANY SUGAR* - I'm actually a little afraid of having any. I have struggled beyond my sugar-addiction for 10 months. I do not want to fight those battles again. I have no plans to eat any sugar.
I want to encourage everyone that you can do this. You can get healthier. You can live longer. You can manage long-term fasting, OMAD, Intermittent Fasting, caloric restriction and time-restricted eating (there's some really interesting research on ETRF - early time-restricted feeding).
You can do this! :)
Fantastic episode! Thank you, thank you, thank you! 🙏🏼
Hey Teeqo, whatchu doing here bro?! Glad to see you’re interested in this😀
No way teeqoooo!
Thank you Dr. D. Sinclair and Mr. M. LaPlante ,a very interesting podcast discussion. Blessings be upon to all humanity for an awesome information.
This is a piece of gold, thanks for your work. The only problem is the way the interview is driven, interrupting all the time and moving to the next subject without giving time to the doctor to elaborate the answer. It's stressful and it fragments the information 😩
Watch it a few times and just relax.
It seems that in order to improve our health and longevity we need to put our body at the mercy of adversity regularly. Thanks for your outstanding insights!!!!
And yet my lack of health is WHY my body constantly faces adversity…
@@capatheist so true for me too, and that is why we crave the few comforts we have.
Following Dr Sinclairs work for a few years now and I really enjoy that he shares more about it on his youtube channel and obviously on Hubermans podcast. Thank you 🙏🏼
Same 🙏
Thank you for finally making things clear as the title is, for the average non scientist humans. What list can we take to the vitamin store and what list to the grocery store and the times to take them. Which vitamins have to be taken with other vitamins and/or fatty food etc. Thank you so much to both of you. Thank you David for bringing Mathew LaPlante onboard to ask the questions that normal people ask and doesn't back down until he has an answer that the normal person can take to the store with them or just use at home. Thanks guys.
I found Matthew irritating.
Matthew is not only irritating, he is distracting! David has to say often “Getting back to…” because of interruptions by Matthew. I say dump Matthew!; take a cue from Andrew Huberman, organize your material and present it. David’s talks are much easier to understand, and in less time.
I found Matthew obnoxious and distracting as well
Matthew is on for media growth. The average human are like Matthew, I also found him irritating but also find his simplistic thoughts to match what the average person could understand and be connected with the information coming in. Without Matthew the podcast would have way less rating. Sinclair I presume got the idea from joe rogans podcast average viewer
The list for the vitamin store is vitamine D + k2, omega 3 DHA 250mg EPA 125mg from algea instead of fish, B12 1000/2000 mg twice a week which now mostly comes with a 600 mg folate boost (5-methylfolate NOT! folic acid). And if you like some creatine. That is it for vitamines. Check your bloodwork wether zink or magnesium might be relevant to you.
Thank you Dr. Sinclair for finally having a youtube channel and everything you have given to this world.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Absolutely amazing, as always! David Sinclair is a genius, and he's literally changing our species for the better. So grateful
Why? its already written in the Bible. Long before the discovery of science.
Do you know what is the natural food to us humans? Lol, only this so called geniuses greedy people made human being live a shorter life. Just ask a doctor any doctor if our food is safe to eat Lol.
@@BawikYT What do you do for a living? How old are you? Have you gone to college? What have you studied on your own?
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
@@lipstick318
Wouldn’t worry about it because once the Holographic Med Beds come out everyone on planet earth will live beyond 100 in very good health. Don’t go to google to look this up as they are corrupt and Big Tech, Big Pharma, Bankers, All Royals around the world, Vatican etc is being taken out
Love your information. I have been eating 2 meals a day for 6 months, no snacks, no sugar, minimal startchy carbs. Love it.
I work hard to keep my children at an absolute minimal sugar intake and junk and processed food. Can you speak more about what would be good for our children in regards to fasting or just in general what kind of food timing and regiment would be healthier for them? Would love an episode on childrens nutrition.
With Sugar you mean refined Sugar or Carbohydrates? Thanks in common 🙏🏼
@@strongman744 yes refined sugars and I limit my carbohydrates. My kids are not as strict of course and they do eat all food groups.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Just a note.The Okinawans eat mostly starch based plant based diet and some fish and the carnivore diet is not best for longevity
@Marina E not so much when the study was done,simply no meat available
Thanks!
Waited the whole week for this episode!
What he's saying about Xeno-Hormesis is 100% true! My father always told me that the grapes from dryer climates always produced better wine. And, when we would plant the family garden, my father would tell me not to water the plants too frequently or they would taste worse. And he's right!
This is good information, thank you👌
Oh thank God! How could I just believe the word of a professor at harvard without you and your father guaranteeing for it
@lol yeah I know and I'm thankful
Argentinan wines 💪🏻
@@Couchlover47 ☹️
Really enjoying the science. I've been fasting since 1978. I'm 62; folks would swear I'm in my 40's. I feel great, seldom tire and never,ever get sick. When we came in and said, "I'm hungry" Momma would say, "Well jump up and catch a Kungry " .😅🤣 I grew up on my family hundred acre farm in South Carolina. We played in the sunshine all day and ate wild plums, berries, sour grass and pecans. Meals were veggies from our garden, rice and meat from our farm. Evening snacks were boiled or roasted peanuts or baked sweet potatoes. Desert was not every meal, peach cobbler in season, cake or pie on Sunday, from scratch. We ran to the other side of the property to see grandma so many times a day, without a 2nd thought.
What is a Kungry? ❤️
@@JLBiddle Haha, I looked it up. Nothing real. Just meant to say, stay hungry until dinner.
@@delphinekirkland1757 That's Cute! ❤️
Where was this...Mayberry? Were ma and pa cousins?
@@cluman1 Actually, I live closer to Mayberry now than I did then, haha. Not just where but when? This was the mid-1960's in the backcountry of the low-country, small town, rural South Carolina, many miles south of Mayberry!
However, we raised our kids similarly in rural PA on a homestead, as far as the level of healthy, fresh foods go. And though my daughter's don't grow their own food, and one lives in the city of Stockholm and the other Quanajuato, they still feed their children this way. I come from an unbroken chain of rural folk; still live in the country and eat the food I grow.
Good sound sensible advice and information thanks Dr Sinclair. My wife and I intuitively decided to cut back to 2 meals per day about 2 weeks ago and we have both lost weight but not been hungry. Cut out all bread, pastries, cakes and processed food. Increased salads, vegetables, fish and a little chicken. Cut out all red meat. We both have more energy and look better. No puffiness or fluid retention. And a bonus is my wife's arthritis in her knee has lost the swelling and she is walking easier.
did the science show humans don't have a physical digestive system for plants?
@@theantiveganchannel3596 why would it? Humans can digest plants just fine. Humans evolved from herbivores. Our ancestors were definitely plant eaters.
It's so valuable to be learning this on the side of doing a molecular biology degree. All this knowledge and insight is greatly beneficial to my focus. Thank you!
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I just want to thank you gentleman. As a parent who is newly looking to transform the health of myself and my daughter, I am overwhelmed with gratitude for the information shared here. Definitely subscribed and look forward to what else I learn her. Truly, thank you so much!
I listened to this a second time and took notes, so I can understand the mechanisms better, and so I can create for myself a more visual representation of it all. Thank you for this podcast!
You can also go to the video and the three little dots to the bottom right of the video click on that and read or download the transcript by copying and pasting it into a document.:-)
Can you share it with us in any way please?
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
By far the best anti-aging health lifestyle information available on RUclips 💡
Eat to beat disease Dr William Li .
Andrew Huberman also.
Beautiful. I’m inspired to make further adjustments, based on my own needs and measurements. How awesome.
I’ve moved through a number of dietary changes in my life-I’m 51 now. In my 20’s I was almost vegan except for butter and some cheese.
Went Westin A Price at age 30. Paleo at age 40. IF and keto at age 45. Ate meat and eggs almost daily while doing keto. Dropped the keto 2 or 3 years ago, and my eating window not as wide.
Now the gears are moving in my head about how best to move forward.
As a biochemist, I am amazed of this channel. I've been following Dr. Sinclair for quite a while now and can for sure say he is top notch. IF mixed witha medit. diet is the way to go. Greetings from Germany!
Keto is proven the way to go. A complete vegetarian diet is bad advice we need protein and not to mention a lot of vegetable have lectins esp night shade.
I’ve done 7 day fasts with just liquids- water, tea, Chinese herbs cooked down- and I do exercise like swimming and biking- the first 3 days are challenging but after my body gets used to it and my hunger comes and goes quickly without being as severe plus my thoughts get very clear and I feel like I have more energy.
For all the cynics out there. You guys need to define fasting or intermittent fasting a bit more. Couple of spoonfuls of yogurt first thing in the morning or Athletic Greens in the morning is technically breaking the fast. Love everything you guys are doing!
Sooo happy you finally launched your podcast/RUclips channel. Read your book “Lifespan” and it changed my life. This medium is ideal for getting millennials/GenZ on board. Hats off!
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Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Dear Dr Sinclair, this is one of the best channel about science and health. I am a cardiologist foccused in longevity and anti aging and you so thanks for all you trials and experience!
Lol. Trolls in the comments
This is similar to the Huberman podcast. I love it and going to love this too.
Thank you for your research and your time in bringing us this valuable information! At 65, I've done a lot of things wrong over the years, even though I knew better! But, I'm excited to know that it's never too late to reestablish better lifestyle and dietary habits that may help make a difference, in my lifespan, going forward!
did the doctor fail basic human anatomy ? where are the human digestive organs for plant sludge he is claim is healthy
Fascinating talk, I wanted to share one farmer I know in the Bay Area who specializes in dry farmed tomatoes. He literally doesn’t water his tomatoes, he grows them in Davenport CA where it’s quite foggy and it results in a more stressed plant (as mentioned around 57:30 is a thing to revere). If you’re in the Bay Area, try out Two Dog Farms, they really are phenomenal.
Excellent podcast. I have a background in neuroscience and have always been passionate about nutrition and exercise. This is the best accessible information I’ve come across in 15 years!
Do you know him ?
It’s full of fallacy and he is a great salesmen. He’s got so many things twisted around to support his products. Example Reveratol - proven to add to toxin load. He sells it. Also check out PUFA oils. So much science coming out , they are the problem not fruit or rice.
@@kaylabryson1932 is he also marketing Metformin
David - I would love to see you talk about the ancient traditions and their take on longevity - the Daoist alchemists, Yogic ascetics and so on. It's a fascinating thing because so much of what they said thousands of years ago is mapping perfectly onto cutting edge research today. (I'm not advocating an esoteric approach here because hey...they did also advocate some insane practices like mercury ingestion, just pointing out how interesting it is)
it is crazy to think for meditation, breath work and fasting are new and groundbreaking science
@@kashkoven4636 finally science catch up with ancient traditions!
Science originated from these regions. University’s, Astrology, Mathematics etc. Astonishing that Western education always downplays this fact.
@Evolving_Soul yes.. but increaseed sensitivity is not recomended for the normal garbage/stress self centered lives modern people live today. to make yourseelf more sensitive and then put yourself into this society would most likely make you worse rather than better from the exposure to toxic stress and toxic people that you will feel to a greater extent. the part that people are missing is that the yogis also simplified thir lives to a bare min.. did not try to eat nothing then do all the garbage the modern person does.
18:39 I really appreciated this statement because it's clear Dr. Sinclair isn't trying to persuade anyone to do anything...he's just providing the information and we are advised to make our own decisions. Great episode.
David, thank you so much! I read you book last August and it changed my life style in a big way, I started watching video from other scientists about nutrition, eating, metaboli… I gave up sugar almost completed, I’ve been taking cold shower since, I eat once or twice a day now, working out about five days a week… I have one question for you, for your plant based diet, what is your main protein source, do you eat a lot of beans to get protein? Thank you!
Ron, even tho you didn't ask me to answer your question, I'll recommend that you vary your protein sources. I eat raw, organic nuts, and nut butters. Lentils are great, chickpeas, and quinoa as well as beans. The nuts also contain healthy, beneficial fats. Remember to store all nuts in the refrigerator, and eat them while their oils are fresh. I also love a nice piece of mahi mahi. Best to you!!
David Sinclair is so awesome! I love his sense of humor besides all the research he's sharing!
I’ve been following this protocol for almost 30 years. I look and feel decades younger. I’m perfectly healthy.
Thank you for sharing this incredible information. Would love to learn more about adding the right supplements to my life.
Fantastic! I'm aggressive about living longer and am so glad I found your book and the podcasts! I feel hope for the first time. Also, love that you are bringing the information directly to us! Please never stop!
Great tips! I actually love intermittent fasting, before starting I remember I had a few days when I ate very low in sugar, then I started eating only once or twice a day, usually between 3pm-8pm. There are very few days when I actually feel hunger. Also, focusing on anything is so much easier.
We are on the same page.
The feelings and the energy is like nothing else provided by junk food.
I’m loving life more than ever .
IF literally saved my life....I feel things and energy I never have felt possible before...amazing method of conscious eating...
So what are the supplements he takes (or better versions) and what quantities? What can I do if I'm on a budget?
@@MrCijuciju me to i always have energy now!
Same her. I’ve been doing it about 4 months and lost nearly 15 lbs. When I do eat, my main meals are high protein to ward off cravings.
Coffee in the morning. Chewing tobacco all day. Drink clean water with lemon. Huge salad at 10 pm. Eat fish or steak with salad. I dropped 60bs in 5 weeks, and it's not the first time I did it. I also use ON protein in the past. I love this new knowledge the Dr. has. Starvation, pain and suffering = clarity, peacefulness and knowing who you are and where your going!
Chewing tobacco leads to oral cancer. Be careful
Thank you so much for these videos! I really appreciate educators, scientists, and doctors that make their knowledge accessible to the general population. The science you present has changed my life.
Thank you so much for sharing all of this information on what a proper, healthy, life saving diet should consist of. I eat up (no pun intended haha) all the info. I can on diet and nutrition, however there is so much contradiction between the different popular diets out there and what’s trending this week that it’s super confusing and frustrating and easy to just give up. I’m grateful for your knowledge and expertise. I’m intrigued with all you’ve shared and excited for what the future holds for each one of us.
Very interesting. Thank you for making this available on RUclips.
There is one thing that remains hazy to me, it's the recommended daily calorie intake. Your body has to "feel" hungry , but you still have to provide it with the necessary calories (whenever you choose to take them) to go through 24 hours and meet your energy needs. Surely you don't want to go below your BMR.
So, how do you calculate this intake?
Also, by reducing the number of meals to only one, you make it more difficult to cram into this unique meal all the variety of vitamins, minerals etc... you body requires, and you have to take supplements - as you do, in the mornings. You become highly dependent on these supplements. What happens if you suddenly don't have access to them, for a prolonged period of time? Do you revert to more meals per day , and does you body remember how to "extract" those elements from actual food?
Take care
So happy you have created a youtube channel David!! Such an amazing gift to share. I went plant based about three years ago, then I kind of fell into IF. I found it easy to go to 16/8 but now I am 20/4. Thank god, working from home now, its kept pandemic weight off. Im almost 60. I lost my meno weight, leaned out and maintain my muscle mass by doing regular Ashtanga. still doing dropbacks and handstands. brain fog gone, IBS gone. also no more jet lag from long flights. I really get an instant feedback loop on what causes inflammation in my body, and when I avoid those foods, I feel immortal most days, like I used to in my twenties. its all amazing except my sleep. that is still a crap shoot.
In lmk k m mp
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
LOL if you had a proper dinner with starchy carbs at night, you would be able to sleep like a baby, thanks to butyrate.
Fern why the LOL? How do you know what I eat? I eat a ton of carbs. But thanks for the unasked for direction with no information
Hi! Andrew Huberman has a great podcast episode on sleep that looks at the whole circadian rhythm. I found it both illuminating and practical.
This is such a useful and pleasant format! I am enjoying getting to see how Matthew La Plant thinks, organizes and interacts with David. I hope. you decide to continue this series for another 30 or more episodes. If you would like some questions and feedback on your first two intros presenting your donors, just ask. A few modifications might work better. I had a radio show and know how difficult it is to read ads. If I knew I would live another 50 good years, I would start my neurology, biology, etc. courses. This is so very thrilling!
You said you drink athletic greens every morning
Then eat a lg dinner meal
Then eat nuts
???
That's not intermittent fasting is it?
Great episode. I've understood all the things you can do to live longer. I am interested if the studies are focusing mainly on how to live longer or on how to live longer and have a good quality of life by doing things important to you? Probably it is easier to live longer if you have a simple relaxed life and just walk around and enjoy yourself, but what if you have to have a very active life : doing intellectual work in the mornings, doing intensive sports in the afternoons , social life...etc ...then how can you put all food in one meal, and all the other things focusing mainly on living longer???
So , is the research taking into consideration the diversity of professions and their needs to function at their best ?
David this knowledge and wisdom from your research that you’re giving away for free is an absolute blessing I hope people realize that because many people that truly understand life realize like you that the way things were given and blessed to you you bless others with
can’t wait to hear this podcast
It‘s really great to having co-host Matthew here, he helps me to understand much better, thank you!
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I back you up 100% I started doing intermittent fasting because an interview you did, whaat you shared made some much sense that I started right away, I skip breakfast and lunch and I have my first meal around 6 pm, now I can tell you that I have never felt better in my entire life, I used to suffer from irritable bowel syndrome and gastritis, and I’m 100% cured with not medication whatsoever, just fasting and exercise, it is amazing to have the science behind it, thanks David for sharing your research ❤️
I suffer from irretable bowel syndrome and gastritis, I'm very skinny.
Always sick, I would like to do intermittent fasting to feel better but don't want to loose weight
Hi David! Great episode!
I've been doing 16/8 fasting since 2009 but is doing 18/6 since I started following you. I am also a glaucoma suspect and your research has given me so much hope and less worrying.
I have two questions:
1. Meat is just slightly higher in BCAA per 100 gram of protein than, fish, chicken, low-fat cottage cheese and whey. Even soy, lentils and quinoa are almost as high in BCAA. Would eating a more plant-based diet still be beneficial if BCAA is still high? I need to get my protein from somewhere. I am an amateur weightlifter but also care about longevity.
2. You mentioned limit fructose. What about whole fruits? I eat a lot of both fruit and green leafy veggies.
Thanks!
A lot
Of comments around this question, Sinclair you should
Make an episode focused on Muscle and longevity, no one has done so
@@aibutttickler My understanding is that blending fruits includes the fiber so is good, whereas juicing removes most of the beneficial fiber.
From my standpoint I believe that the issue of meat is not only the high amount of bcaa (which activates mTOR) but also the substances that are toxic for us and causes cardiovascular diseases... But are just my thoughts about it..
Fruit will lead you to diabetes.
@@ntrelis wtf🤣
Would love a little more info on fasting times for women of reproductive age. I'm 34 and have been doing 14 hour fasts sometimes can stretch to 15 but it's pretty difficult. I am breastfeeding a 2 year old although it's really for comfort not food so I'm not too worried about that, but also have a short menstruation cycle ~21-23 days and would like to try get pregnant again in the next year. I always wake up hungry and I'm waiting to eat at 9am instead of 6/7... If I make dinner any earlier I'll be eating at 430 and might get too hungry to sleep. I've seen lots of articles but not peer reviewed about how fasts have been studied more on men and give men energy bc they evolved to get energy from starvation to be motivated to hunt. For women I read we just hold onto fat to preserve pregnancy/milk production/periods etc. This is such an awesome podcast but like some others it would be so awesome to hear a little more about actual biological sex differences.
100 % agreed!
It's an Interesting topic to bring up for sure.
These aren’t really fasts. 14-15 hours that is . Try to push to a day, say on a Sunday with a holiday after a few times a year.
🌷
If you look up doctor Mindy Pelz she has an entire channel dedicated to women and fasting. Essentially the best way to fast is working with your cycle. So I fast for as long as I can on days 1-20 of my cycle (starting the day after I begin my period), low carb, higher fat. After we hit the luteal phase (10 days before your period until you get your period, but especially the week leading up to your period), don’t fast as hard and up your carbs. This way you can maintain the benefits of fasting but still keep your hormones happy and functional. So if I’m fasting normally I might do 18-6 or even 20-4, but on the days leading up to my period I try not to fast more than 16-8 and sometimes even have breakfast if I’m ultras hungry that day. I used to fast way too hard/without breaks/no carbs and my hormones tanked really quickly (lost period, major anxiety, extreme insomnia, irritability, panic attacks), and doing it this way really seems to fix that.
The cohost makes it even more interesting! Thank you!
I had been working graveyard shifts for 5 years so I ate differently then went back to a day schedule that was sedentary due to an injury. To say the least my body gained so much weight due to sleep eating and not being able to exercise like I used to. Thank you for the info. It's been hard trying to get back to a beneficial eating pattern!
So one meal a day did not work for you? I did not understand your comment, thx,
You may know already but night or shift work long-term is very detrimental to your long-term health. So much that it's classified as a carcinogen by the WHO. Dr Rhonda Patrick and numerous others have discussed it as well. Just FYI that it's not the day schedule part of your change that specifically made you more unhealthy.
were you eating the following foods: starches, homogenized milk (or products), seed oils or other isolated oils (including in processed foods)….?
@Street Fighter Indeed..!
Hi, I work a lot of night shifts for 8 years now. I am self teaching coding from online classes. My goal is to get out of night shifts in one year
I’ve read articles summarizing research that suggests increased NAD levels (from NMN supplements) may fuel tumor growth - specifically brain cancer. What say you, Dr. Sinclair?
Also, in an interview with Lewis Howes, Dr. Longo expressed concern about the possibility of intermittent fasting negatively affecting the heart/circulatory system. He also referenced research indicating a link between breakfast and positive health outcomes - with the inverse being true for people who don’t eat breakfast. Do you and Dr Longo have conflicting points of view about this? I’d love to hear your perspective, Dr. Sinclair!
We need more of these podcasts. Maybe Q&A.
It would be very interesting to find out if Dr. David Sinclair has done any research on some of "longevity foods" like: dark chocolate, honey (it is thought that bee keepers always live long), nuts, beans, mushrooms, garlic. turmeric, cinnamon. Also how to bridge between "eat less often" and well known "eat 5 servings of fruits or vegetables a day"? Witing for new podcast Q&A_001 🙂
Please cover when to workout during the Fasting window and when to feed following exercise. For your upcoming Sauna, Cold, exercise, show, please cover when is it best to exercise before cold, or heat or after? Any relationship with Heat Shock proteins, fasting, exercise, feeding and timing? Thank you! Great talk and questions!
Work out after eating if you want better athletic performance. Fasted workouts are just plain harder and you don't get as much improvement. But fasted exercise MIGHT be better for weight loss (if you can burn as many calories, which I never can....I can't even work out before breakfast without feeling beaten with a 2x4).
Also, sauna AFTER exercise is great. But you can do it whenever. No cold until your body as totally cooled off or you'll throw away effects of exercise. If you want to do contrast, don't do it right after exercise.
Perfect investment. Great dialogue. Question: for competitive athletes (I'm 62, train 10 hours a week, have a BMI under 20, a RHR of 48, and I do struggle a little with moderate systolic BP/in the 135-140 range) how do we eat? I'm burning tons of calories, and need energy to train, so where's the balance? What's a good reco? Do we just eat more and hydrate more than a person who doesn't?
Curious
What about oxalates contained in greens, nuts and vegetables ?
Vitamin k2
@@federicoboldrin8912 Eat citrus to combat these eg lemons and limes.
My #1 rule for health is "NEVER eat after sundown." Per Dr. Satchin Panda that causes massive inflammation that doesn't get resolved until the next day. He also said that given a choice between eating bad /unhealthy food during the day or nutritious food in the evening, it is better to eat during the day because "eating late turns even nutritious food into junk."
I told this to a stranger on a golf course a year ago. A month later he saw me at the golf course and told me that he had stopped eating after sundown (he overhead me talking about this with others). he said he was 73 and a LONG time Type 2 diabetic andoften taking insulin. He said he decided to change "just one thing". he confessed that he was, as before, still cheating on the diabetes diet even drinking some beer and wine on occasion. He then said that his AM glucose that morning was 78 and he "hadn't seen such a low number in a very long time." He saw a downturn of his am glucose reading within the first week. And that's all he had changed.
Another man that I know of, was morbidly obese (nearly 300 lbs) and out of desperation he decided to never eat after 6PM. he didn't know of the above but was frustrated that he had no self-control. He also decided to drink more water and he started to crave it. He lost almost one-third of his body weight in 12 months with just these two changes. And he confessed that he was still eating his favorite snack: donuts.
True story from an old man who turned his health around with time-restricted eating, intermittent fasting, a few multi-day fasts and "NEver eating after sundown."
This is supported by the Vedas. In Ayerveda we are asked to fast after sundown and try to go to bed by 10pm ( for body & mind to detox and regenerate) . Upon waking at sun up - scrape the tongue to remove trash 🙏
I follow the 16-8 protocol for years now and I'm trying the extended version of it)(20-4)more or less like suggested by doc sinclair currently... It's is quite tough to get into it - I can definetly agree to the fact that sufficient drinking is key to magae hunger until the evening! I'm currently evaluating whether the effects (caloric deficit, focus, and longterm health befits) are worth and doable the effort. Love this kind of scientic and life hacking content! 😁
Yes , intermitent fastic 16-8🙏
Love watching you guys! I've been a vegetarian since '75, I'm 51yo, glad to
see the science behind the morality
So you’ve been a vegetarian since you were four years old?
This was so great. Thank you so much, I have learned quite a lot of helpful information! Both the Host and the Doctor are highly intelligent and have a sense of humor. I will return next week. Joy, Peace!!!
I thought David would've gone into more depth than he has in his previous podcast episodes with other hosts, but it seems to be the safe information. Would've been nice for more detail on, for example, cooked vs raw vegetables, what he specifically eats to get enough calories in such a small window, etc. I know people have been asking him these things for a while and he continues to dodge for whatever reason.
I totally agree with you. Its not clear to me how fructose and glucose are so bad if vegan is the way to go. At least half of the food vegans are eating are high in both of them. Did he thought on refined sugars?
I would've appreciated a deeper look at this topic, too. I mean it's great he does this podcast :) but what he says in this episode was stated by him (and others) quite often. Would've been great if he talks more about studies and what makes them good/bad etc. and discuss some of the conflicting informations regarding healthy eating (e.g. walter longo states that skipping breakfast might be detrimental).
Leo and Longevity is far better for this kind of content. Sinclair shouldn't be viewed as more than somebody who can spread the word.
@@juliusmotocikli Frankly you need to understand the difference between glucose and a carbohydrate. The latter is not just a glucose molecule but bound to other element where it takes much longer to release. Also the latter mostly contains fiber slowing down digestion and absorption. This is why the glycemic index needs to be combined with glycemic load to see the real impact on your blood glucose levels.
For frustose he means refined fructose in the sense of fructose corn syrup. Where fructose found in fruit actually does not overload the liver shown in studies and does not cause fatty liver disease. This again is due to slower and constant release and the combination with fiber. Where the liver can offload excess of fructose to fiber in the gut. But if you do not eat fiber it will have to process all of the frutose digested.
So it is really refined versus naturally occuring. Refined is bad guy, the natural occuring has mechanisms in our system to regulated and slow down absorption or prevent over excessive absorption. Same for Iron where heme-iron is absorpted fully where non-heme iron is only absorbed to the amount we need. Downside need to eat non-heme iron rich food regularly, upside no oxidative stress from the heme-iron overflow.
@@juliusmotocikli I agree, - overall content doesn't gel, or make much sense to me, either.🙄 but maybe he'll improve with age haha... no pun intended.😅 (meaning, he's fairly new to the podcast scene, so maybe his narrative will improve as he goes).
So far, IMO, he doesn't seem to be communicating like the serious and accomplished scientist I know he is.
Still, however, he is very well-intentioned. I'm definitely subscribing, precisely because he is not confirming my protein (animal) bias at all, and its infuriating 😅.
I want to make sure I don't try to stay comfortably within my own biases when choosing who or what I l listen to - no growth there!
My great grandfather lived 110 years with no diseases and he was active till the last day of his life. He followed an Arab lifestyle, eating mainly dates, olive oil, with milk, and lamb meat from time to time, their bread was from unrefined Barely, and they were usually mixing dates with olive oil. But the most important he eats less always, as a lifestyle.
You can restrict calories without killing innocent animals.
@@pinkiepinkster8395 I said from time to time. Maybe a few times a year. People need to consume that amount from time to time or they will die and get ill.
@@pinkiepinkster8395 we need the nutrition.
Especially women.
@@pinkiepinkster8395 The point of the comment was to describe his great granddad's lifestyle. I don't think he was trying to restrict calories purposefully. There weren't much information on dieting and living longer back then, so he probably just ate what was available to him. I don't understand the judgement of an old person you don't even know about.
@@pinkiepinkster8395 very judgmental. Eating plants have impact on environment and plants are innocent life
Brilliant presentation Dr David Sinclair. Thank you so much for your eye opener studies on longevity. You're the best. I'm doing my utmost 👏👏👏
I had been listening to all your interviews...but this podcast is the ultimate one. It made everything super clear. Thank you Dr Sinclair.
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
I only eat on Saturday and Sunday now the rest of the week I fast water only . Life is so amazing I don’t have to worry about deciding what to eat during the week which frees me up to do so much more . I’m 62 and now can run better than I did 30 years ago and I look 20 years younger
holy mackerel; didn't know that was even possible
What do you gorge on the weekend?!?!
🤣🤣🤣
For how long have you been doing this?
When I first asked my friend who got me into fasting about being hungry, he said hunger is a feeling you can get comfortable with it.
You can retrain your brain. I literally forget to eat and only know I’m hungry when my chest starts rumbling and or roof of my mouth feels sore/dry even when drinking water
Sounds like the beginning of anorexia
When I started intermittent fasting, three weeks ago. I decided I'd be able to do the 8:16 approach, and a bunch of friends and I all started trying this at the same time(mutual support). Unlike my friends, I assumed I was in for a rough three or four days as I got used to the hunger periods. I was right. I got headaches, had very low energy, and honestly felt a little sick at times the first day. Fortunately I started at the beginning of 2 days off from work, so I wrote off that first day. By the second day, I felt a good bit better, though still was bothered by the hunger pangs. By the third day, I felt "normal" and have felt less and less hungry, even though I was not eating as many calories. I have also been eating better without really trying. Don't know if that's a benefit of fasting or I'm just paying more attention than I used to. Now I am eating far less than I used to and not feeling at all hungry until just before feeding time.
hunger goeas as your stomach shrinks, what this guy is selling on here is simply dangerous as people blindly follow withought consulting naturopath nor herbalist with a naive thinking dr sinclair said it online so it must be truth.. your bravurous behavior may have life threatening consequences long term which you will never link later with your actions on fasting.. he is not in position to advise people and is not doing that . he is just sharing his own experience and his research that has nothing zero nada to do with individual person in front of the computer !apart from bringing himself lucrative profits into his bank account selling pharmaceutical drugs as lollypops....to me he is another puppet of Jesuits
It's simply keto sickness withdrawal from sugar and carbohydrates literally like coming off heroin happened to me wen I went zero carb and only eat meat got sick puking , diarrhea,sweats,headaches it was horrible I couldn't believe sugar and carbs were similar to narcotics and can only wonder what they were doing to my body now I fast 20 hours a day and only eat animal products,gray hair went away ,my wrinkles are diminishing,more energy than a teenager and a libido like one , today like is getting better and better as time goes on and I always thought it got worse
You mentioned drinking AG in the morning. Is there no insulin response from doing that? I'm wondering because I am doing 20:4 but maybe I should drink it during the 4 hour eating window???? Your thoughts please?
Great episode! A couple of questions:
1. Any recommendations on types of fish (low toxic bioaccunulation, good fatty acid profile)?
2. Are lectins, phytates, and oxalates as bad as some claim? Steer clear of legumes, etc?
1. If you opt for fish choose the kind low in fat. Fat is where contaminanta are stored in fish so Tuna can contain alot of what we dump in the ocean. Rather opt for white fish with low fat content.
2. Only if you are hyper sensitive to lectines are these a problem. But you cannot eat legumes and beans raw anyway. Cooking them removes lectines from them. Even the biggest proponent of lectines Steven Gundry did a 180 on thus subject and now even advices them as long as you properly cook you grains and legumes. But like Sinclair says, opt for the protein sources that have less mTOR activating proteins in them. Which are from plants.
Bonus content: don't like fish or contaminated food? Just opt for a tablespoon od broken flax seed a day with a dha 250 + epa 125 algea supplement and you will be clear in the omega 3 part.
These are great questions, I hope they can get answered in this series
Look up an interview of Sinclair with Dr. Paul Saladino. All answers are there and then some. I'm never going back to being a vegetarian.
Salmon is the best fish because it's high in Omega 3 and they only live for 2 years so they're not going to accumulate heavy metals.
Eat fatty fish with lower accumulation of heavy metals and pollutants. The best fishes are salmon, anchovies, sardines, and mackerel.
Love this episode. It is a great follow-up to the first one. Thank you, Dr. Sinclair!!! Your willingness to share the work that you have done over the last couple of decades is helping mankind in ways that we will all benefit from. Thank you!!
I am watching this while eating Chick - fil - A, I am enjoying eating fast food/junk food once a month. Depriving yourself of foods you enjoy is a bad idea, something that this episode highlights, and I agree.
You two are working perfect together! I’m a big fun and exciting I actually living the life style as you suggested in last 10 years.
What qualifies as too much protein? Is it proportional to body weight? Is it proportional to the amount of other macronutrients you eat? You mention red meat in particular, does that mean white meats are fine? Asking because I want to build muscle but I also want to think about the long run!
0.8g of protein per kg of body weight is pretty standard. If you're working out more, you could increase it to 1.1g/kg. Building muscle is more dependent on the way in which you exercise - less aerobic and more high intensity training with weights. White meat isn't much healthier, at least not at the levels consumed by most people.
Hi Dr. Sinclair. I purchased the Athletic greens. I practice Intermittent fasting - is it okay to drink the daily dose of Athletic greens in the morning when I'm fasting? I typically skip breakfast and eat my first meal at 11.30 am.
Thanks!
Following
I feel so happy that we are getting true science through this great episode! Taking all the valuable notes! Thanks Dr. Sinclair! 🙏 😍
Listen David: Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
The Body already Does it, why can't we do it, TODAY, NOW?????
I Want to Live to be 351 Years Old, Period...
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
Why Can't We Just Splice New or Used Telomeres on to the Ends of Our X Chromosones???
This information is so valuable, that even the immortal Dracula is taking notes! Thank you so much, Dr. Sinclair 🧛♂️👍
Haha so funny lol 🤣😂🤣😂
I watch all the videos that I can with dr. David Sinclair. He is a legend. I love to see how younger he looks compared to some older videos. I have only one question: did dr. Sinclair have some cosmetic procedures done? Botox? Face lifting? Or his appearance is 100% due to his lifestyle and supplements?
I don’t care if he had cosmetic procedures done but I would like to have an honest answer.
Such interesting content! I have a question…
When sick with a cold or flu for example, my parents would always try to encourage me to eat in order to keep up my strength and help me fight the illness, but listening to the podcast leads me to believe that the lack of appetite when sick is an intended side affect to assist the body in healing itself during a ‘fast’
Can you shed some light on this? Should we force feed ourselves when sick or is it just fluids which are important?
I have Covid for the third time. I have always believed the natural inclination to fast while ill is listening to your body
@@carriesilvinaespinozavilla5177 catching covid 3 times is bad though… isn’t it?
@@Boriskbjj COVAIDS is just a regular Corona Virus...Polymer Chain Reaction Tests were NEVER intended to detect illness. Fauci misused it back in the Late 1980's for AIDS just like he is now. To answer your original question, "Feed a Fever but STARVE a Cold" is what my 101 year old grandfather told me HIS Grandmother told him. 😁
@@codybanks9944 What's with this "COVAIDS" nonsense? Sorry, but you're wrong about PCR. It works for detecting viral DNA. Stay off of Facebook.
He can express himself even if you don’t agree. That’s what discussions are for.
A lot of this sounds very familiar to those of us who follow the HFLC (KETO) diet. But getting enough protein and fat to be able to avoid( or keep very low) in Carbohydrates is very difficult with a vegetarian regimen! Some would say near impossible if you want to keep to 20 - 30 gms of Carbs to stay in ketosis, which is very beneficial for type 2 diabetics or pre diabetics. And is it the low carb diet that extends life or the protein avoidance? I do not think that has been clearly determined yet as far as I can see.
He was saying to keep your blood sugar steady (no big ups and downs), not (limit) your carbs. Simply fasting, and monitoring what foods/carbs significantly spike your blood sugar when you eat is all you need. Also, high amounts of lipids can also cause or at least promote (pre) diabetes, so it’s not just sugar :( BUT he still recommended Mediterranean so you can have a bit of your fatty fish if you want :D
David Sinclair is such a great communicator, slightly difficult to catch all he is saying because the interviewer talks before he finishes his sentences. DC - always hugely informative, clear, and succinct. Thank you.
Thank you for this episode, I have gained so much information on how fasting helps in longevity. I fast 19- 20 hrs. and this was very informative.
How can we follow a low-carb diet (as gluten and starch are proven to be some of the strongest triggers of inflammation and disease) while avoiding meat and still getting enough high-quality protein?
I thought this Aswell because I’m on my strength training journey & I keep being told repeatedly I need 140g of protein per day to grow muscle but I started studying blue-zones and they just don’t eat alot of meat period. So I guess since this podcast is specifically about longevity and not necessarily strength or being crazy fit then I think minimal amounts of protein is what’s consumed. So I’m guessing from plants and beans is where protein is taken from