This was another great episode! Learning so much. Just sharing my notes here. Too much iron is dangerous for longevity. Drives the accumulation of zombie cells. Survival sensors: - Mtor: senses amino acids. Lower levels of BCAAs are good - Ampk: senses energy (glucose). - Sirtuins: sense NAD (goes up and down with food and exercise) Insulin tells the body that's there sugar to use. -Exercise prevents diseases. Reduces mortality. -Walking after a meal stimulates the production of new blood vessels and turns on ampk (registers energy -atp-). -Vigorous exercise. Low levels of oxygen (Hypoxia) are good (though doesn't feel good). -As we get older, our muscles become less sensitive to the insulin that the pancreas is putting out. This is due to aging. -glucose in the bloodstream damages blood vessels. -Exercise impacts epigenome (regulator of DNA). -80% of future health is manipulable and modifiable (epigenome) Weight training: - Maintain hormone levels, ability to walk well and have good posture, makes look better - Is hard to get muscle as you get older. - Breaking your hips is equivalent to have stage 4 cancer. Mortality rates are that bad after hip injury. ○ How to avoid breaking hips? Build muscle and work on flexibility. - Senescent cells: when the epigenome becomes deregulated, cells can either die or they can be shut down, so they are zombie cells. Slowing the formation of zombie cells or killing them is important. Exercise kills these cells. Hyperbaric Oxygen Therapy (HBOT) - Hyperbaric chamber where pressured is increased. - Can reverse aging. - It's similar to hypoxia. So it's similar to exercise. Cold Therapy - Production of brown fat (burns white fat and enhances metabolism). - Cryotherapy, cold showers, sleep with few blankets. Heat - Saunas reduce 20% in cardiovascular disease. Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich
These are amazing. I get too anxious about watching the whole video when all I want is the actionable info. Would rather just know key points. Thank you for these notes.
Thank you very much for your notes! The only problem with your notes is that now I'm always going to wait to read your notes first before watching the video. Because your notes really help to absorb the important information while he talks.
@@miloradmilutinovic7691 today we can study what works and what doesn't by applying methods that proved effective because they show consistency with cause and effect.
Hi, great info and presentation. I am 72 years young and every new person I meet, find it hard to believe that I am really that age. I am ex military and have maintained my fitness throughout my life by keeping flexible and using my lungs with purpose. From my Army days I have always finished off my shower with full cold water. In recent times I have been using the Wim Hof Method of breathing and cold showers and exercises. It has taken me to a new level of energy and well being. My only medical complaint is a hole in my esophagus from acid reflux. I have nearly always only eaten when hungry, and usually only enough to satisfy that hunger, knowing it will take 20 minutes or so to get that satisfaction. Being human, there have been times when this wasn’t always the case, but I am not fanatical about it. It feels great to be alive.
I have now started to go to steam bath or sauna again for about 30 mins, start with cold showers and also in between. I do pilates, yoga and cardio classes and some weights. I need to increase with more weights, than cardio to get rid of osteoporosis. People do not believe I am 67. I do not have any wrinkles but a light lines down the nose and past tge mouth. I still have large eyes. I have not had gluten for about 11 years, being coeliac. I have stopped having dairy and eggs, as following a thyroid healing diet from this month. Every 3 days, do a juice diet for 48 to 72 hours. I am hoping to increase the juice diet to 7 days and soon also do 72 hours fasting, which I followed in 2019 and felt good. I have about 4 to 6 hours window for having the juices and 2 avocados to eat and feel good.
release fear of death so you dont keep swallowing your emotions with mind over matter. The days of repressing your humanity is eating you from the inside.
As an Exercise Physiologist I applaud how accurate the exercise based information was! I did a little cheer when he said ‘no one type of exercise is the best’, because people are constantly saying there is a secret special exercise that fixes it all.
OOOO MY GOD... I've been doing this for YEAR.. giving my stomach a break. Intermitted fasting for the past 24 year.. Im 53 in June and still in great shape. Thanks Dr. Sinclair.. Also im preparing for my MCAT, will be a Dr. soon myself..
You are my type of Professor, Dr and Scientist, I am 80 years old do not take medication, do yoga walk 10,000 or more steps a day and do some resistance exercises , I am up by 5 am. Have been a researcher for Holistic medicine ,Beauty and Longevity, for a long time, I am very happy to have found you, I will follow you as much as I can,🙏
This channel is going to the Moon! I have watched every video and will watch every video. This information is more valuable then all the gold in the world! Thank you both for all you have done are continue to do.
@@zanshin720 Sure, great. But a handful of youtube videos featuring largely unvalidated information is more valuable than hundreds of trillions of dollars worth of gold? Just saying, tone down your praise a couple notches, and let's wait for the results of these theories (which are thus far, theoretical.)
I devotedly started listening to this podcast ... i learned the right things... i am presently implementing low glycemic food, exercise, fasting in my daily regime. i dont feel tired or stressed .... i exercise daily for half an hour and vigrous exercise around e times a week... my focus increases... my brain fog gone...my memory enhanced...my organizational skill increases. this is what happens when you learn from right people. We genuinely thank you for sharing this valueble knowledge for free ..i am sure i will not get such knowledge even by sharing thousand of dollars anywhere in the world. Really thanks !!
Dr. Sinclair and other scientist in his field that are tying to solve aging are literally doing the most important work in modern times. We'll have to solve our short life spans if we ever want to explore the cosmos and visit other worlds.
I'm 73 years old and have engaged in resistance training for over thirty years. My current exercise activity and nutrition focus on slowing the process of sarcopenia and the decline in other physiological functions. I have used supplements to augment my food diet. Currently, my supplements concentrate on the mitochondria. Your "Lifespan with Dr. David Sinclair" RUclips series is excellent.
-Have Low Levels Of Iron -Get Off Your Butt -Walk After Eating -Low Impact Excercise For 50 Minutes A Day 4000 Thousand Steps A Day (Walking, Running, Cycling) -Have A Hypoxic For Atleast 10 Min A Day; Recommendation: Do HIIT Or Vigorous Excercise 75 Min A Week -Bio-Tracking -Weight Training Maintain Muscle Mass Focus On Big Muscles -Hyperbaric Oxygen Therapy 90 Min A Day; Helps In Mimicking Excercise -Cold Exposure: Cold Shower Or Cryotherapy, Leave a Window Open While You Sleep, Put Fewer Clothes On And Move Out Specially In Winter, Etc. -Heat Exposure - Sauna Bathing Recommendation: Heat-Cold Contrast Shower Or Bath; 5 Or More Cycles
Dr. Sinclair you are awesome! Thank you for the insights, very pleasant to listen to. I've been learning a lot from you. Thank you for the free information!
I am reading your book 'Lifespan'. Your written style is pleasing, funny, you go to the point, it's knowledge rich, and you are a very lively person. I feel lucky to be alive right now witnessing the development of this longevity research. What a gift you're building, David, among others. My most meaningful thank you. Really!
I’ve loved and learned from every single one of these so far ! I am so grateful to you both. I really feel there should be a Dr. Sinclair health class taught at every level of education! Starting now.
Premium quality content. Thank you so much Dr. Sinclair. Reading your book and listening to these podcasts has fundamentally changed the way I view human life and it's duration.
Love the podcast, I’ve listened to many podcasts, initially with Joe Rogan. I read the book as well. I started taking NMN and Resveratrol a year or so ago. Prior to taking the supplements I got a blood test and determined my internal clock with Inside Tracker, a couple years later I Re tested my blood and my internal clock reduced by 4 years. Amazing!
I love this podcast so much! 🥰 I work out everyday, but I prefer short 15-20 minutes workouts and 20 minutes stretches, and it is hard for me to work out 1 hour at a time and then do stretches, I just don’t have time for that. So it is good to know that 15 minutes per day can be enough ☺️ Plus, I walk every morning for 30 minutes. I should be fine 😁 Thank you for making me feel good about my routine! 🙏❤️
Dr. David, would it be possible to measure Biological Age from Europe? Please please make it happen. And if there is a chance for Inside tracker to provide full service for European market, would be amazing. Or any chance to cooperate with Inside tracker to open the European lab / center?
Get off your ass!🔥❤️🔥🔥 62 and loving life. I gave up driving in 1998 and choose to live within 2 miles from where I work. I ride my beach cruiser bike and walk everywhere. I am always amazed how people tell me those are strange choices, yet clearly they are healthy choices. I look far younger than most my age, but more importantly, I feel younger. Your health is your wealth. We must take accountability for our own health and happiness. Love this podcast. I did a lot of intermittent fasting in my youth, not understanding how healthy it was for me, I only knew I felt better while doing it. Thanks for explaining it all here.
Another great podcast ! It would be amazing though, if Dr. Sinclair and Mr. Matthew LaPlante could take some questions and dedicate 2-5min segment to them, either from comment section or submitted upfront. Good job 👌!
Thank you Dr Sinclair ! You don’t have idea how much I appreciated and love you for all great things that you are doing. ! I follow you and check up your need. Thanks again for makes the science for us , the regular people👍👏🏼👏🏼
I would be remiss Not to Mention: “I have been ‘practicing’ Aerial Silks & Lyra (Hoop) & Flexibility for 1 year to this day…6-8 hrs. per week. Literally, this Full Body ‘Workout’ has changed my life❣️Ladies, You Can Do It..Give it a shot⭐️⭐️⭐️⭐️⭐️
Wow, I'm awesomely pleased to see Dr Sinclair with a podcast of his own! I've followed many podcasts he's spoken on. I'm glad to hear him say he skips breakfast AND lunch; just hope I'm doing the best for myself by typically doing so although sometimes I eat a package of seaweed in the early hours of the day or make myself a beetroot and chlorella powder simple smoothie to keep my body calmed.
"We don't have to run from predators very often. And this is a real problem" - Dr David Sinclair I know it's completely out of context but I found it hilarious.
These are some of the most interesting podcasts I have listened to on anything health related. I am still not 100 percent convinced "vigorous" exercise is really that critical to healthspan, even though I totally agree it is good for you! I have at least a dozen people in my close family that are in their 90s and some lived to 100, while staying healthy. Of course I am aware that given the right method and environment we can live to around 120 and that is many modern peoples goal. But I think making it to 95 and still being able to have fun, feel good, and hike is really successful itself. They had a few things in common. They did not eat a lot ever (none were vegetarians or vegans). They used alcohol in moderation. Did not smoke. They stayed active as in cleaning, shopping, walking places, card games, family gatherings, cooking, working. They did not sun-bathe and hardly ever got angry. Not one of them took any vitamins, fasted, did vigorous exercise or cut out eating meat. I still say for them the most important factors were moderate exercise and not eating a lot ever. To me if you can do just those 2 things and nothing else, you are well on your way to long term health. However I also do breathwork exercises daily and I am a vegan. I highly, HIGHLY recommend both for optimum long term health and to just plain feel good! The evidence is overwhelming for both.
Thank you for this amazing information! I was wondering if you had any information regarding using Breathwork such as the Wim Hof method or Buteyko breathing to induce hypoxia. Is the hyperventilation / hypoventilation we see in Wim Hof doing the same thing as the Hyperbaric chamber you mentioned, due to the large differential created during the practice? Thanks again!
Dr David, Do you have any advise/opinion/evidence on the effect of aromatase estrogen blockers when given as a 5 year post preventative treatment after mastectomy/breast cancer? .is there any protocols to offset this deficiency in women(as read women suffer huge age acceleration due to this)? Thank you…
I have listened to it breathlessly. Many thanks for making this channel available for us. I feel myself privileged for discovering Prof.Dr. David Sinclair years ago in RUclips. I have been amazed with the information he has been giving out since then. I try my best to follow his recommendations and yes they do work🥰. I have been always wishing that he would have his own channel. And here He is. I appreciate all the efforts being invested here. Wish you all in 2022 all the best.
My local spa has a sauna and cold pool (60 degrees F). I LOVE to cycle between them. At first, the time in the cold pool is brief, maybe 30 seconds. But as I keep doing it, I can eventually stay in long enough to do some stretches and use their waterfall (it cascades out of the wall) on my shoulders. For me, I do it because it helps with muscle soreness. But also, I do come out of it feeling very exhilarated yet very relaxed. Now I understand why.
Great episode, I was looking forward to this episode all week! I usually watch all podcasts at 1.5x but I watched this at 1x so I could enjoy it longer :D
Hi David! Great podcast, I have been following your work for years. On the other hand, having a standing desk injured me. I was standing half of the time and my foot got injured. I recommend doing 5 minute active pauses each hour instead
Great episode, couple of follow up questions: How much iron is too much? If I can afford the blood test, what numbers should I be looking for as a male? What should the timing of the heat/cold exposure be in relation to exercise? Distanced from it or immediately around it?
Dr. Sinclair, What do you think about high calorie, high protein diets like the ones that are recommended for muscle building (hypertrophy) programs? For what I understand, you can't have that much calories overall in a single meal, but it's been proven to be effective on building muscle. Is it worth it to go that path if slowing down aging is your goal or it's actually not beneficial?
Absolutely love this channel. Reading the book, been listening to every podcast and you tube video since last May. Taking some of the supplements and at 46, I have noticed a difference. Thank you! This is the best thing to listen to while you walk you dog, folks.
There is constant mention of eating less. What if you are thin from the start don't restricted feeding serve one better? Then again do you avoid foods like rice, flour and the likes of foods with high glycemic index?
Great podcast!!! ❤️ In case you could do Q&A in a future episode I'd love to know how pregnancy and breastfeeding affect ageing and whether the suggested protocols have been studied on pregnant and/or breastfeeding women.
So many thought provoking tidbits but the hyperbaric chamber information...I've been screaming how beneficial it has to be for more than just wound therapy. Tried to get Medicare to pay for treating both my parents with it after strokes which seemed to be a no brainer but wasn't covered and I didn't have the funds at the time to cover it myself. Bringing hope to so many with all of this thought provoking data:) Thank you both.
Thank you so much for the free education! And it's really not so hard to understand either for a layman like me. Right now I'm getting the key ideas and translating them and explaining them in details in Chinese, putting them in my blog hoping to convince more people cognitively to get more exercise including my parents. Now I seem to have very strong arguments to back me up! Exercise is so important. Thank you both, please keep up more updates.
Can you comment further about iron consumption? I did an inside tracker test and mine was slowly below optimal so I’ve been looking for ways and have increased consumption a bit through my plant based diet but want to be sure I’m not overdoing it. Any recommended daily amounts based on body weight or more specific guidance you can give?
This is golden information. Explained in the correct way (for me) by explaining the mechanisms in enough detail to get the gist of it, without making it too difficult (which in reality it probably is).
This really really outstanding. Naturally with David Sinclair. Covering so much ground in a little over an hour is so useful. I think the 1 hour podcast will become the new standard.
Thank you so much for what you do Dr. Sinclair. In regards to walking after eating, I personally fast until late afternoon when I then exercise before I eat my first meal shortly after. Is my body already in the AMPK state or should I go for a walk after my meal still? My exercises vary between strength and cardio but I always eat soon after.
@@GabrielCazorlaPersson1 At 22:35 , Dr Sinclair can be quoted as saying that "moving activates the longevity pathway AMPK". I get exercise helps with glucose sensitivity, I was just curious if we exercise before we eat, are those benefits still there if I eat soon after if not immediately after working out or did I need to go on another walk anyways.
Eating while fasting is very good to accelerate autophagy by excercises.walking after meals has glycemic control ,meaning utilise the glucose consumed ,also build the muscles and maintains musecles especially in old age when most elderly have sarcopenia.I keep my fridge empty .cooked complex carbohydrate and freeze to make it resistant starch ,like cooked brown rice,potatoes,one small potato in soup,three tablespoon cooked rice.Always watch portions.
It's great to finally have interesting things to watch and listen to. Mainstream TV and BBC radio only hits the average iq. With this, I am pressing rewind and writing things down, looking up and listening again. Thank you.
Very much enjoy your podcast. Thank you. If, approaching the last of my 20 hours of daily no-food, I fill my tummy up with something non-calorific (like water or husk), my hunger pangs will go away. My question is: As I make myself feel not hungry, what happens to the "body-believes-I-am-starving-and-switches-on-live-longer-effects?" Do the beneficial longevity "buckets" listen to my psychological hunger (and turn off): "He's not in starvation mood any longer," or physiological hunger (and stay on); "He is mistaken because, in reality, he is still in starvation mood?
I like it when you do the advertising - business regarding the sponsors of your podcast, and your eyes lock into the wording as you read the data and the stare forward and the eyes look all serious and locked into each letter. As you talk about getting younger as you take trips around the sun! My mindset too 👍👍
Do glad you're continuing to keep us up to date! Thank you so much! Could you please put together a terminology glossary that could be understood by a lay person not in your field.
I have a request: future research on aged folks like 60s,70s to 80+, my reasoning is that we ate living with some pathology and refuse meds offered since I just exercise the best I can. Thank you terrific video and more and more clarity from the lab and life styles.This is not the first video I have listened to with Dr S's research yet the added information here is so hopeful.
Thank you for all the interesting information. Some questions for the next episode: In what quantities and time intervals should a typical person take the supplements? Is is for example bad to take NMN every other day or only a few times every week instead of every day? For how long will the different supplements remain active in the body after ingestion? What happens if a person overdoses with a supplement? What are the dangers or positive synergy effects of combining different supplements?
Beaus Aestate - Good questions! Did you ever get a response? If so, I'd certainly be interested in what he has to say if you could pass it on it would be much appreciated. Thanks!
3 months later rewatching this and quite surprised that david sinclair doesnt have sauna and icebath at home. after hearing this episode i bought an infrared sauna instantly and 2 days ago i finally took delivery of my personal icebath. lowest temp the machine can achieve is 5 degress celsius / 41 fahrenheit, but ive started with 10 celsius for 10 minutes. feels amazing. if youre priviledged enough to live in a country with cold mountain water and water heaters, you could probably fill your bathtub with cold water and stand under a hot shower. sadly i live on a beautiful island, where the coldest water you will find is around 30 celsius :-P
I really LOVE this series. What would make the take-aways even better is talking about how many years each suggestion would likely add to your life IF that information is available (even if you have to infer that from the rat studies). Great job again on the podcast! Love the format and info.
Are you acquainted with or have read a book published by Durk Pearson & Sandy Shaw in the 1980s called The Life Extension Companion? We read that book when it was published. We were impressed. But I don't think it has extended our life. There are so many things that makes a lot of people live longer and many others that will make our lives shorter. If you do have a way for us to reverse genetic and environmental damage it would be amazing. We are in our 70s and our chances of success are limited. Thanks for the series. Good luck!
Does "cold" have to be actually cold or just relative? For example if you live in the Middle East with no air conditioning even a 20degC bath would seem very cold, where as a resident of Alaska would thing the same 20degC bath to be quite warm I'd think.....
I have been doing all this for years without knowing :) I ride my motorcycle in winter in the uk (cold) to the gym (exercise) then have a shower (heat) then back on the motorbike (cold). The motorbike also gets my heart pumping
Thanks for a interesting series. So I wondered in regard to calorie restriction, should one not eat anything at all until dinner, if one is to follow Dr Sinclairs model? What is considered fasting? Water is ok I presume. How about coffee? (Also what is your take on the use of caffine?) Also, how would one keep up their energy level during a work day? With regards, Ronny.
Dear Dr. Sinclair, this podcast is amazing ! Thank you so much for your time and dedication! What a hightlight of the week! Unfortunately, the link to levels does not seem to work, would you be able to provide us with the right one? Thank you!
Can you post the clinical study which justifies the infra red sauna studies? The manufacturer claims are all over the map. If possible I would like to know which type, [or brand] ,of infra sauna red was used in the better studies. Absolutely love your knowledge and your wisdom
I have been following Dr. Sinclair since I was 25.
I am 22 now.
This was another great episode! Learning so much. Just sharing my notes here.
Too much iron is dangerous for longevity. Drives the accumulation of zombie cells.
Survival sensors:
- Mtor: senses amino acids. Lower levels of BCAAs are good
- Ampk: senses energy (glucose).
- Sirtuins: sense NAD (goes up and down with food and exercise)
Insulin tells the body that's there sugar to use.
-Exercise prevents diseases. Reduces mortality.
-Walking after a meal stimulates the production of new blood vessels and turns on ampk (registers energy -atp-).
-Vigorous exercise. Low levels of oxygen (Hypoxia) are good (though doesn't feel good).
-As we get older, our muscles become less sensitive to the insulin that the pancreas is putting out. This is due to aging.
-glucose in the bloodstream damages blood vessels.
-Exercise impacts epigenome (regulator of DNA).
-80% of future health is manipulable and modifiable (epigenome)
Weight training:
- Maintain hormone levels, ability to walk well and have good posture, makes look better
- Is hard to get muscle as you get older.
- Breaking your hips is equivalent to have stage 4 cancer. Mortality rates are that bad after hip injury.
○ How to avoid breaking hips? Build muscle and work on flexibility.
- Senescent cells: when the epigenome becomes deregulated, cells can either die or they can be shut down, so they are zombie cells. Slowing the formation of zombie cells or killing them is important. Exercise kills these cells.
Hyperbaric Oxygen Therapy (HBOT)
- Hyperbaric chamber where pressured is increased.
- Can reverse aging.
- It's similar to hypoxia. So it's similar to exercise.
Cold Therapy
- Production of brown fat (burns white fat and enhances metabolism).
- Cryotherapy, cold showers, sleep with few blankets.
Heat
- Saunas reduce 20% in cardiovascular disease.
Let me know if you want me to keep posting these notes, I am on Twitter @juampiaranovich
hi Juan, you are a great guy to share your key notes from this David Sinclair's video lessons on our longevity and health span.
Thanks for sharing!
Thanks
These are amazing. I get too anxious about watching the whole video when all I want is the actionable info. Would rather just know key points. Thank you for these notes.
Thank you very much for your notes!
The only problem with your notes is that now I'm always going to wait to read your notes first before watching the video. Because your notes really help to absorb the important information while he talks.
What an exciting era to be alive thank you professor Sinclair!
That's kind of you.
Well, 2000 years ago it was written already that people are living around 1000 years. No body made it. Why should it be different this time?
@@miloradmilutinovic7691 today we can study what works and what doesn't by applying methods that proved effective because they show consistency with cause and effect.
Really??
@@miloradmilutinovic7691 I guess the podcast targets 130 years (maximum)
Hi, great info and presentation. I am 72 years young and every new person I meet, find it hard to believe that I am really that age. I am ex military and have maintained my fitness throughout my life by keeping flexible and using my lungs with purpose. From my Army days I have always finished off my shower with full cold water. In recent times I have been using the Wim Hof Method of breathing and cold showers and exercises. It has taken me to a new level of energy and well being. My only medical complaint is a hole in my esophagus from acid reflux. I have nearly always only eaten when hungry, and usually only enough to satisfy that hunger, knowing it will take 20 minutes or so to get that satisfaction. Being human, there have been times when this wasn’t always the case, but I am not fanatical about it. It feels great to be alive.
I have just started ending my showers with a 'cold blast.' I'm 68 y\o female and people ask me if i have had any 'work done'. Hilarious!
Tried leaving gluten out of your diet for a while? And milk products. Those are two that are high on the list for causing gastric reflux.
could be caffeine or low stomach acid
I have now started to go to steam bath or sauna again for about 30 mins, start with cold showers and also in between. I do pilates, yoga and cardio classes and some weights. I need to increase with more weights, than cardio to get rid of osteoporosis. People do not believe I am 67. I do not have any wrinkles but a light lines down the nose and past tge mouth. I still have large eyes. I have not had gluten for about 11 years, being coeliac. I have stopped having dairy and eggs, as following a thyroid healing diet from this month. Every 3 days, do a juice diet for 48 to 72 hours. I am hoping to increase the juice diet to 7 days and soon also do 72 hours fasting, which I followed in 2019 and felt good. I have about 4 to 6 hours window for having the juices and 2 avocados to eat and feel good.
release fear of death so you dont keep swallowing your emotions with mind over matter. The days of repressing your humanity is eating you from the inside.
As an Exercise Physiologist I applaud how accurate the exercise based information was!
I did a little cheer when he said ‘no one type of exercise is the best’, because people are constantly saying there is a secret special exercise that fixes it all.
for what ?
Yeah but bench press is still king
Gina... 65 with torn meniscus in both knees... Any suggestions as to what exercise I can do, please??
What? This guy's in his fifties, dyes his hair and he's built like a child.
@@Sunnysue31 yoga
This is the only series of podcast which I watch from starting to ending without skipping.
Thank you David sir for all the knowledge 🙏🏻
Series ?
You watch the sponsors ;)?
@@JkBee nope but ya sometime i watch with curiosity
100%
@@Junaid_x01 I believe there are 8 videos in this series...and a number of other videos by Dr. Sinclair.
OOOO MY GOD... I've been doing this for YEAR.. giving my stomach a break. Intermitted fasting for the past 24 year.. Im 53 in June and still in great shape. Thanks Dr. Sinclair.. Also im preparing for my MCAT, will be a Dr. soon myself..
You are my type of Professor, Dr and Scientist, I am 80 years old do not take medication, do yoga walk 10,000 or more steps a day and do some resistance exercises , I am up by 5 am. Have been a researcher for Holistic medicine ,Beauty and Longevity, for a long time, I am very happy to have found you, I will follow you as much as I can,🙏
This channel is going to the Moon! I have watched every video and will watch every video. This information is more valuable then all the gold in the world!
Thank you both for all you have done are continue to do.
Thank you for your encouragement and interest in science. Can't wait to do Series 2 - David
All the gold in the world? Take it easy there, sport.
@@scottk1525
Quote by Theophrastus: “Time is the most valuable thing a man can spend.”
@@zanshin720 Sure, great. But a handful of youtube videos featuring largely unvalidated information is more valuable than hundreds of trillions of dollars worth of gold? Just saying, tone down your praise a couple notches, and let's wait for the results of these theories (which are thus far, theoretical.)
@@scottk1525 Not that this is relevant but gold market is $11.729 T. lol Have a nice day.
I devotedly started listening to this podcast ... i learned the right things... i am presently implementing low glycemic food, exercise, fasting in my daily regime. i dont feel tired or stressed .... i exercise daily for half an hour and vigrous exercise around e times a week... my focus increases... my brain fog gone...my memory enhanced...my organizational skill increases. this is what happens when you learn from right people. We genuinely thank you for sharing this valueble knowledge for free ..i am sure i will not get such knowledge even by sharing thousand of dollars anywhere in the world. Really thanks !!
Dr. Sinclair and other scientist in his field that are tying to solve aging are literally doing the most important work in modern times.
We'll have to solve our short life spans if we ever want to explore the cosmos and visit other worlds.
Obsessed with this podcast! Recommending all my clients follow along too so we can all learn together and have discussions
This is my favorite podcast, 2022 will be great
I'm 73 years old and have engaged in resistance training for over thirty years. My current exercise activity and nutrition focus on slowing the process of sarcopenia and the decline in other physiological functions. I have used supplements to augment my food diet. Currently, my supplements concentrate on the mitochondria. Your "Lifespan with Dr. David Sinclair" RUclips series is excellent.
-Have Low Levels Of Iron
-Get Off Your Butt
-Walk After Eating
-Low Impact Excercise For 50 Minutes A Day
4000 Thousand Steps A Day
(Walking, Running, Cycling)
-Have A Hypoxic For Atleast 10 Min A Day; Recommendation: Do HIIT
Or Vigorous Excercise 75 Min A Week
-Bio-Tracking
-Weight Training
Maintain Muscle Mass
Focus On Big Muscles
-Hyperbaric Oxygen Therapy 90 Min A Day; Helps In Mimicking Excercise
-Cold Exposure: Cold Shower Or Cryotherapy, Leave a Window Open While You Sleep,
Put Fewer Clothes On And Move Out Specially In Winter, Etc.
-Heat Exposure - Sauna Bathing
Recommendation: Heat-Cold Contrast Shower Or Bath; 5 Or More Cycles
Thank you for summarizing it.
thanks for summery man. these health videos can be so complicated
Thank you for the summary...the clip is way too long.
Thank You Mr. Singh! Awesome summary and Podcast! "live long and prosper"
Thank you kind sir. 🙏
One of the few channels/podcasts I am eagerly waiting for the next episode!
Same here😃👍
Dr. Sinclair you are awesome! Thank you for the insights, very pleasant to listen to. I've been learning a lot from you. Thank you for the free information!
I am reading your book 'Lifespan'. Your written style is pleasing, funny, you go to the point, it's knowledge rich, and you are a very lively person. I feel lucky to be alive right now witnessing the development of this longevity research. What a gift you're building, David, among others. My most meaningful thank you. Really!
I’ve loved and learned from every single one of these so far ! I am so grateful to you both. I really feel there should be a Dr. Sinclair health class taught at every level of education! Starting now.
Premium quality content. Thank you so much Dr. Sinclair. Reading your book and listening to these podcasts has fundamentally changed the way I view human life and it's duration.
I appreciate
do you take metformin
I’m so glad I discovered his podcast. This is my first episode and I’m already in love.
Love the podcast, I’ve listened to many podcasts, initially with Joe Rogan. I read the book as well. I started taking NMN and Resveratrol a year or so ago. Prior to taking the supplements I got a blood test and determined my internal clock with Inside Tracker, a couple years later I Re tested my blood and my internal clock reduced by 4 years. Amazing!
Can't get enough DR! THANK YOU! YOU ARE CHANGIN LIVES !
Anti-aging and Longevity is Priceless!! Never stop investing in yourself. THANK YOU DAVID 😊 💓
Yes! because our bodies are our only CAPITAL and health is the most important resource we have. 💯
Watched this video while on my elliptical. The podcast sure kept me motivated!!
I just spent 4 hours learning how the mitochondria works because of this amazing episode ... Life is bazar. Thank you David & Matthew!
Hi. Did you find a good book or just by googling? Thanks!
I love this podcast so much! 🥰 I work out everyday, but I prefer short 15-20 minutes workouts and 20 minutes stretches, and it is hard for me to work out 1 hour at a time and then do stretches, I just don’t have time for that. So it is good to know that 15 minutes per day can be enough ☺️ Plus, I walk every morning for 30 minutes. I should be fine 😁 Thank you for making me feel good about my routine! 🙏❤️
Dr. David, would it be possible to measure Biological Age from Europe? Please please make it happen. And if there is a chance for Inside tracker to provide full service for European market, would be amazing. Or any chance to cooperate with Inside tracker to open the European lab / center?
Get off your ass!🔥❤️🔥🔥
62 and loving life. I gave up driving in 1998 and choose to live within 2 miles from where I work. I ride my beach cruiser bike and walk everywhere. I am always amazed how people tell me those are strange choices, yet clearly they are healthy choices. I look far younger than most my age, but more importantly, I feel younger. Your health is your wealth. We must take accountability for our own health and happiness. Love this podcast. I did a lot of intermittent fasting in my youth, not understanding how healthy it was for me, I only knew I felt better while doing it. Thanks for explaining it all here.
Dr. Sinclair is always interesting. One hour goes so fast 💨 and the topics are so amazing 🤩
It is crazy anyone can come and get this information for free!!!! Thanks so much for putting these together.
Hey thank you both for this PodCast! I am trying to make a new life long routine starting at 26. Can't wait to track myself.
I just turned 24 also looking to start a new great routine for the rest of my life. I wish you success with it fellow human :)
26 is a good age to start.
Information like this should be spread to the masses. Thank you for your hard work & research!
Another great podcast ! It would be amazing though, if Dr. Sinclair and Mr. Matthew LaPlante could take some questions and dedicate 2-5min segment to them, either from comment section or submitted upfront. Good job 👌!
I love love love David Sinclair and the information he provides. Perhaps another ‘co-host’ would be a better fit.
These episodes were pre taped some time ago.
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Thank you Dr Sinclair ! You don’t have idea how much I appreciated and love you for all great things that you are doing. ! I follow you and check up your need. Thanks again for makes the science for us , the regular people👍👏🏼👏🏼
( correction): Check up your great work!
Very thankful for this video from Korea. I also would like to know more on relationship between sleep and longevity through the view of Dr. Singlair !
Professor David Sinclair,
I just salute you from my Heart.....
Excelent podcast, two intelligent brains, fantastic educative and pleasant discussion of very important health issues! Thank you!!
At 57 & 1/2…I am making progress❣️Blessings to you, Dr. Sinclair..Staying close to your podcast, Here, Lake Tahoe, NV🏔
I would be remiss Not to Mention: “I have been ‘practicing’ Aerial Silks & Lyra (Hoop) & Flexibility for 1 year to this day…6-8 hrs. per week. Literally, this Full Body ‘Workout’ has changed my life❣️Ladies, You Can Do It..Give it a shot⭐️⭐️⭐️⭐️⭐️
@@lisafalanga8457 you go girl !
Dr Sinclair, Thank you for the time and dedication to share this valuable information. I appreciate it.
David is one of THE best science on the level understandable to the layman -
Folks, get ready. David is soon becoming a rock star! Thanks for sharing your expertise!
Becoming? He already is. The world is just now realizing it. 😁
WOW!
Wow, I'm awesomely pleased to see Dr Sinclair with a podcast of his own! I've followed many podcasts he's spoken on. I'm glad to hear him say he skips breakfast AND lunch; just hope I'm doing the best for myself by typically doing so although sometimes I eat a package of seaweed in the early hours of the day or make myself a beetroot and chlorella powder simple smoothie to keep my body calmed.
This is such an important podcast . Health longevity good healthspan is the key to living better. Get off your seat so true sitting is the new smoking
I'm in a wheelchair.
This podcast is a true public service. Thank you. Can you please talk about how to prevent glycation?
"We don't have to run from predators very often. And this is a real problem" - Dr David Sinclair
I know it's completely out of context but I found it hilarious.
Fasting is a bitch
Yah, comedic irony🤣
Dr. Sinclair is actually pretty funny IMO. I cracked up when he said "We just made it up".
Kids who visit The White House in 2022 would disagree with that statement.
These are some of the most interesting podcasts I have listened to on anything health related. I am still not 100 percent convinced "vigorous" exercise is really that critical to healthspan, even though I totally agree it is good for you! I have at least a dozen people in my close family that are in their 90s and some lived to 100, while staying healthy. Of course I am aware that given the right method and environment we can live to around 120 and that is many modern peoples goal. But I think making it to 95 and still being able to have fun, feel good, and hike is really successful itself. They had a few things in common. They did not eat a lot ever (none were vegetarians or vegans). They used alcohol in moderation. Did not smoke. They stayed active as in cleaning, shopping, walking places, card games, family gatherings, cooking, working. They did not sun-bathe and hardly ever got angry. Not one of them took any vitamins, fasted, did vigorous exercise or cut out eating meat. I still say for them the most important factors were moderate exercise and not eating a lot ever. To me if you can do just those 2 things and nothing else, you are well on your way to long term health. However I also do breathwork exercises daily and I am a vegan. I highly, HIGHLY recommend both for optimum long term health and to just plain feel good! The evidence is overwhelming for both.
Thank you for this amazing information! I was wondering if you had any information regarding using Breathwork such as the Wim Hof method or Buteyko breathing to induce hypoxia. Is the hyperventilation / hypoventilation we see in Wim Hof doing the same thing as the Hyperbaric chamber you mentioned, due to the large differential created during the practice? Thanks again!
Thanks!
Dr David, Do you have any advise/opinion/evidence on the effect of aromatase estrogen blockers when given as a 5 year post preventative treatment after mastectomy/breast cancer?
.is there any protocols to offset this deficiency in women(as read women suffer huge age acceleration due to this)?
Thank you…
I have listened to it breathlessly. Many thanks for making this channel available for us. I feel myself privileged for discovering Prof.Dr. David Sinclair years ago in RUclips. I have been amazed with the information he has been giving out since then. I try my best to follow his recommendations and yes they do work🥰. I have been always wishing that he would have his own channel. And here He is. I appreciate all the efforts being invested here. Wish you all in 2022 all the best.
My local spa has a sauna and cold pool (60 degrees F). I LOVE to cycle between them. At first, the time in the cold pool is brief, maybe 30 seconds. But as I keep doing it, I can eventually stay in long enough to do some stretches and use their waterfall (it cascades out of the wall) on my shoulders. For me, I do it because it helps with muscle soreness. But also, I do come out of it feeling very exhilarated yet very relaxed. Now I understand why.
@19Jetta - Check out the Wim Hof breathing technique that incorporates cold showers too.
Great episode, I was looking forward to this episode all week!
I usually watch all podcasts at 1.5x but I watched this at 1x so I could enjoy it longer :D
Swim a mile every day, 50 minutes in a sauna, then five minutes in an ice cold shower. My energy levels and feeling of wellness go through the roof.
Dr. Sinclair thank you for your information. Loving the podcast too.
Hi David! Great podcast, I have been following your work for years. On the other hand, having a standing desk injured me. I was standing half of the time and my foot got injured. I recommend doing 5 minute active pauses each hour instead
Great episode, couple of follow up questions:
How much iron is too much? If I can afford the blood test, what numbers should I be looking for as a male?
What should the timing of the heat/cold exposure be in relation to exercise? Distanced from it or immediately around it?
Dr. Sinclair, What do you think about high calorie, high protein diets like the ones that are recommended for muscle building (hypertrophy) programs? For what I understand, you can't have that much calories overall in a single meal, but it's been proven to be effective on building muscle. Is it worth it to go that path if slowing down aging is your goal or it's actually not beneficial?
Absolutely love this channel. Reading the book, been listening to every podcast and you tube video since last May. Taking some of the supplements and at 46, I have noticed a difference. Thank you! This is the best thing to listen to while you walk you dog, folks.
There is constant mention of eating less. What if you are thin from the start don't restricted feeding serve one better? Then again do you avoid foods like rice, flour and the likes of foods with high glycemic index?
Last Friday I hit ten gallons of blood donated since 1993. I was doing it to help others. Nice to learn it helps me too. Thanks for all you do.
Great podcast!!! ❤️
In case you could do Q&A in a future episode I'd love to know how pregnancy and breastfeeding affect ageing and whether the suggested protocols have been studied on pregnant and/or breastfeeding women.
How amazing it is to have all this info direct from the fount and for free. Thanks a lot
Question, do these things change (eating less, taking cold showers etc etc...) if you live somewhere that is already damp and cold?
So many thought provoking tidbits but the hyperbaric chamber information...I've been screaming how beneficial it has to be for more than just wound therapy. Tried to get Medicare to pay for treating both my parents with it after strokes which seemed to be a no brainer but wasn't covered and I didn't have the funds at the time to cover it myself. Bringing hope to so many with all of this thought provoking data:) Thank you both.
How much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]?
Which values are optimal (for an adult)?
Thank you so much for the free education! And it's really not so hard to understand either for a layman like me. Right now I'm getting the key ideas and translating them and explaining them in details in Chinese, putting them in my blog hoping to convince more people cognitively to get more exercise including my parents. Now I seem to have very strong arguments to back me up! Exercise is so important. Thank you both, please keep up more updates.
I feel younger when I watch this interview, awesome people keep it up good work 👍🏼
Lol
That intro is just so beautiful *chef's kiss*
Can you comment further about iron consumption? I did an inside tracker test and mine was slowly below optimal so I’ve been looking for ways and have increased consumption a bit through my plant based diet but want to be sure I’m not overdoing it. Any recommended daily amounts based on body weight or more specific guidance you can give?
This is golden information. Explained in the correct way (for me) by explaining the mechanisms in enough detail to get the gist of it, without making it too difficult (which in reality it probably is).
Reminds me of Huberman Lab. Another great channel! Thanks!
Been following you since your episode in Tom Bilyue's show. The way you explain things in awesome. Thank you for sharing your knowledge.
Great podcast. Would love to hear some commentary on how protocols and methodology changes for those that haven't started "getting old" yet
Amazing to learn about the science behind Wim Hof's entire practice!
Amazing work! I really appreciate the sharing of your knowledge and time.
This really really outstanding. Naturally with David Sinclair. Covering so much ground in a little over an hour is so useful. I think the 1 hour podcast will become the new standard.
Thank you so much for what you do Dr. Sinclair. In regards to walking after eating, I personally fast until late afternoon when I then exercise before I eat my first meal shortly after. Is my body already in the AMPK state or should I go for a walk after my meal still? My exercises vary between strength and cardio but I always eat soon after.
Confusing
@@GabrielCazorlaPersson1 At 22:35 , Dr Sinclair can be quoted as saying that "moving activates the longevity pathway AMPK". I get exercise helps with glucose sensitivity, I was just curious if we exercise before we eat, are those benefits still there if I eat soon after if not immediately after working out or did I need to go on another walk anyways.
Eating while fasting is very good to accelerate autophagy by excercises.walking after meals has glycemic control ,meaning utilise the glucose consumed ,also build the muscles and maintains musecles especially in old age when most elderly have sarcopenia.I keep my fridge empty .cooked complex carbohydrate and freeze to make it resistant starch ,like cooked brown rice,potatoes,one small potato in soup,three tablespoon cooked rice.Always watch portions.
It's great to finally have interesting things to watch and listen to. Mainstream TV and BBC radio only hits the average iq. With this, I am pressing rewind and writing things down, looking up and listening again. Thank you.
I really want to know what your thoughts are on ghrelin suppressants would you recommend people take them?
Great stuff, thank you. I would love to hear your thoughts on the effects of mental stress and if those can be reversed, please!
Very much enjoy your podcast. Thank you. If, approaching the last of my 20 hours of daily no-food, I fill my tummy up with something non-calorific (like water or husk), my hunger pangs will go away. My question is: As I make myself feel not hungry, what happens to the "body-believes-I-am-starving-and-switches-on-live-longer-effects?" Do the beneficial longevity "buckets" listen to my psychological hunger (and turn off): "He's not in starvation mood any longer," or physiological hunger (and stay on); "He is mistaken because, in reality, he is still in starvation mood?
I like it when you do the advertising - business regarding the sponsors of your podcast, and your eyes lock into the wording as you read the data and the stare forward and the eyes look all serious and locked into each letter. As you talk about getting younger as you take trips around the sun! My mindset too 👍👍
Amazing series. Can't wait for the next episode
Do glad you're continuing to keep us up to date! Thank you so much! Could you please put together a terminology glossary that could be understood by a lay person not in your field.
Love all of your episodes. Thank you so much 😊
Do we do the same things if you are over 60 or 70? Love your work.
I have a request: future research on aged folks like 60s,70s to 80+, my reasoning is that we ate living with some pathology and refuse meds offered since I just exercise the best I can. Thank you terrific video and more and more clarity from the lab and life styles.This is not the first video I have listened to with Dr S's research yet the added information here is so hopeful.
Thank you for all the interesting information. Some questions for the next episode: In what quantities and time intervals should a typical person take the supplements? Is is for example bad to take NMN every other day or only a few times every week instead of every day? For how long will the different supplements remain active in the body after ingestion? What happens if a person overdoses with a supplement? What are the dangers or positive synergy effects of combining different supplements?
Beaus Aestate - Good questions! Did you ever get a response? If so, I'd certainly be interested in what he has to say if you could pass it on it would be much appreciated.
Thanks!
3 months later rewatching this and quite surprised that david sinclair doesnt have sauna and icebath at home. after hearing this episode i bought an infrared sauna instantly and 2 days ago i finally took delivery of my personal icebath. lowest temp the machine can achieve is 5 degress celsius / 41 fahrenheit, but ive started with 10 celsius for 10 minutes. feels amazing. if youre priviledged enough to live in a country with cold mountain water and water heaters, you could probably fill your bathtub with cold water and stand under a hot shower. sadly i live on a beautiful island, where the coldest water you will find is around 30 celsius :-P
I really LOVE this series. What would make the take-aways even better is talking about how many years each suggestion would likely add to your life IF that information is available (even if you have to infer that from the rat studies). Great job again on the podcast! Love the format and info.
i am waiting for next episodes as i am waiting for A PREMIERE of a NEW MOVIE!!!!
This is an excellent podcast. Really enjoying the episodes
Are you acquainted with or have read a book published by Durk Pearson & Sandy Shaw in the 1980s called The Life Extension Companion? We read that book when it was published. We were impressed. But I don't think it has extended our life. There are so many things that makes a lot of people live longer and many others that will make our lives shorter. If you do have a way for us to reverse genetic and environmental damage it would be amazing. We are in our 70s and our chances of success are limited. Thanks for the series. Good luck!
Does "cold" have to be actually cold or just relative?
For example if you live in the Middle East with no air conditioning even a 20degC bath would seem very cold, where as a resident of Alaska would thing the same 20degC bath to be quite warm I'd think.....
thanks for this great information we all need this i deeply appreciate and i am most grateful for your success.
I have been doing all this for years without knowing :) I ride my motorcycle in winter in the uk (cold) to the gym (exercise) then have a shower (heat) then back on the motorbike (cold). The motorbike also gets my heart pumping
Awesome Shit 👍🏽
Why do you get your heart pumping when riding a motorcycle?
@@leandrog2785 cold weather after hot shower
In extremely trying times a glimpse of an extraordinary better future. Thank you.
Thanks for a interesting series. So I wondered in regard to calorie restriction, should one not eat anything at all until dinner, if one is to follow Dr Sinclairs model? What is considered fasting? Water is ok I presume. How about coffee? (Also what is your take on the use of caffine?) Also, how would one keep up their energy level during a work day?
With regards,
Ronny.
I can't wait for next #4 podcast..
Dear Dr. Sinclair, this podcast is amazing ! Thank you so much for your time and dedication! What a hightlight of the week! Unfortunately, the link to levels does not seem to work, would you be able to provide us with the right one? Thank you!
Can you post the clinical study which justifies the infra red sauna studies? The manufacturer claims are all over the map.
If possible I would like to know which type, [or brand] ,of infra sauna red was used in the better studies. Absolutely love your knowledge and your wisdom