Correction and clarification: At time point 1:07:37, I said I take 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. I apologize for the confusion.
The co host is great. He has a very effective way to be both a “layman” as he asks questions while at the same time, generally savvy on the topics. Also, I congratulate you both on not taking yourselves too seriously. We already get enough of that with certain scientists.
Technically he's the host, given that he's the one conducting the interview. But you're right. It's like nearly every time a question pops into my head, it's the very next question out of Matt's mouth.
I’m obsessed. I’m so excited about this research. I’m 50yo. I haven’t had any living parents, grandparents etc in over 10 years. I’m determined to change this for my family!
My uncle was more educated than this man, and in the same field, and he died in his late 50s from cancer. I promise you none of this stuff has any real effect on your longevity. Live a healthy life, don't go taking a bunch of pills and potions and spending a load of money. Take care lovely.
I just finished your incredible book Lifespan-for the third time. First reading was an audio version and I stopped every hour to cry hard. I read a lot for a leadership program that I teach for the Air Force and thank you btw for mentioning USA air supremacy. LITERALLY THE MOST INCREDIBLE INFORMATION!!!! I tried to relay it all to my own adult professional child and her husband and sounded like a blithering idiot bc I get so emotional. I am thrilled to find this podcast so I do not have to try. Your optimism is a leadership trait; you’re an educator, not merely a scientist. Your book’s messages were mostly about longevity, but also part existential, part environmental, and part economical. As a teacher myself a huge obstacle is keeping my students and coachees happy about humanity. I am as wound up at the end of your book as I am at the beginning. Thank you for your genius and your optimism.
I'm taking a similar supplement regime myself and have been doing it for a couple of years now. 67 Y.O and feel more energetic and certainly fitter than any time since my early 50s. loving these podcasts learning so much from them, thank you.
Hi can you tell me please some names you take I need more to know the spelling , when he said Nmn quercetin and visetin or I don’t think writing right he mention desitin too, if I’m right. Thank you in advance
I have been taking resveratrol for several years now. Unfortunately I am confused. Many evidences suggest on the contrary. Why doesn't Dr. Sinclare clearly answer the question raised by Dr. Brad Stanfield. I think there are many worried people around the world who have been taking resveratrol waiting for Dr. Sinclair's response. Please!
Love this series of episodes. Very informative and hopeful for those of us in their 70s. Vanity would have driven my interest before, now it is quality of life. Especially cognitive function as I'm watching friends in their late 70s and 80s, mentally declining. Not all but so many.
Right behind you! 68 mother of two. Need to remain here as long as possible with healthy body and mind! My son passed during COVID. Being a mom of a 9 & 8 years of age need all help available!
I am a physicist by education. I used to think the biology was an easy subject. Not any more. Listening to this very interesting podcast, I marvel at the complexity of biological systems. This podcast is very informative and easy to understand. I plan to use some of the supplements outlined in this podcast. Excellent
Wow exactly my thoughts. Physics and mathematics is very simple compared to biology. I came to the conclusion biology plays with physics the way we play with math, which makes it very difficult to predict and understand
@@creativesource3514 perhaps. But it is an elementary matter. I can explain to you the orbits of planets, their gravitational pull, their magnetic sphere. I can plot trajectories across the stars, how the stara form, hell i can make a star here on earth. I can tell you the age of the universe. In the same breath I cannot tell you in a fundamental level how a cell transcribes genes, I cannot tell you how the proteins are transported and constructed, I cannot tell you how a protein is folded, I cannot tell you how a cell structures it's self, I cannot tell you how all this produces consciousness, I cannot explain the quantum mechanical effects of biology and how cells utilize it. My point isn't that we don't know per se, as there are things we don't know about physics. But my point is more so to showcase that to understand how these biology systems fully function is nearly impossible due to the complexity. I can breakdown the solar system and its functions and interactions much more easily then I can explain a drop of blood.
@@EmperorFist323 I'm a head and neck cancer surgeon. I find what I do pretty basic compared to what you do, general relativity and quantum and what's going to be next. I study undergrad physics in those two in my free time and my mind boggles at the complexities.
I had heard of NMN on another podcast about a year ago. I then dud a little research and started taking NMN. I found out it that it has changed my life for the better. My anxiety had pretty much gone away. My energy is by far more focused, and for the most part, I feel great. I have other heath issues that dragged me down prio to NMN. I've tried many supplements and haven't had any luck, but NMN is doing wonders for me. I have bought a year supply since places have quit selling the product.
hello Dr. SInclair, are there any studies and recommendations especially for women regarding hormones, menopause and intake of bioidentical hormons or herbs, or supplements etc. and prevention of diseases related to decline of hormones. I would like to learn more especially about womens health (so rare in the school medicin). Thank you.
I also regret that there is no specific notion as to the women health. Men and women differs, however I found no studies on specific regime /supplements for woman at different age. Could any future podcast focus on this topic, please?
@@ewastykowska3460 yes, it's sad how gynecologists and general practinioners still react when you ask about hormons, according to the motto: “ You are a woman, you just have to go through it! “And such myths like bioidentical hormons cause cancer, what a bullshit and how many suffer every month on pmd or pmdd and all of the damage from the anti baby pills & Co. They just don't know how it all works together, even if you give them numbers
I HAVE BEEN ON NMN FOR 2. MONTHS AND HAVE NOTICED A DRAMATIC IMPROVEMENT IN MY ENERGY & A DECREASED NEED FOR SLEEP. THANKS FOR YOUR AMAZING CONTRIBUTION ❤❤❤❤❤❤❤❤❤❤
Good for you 👍✌️. May i ask if you noticed any changes with your face skin? In terms of acnes and scar marks, if you have.... hopefully you don't have though....
Second comment: I want to add that I am following much of your protocol and I have so much energy it is incredible! I am relatively young (33), but have been dealing with fatigue for a long time. Particularly the day after intense exercise (BJJ). I have trouble focusing and getting through the day even with heavily optimized sleep. I am currently alternating between 16 and 22 hour fasts. When I do eat, it is mostly a low protein, high carb, plant based food (with some junk thrown in because I'm human and still working on things). I am taking NMN, resveratrol and Metformin. And I feel like a million bucks! I am recovering well, focused, creativity is up. I am honestly shocked and hope this is able to sustain itself for the next few months (I do not plan on doing all of this indefinitely).
Highlight of my week. As soon as I listened to these I started OMAD, changed my diet and exercise routine. I've sent this to all my friends and family. Pure gold!
I was hoping that you would discuss Methylation concerns and the use of TMG to mitigate. Also, I find the piece that’s often missing from Such discussions is for pregnant & breastfeeding mothers.
My biggest takeaway: the conversation about mice being predisposed to cancer (certain type(?)) and NMN stimulating cancer growth (as in the 2019 study that was discussed). It feels as though that wasn't given enough emphasis, should I be cancelling my order for NMN?
It stimulates it because if the body inside is younger cancer would also act as if it is in younger body, but then again, if you don't take nmn you will get older faster and chances to get cancer and other increse...
Have been following David since the early Resveratrol days. Was super excited when this series started. Thank you for your continued efforts to expand our knowledge on this topic. You and Matt make a great duo and I hope this series continues beyond the current scope.
Can Dr Sinclair address the Resveratrol/Pterostilbene battle that's going on from Dr Brad Stanfield? As an observer, I'm confused how David says X and Brad says YYYYY To take or not to take?
@@nickl826 We already have NMN, resveratrol, quercetin, fisetin, berberine & spermidine which he talks about here. Jump on our email list, we do the research so you don't have to 🙂
@@donotageteam I don't see the email here. Should Berberine be taken in the morning too? What happens to traditional supplements, take them also or not?
I discovered Dr. Sinclair from Dr. Andrew Huberman's youtube channel. This is amazing information from Dr. Sinclair. Thank you for sharing your knowledge!
Thank you for another amazing podcast! The shows notes, the timestamps and the explanations were very digestible (pardon the pun). Seriously thank you David, Matthew, And the team at Harvard medical school working hard to bring us the best longevity science to date. I can't believe that this information is freely available for all of us
My life has changed after taking NMN supplement... I was very sickly and weak years ago, but when I learned about this product, it gave me hope to progress all the things I stopped doing before, like gardening.. I feel so alive and well with vitruvin NMN and trans-resveratrol..
What are your thoughts on apigenin? Especially in a post menopausal female on estrogen replacement-thank you for this terrific podcast and lending us your knowledge
Dear Dr. Sinclair. I suppose you test for NAD to check the effects of resveratrol, NMN and Spermidine. What are the marker to look for regarding the supplements that aim at mTOR reduction (Fisetin, Quercetin) and AMPK aktivation (Metformin)?
Thanks for this podcast, I appreciate all your work and I been trying to follow your regimen. I wish that you could tell or advise us which you think is the best choice NMN supplements. I been paying a lot for it and still not sure if they are true to their advertising or I pick the right one.
Thanks David & Matthew absolutely amazing series. I have a very important request: Can you do an episode on what molecules/drugs are safe if we already have cancer... some of the common cancers .. prostrate, breast, bowel, lung cancer .... that would b gr8.... if that's possible given the huge diversity that's present in these disease processes & stages. Are there any universals for particular molecules or types of cancer? Etc
Thanks David. Great podcast. Could you comment on the study that "Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults" from 2014 that found no possitive impact in humans (in JAMA Internal Medicine (2014; doi: 10.1001/jamainternmed.2014.1582)
GlaxoSmithKline has to entirely drop all research and studies based off the company bought from Sinclair, as the results were not only bad, but in fact produced negative outcomes.
Taking a supplement or injecting young plasma in a very old body would likely lead to rejuvenation in some tissues, but would also lead to rescue of some very damaged cells and since the all tissues and cells are not rejuvenated to the same extent can lead to undesirable outcomes such as cancer. For e.g. suppose a supplement rejuvenates the liver and does not rejuvenate the immune system to the same extent, some liver cells on the brink of senescence would be rescued, but with mutations or damaged DNA and the dysfunctional and aged immune system would not be able to eliminate them
Can you elaborate more on metformin and berberine for (aging) athletes? What is happening with glucose? Is the total amount of glucose storage in the body reduced? Are we excreting it? Or do the molecules just help glucose more effectively get into tissue? So let's say I have a big ride the next day and I'm trying to tank up on carbohydrates. What's happening if I take one of these molecules with my high carb dinner? THANK YOU!!! LOVE YOUR WORK!!!
If you can not get Metformin.... Is quercetin plus fisetin in combination a good backup plan.... Already doing resveratrol and NMN. It is hard as a lay person to understand some of the details... Appreciate all of your efforts to reach average people like me.
Maybe it is time for an update soon, regarding drugs and dosages? Would be very interested to know Mr Sinclairs view on liposomal delivery of MNM and resveratrol, for instance. Is a season two upcoming?
Can the anti-aging medications/supplementation strategies serve as a proxy to help correct menopause hormonal loss in a way like HRT does? In other words in the absence of HRT, can these improve or affect hormone balance. Any insights? Thank you 🙏
Dr. Sinclair - I follow another RUclipsr named Dr. Brad Stanfield - he posted a rather effective aggregate of resveratrol research that was very persuasive that resveratrol is not just ineffective, but unhealthy. Could you please address?
Resveratrol, 1gram per day, in the morning with yogurt or olive oil,basil, and vinegar (needs fat to be absorbed) Nicotinamide mononucleotide(NMN), 1-2 grams, in the morning with same yogurt/olive oil Quercetin and fisetin, 500 mg each, once per day, in the morning Spermidine, 1-2 mg per day, in the morning Metformin (prescription drug), 800 mg, in the evening
Lord David really does look younger and his Skin is glowing.. Gosh hopefully he will do a podcast in the near future regarding supplements that are effective and proven to be safe that we can consider using at this very moment .
I am marco from Italy, I have already read your book and I have found it fantastic! Naturally all your suggestion are focused on US market, I hope one day you'll have also some suggestion about italian or european provider for blood rest, dna test etc. Supplement are quite easy to find though.
Hi David - I understand Metformin is a chemical derivative of Goat's Rue (Galega officinalis), which you can buy as a herbal supplement. Would this be as effective as Metformin?
NR consistently raised my alt and ast liver enzymes during a year's worth of regular blood tests. NMN lowered my enzymes even lower than they were before taking NR in the first place.
Hi Tim :) given what Dr Sinclair said about Pancreatic Cancer and NMN, I’m wondering if you screened for that genetic propensity and if so what test you used? It’s my only concern regarding starting that supplement. Thanks!
@@larnapike6992 under my 23 and me account, I don't see anything that would indicate a propensity for that or any other form of cancer. There are others who've had this issue with NR, since NR requires additional methyl groups in order to be converted into a usable form. To get these methyl groups, your body has to borrow them from other molecules in the body, taxing the liver more. Which by the way, I'm discussing the liver, not the pancreas. As far as my pancreas goes, all of those health numbers, such as A1C are optimal.
@@AmeliaLi-lz6kc yes, I stocked up a year or so ago when the FDA announced they were going to take it off the shelf for over the counter and rewarded a pharmaceutical company with the license to sell it as a drug
@@therealtimray thanks for responding. Do you also fast? Have you slowed down or reversed aging? I've read and seen some some videos that Dr Sinclair is a fraud. What's your opinion on that?
David, thank you for sharing your knowledge to help others! Question about Berberine- when should I take it? At night, the same as when you take Metformin?
Thank u! Really appreciate you being so direct about how to supplement these ingredients. And David you look amazing for ur age and that make me believe you… and love the fact that u do so much in your own labs… instead of reading from others’ report only!
Thank you Dr. Sinclair and Mr. LaPlante for the podcast. I have been fasting since I saw your interview at Joe Rogans and like to try some of the supplements you are taking. I understand you do not recommend taking any of these but do you have any trusted source where we can purchase these? Your good friend (and podcast twin) Dr. Huberman recommends Thorne which does not have what you were speaking of in this episode. Thanks again for your work
Thank you for all your hard work Dr. Sinclair. I listened to your channel and then went out and bought resveratrol and yogurt. I've been taking it for a few days now (along with NMN and metformin) and I'm feeling great. But then I get a video on my feed from Dr Brad Stanfield saying that resveratrol is harmful to humans. Now I'm confused. Still taking the resveratrol with my yogurt, but I'm a little worried. Will my daily metformin dosages overcome any issues with resveratrol?
Hi David! I’ve been implementing what you suggest (I haven’t yet implemented supplements yet) and I feel a lot better! One of the things I’ve done that’s helped a lot is actually something you haven’t mentioned in the podcast yet. I took a food sensitivity test and cut out the foods that tested positive for sensitivities. Milk was apparently causing me muscle and joint inflammation as well as stomach problems.
Thank you both for this weekly series. Great job. Very informative. I just wish a could find a Dr who is willing to prescribe such molecules & drugs. Blessings🙏💙💙
Tweets, "David just tell us what to take." LOL! I've already implemented a bunch of lifestyle changes. These interventions will change medicine (which many will be unhappy with) but you all better change what you're eating and get to the gym too. Thanks David for the awesome podcast!
As a person without any medical background I really wonder how to check my body response to the supplements recommended in this podcast🤷🏻♀️. I would like to know what blood parameters/blood tests I should check before taking the supplements and when to check out the results by retesting. My kind wish is to have the professor’s opinion whether the recommended supplements are safe for people with celiac disease? Could you also recommend supplements for people with serious problems with knees (deficiency of collagen and how to reverse that ?) Thank you for helping people understand what is going on with their own body❤️
Now when you know such a good info about the supplements what is the rule of thumb to pick the quality ones? I mean there is NMN sold on Aliexpress for third of a price, there are comments of producers using GMO in production of those supplements etc etc How to choose?
I've been taking metformin for 6 months. I recently bought a red light/Near Infrared light. As I understand this video, metformin reduces mitochondrial energy whereas the red/NIR light increases mitochondrial energy. Is there a conflict with using both, e.g. daily metformin and every other day light therapy?
Great podcast and a lot to learn. I live in europe and looked up what your whole supplemention would cost. For this I have exchanged metformin with berberine because you cant buy it. And im not sure if every supplier is 100% thrustworthy. That would be the equivalent of 250 dollars per person per month. Without Inside Tracker / Levels or vitamin supplement. Is this really affordable for the everyday person in the US?
Love the podcast- great episode! I have heard I should be taking TMG with NMN - would love to hear if you do this. Thanks again for your work in the area of aging!
Important to emphasize ‘the threshold level’ as David discussed in his interview with Rhonda Patrick PhD , the ‘natural clearing process ‘ of the body that will eliminate NMN supplements , Resveratrol from the body - and David’s idea of ‘pulsing ‘ these supplements every other day , then fasting and exercising
In that interview with Dr. Patrick he mentions that young mice lived longer if the protocol was pulsed rather than if they received the supplements daily, but he doesn't pulse his own protocol. Is that because he's middle aged and every day is more efficacious, or did you come away thinking that the pulsing is an emerging idea which he is still vetting before switching his own protocol
Thanks for all your great advice. I really enjoy watching your videos, they provide a lot of knowledge and are very helpful on a daily basis in choosing food when shopping, etc. Thank you ❤✨
Hello, really liking the series so far. When talking carbohydrate there is a lot of talk about how many plants utilize certain chemicals to ward of predation, and that because of this they are harmful to humans and should be avoided, making the case for "primal"/keto. The question I have is: is it possible that these chemicals could actually be stimulating an "adversity" response and in fact be very beneficial to humans?
He addressed this in the previous episode or the one before I think. In short, the more stressed the plant, the better they are for you. Somebody correct if I’m wrong, btw.
@@paulgennaro2001 the question is not the fact that the plants were stressed, but whether the chemicals that were stressing the plants is actually harmful to humans or in the end beneficial. Many people in the low carb, keto camp feel that those chemicals are very harmful to humans, really getting into the weeds now.
What age would you recommend a person begin? Also, are there negatives to microdosing, say 2-3 days on, take a 2 weeks off, back on for 2-4 days , 1 week off. I am 28.
Thank you for the information.. just joined the levels membership.. inam diabetes. But my doctor refused to prescribe CGM for me for two years ..I need this machine for supervising my intermittent diet . Finally got it ..
I have a question. How does histamine in the body and brain affect aging? Should we aim for low histamine levels? I note resveratrol and quercetin lower histamine levels. Is this significant?
Why don't ask google. You're literally asking this man for his valuable time, to answer a question that would take 15 minutes of reading to understand.
I love this podcast, and the format. However, I was wondering if there is room for special episodes where you have another researcher alongside you that might be able to add some criticism or another perspective to the research. I came across Dr Rhonda Patrick's video on Metformin for healthy people who exercise, and she seems less enthusiastic about the research. I finally found a review of the literature from last year that gave me a better understanding, but I was wondering if you could make this more efficient. My thought is, maybe you can have someone like Dr Rhonda Patrick on, and discuss a set topic that neither of you too fully agree on, like Metformin. Not to debate necessarily, but to get a more complete view and really flesh out the current state of the research from multiple angles. Matt can still be the moderator, he's great!
I saw Dr. Sinclair on a podcast giving a lecture on Resveratrol, it was for a wine convention, everyone, including Dr. Sinclair was drinking red wine!! The lecture was very educational and entertaining!!🤩👍🏽
Hi David, there seems to be some confusion with the info you are giving on Spermidine. Everywhere I’ve looked it’s measured in grams not milligrams, even the highest dose supplements offer 8mg a day. How come you are taking 1 gram? Thanks!
Am inceput postul intermitent in ultimele zile ale anului trecut.După trei saptamani am facut o verificare si vârsta metabolica a scăzut cu 4 ani.fata de cat era anterior...inca mai am de recuperat,dar imi place foarte mult noul stil de viata.
This is exceptionally interesting. I wonder if there are any studies addressing the additivity of the benefits of different supplements! If two different supplements increase the lifespan of mice by say 30% each, what is the combined effect of the two?
Correction and clarification: At time point 1:07:37, I said I take 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. I apologize for the confusion.
You mentioned physedin or fysadine, but I can’t seem to find the correct spelling. If you could spell that I can investigate. Thank you for your time.
@@brianruppert1071 Fisetin
@@ExbotHero , thank you!! For some reason my computer couldn't track it down. I appreciate it, mate.
@@brianruppert1071 You're welcome my friend. 😊
Can you share what brands he recommends
The co host is great. He has a very effective way to be both a “layman” as he asks questions while at the same time, generally savvy on the topics. Also, I congratulate you both on not taking yourselves too seriously. We already get enough of that with certain scientists.
I couldn’t agree more. Cohost totally makes this a next level podcast/conversation.
Agreed 100% - you took the words out of my fingers. 😁
Yes I thought that too - big shout out to Matt
Agree. He’s lovely as Sinclair mentioned 🥰
Technically he's the host, given that he's the one conducting the interview. But you're right. It's like nearly every time a question pops into my head, it's the very next question out of Matt's mouth.
I’m obsessed. I’m so excited about this research. I’m 50yo. I haven’t had any living parents, grandparents etc in over 10 years. I’m determined to change this for my family!
cute pic
My uncle was more educated than this man, and in the same field, and he died in his late 50s from cancer.
I promise you none of this stuff has any real effect on your longevity.
Live a healthy life, don't go taking a bunch of pills and potions and spending a load of money.
Take care lovely.
@@DoubtingThomas333 what does your uncle being more educated have to do with this. How was his lifestyle???
You re so cute fem
@@lizzie2301Look up criticisms of David Sinclair. There is at least one drug he claims reduces aging that has been proven over and over does not.
I’m a simple man. I see a new Video from Dr. Sinclair and I immediately hit “like”.
This comment will age well, I predict
Me also, like first😂
As do I !
Me too!
This comment is great on the molecular level 🤐😅
I just finished your incredible book Lifespan-for the third time. First reading was an audio version and I stopped every hour to cry hard. I read a lot for a leadership program that I teach for the Air Force and thank you btw for mentioning USA air supremacy.
LITERALLY THE MOST INCREDIBLE INFORMATION!!!! I tried to relay it all to my own adult professional child and her husband and sounded like a blithering idiot bc I get so emotional. I am thrilled to find this podcast so I do not have to try.
Your optimism is a leadership trait; you’re an educator, not merely a scientist. Your book’s messages were mostly about longevity, but also part existential, part environmental, and part economical. As a teacher myself a huge obstacle is keeping my students and coachees happy about humanity. I am as wound up at the end of your book as I am at the beginning.
Thank you for your genius and your optimism.
I can't believe this is free content
I aged a full week waiting for this podcast 🙃
Well, you can reverse it back now 🤣🤣
🤣😂😳
double dose for a week and you will have gained an extra week ,im dreading the leap year I can't order enough
@@StarBoyyX you have some time...nxt L/Y 2024...🙃
@@fitafita7931 yup! Sinclair speaks and we're instantly younger😅
Great that you go deep into dosage, timings and other details on the supplements. So frustrating when others don’t do that.
I was so stoked when I saw you started this channel. Loved watching you as a guest on other podcasts, so this is a treat.
Great job so far!
Why ?
@@mixalis6168 Why what?
@@ashleyjwilliamshand very good point!
@@ashleyjwilliamshand why, so you can grow a brain and ask better questions lol
@@bozorebebo9422 I didn't ask a question in my original comment post on this video, I asked "why what?" to the person that commented "why?"
I'm taking a similar supplement regime myself and have been doing it for a couple of years now. 67 Y.O and feel more energetic and certainly fitter than any time since my early 50s. loving these podcasts learning so much from them, thank you.
Hi can you tell me please some names you take I need more to know the spelling , when he said Nmn quercetin and visetin or I don’t think writing right he mention desitin too, if I’m right. Thank you in advance
I have been taking resveratrol for several years now. Unfortunately I am confused. Many evidences suggest on the contrary. Why doesn't Dr. Sinclare clearly answer the question raised by Dr. Brad Stanfield. I think there are many worried people around the world who have been taking resveratrol waiting for Dr. Sinclair's response. Please!
@@jaihanjqx1140 take curcumin. It also activates Sert 🧬
Finally an interviewer that makes good use of time by letting Dave talk without interrupting and pushing off tangent. Thanks
Love this series of episodes. Very informative and hopeful for those of us in their 70s. Vanity would have driven my interest before, now it is quality of life. Especially cognitive function as I'm watching friends in their late 70s and 80s, mentally declining. Not all but so many.
7-Oh and I drive a van full of handicapped and You and I both want my brains to work at capacity lol
We could talk about Huperzine A
Right behind you! 68 mother of two. Need to remain here as long as possible with healthy body and mind! My son passed during COVID. Being a mom of a 9 & 8 years of age need all help available!
I am a physicist by education. I used to think the biology was an easy subject. Not any more. Listening to this very interesting podcast, I marvel at the complexity of biological systems. This podcast is very informative and easy to understand. I plan to use some of the supplements outlined in this podcast. Excellent
Wow exactly my thoughts. Physics and mathematics is very simple compared to biology. I came to the conclusion biology plays with physics the way we play with math, which makes it very difficult to predict and understand
You should look up quantum biology.
@@EmperorFist323 This is incorrect. Physics and maths are not simple in comparison. They are the hardest subjects.
@@creativesource3514 perhaps. But it is an elementary matter. I can explain to you the orbits of planets, their gravitational pull, their magnetic sphere. I can plot trajectories across the stars, how the stara form, hell i can make a star here on earth. I can tell you the age of the universe.
In the same breath I cannot tell you in a fundamental level how a cell transcribes genes, I cannot tell you how the proteins are transported and constructed, I cannot tell you how a protein is folded, I cannot tell you how a cell structures it's self, I cannot tell you how all this produces consciousness, I cannot explain the quantum mechanical effects of biology and how cells utilize it.
My point isn't that we don't know per se, as there are things we don't know about physics. But my point is more so to showcase that to understand how these biology systems fully function is nearly impossible due to the complexity. I can breakdown the solar system and its functions and interactions much more easily then I can explain a drop of blood.
@@EmperorFist323 I'm a head and neck cancer surgeon. I find what I do pretty basic compared to what you do, general relativity and quantum and what's going to be next. I study undergrad physics in those two in my free time and my mind boggles at the complexities.
People should look into the FDA nmn supplement ban and its connection with Sinclair.
I did. Nothing burger.
I really enjoy these two and how well they get along. I learn so much in each of their podcasts.
Thank you, Dr. Sinclair! I look forward so much to this podcast series. You truly are helping me 🙂
I had heard of NMN on another podcast about a year ago.
I then dud a little research and started taking NMN. I found out it that it has changed my life for the better. My anxiety had pretty much gone away. My energy is by far more focused, and for the most part, I feel great.
I have other heath issues that dragged me down prio to NMN. I've tried many supplements and haven't had any luck, but NMN is doing wonders for me.
I have bought a year supply since places have quit selling the product.
I really like the chat/questions format with this super knowledgeable co-host that makes it so much more valuable than with a real layman! Thanks both
hello Dr. SInclair, are there any studies and recommendations especially for women regarding hormones, menopause and intake of bioidentical hormons or herbs, or supplements etc. and prevention of diseases related to decline of hormones. I would like to learn more especially about womens health (so rare in the school medicin). Thank you.
I also regret that there is no specific notion as to the women health. Men and women differs, however I found no studies on specific regime /supplements for woman at different age. Could any future podcast focus on this topic, please?
@@ewastykowska3460 yes, it's sad how gynecologists and general practinioners still react when you ask about hormons, according to the motto: “ You are a woman, you just have to go through it! “And such myths like bioidentical hormons cause cancer, what a bullshit and how many suffer every month on pmd or pmdd and all of the damage from the anti baby pills & Co. They just don't know how it all works together, even if you give them numbers
The co-host is such a nice guy!!! Makes the podcast just perfect
Dr. Sinclair, hope you will discuss how NMN affects kidneys. Kidneys are crucial to life but are not discussed often. Thank you!
How does it effect the kidneys?
I HAVE BEEN ON NMN FOR 2. MONTHS AND HAVE NOTICED A DRAMATIC IMPROVEMENT IN MY ENERGY & A DECREASED NEED FOR SLEEP. THANKS FOR YOUR AMAZING CONTRIBUTION ❤❤❤❤❤❤❤❤❤❤
Good for you 👍✌️. May i ask if you noticed any changes with your face skin? In terms of acnes and scar marks, if you have.... hopefully you don't have though....
Huge benefits for my face and skin
@@roberttorrie2651 thanks a lot, appreciated 👍
Which Brand please?
@Meem Aly wow I've been using it maybe 10 days and I swear my birthmark on my neck which is light in color is fading.
Any Q&A session some day on your channel?
Thank you for the invaluable information.
Second comment: I want to add that I am following much of your protocol and I have so much energy it is incredible! I am relatively young (33), but have been dealing with fatigue for a long time. Particularly the day after intense exercise (BJJ). I have trouble focusing and getting through the day even with heavily optimized sleep. I am currently alternating between 16 and 22 hour fasts. When I do eat, it is mostly a low protein, high carb, plant based food (with some junk thrown in because I'm human and still working on things). I am taking NMN, resveratrol and Metformin. And I feel like a million bucks! I am recovering well, focused, creativity is up. I am honestly shocked and hope this is able to sustain itself for the next few months (I do not plan on doing all of this indefinitely).
Same!! Wow
What brand of NMN, reservatrol amd metaform are you taking?
Where do you get those? Is there reliable source?
Brand name please
You're fatigued AND spend your days doing "intense exercise?"
Highlight of my week. As soon as I listened to these I started OMAD, changed my diet and exercise routine. I've sent this to all my friends and family. Pure gold!
What is OMAD?
@@cmsotube One Meal A Day = OMAD, IF = Intermittent Fasting. You're wellcome.
I was hoping that you would discuss Methylation concerns and the use of TMG to mitigate.
Also, I find the piece that’s often missing from
Such discussions is for pregnant & breastfeeding mothers.
Women in general are always missing from specific discussions. Because of hormones, women may respond to fasting differently than men, for example.
My biggest takeaway: the conversation about mice being predisposed to cancer (certain type(?)) and NMN stimulating cancer growth (as in the 2019 study that was discussed). It feels as though that wasn't given enough emphasis, should I be cancelling my order for NMN?
It stimulates it because if the body inside is younger cancer would also act as if it is in younger body, but then again, if you don't take nmn you will get older faster and chances to get cancer and other increse...
People are not mice.
Have been following David since the early Resveratrol days. Was super excited when this series started. Thank you for your continued efforts to expand our knowledge on this topic. You and Matt make a great duo and I hope this series continues beyond the current scope.
@@johnf4680 what do you mean?
Biggest Salute to professor David Sinclair...
Can Dr Sinclair address the Resveratrol/Pterostilbene battle that's going on from Dr Brad Stanfield? As an observer, I'm confused how David says X and Brad says YYYYY To take or not to take?
Another excellent podcast David - we love your work!
A few drugs to add to your inventory list where possible ;)
@@nickl826 We already have NMN, resveratrol, quercetin, fisetin, berberine & spermidine which he talks about here. Jump on our email list, we do the research so you don't have to 🙂
@@donotageteam I don't see the email here. Should Berberine be taken in the morning too? What happens to traditional supplements, take them also or not?
came here to post this
Hello. Are these products refundable if we don't like them. The do not age..
I discovered Dr. Sinclair from Dr. Andrew Huberman's youtube channel. This is amazing information from Dr. Sinclair. Thank you for sharing your knowledge!
which supplement companies does he recommend? I know he said he doesnt endorse but which ones are trustworthy?
David, when are you going to comment on the recent rumor banning NMN?
If you take these supplements, does it reduce your body's capacity to produce them? (NMN etc)
Very good question
Very good question. If you take Nad injections will your body stop making it then you need to take them for life?
sharp
I'm guessing they don't know and that there is a ton still unknowed overall. Always risking taking anything especially something newly studied.
Great to see David covering rapamycin a bit more than in the past.
Thank you for another amazing podcast! The shows notes, the timestamps and the explanations were very digestible (pardon the pun). Seriously thank you David, Matthew, And the team at Harvard medical school working hard to bring us the best longevity science to date. I can't believe that this information is freely available for all of us
My life has changed after taking NMN supplement... I was very sickly and weak years ago, but when I learned about this product, it gave me hope to progress all the things I stopped doing before, like gardening.. I feel so alive and well with vitruvin NMN and trans-resveratrol..
You must be rich..I can’t afford these supplements ☹️
What about taking resveratrol with MCT oil in the morning fasted?
Ευχαριστούμε!
This is all so very fascinating! Thank you for speaking to the public directly without the media filter! You are both of a lovely generous spirit
Thanks
Sinclar, the god of anti aging
What are your thoughts on apigenin? Especially in a post menopausal female on estrogen replacement-thank you for this terrific podcast and lending us your knowledge
Any thoughts on the phytochemical sulforaphane?
Dear Dr. Sinclair. I suppose you test for NAD to check the effects of resveratrol, NMN and Spermidine. What are the marker to look for regarding the supplements that aim at mTOR reduction (Fisetin, Quercetin) and AMPK aktivation (Metformin)?
Thanks for this podcast, I appreciate all your work and I been trying to follow your regimen. I wish that you could tell or advise us which you think is the best choice NMN supplements. I been paying a lot for it and still not sure if they are true to their advertising or I pick the right one.
Thanks David & Matthew absolutely amazing series. I have a very important request: Can you do an episode on what molecules/drugs are safe if we already have cancer... some of the common cancers .. prostrate, breast, bowel, lung cancer .... that would b gr8.... if that's possible given the huge diversity that's present in these disease processes & stages. Are there any universals for particular molecules or types of cancer? Etc
Thanks David. Great podcast. Could you comment on the study that "Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults" from 2014 that found no possitive impact in humans (in JAMA Internal Medicine (2014; doi: 10.1001/jamainternmed.2014.1582)
interesting , I thought the resveratrol steps on the gas for the nmn
GlaxoSmithKline has to entirely drop all research and studies based off the company bought from Sinclair, as the results were not only bad, but in fact produced negative outcomes.
Taking a supplement or injecting young plasma in a very old body would likely lead to rejuvenation in some tissues, but would also lead to rescue of some very damaged cells and since the all tissues and cells are not rejuvenated to the same extent can lead to undesirable outcomes such as cancer. For e.g. suppose a supplement rejuvenates the liver and does not rejuvenate the immune system to the same extent, some liver cells on the brink of senescence would be rescued, but with mutations or damaged DNA and the dysfunctional and aged immune system would not be able to eliminate them
Thanks!
Can you elaborate more on metformin and berberine for (aging) athletes? What is happening with glucose? Is the total amount of glucose storage in the body reduced? Are we excreting it? Or do the molecules just help glucose more effectively get into tissue? So let's say I have a big ride the next day and I'm trying to tank up on carbohydrates. What's happening if I take one of these molecules with my high carb dinner? THANK YOU!!! LOVE YOUR WORK!!!
If you can not get Metformin.... Is quercetin plus fisetin in combination a good backup plan.... Already doing resveratrol and NMN. It is hard as a lay person to understand some of the details... Appreciate all of your efforts to reach average people like me.
Really looking forward to the Centennial podcast! brilliant podcast, you two are a great team!
Maybe it is time for an update soon, regarding drugs and dosages? Would be very interested to know Mr Sinclairs view on liposomal delivery of MNM and resveratrol, for instance. Is a season two upcoming?
Can the anti-aging medications/supplementation strategies serve as a proxy to help correct menopause hormonal loss in a way like HRT does? In other words in the absence of HRT, can these improve or affect hormone balance. Any insights? Thank you 🙏
Dr. Sinclair - I follow another RUclipsr named Dr. Brad Stanfield - he posted a rather effective aggregate of resveratrol research that was very persuasive that resveratrol is not just ineffective, but unhealthy. Could you please address?
Hi Dr. Sinclair, what is your opinion on the reported adverse effects of NR/NMN on protein synthesis and hypertrophy?
Resveratrol, 1gram per day, in the morning with yogurt or olive oil,basil, and vinegar (needs fat to be absorbed)
Nicotinamide mononucleotide(NMN), 1-2 grams, in the morning with same yogurt/olive oil
Quercetin and fisetin, 500 mg each, once per day, in the morning
Spermidine, 1-2 mg per day, in the morning
Metformin (prescription drug), 800 mg, in the evening
What about TMG along with NMN?
Lord David really does look younger and his Skin is glowing.. Gosh hopefully he will do a podcast in the near future regarding supplements that are effective and proven to be safe that we can consider using at this very moment .
I am marco from Italy, I have already read your book and I have found it fantastic! Naturally all your suggestion are focused on US market, I hope one day you'll have also some suggestion about italian or european provider for blood rest, dna test etc. Supplement are quite easy to find though.
Ciao Marco. Dove e quali hai preso di integratori se posso sapere?
@@ElectronicApocalypse amazon
Nmn che compagnia l'hai preso?
Hi David - I understand Metformin is a chemical derivative of Goat's Rue (Galega officinalis), which you can buy as a herbal supplement. Would this be as effective as Metformin?
NR consistently raised my alt and ast liver enzymes during a year's worth of regular blood tests. NMN lowered my enzymes even lower than they were before taking NR in the first place.
Hi Tim :) given what Dr Sinclair said about Pancreatic Cancer and NMN, I’m wondering if you screened for that genetic propensity and if so what test you used? It’s my only concern regarding starting that supplement. Thanks!
@@larnapike6992 under my 23 and me account, I don't see anything that would indicate a propensity for that or any other form of cancer. There are others who've had this issue with NR, since NR requires additional methyl groups in order to be converted into a usable form. To get these methyl groups, your body has to borrow them from other molecules in the body, taxing the liver more. Which by the way, I'm discussing the liver, not the pancreas. As far as my pancreas goes, all of those health numbers, such as A1C are optimal.
Hey, are you still taking nmn?😊
@@AmeliaLi-lz6kc yes, I stocked up a year or so ago when the FDA announced they were going to take it off the shelf for over the counter and rewarded a pharmaceutical company with the license to sell it as a drug
@@therealtimray thanks for responding. Do you also fast? Have you slowed down or reversed aging? I've read and seen some some videos that Dr Sinclair is a fraud. What's your opinion on that?
Would you please tell what to look for in blood profile to see if NMN is working in the body after having it for a month?
David, thank you for sharing your knowledge to help others! Question about Berberine- when should I take it? At night, the same as when you take Metformin?
Where can we find these substances? Is there any suggestions for products for the general public?
I don't have a script for Metformin but am taking Berberine. Is it as effective as Metformin or should I get Metrormin?
I know you won't recommend specific manufacturers but can you give an idea of how to find quality sources?
I remember in the first episode we where promised information about brands of these additives that are safe to use. Is that still coming?
Great question , would love to know the best brands .
Thank u! Really appreciate you being so direct about how to supplement these ingredients. And David you look amazing for ur age and that make me believe you… and love the fact that u do so much in your own labs… instead of reading from others’ report only!
Thank you Dr. Sinclair and Mr. LaPlante for the podcast. I have been fasting since I saw your interview at Joe Rogans and like to try some of the supplements you are taking. I understand you do not recommend taking any of these but do you have any trusted source where we can purchase these? Your good friend (and podcast twin) Dr. Huberman recommends Thorne which does not have what you were speaking of in this episode. Thanks again for your work
David Sinclair and his Co author have produced one of the greatest blog for those managing their health. Bravo.
Thank you for all your hard work Dr. Sinclair. I listened to your channel and then went out and bought resveratrol and yogurt. I've been taking it for a few days now (along with NMN and metformin) and I'm feeling great. But then I get a video on my feed from Dr Brad Stanfield saying that resveratrol is harmful to humans. Now I'm confused. Still taking the resveratrol with my yogurt, but I'm a little worried. Will my daily metformin dosages overcome any issues with resveratrol?
Your partner contributes a lot to the interview! Excellent match, glad to see this information presented in an accessible way.
Hi David! I’ve been implementing what you suggest (I haven’t yet implemented supplements yet) and I feel a lot better! One of the things I’ve done that’s helped a lot is actually something you haven’t mentioned in the podcast yet. I took a food sensitivity test and cut out the foods that tested positive for sensitivities. Milk was apparently causing me muscle and joint inflammation as well as stomach problems.
How does one go about taking a test like this?
@@d3f34t you can ask your doctor they usually refer you to an allergist/immunologist who does it.
do try metformin unless your doc says diabetes there's a risk
@@d3f34t find a functional medicine doctor.
Thank you both for this weekly series. Great job. Very informative. I just wish a could find a Dr who is willing to prescribe such molecules & drugs.
Blessings🙏💙💙
Tweets, "David just tell us what to take." LOL! I've already implemented a bunch of lifestyle changes. These interventions will change medicine (which many will be unhappy with) but you all better change what you're eating and get to the gym too. Thanks David for the awesome podcast!
As a person without any medical background I really wonder how to check my body response to the supplements recommended in this podcast🤷🏻♀️. I would like to know what blood parameters/blood tests I should check before taking the supplements and when to check out the results by retesting.
My kind wish is to have the professor’s opinion whether the recommended supplements are safe for people with celiac disease?
Could you also recommend supplements for people with serious problems with knees (deficiency of collagen and how to reverse that ?)
Thank you for helping people understand what is going on with their own body❤️
Now when you know such a good info about the supplements what is the rule of thumb to pick the quality ones? I mean there is NMN sold on Aliexpress for third of a price, there are comments of producers using GMO in production of those supplements etc etc How to choose?
I've been taking metformin for 6 months. I recently bought a red light/Near Infrared light. As I understand this video, metformin reduces mitochondrial energy whereas the red/NIR light increases mitochondrial energy. Is there a conflict with using both, e.g. daily metformin and every other day light therapy?
Use green light.
His voice for his sponsors soooo smoothing Ok David ill buy everyone of your sponsors products cause you said so
Great podcast and a lot to learn. I live in europe and looked up what your whole supplemention would cost. For this I have exchanged metformin with berberine because you cant buy it. And im not sure if every supplier is 100% thrustworthy. That would be the equivalent of 250 dollars per person per month. Without Inside Tracker / Levels or vitamin supplement.
Is this really affordable for the everyday person in the US?
Yes, exactly! Once again if you are rich, life is grand! And longer!!
Dr. Sinclair can you please tell us how to find good quality NMN? So many brands out there but unclear testing.
Love the podcast- great episode! I have heard I should be taking TMG with NMN - would love to hear if you do this. Thanks again for your work in the area of aging!
Curious about TMG - thought you are supposed to take it if you are supplementing with MNM
Important to emphasize ‘the threshold level’ as David discussed in his interview with Rhonda Patrick PhD , the ‘natural clearing process ‘ of the body that will eliminate NMN supplements , Resveratrol from the body - and David’s idea of ‘pulsing ‘ these supplements every other day , then fasting and exercising
In that interview with Dr. Patrick he mentions that young mice lived longer if the protocol was pulsed rather than if they received the supplements daily, but he doesn't pulse his own protocol. Is that because he's middle aged and every day is more efficacious, or did you come away thinking that the pulsing is an emerging idea which he is still vetting before switching his own protocol
Thanks for all your great advice. I really enjoy watching your videos, they provide a lot of knowledge and are very helpful on a daily basis in choosing food when shopping, etc. Thank you ❤✨
Hello, really liking the series so far. When talking carbohydrate there is a lot of talk about how many plants utilize certain chemicals to ward of predation, and that because of this they are harmful to humans and should be avoided, making the case for "primal"/keto. The question I have is: is it possible that these chemicals could actually be stimulating an "adversity" response and in fact be very beneficial to humans?
He addressed this in the previous episode or the one before I think. In short, the more stressed the plant, the better they are for you. Somebody correct if I’m wrong, btw.
@@paulgennaro2001 the question is not the fact that the plants were stressed, but whether the chemicals that were stressing the plants is actually harmful to humans or in the end beneficial. Many people in the low carb, keto camp feel that those chemicals are very harmful to humans, really getting into the weeds now.
Hey David ! just wondering, what are your thoughts on HRT?
What age would you recommend a person begin? Also, are there negatives to microdosing, say 2-3 days on, take a 2 weeks off, back on for 2-4 days , 1 week off. I am 28.
He said in a past podcast that individuals should ideally start in early to mid 20's to maximize longevity.
Juan Estrada NAD?
@@PA-eo7fs No, for fasting protocols and diet.
Thank you for the information.. just joined the levels membership.. inam diabetes. But my doctor refused to prescribe CGM for me for two years ..I need this machine for supervising my intermittent diet .
Finally got it ..
I have a question. How does histamine in the body and brain affect aging? Should we aim for low histamine levels? I note resveratrol and quercetin lower histamine levels. Is this significant?
Why don't ask google. You're literally asking this man for his valuable time, to answer a question that would take 15 minutes of reading to understand.
@@palana8870 overall, I agree, but this could be a useful question for a future podcast.
I would love to have an episode on the different markers to look out for and why.
Dr. Sinclair have you heard about the a new study out of the university of Missouri from Elena goun. Developing cancer with higher nr. Please comment.
34:00
@@maliceChann this is humans and nr just came out
I love this podcast, and the format. However, I was wondering if there is room for special episodes where you have another researcher alongside you that might be able to add some criticism or another perspective to the research. I came across Dr Rhonda Patrick's video on Metformin for healthy people who exercise, and she seems less enthusiastic about the research. I finally found a review of the literature from last year that gave me a better understanding, but I was wondering if you could make this more efficient. My thought is, maybe you can have someone like Dr Rhonda Patrick on, and discuss a set topic that neither of you too fully agree on, like Metformin. Not to debate necessarily, but to get a more complete view and really flesh out the current state of the research from multiple angles. Matt can still be the moderator, he's great!
Great idea, and Valter Longo. For the moment I tend to put my trust in David Sinclair but a discussion would be great
To "Andre Salazar" the Master of metformin is Nir Barzilai, MD.
Great idea, was thinking the same!
Agreed, a podcast on NCEs will be important.
I saw Dr. Sinclair on a podcast giving a lecture on Resveratrol, it was for a wine convention, everyone, including Dr. Sinclair was drinking red wine!! The lecture was very educational and entertaining!!🤩👍🏽
Hi David, there seems to be some confusion with the info you are giving on Spermidine. Everywhere I’ve looked it’s measured in grams not milligrams, even the highest dose supplements offer 8mg a day. How come you are taking 1 gram?
Thanks!
Am inceput postul intermitent in ultimele zile ale anului trecut.După trei saptamani am facut o verificare si vârsta metabolica a scăzut cu 4 ani.fata de cat era anterior...inca mai am de recuperat,dar imi place foarte mult noul stil de viata.
I’m so grateful for having discovered you!! I hope to find the right manufacturers for these products.. 🙏🏼
This is exceptionally interesting. I wonder if there are any studies addressing the additivity of the benefits of different supplements! If two different supplements increase the lifespan of mice by say 30% each, what is the combined effect of the two?