I swear, I'm rendered speechless throughout and at the end of all of your videos. Even though you're throwing a whole load of information at me and it's definitely content heavy, I find myself memorising everything along the way and I don't even realise it until you do your little recaps. You just have a way to make all of seem digestible. Thank you so much for the time and effort you spend on these videos
First year med student here and I think I'll watch every single Ninja Nerd video, because they facilitate our journey making it easier to understand very complex mechanisms in our body. Can't thank this team enough for their educational delivery.
He is!! Damn i wish you were my teacher for my entire school life.. (as well my meds school teacher 😉) i love❤️ your detailed explanation.. lotts of love❤️❤️❤️❤️❤️ from INDIA..
My husband had a type a aortic dissection in July and I’ve been deep dive learning into all things cardiovascular for the last several months. Your videos have helped me to have a much better understanding of the medical documents I’ve been reading as well as medical records and charts. Thank you so very much.
These videos are BY FAR the most useful, helpful, perfectly explained, videos i've ever seen. I'm so grateful you did this. I read over 100 pages from my advanced patho book and did not understand this immunology process until i watched your entire playlist. THANK YOU!!!!
You are by far the best teacher I've ever had. You make it easy to understand very complex topics. I want to watch every video that you have produced. Thank you for your hard work!!!
It is amazing to me how logically and confidently you explain this stuff. My professor's videos are not even worth watching. So glad I found you! Thank you for all your hard work!
once i tried to understand this concept a lot of time, now my great teacher, you are the god of med students, is explaining easy way so so beneficial, thank you so much.
Thank you so much you make my life in NP school easier... You are such a brilliant guy. I just can't comprehend how are you remembering so easily with all these stuff.
I watch these videos with earbuds in and my family always think I'm watching a TV series or movie or something lol. Typical things I say outloud while I watch Ninja nerd Science video lectures include: "Wowwwwww." "Woah, that makes so much sense." "Huh, wow." "Hahahaha" "Phagocytosis!" "😮🤯🤩🙌🤓" (It's more of an awe-related gasp noise followed by compete joy of understanding a concept while simultaneously so intrigued with a new ignited interest to learn more about that concept and the inter-related web connected to it... Lol) "Yes!!! Yaaaaaay!!!!" "Omg, really?!?!" "Well that makes sense." "No way 😲" "That's amazing" "That's awesome!!!" Laughing, giggling, and appreciating irony and humor in our own biology that I'd never appreciated our understood before. These videos are soooooo helpful. Seriously, thank-you to your entire team!!!! THANK-YOU THANK-YOU THANK-YOU 🌟💫🙌❣️😁
Dude! You are a flat out BEAST/BOSS!!!! I'm an engineer and can't help but appreciate your mastery of what you're talking about. You're a natural!! Keep up the GREAT work!! Love this site - best site out there.
Brother I can't explain how much I'm thankful to you for explaining the all the connection in single go... I've watched Dr.Nejeeb's immunity video but it's important to explain all the IL's and other stuff in one single go for overall understanding... Dr.Najeeb is legend we all know but you summarised it very well...! Thank you so much man thank you 🙏
This video is so useful and thanks to you I learned a lot about adaptive immunity. Before I watch this video I was really sad because I couldn't learn this at school but now I'm more confident and positive for my midterms.
theres literally no words to express how grateful i am for your videos. from the bottom of my heart i truly appreciate all the time spent making these videos and explaining these systems. you're an amazing person, thank you.
I'm so grateful for these videos. The ability to binge learn such well explained topics is so amazing. Thanks for helping all of us get smarter, understand more, and make these pivotal connections!
Who needs a horse and a prince? I would never even notice because this video like the priors leading to REQUIRE MY EVERY SECOND OF ATTENTION IN ORDER TO CONTINUE ON WITH THIS BEAUTIFUL MERCIFUL LESSON! THANK YOU THANK YOU THANK YOU, IM FLOATING
I feel like if 1/3 of the adult population age 18-48 had even 1/2 this level of understanding of physiology, we'd all be so much healthier aaaaaaand our Dr's appointments would be real discussions that are valuable and informative partnerships instead of receive bandaid style treatments to chronic diseases that are preventable with lifestyle modifications (and patients that become intrinsically motivated because they understand what's happening, and know the difference between the parts they can control and the parts that they can't control, and have the courage to make the changes they need to make).
Fantastic work, I do not know what students with confusing professors did to better synthesize information before Apr 7, 2017. Thank you for making these videos.
Thank you so much for all these helpful videos. my professors weren't the best in explaining topics of my immunology course, but I managed to keep up because of your videos!! you're explanation is brilliant and clear and it helped me understand it a lot. I can't thank you enough
Thank you so much! I spent a lot of time trying to look at multiple sources and compile these sequences of events, but I should have just started with you!
Hello ninja nerd, first thank you so much for your videos they saved my life. Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse). Thank you deserve so much more recognition.
I love that I can back-up and watch again if I don't fully understand something (without feeling like I'm frustrating someone else making them repeat it verbatim lol)
13:26 wow moment... I now better understand sin and cosin math concepts because I watched this. Unexpected, unrelated, but unbelievably helpful for solidifying my understanding of everything. Lol I get so much out of these videos, and so much more than I could've imagined too. Like, for example, when I clicked on the 3 year old video playlist to cover immunology, I was expecting the pathology of inflammation etc but I definitely didn't expect to realize that grade 10 pre-cal has a place in my head at all (especially considering I'm almost 36 now, so I quite literally took it 20 years ago in high school, and I took no calc at all in university)... So I'm impressed it's a concept that is there at all, nvm the mind-blowing realization that it's actually a USEFUL concept to help in BIOLOGY (next you'll tell me it works in sociology and psychology and my jaw will drop lol), so that we can better understand, analyze, track, assess and measure the historical log (ack, more math!) data left behind by the biochemical reactions due to the underlying properties particle physics and laws of the universe. 🤦♀️😂🤯🤩🤓
Yes, seriously, that's the revelation that I had watching this video. I had to back up 10 seconds because my mind wandered, but that's the beauty of this valuable asset (your lecture videos and notes)...I can pause, rewind, rewatch. Amazing. ... Also, it means I can binge watch lectures instead of waiting days between classes. This is awesome. Thanks again 😁❣️😂
thank you so much for making this video i just watched it and it helped me alot i've been working on my immune system because when i grow up i am gonna be a doctor, tysm!
Amazing lecture, the only thing I would say is that macrophages cannot present to naive t cells at the START of the immune response, it always has to be a dendritic cell due to cross presentation. Also I would love an even more In depth video of t cell activation. Thanks for the lecture.
Hey Ninja Nerd... Its always great to go through your video series...The videos are very informative and brush up the concepts real quick..There is a small request though..Can you please make some videos on Molecular Genetics and Microbiology ?
Sua explicação é espetacular e exaustiva; muuito boa!!!! Vc torna tudo fácil de entender. Obrigado pelo tempo dedicado a isso, para todos nós!!! [Buddy, thank you very much. Congratulations por your obvious talent, unique!!!!]
where did the IL-4 activating the naive T-cell come from? you just said (approx 18:30) that IL-4 came from Th2 cells and they produce the IL-4. however, you said IL-4 was needed along with IL-2 before the proliferation can occur and become Th2 cells
Here is what I have found. --Immune system makes Th2 to fight off helminth organisms, like parasites and worms. --Basophils are the first cells that interact with antigens from the parasites. When activated by these antigens, basophils produce IL-4 --As the adaptive immune system begins to respond to the downstream effects of the infection, the predominant cytokine is IL-4. It's a small amount but it is enough to preferentially turn naive T-cells into Th2 --The process is a positive feedback from there, because the Th2 cells make more IL-4, which in turn ramps up the number of T lymphocytes becoming Th2 cells. So, to answer your question, I believe the initial IL-4 comes from basophils which react to the helminth organisms. I am still studying this in my first year, however, and would love confirmation from someone with more mastery on the subject!
"Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th2 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell.[5]" - Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. (2008). "A mechanism for the initiation of allergen-induced T helper type 2 responses". Nat Immunol. 9 (3): 310-318. doi:10.1038/ni1558. PMC 3888112. PMID 18300366. from en.wikipedia.org/wiki/Interleukin_4
Not be dramatic but finding your channel has saved my life
Haha heard that!
agreed
So true
I totally agree with you! :)
Totally agree 👍
Summarised:
Summary 1 = 6:12 (B-cell)
Summary 2 = 14:05 (macrophage - naive T-cell interaction)
Summary 3 = 18:20 (naive T-cell making T helper cell to produce specific IL)
summary 4 = 22:15 (IL and B-cell interaction producing memory B-cells and plasmacells)
Summary 5 = 27:47 (antibodys different ways of eliminating antigens)
Summary 6 = 38:25 (NK-cell)
I wish our professor taught immunology this way. This makes so much more sense to me than static pictures on a slide with words.... thank you!
I swear, I'm rendered speechless throughout and at the end of all of your videos. Even though you're throwing a whole load of information at me and it's definitely content heavy, I find myself memorising everything along the way and I don't even realise it until you do your little recaps. You just have a way to make all of seem digestible. Thank you so much for the time and effort you spend on these videos
Same la
First year med student here and I think I'll watch every single Ninja Nerd video, because they facilitate our journey making it easier to understand very complex mechanisms in our body. Can't thank this team enough for their educational delivery.
You are an extremely hard working person! Thank you for making time for this... it clears a lot of complicated mechanisms. Thankyou!
Thanks! There is an entire team here and we do love to put in the work to make these videos great!!
He is!! Damn i wish you were my teacher for my entire school life.. (as well my meds school teacher 😉) i love❤️ your detailed explanation.. lotts of love❤️❤️❤️❤️❤️ from INDIA..
U won my heart sir , such a great teacher sir u are.❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️❤️
@@NinjaNerdOfficial please what is the order of this particular playlist?
My husband had a type a aortic dissection in July and I’ve been deep dive learning into all things cardiovascular for the last several months. Your videos have helped me to have a much better understanding of the medical documents I’ve been reading as well as medical records and charts. Thank you so very much.
thanks to your husband, now you can attend the medical exam.
Professor Zach Murphy, You are a gift that keeps on giving. God bless you and your family. Much Aloha from Oahu
Thanks you so much sir
You explaining immunology is basically like opsonization - presenting the information as more appetizing to us, so we can eat it. Thanks!
How can somebody be so smart and Know so much? Thanks for all your videos and know that you have impacted student's lives all over the world!
These videos are BY FAR the most useful, helpful, perfectly explained, videos i've ever seen. I'm so grateful you did this. I read over 100 pages from my advanced patho book and did not understand this immunology process until i watched your entire playlist. THANK YOU!!!!
WOW. You saved my whole life. This type of detailed explanations are unmatched. You deserve like an award or something
When i start watching this channel i was at my first year now am at my fourth. Still in Love with this god bless you
This channel is only 2 years old. so...
With your videos I have cracked my 2nd year of MBBS And topped it, thank you May you be always in Blessings... ❤️
You are by far the best teacher I've ever had. You make it easy to understand very complex topics. I want to watch every video that you have produced. Thank you for your hard work!!!
It is amazing to me how logically and confidently you explain this stuff. My professor's videos are not even worth watching. So glad I found you! Thank you for all your hard work!
I sincerely thank you. From the bottom of my heart.
Sir i have to tell you this You are the bringer of light to my curiosity
Thank you for these videos
this is the blueprint to study adaptive immunity. i can't tell you how many times i watched this video. thankyou!
These lectures are SO valuable! Please add presentations on cytokines and autoimmunity/autoimmune diseases!
once i tried to understand this concept a lot of time, now my great teacher, you are the god of med students, is explaining easy way so so beneficial, thank you so much.
Thank you so much you make my life in NP school easier... You are such a brilliant guy. I just can't comprehend how are you remembering so easily with all these stuff.
I love that I can pause and backup 10 seconds if my mind wanders off, or if I didn't hear a word, etc.
Every single Romanian med student knows you! You are a legend!
I watch these videos with earbuds in and my family always think I'm watching a TV series or movie or something lol.
Typical things I say outloud while I watch Ninja nerd Science video lectures include:
"Wowwwwww."
"Woah, that makes so much sense."
"Huh, wow."
"Hahahaha"
"Phagocytosis!"
"😮🤯🤩🙌🤓" (It's more of an awe-related gasp noise followed by compete joy of understanding a concept while simultaneously so intrigued with a new ignited interest to learn more about that concept and the inter-related web connected to it... Lol)
"Yes!!! Yaaaaaay!!!!"
"Omg, really?!?!"
"Well that makes sense."
"No way 😲"
"That's amazing"
"That's awesome!!!"
Laughing, giggling, and appreciating irony and humor in our own biology that I'd never appreciated our understood before.
These videos are soooooo helpful. Seriously, thank-you to your entire team!!!!
THANK-YOU THANK-YOU THANK-YOU 🌟💫🙌❣️😁
Dude! You are a flat out BEAST/BOSS!!!! I'm an engineer and can't help but appreciate your mastery of what you're talking about. You're a natural!! Keep up the GREAT work!! Love this site - best site out there.
Brother I can't explain how much I'm thankful to you for explaining the all the connection in single go... I've watched Dr.Nejeeb's immunity video but it's important to explain all the IL's and other stuff in one single go for overall understanding... Dr.Najeeb is legend we all know but you summarised it very well...!
Thank you so much man thank you 🙏
I can't like ninja nerd Science videos enough !!!!!! best youtube channel
This video is so useful and thanks to you I learned a lot about adaptive immunity. Before I watch this video I was really sad because I couldn't learn this at school but now I'm more confident and positive for my midterms.
i hope RUclips monetizes you’re channel.
You more than deserve it.
Thank you so much for these videos ❤️
Ninja Nerd! You literally save my grade, and give me the confidence I need on these exams. THANK. YOU.
needed a touchup on immunology for a paper I'm reading for my PhD. This is everything I needed and more, thank you so much!
theres literally no words to express how grateful i am for your videos. from the bottom of my heart i truly appreciate all the time spent making these videos and explaining these systems. you're an amazing person, thank you.
I'm so grateful for these videos. The ability to binge learn such well explained topics is so amazing. Thanks for helping all of us get smarter, understand more, and make these pivotal connections!
Who needs a horse and a prince? I would never even notice because this video like the priors leading to REQUIRE MY EVERY SECOND OF ATTENTION IN ORDER TO CONTINUE ON WITH THIS BEAUTIFUL MERCIFUL LESSON! THANK YOU THANK YOU THANK YOU, IM FLOATING
you're a genius, thank you so much. I love the integration you do in such a simple way
My brain is hurting. So much to learn.
Definition of love at first sight, thanks so much sir, you help a ton of struggled students out there. Much love from me 💕💕
I feel like if 1/3 of the adult population age 18-48 had even 1/2 this level of understanding of physiology, we'd all be so much healthier aaaaaaand our Dr's appointments would be real discussions that are valuable and informative partnerships instead of receive bandaid style treatments to chronic diseases that are preventable with lifestyle modifications (and patients that become intrinsically motivated because they understand what's happening, and know the difference between the parts they can control and the parts that they can't control, and have the courage to make the changes they need to make).
Fantastic work, I do not know what students with confusing professors did to better synthesize information before Apr 7, 2017. Thank you for making these videos.
He is best till date 🥺❤️🔥🔥
Thank you so much for taking your time to produce these videos to help thousands of students like me. May God bless you.
You are the best professor ive ever met. thank youuu - crying medical student from South Korea 🥹🥹❤
Honest to God, this dude teaches better than half of my professors.
You deserve a Nobel prize.
You just nailed it. Thank you professor 😊
Superb! Noone can replace you. Very clear,apt and expressive.
I needed a review on the adaptive immune response and this was such a great summary!
thank u a good lucture وما أوتيتم من العلم إلا قليلا صدق الله العظيم
احسنتم
remarkable way of his presentation. God gifted !
the smile on the end literally saving my grade, tqysm
Honestly this is a great overview with the perfect amount of detail!! Awesome job!
You're a pro man... seriously you are awesome, i loved this and i reallllllllly understand this thing now ... Thank you so so much
Thank you so much for all these helpful videos. my professors weren't the best in explaining topics of my immunology course, but I managed to keep up because of your videos!! you're explanation is brilliant and clear and it helped me understand it a lot. I can't thank you enough
Thank you so much! I spent a lot of time trying to look at multiple sources and compile these sequences of events, but I should have just started with you!
Thank you so much. I've learned a great deal from your Immunology videos. If you would make one on B-cell development that would be amazing
Hello ninja nerd, first thank you so much for your videos they saved my life.
Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse).
Thank you deserve so much more recognition.
I don´t have enough words to say how thankfull I am
You helping us achieve our degrees with these videos. Thank you so much for all you do!,
Smartest dude on youtube period
This just helping me nowadays reading can be very tough and boring, thanks for making learning easier 👍🏾👍🏾
I love that I can back-up and watch again if I don't fully understand something (without feeling like I'm frustrating someone else making them repeat it verbatim lol)
In other words, ''U ARE SIMPLY AWESOME!!!!!''😄😄😄😄😄😄
13:26 wow moment...
I now better understand sin and cosin math concepts because I watched this.
Unexpected, unrelated, but unbelievably helpful for solidifying my understanding of everything. Lol
I get so much out of these videos, and so much more than I could've imagined too.
Like, for example, when I clicked on the 3 year old video playlist to cover immunology, I was expecting the pathology of inflammation etc but I definitely didn't expect to realize that grade 10 pre-cal has a place in my head at all (especially considering I'm almost 36 now, so I quite literally took it 20 years ago in high school, and I took no calc at all in university)... So I'm impressed it's a concept that is there at all, nvm the mind-blowing realization that it's actually a USEFUL concept to help in BIOLOGY (next you'll tell me it works in sociology and psychology and my jaw will drop lol), so that we can better understand, analyze, track, assess and measure the historical log (ack, more math!) data left behind by the biochemical reactions due to the underlying properties particle physics and laws of the universe. 🤦♀️😂🤯🤩🤓
Yes, seriously, that's the revelation that I had watching this video. I had to back up 10 seconds because my mind wandered, but that's the beauty of this valuable asset (your lecture videos and notes)...I can pause, rewind, rewatch. Amazing.
... Also, it means I can binge watch lectures instead of waiting days between classes. This is awesome. Thanks again 😁❣️😂
Blows my mind every time. Such a good resource.
my dream is this video with subtitles
You are my hero. The Clark Kent of science
SO BRILLANT GIVES SO MUCH HOPE..WATCHING ALL TO UNDERSTAND AUTO IMMUNE AS WELL..SJORGENS SYNDROME & ALL COMPLICATIONS ORGANICALLY SO GRATEFUL..☺❤
These will big help. Thank you so much,
Ninja Nerd
thank you so much for making this video i just watched it and it helped me alot i've been working on my immune system because when i grow up i am gonna be a doctor, tysm!
Thaaanks Zack from Algeria 🇩🇿🇩🇿
Your explanation is very clear and concise and you cover all that information in such a short duration awesome work
you are the reason why I can be a good Doc
Currently saving me in my covid fueled online nursing courses! Thank you for this!
Your videos are literally saving lives, thank you so much!
This guy is a rockstar. Thank you for the knowledge🙏
Amazing lecture, the only thing I would say is that macrophages cannot present to naive t cells at the START of the immune response, it always has to be a dendritic cell due to cross presentation.
Also I would love an even more In depth video of t cell activation. Thanks for the lecture.
Great tutorial master! Thx so much from Thailand🇹🇭💕
Great video. Better than anything I learned in undergrad!
Thanks for these incredible immunology series....I owe you my whole life😇🤗
Literally educational saviour 😅
Thanks
I swear i thought i was watching netflix ... this is so so smoooth ❤
Thank you so much, lots of love from Greece!
This guy is absolutely brilliant
Hey Ninja Nerd... Its always great to go through your video series...The videos are very informative and brush up the concepts real quick..There is a small request though..Can you please make some videos on Molecular Genetics and Microbiology ?
This video put everything in order in my head, thank you
Thanks man being an engineer, i have been watching ur videos, learned a great deal.
Sua explicação é espetacular e exaustiva; muuito boa!!!! Vc torna tudo fácil de entender. Obrigado pelo tempo dedicado a isso, para todos nós!!! [Buddy, thank you very much. Congratulations por your obvious talent, unique!!!!]
Thank you bro for me helping me pass my semester
that's so amazing.. thank you for converting the hard concepts into clear and interesting ones ^-^
Very good explanation sir . Thank u very much 🙏🙏
no way you just did all that off top.... you're a genius my guy!!! ahahaha appreciate the video
Thank you very much!
Best wishes from Hungary
Levente
Sir you should give us brief over view regarding USMLE related questions.
where did the IL-4 activating the naive T-cell come from? you just said (approx 18:30) that IL-4 came from Th2 cells and they produce the IL-4. however, you said IL-4 was needed along with IL-2 before the proliferation can occur and become Th2 cells
Here is what I have found.
--Immune system makes Th2 to fight off helminth organisms, like parasites and worms.
--Basophils are the first cells that interact with antigens from the parasites. When activated by these antigens, basophils produce IL-4
--As the adaptive immune system begins to respond to the downstream effects of the infection, the predominant cytokine is IL-4. It's a small amount but it is enough to preferentially turn naive T-cells into Th2
--The process is a positive feedback from there, because the Th2 cells make more IL-4, which in turn ramps up the number of T lymphocytes becoming Th2 cells.
So, to answer your question, I believe the initial IL-4 comes from basophils which react to the helminth organisms. I am still studying this in my first year, however, and would love confirmation from someone with more mastery on the subject!
"Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th2 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell.[5]" - Sokol, C.L., Barton, G.M., Farr, A.G. & Medzhitov, R. (2008). "A mechanism for the initiation of allergen-induced T helper type 2 responses". Nat Immunol. 9 (3): 310-318. doi:10.1038/ni1558. PMC 3888112. PMID 18300366. from en.wikipedia.org/wiki/Interleukin_4
Thank you for this knowledge😊😊😊
Thank you so much for this vedio.... it's really helpful ❤️
Thank you so much, Jarur, Murshidabad, WB, India.
This is a lot of Infor. Thanks, Zach!💙👍🏻☮️💫
Grate work 😊😊🌹 I’m so proud of you ,you are an amazing person
.