Immunology: T cell receptor structure and function
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- Опубликовано: 29 июл 2024
- The T cell receptor or TCR is a molecule found on the surface of T lymphocytes (or T cells)[1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR.
The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans 95% of T cells the TCR consists of an alpha (α) and beta (β) chain, whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains. This ratio changes during ontogeny and in diseased states as well as in different species.
When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction, that is, a series of biochemical events mediated by associated enzymes, co-receptors, specialized adaptor molecules, and activated or released transcription factors.
1976 copyright act entitles fair use for non profit educational purposes and is extended under the DMCA my videos are not monetized I do this for myself
this is fantastic, thanks
your comments are always welcome! let me know if a video doesnt explain something fully or doesnt address a specific question you have
This was a very helpful video!! I was hoping to review Ig/BCR as well as this. Where can I find the BCR videos you mention in this video?
+Jesse Connors thank you so much jesse!
heres a review for Ig/BCR: ruclips.net/video/5GhNB8avRYU/видео.html
heres a map for Ig/BCR: ruclips.net/video/5GhNB8avRYU/видео.html
let me know if you have any questions, feel free to like/subscribe to my channel
i am always looking for suggestions and feedback
i guess it is kinda randomly asking but does anybody know of a good website to stream new tv shows online ?
@Kace Angelo I would suggest FlixZone. You can find it by googling :)
great little summary, appreciated!
Thank you, just out of curiosity, what are you studying ?
medical student! :)
always humbling when med students comment!!! good luck on your exam!
thank you - i passed :)
Hi! awesome video, is ITAM apart of the TCR complex? also if so how is its function different than CD3? Thank you!
thanks for the comment, the CD3s sub-units all have ITAM domains I have a playlist on lymphocyte development if you are interested check it out here: ruclips.net/p/PLC8lVQV4Hx6cngG1q9TXlJHqyjoOR0oB_
Are TCRs structurally also similar to MHCs?
not really, I mean Im willing to bet all PRR's evolved from either the same gene duplication and genome acquisition
Fantastic summery
Dr.
Thomas Underhill but for a histopathologist it needs more opsonisation to digest the data.
best regards
LOL you are very punny >_< feel free to view some more of my videos and let me know if it doesnt explain something well enough ^w^
how does CD3 direct the TCR to membrane?
Ehh it kind of depends on the context of the question: Vesicular to membrane transport is still a hot topic of nobel prize winning research and is poorly understood.
CD3 Knockout leads to the TCR staying in the ER forever and not progressing further, so its definitely critical.
CD3 and TCR are considered to be "associated" (horrible word choice) with each other before it even arrives at the golgi complex for glycosylation.
Notice that I have not given you an EXPLANATION, i have merely described how things happen, how the "association" was determined I have no idea (FRET would be my guess). I really absolutely hate the use of the word "association" here too bc it doesnt say anything about the type of molecular connectivity between the two (covalently, non covalently, which one ? idk)
welcome to immunology: where the most frequently used word in your textbook is "may"
we can barely describe these events, let alone explain them. let me know if you have any questions and if you have read this entire light novel I wrote you thanks alot
This article is pretty similar to what my textbooks say on the subject: www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/cd3-antigen
εισαι ωραιος
Thanks for the feedback!!! You feel free to let me know if you have questions
Are you still active? First of all thank you very much for your teaching.
I do have a really important question to ask you.
It s the regard the production of IgE, IgG and IgA with the different TCR.
I hope to hear from you soon.
How many different types of T cells are there? and can you list them please
helper (cd4) and killer (cd8)
thanks! also how do they get to the infected site? what molecules do they used to get their?
what course are you taking ? depending on the class that can be a very short question, or a very VERY long one
BSc Biomedical Science. Final year student :)
awesome, I assume you are working on immunochemistry ?
this might help answer your question: ruclips.net/video/CQie-N9MnSw/видео.html
I also have the following playlist that might help as well : ruclips.net/p/PLC8lVQV4Hx6fqdOs4mr5TJzmTNp-Csex1&spfreload=10
good luck !
I believe at 9:10 you mean zeta chain! I had to look it up too. Other than that, great explanation.
+Brian Tran Thanks for pointing that one out, you are absolutely correct! its zeta chain, sorry, I actually have a roommate from greece I would always mispronounce the words. let me know if you have any questions (immunology related, I'm horrible with greek)
Excellent, excellent video. Please update title: "function" is not a word!
THANK YOU FOR POINTING THAT OUT!!!!
need more clarity and elaborateness in explaination
May I ask what you are studying this for ? There may be other videos I could recommend that elaborate more
actually more focus could be done on tcr gene rearrangement for cancerous markers .... and how tcr alpha and beta chain were cloned ..hoe tcr were isolated ..i was looking for that ..btw that videos was good..
I do have a playlist on TCR/BCR Genetic Variation / selection. I dont focus much on cancer however.
what you thought was kappa is actually zeta (ζ) this is kappa: κ
its zeta.
yes
the green one I think it's called xhi
what kind of name is "hobosrockemtrashcans"?
@@medaphysicsrepository2639 Honeslty i ask myself that everynight
you get points for the randomness, the kind of internet I miss circa 2013
@@medaphysicsrepository2639 Youre welcome lol
To answer your original question though: I think its zeta, it seems less squiggily than xhci, idk.
pretentious greek nomenclature aside as long as you understand the function you should be good!
thats zeta not kappa!! ahaha(9:10)
I am not greek =^.^=