Immunology: MHC Antigen Processing and Presentation
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- Опубликовано: 7 сен 2024
- Peptides are processed and presented by two classical pathways:
In MHC class II, phagocytes such as macrophages and immature dendritic cells take up entities by phagocytosis into phagosomes-though B cells exhibit the more general endocytosis into endosomes-which fuse with lysosomes whose acidic enzymes cleave the uptaken protein into many different peptides. Via physicochemical dynamics in molecular interaction with the particular MHC class II variants borne by the host, encoded in the host's genome, a particular peptide exhibits immunodominance and loads onto MHC class II molecules. These are trafficked to and externalized on the cell surface.[12]
In MHC class I, any nucleated cell normally presents cytosolic peptides, mostly self peptides derived from protein turnover and defective ribosomal products. During viral infection, intracellular microorganism infection, or cancerous transformation, such proteins degraded in the proteosome are as well loaded onto MHC class I molecules and displayed on the cell surface. T lymphocytes can detect a peptide displayed at 0.1%-1% of the MHC molecules.
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Thank you John! Ill be making more videos for sure!
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LOL, > .< / feel free to show that love with a subscription please! I intend to to do some cell biology stuff starting around june/july-ish assuming I can get everything in order, and as always feel free to ask me questions if a video doesn't address something well enough.