Specific (Adaptive) Immunity | Humoral and Cell-Mediated Responses
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- Опубликовано: 2 июл 2024
- CORRECTION: What I labeled "CD4+" in the diagram is actually the "TCR," which stands for "T-Cell Receptor." The CD4 glycoprotein is a coreceptor with the TCR, but it's not shown in my diagram.
This is how our bodies learn to identify a new pathogen and develop immunity to that pathogen in the future.
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0:00 Introduction
0:48 A Wild Pathogen Appears!
2:11 Phagocytosis and Presenting the Antigen
3:27 T-Helper Cells
4:29 Humoral Response (B-Cells and Antibodies!)
7:07 Cell-Mediated Response (Killer T-Cells!)
9:18 Recap
11:13 More bad acting...
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Image used:
“6VSB spike protein SARS-CoV-2 monomer in homotrimer” commons.wikimedia.org/wiki/Fi..., 5-HT2AR, CC0, via Wikimedia Commons
To add a bit to the cell-mediated response for people reading the comments, the infected cell presents the antigen via the MHC-I (instead of the MHC-II of the APC cells) and the T-killer lymphocyte uses the CD8 receptor for that antigen
Thank you it was actually helpful
Fantastic lecture and comments.
But T8 lymphocytes need T4 lymphocytes so how did T4 lymphocytes get activated if they don't recognize CMH1
@@zizojaezekeom3565 well the macrophage has MHii that presents the antigen,the MHii and is recognised by cd4.while the affected cell has MH i that it presents the antigen with and is recognised by cd8 in short
macrophage MHii - cd4
affected cell MHi - cd8
I've been trying to get my head around this topic for months now and I stumbled across this video, ive never heard it explained so well and so precisely yet in a way so easy to understand. You're an extraordinary teacher, THANKS!
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Thanks so much for the kind words! Glad you found it helpful.
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Aw, thank you for the comment! Glad it was helpful!
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I have been researching this topic over the past week for an assignment, struggling to find anything as clear and helpful as this video by a mile. This video literally feels like the best video on the whole internet for explaining B cell and T cell functions and specific immune responses in general. The detail is perfect, the whole video flows. Thank you so much, I really appreciate your work!
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This is the most helpful video I have seen on the interaction within the adaptive immune system. Thank you for such a clear explanation
Thank you so much! Adding the etymology of the cell and biochem names is super helpful
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You're welcome!
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awesome explanation. you connected the processes of cell-mediated and humoral immunity really well
Reviewing my Physiology notes to take my TEAS exam. I looked through so many videos that were either too complex or too simple. This was perfect! Loved the artwork and the clean separation of processes. Thank you!!!
You're welcome! I'm glad you found it helpful.
Yeah, it's hard to find resources at the right level for a lot of this stuff.
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Glad it helped! I plan to keep making more videos!
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Oh thanku so much for that wonderful class helped me to understand the topic very much... plz keep going and post more videos..
You are wonderful ... clear and crisp ... wish youtube present u to the needful learners in the manner how our cells present the antigens for betterment of body :)
Thanks! I hope RUclips listens to your advice, haha! :)
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You're welcome!
Really awesome big picture video. Thank you🙏🧬
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You're welcome! I plan to keep making them!
I have a class test in 4 hours and now I am fully confident that I'll ace that! Thank you.
This is so concise, Thank a lot Prof. !!!
I
Spent a week trying to figure this out and u explained it in a few minutes. You are truly a teacher indeed. Can you couple this with the Mac 1 and two? Omg you are good. I have hope now of passing this section of the exam tomorrow!
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Nursing student here! Thank you so much for these videos!! You are a hero!
Brother one of the finest video on this topic.....you got my respect 👍🏻🤝🏻
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Question about the immune system: So what is the difference between MHC-II and MHC-I? Are MHC-II's only present on macrophages?
Seriously thank you x 1000 and I hope to use your videos throughout medical school once I make it there :)
Extremely beautiful and beneficial. I love that so much.. please continue
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Thanks! I plan to keep making videos 👍🏼
Fantastic lecture and comments
I'm a very visual learner and the way you drew it all out and separated the different processes! thank you for finally helping my brain understand this topic :) If I get an A on my exam today I can thank you!!
Glad the videos were helpful. Let me know how you did on your exam!
Great video! Thanks!
i didnt had a problem with focusing on your lecture. That's rare for me thank you for the video
so far your videos have been very helpful:) thank you for making it easier for us. although I didn't believe you were sick :x
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Thank you so much for this amazing video
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You're welcome! Glad it helped!
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I'm not a Bio major but this is probably the best video explaining anything ever. Helps me understand research I'll have to read for my extra-credit assignment. Thanks!
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I watched the lymphatic system video and now this … and I want to watch the blood one next. For the very first time I’m finding human body systems fascinating. Never had such a great teacher before. I might have gone into medicine if I had had videos like this in my younger life!
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Aw, thanks for the kind words! Best of luck with homeschooling anatomy this year!
very clear and specific video, just hoped you would take about the types of interferones and the "component system" too. This would have helped to be even more complete. Maybe talking about the NK-cells too but overall very very good video
NK cells are part of the innate immune system, that's why they are not being discussed here
Many thanks very good video
Thank you
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I've been watching a couple of videos on the Immune System and I could easily admit that you're the Phil Jackson of Immunology.
Well, Phil Jackson with a touch of DiCaprio (nice fake acting lol). You've mastered the act of transferring knowledge.
Thank you!!!
Hey, my students tell me my acting is improving! But they’re probably just being nice...
Thanks for the comment!
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Thank you,
When you're taking a 6 week online accelerated A&P 2 class before nursing school starts-- you're freaking out and then you find Siebert Science. I may pass now. THANK YOU. lol
same lol
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Not so convincing coughing, but the lecture was amazinggggg. Thanks!
So you’re saying I shouldn’t quit RUclips to become an actor??? ;)
You’re literally the best!!! I don’t know why you don’t do biochemistry😭
I’d love to do biochemistry someday. But this isn’t my job…I do all this stuff in my spare time, so I’m pretty limited in how much content I can make.
thank you
oh my god, thank you so much for this video, immunology is driving me crazy
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hataraku saibou in the background! It's a good show focusing on body immunology ! 😄
I was hoping some people would notice that! Great show!
Can you make vd about the non-specific?
Do you have a video on Hypersensitivity Reactions?
wonderful and help tutorial, I like it
Thanks for the comment!
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Thanks!
the best video to explain this. I really wanted a clear cut, step by step demonstration and this is incredibly helpful. thankyou!
What about MHC 1 that present the antigen for T cytotoxic?
I have a question regarding the B cell maturing in the bone marrow i read in multiple sources that it start’s developing in the bone marrow but continues in the spleen to final maturation but i also read it matures in the bone marrow so can you tell me which is true?
The intelligence of our body
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I like the Cells at Work easter egg.
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can you just clear a doubt ? How can cells retain specific memory of any pathogen in spite of having average life span?
they keep dividing into new cells and passing on the information.
Goat
this guy made my life a lot easier
The problem is, everybody start to modify the truth at the moment of the cross between innate and adaptive immunity so I can’t know what is real or not real ...
- The T helper cell learn the shape of the antigen presented by the APC and goes on ?
OR
- The T helper cell have already learn a antigen specificity at the birth and goes on only if himself and the APC match ?
Cells At Work!! i love that anime!
This is for class 12??
goated
APC: the body’s way of wearing the blood of our enemies 😂
Those cells literally decapitate the invader and WEAR it’s body to alert other cells!! How cool is that!!!