Immunology | Inflammation: Toll Like Receptors and Interferons: Part 4
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- Опубликовано: 30 мар 2017
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join Professor Zach Murphy for our final discussion on the physiology of inflammation. During part 4 of this lecture series, we discuss toll like receptors and interferons along with their signaling pathways. We hope you enjoy this lecture and be sure to support us below!
Inflammatory Response Video Series:
Part 1: • Immunology | Inflammat...
Part 2: • Immunology | Inflammat...
Part 3: • Immunology | Inflammat...
Part 4: • Immunology | Inflammat...
References:
● Asa Cusack. The London School of Economics and Political Science. Interferon functions [Digital image] LSE
● Ji-Yoon Noh, Suk Ran Yoon, Tae-Don Kim, Inpyo Choi, Haiyoung Jung, "Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy", Journal of Immunology Research, vol. 2020, Article ID 2045860, 9 pages, 2020. [Digital image] www.hindawi.com/journals/jir/...
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● lberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Science; 2002
● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012
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#ninjanerd #Inflammation #Immunology
Your drawing and knowledge goes hand in hand so well, which is much better and easier than reading any books listening to some dry lectures
Dr zachary we need more lectures about immunology I can say somehow it's the beast for all students although we pleased learning it from you still we need a lot of lectures specially from you
you have a very specific method of explanation just makes infos drop into our mind
THANK YOU A LOT ❤❤❤
Its incredible how much knowledge can fit into a video
You have literally, in 2 hours or less, across this series, explained to me what almost 8 hours of lecture attempted to cover!!
Who else here is a certified expert after watching this?
0:45 wow
Thank you so much! This is what missing in NP and PA schools! I learned so much! You are so brilliant!
Finally. I've been looking for a good lecture that will help me understand interferons and toll like receptors. Thank for this.
Thank you so much. Your explanations are clear, concise, and I can cram an entire semester worth of knowledge into 3 hours. You are awesome!
Iam addicted to your words and to every single word you say
Thanks from the bottom of my heart ❤
Hello ninja nerd, first thank you so much for your videos they saved my life.
Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse).
Thank you deserve so much more recognition.
u are absolutely amazing, bro u deserve much much more recognition. u really are a blessing for students like me. thank u...
You are literally saving my life in PA school... thank you so much!
I have my exam after 2 days and here u r explaining everything so simply, Thankyou so much
Just wanted to say, your videos are amazing!!!!
They help sooo much to see the general picture
Video by video i get more in love with u!! Thank you for this❤️ merry christmas
Please release a book about all these videos, they are so helpful!! Love your videos, keep going man!
thank you so much sir for making this difficult topic so much easier to comprehend and memorize!
Your vids are making immunology like a piece of cake for me
In the book Essentials of Medical Microbiology, It says that both TLR 7 & 8 respond to ssRNA.
.
Any which way, I'd like to say :
All your videos are precise and extremely informative. Thank you so much!
thank you for all you do, your videos are always my go-to learning videos except you haven't done a topic on it
After 5 years, that is still the best!
What prevents RBCs and platelets from normally undergoing apoptosis by the Natural killer cells? Because these cells do not have nuclei and hence lack MHC-1.
Genio . Más simple la explicación no puede ser. Muchas gracias !!
10:40 , 24:02 revision of the lecture
Very helpful !!! 👍 Gratitude from India 🙏
Thank you for delivering this lecture so perfectly! Was wondering if you could add to this by talking about NOD like receptors and inflammasomes?
Just got a ad about a guy saying he was absorbing the material by just touching the cover of the book. 25 min later I've been holding my hand over the computer screen, and I have absorbed the lecture.. Thanks Ninja ;))
🤣🤣🤣🤣🤣🤣
I think tlr 7 and tlr 8 respond both to ssrna but in different patways.
Thank y so muccchhhh.
Hi Nerd Ninja, I'm going over this video to refresh my memory on the innate immune system to better understand the research into the covid virus. I believe that a slow innate sytem response coupled with an agreassive adaptive response is in part responsible for higher mortality...
There is no better way how to celebrate Easter Monday than studying for exams with Zach
❤❤❤ HAPPY EASTER ❤❤❤
and New Year's Ever :)
Thank you so much for such an amazing lecture. Are interferons only secreted by infected host cells (like tissue cells) or can immune cells themselves secrete them like monocytes?
Love what you're doing. Super helpful. Just wanted to point out acyclovir is a guanosine analogue not an interferon. Otherwise great lectures!! Keep it up.
love all your videos and i'd like to know what textbooks you use to study ?
Great series!
thank you so much ..
it's so helpful
Thank you, thank you!
This makes me cry.
God bless you sir
Ninja .... you are a super hero 🦸♂️
love u and ur lecture
🥰🥰🥰 the best teacher!
I long for your pathology lectures.
Kind regards, thank you.
Nice video. I thought- Protein Kinase R is inhibiting the eIF2 by phosphorylation.Therefore, the cell can not doing proteinbiosyntheses of their own and the virus proteins. The enzyme destroying virus DNA or RNA ist RNAse L, which is activated by the 2'5' OASE (also activating by INF alpha and beta).
Awesome explanation!
Hi Zack, thank for your amazing videos, I just think there is a mistake here IFN gamma is not secreted by macrophages, it is secreted by TH1 cells and Natural killer cells and work on macrophages, IFN alpha and Beta work on natural killer cells
You’re a legend literally🔥
Nice video zach.howd u miss PDC cells when u explained Interferon beta.nice video though,truly inspirational teaching style
The macrophage is fricked, I am not, thanks to you. Thank you so much for putting living visual associations to the knotted bundle of facts and names I had in my head before watching this. As always, immensely helpful. Thank you so much.
Thank you so much!
You are a Legend Sir❤
much much much helpful.🙏
Amazing!
you are a blessing!
Thankew soo much ♥️
BLESS YOU & WORK...SUPEME TEACHER & I KNOW W BACKGROUND IN ANATOMY & PHSYOLGY..NOW EXPERIENING SJORGRES & COMPLICATIONS...VASCULAR, EXOCRINE INFECTIONS , ETC...AM DETERMINED TO FIND NATURAL CURE..,GOD BLESS U..HOPEFUL NOW..❤
thank you
Can you plz put subtitles in part 2 3 and 4.. i am little hearing impaired
Have any videos on NOD like receptors???
exactly what i need.
so are IFN cytokines only released why a virus infects the cell or it can be released when a bacteria is present as well?
Waiting for website launch 🎊
You are a savior 🙏
superb
which video is next, IBD is in the top right corner, other vids on adaptive immunity and t cells and antibodies exist...found it, immune review, adaptive, t cells, antibody structure, he has 8 immunology lectures and now notes on his website :)
thank you thank you thank you thank you
you lecture is amazing, can we get your note ?
Are we able to download pictures of your drawing board? Your lectures are amazing.
Sir Can You make Video on The Cell Repair Mechanism?
LIFE SAVING!
Can you please write the expanded forms of symbols you use in a side of the board.
Is there a video on chronic inflammation?
perfect
One of these days when it is safe to discuss COVID-19 , maybe they will tell how they tried to find ways to negate these receptors
great
Note: TLR-8 responds to ssRNA, single stranded RNA
What is part 1 called? Tried to look up
Is there a micro Playlist anywhere?
We need a video on B cell development
Where’s the icon where I can double or triple like, u are amazing 🤩
Sir Cover the Whole Micro And Pathology
Just a quick note you mentioned that TLR 8 responds to double-stranded RNA which is incorrect. TLR8 responds to single-stranded ssRNA and not dsRNA.
agree
Please can you put english subtitile in many videos that Don't.
hey man, what book do you use to study the immunology?
I hope your all wishes come true
bro，could you add the subtitles？thanks for doing this！！！
Where do defensins come in?
According to basic immunology (6th) by abbas and Lictman TLR-8 respons to ssRNA and not dsRNA.
ss or ds is either umimportant, the point is to understand and remember basic concepts, not the example
@@nhanquang8884 Understanding that TLR-8 responds to ssRNA is the basic concept though.
Nope, basic concepts answer these questions: what is a TLR? and what such things do it do?. You dont need to go into too much detail cause it's impractical. If you wanna be pratical, for your records, TLR8 not only recognizes dsDNA, it also goes for ssDNA, ARN and some proteins in specific conditions. You see how complicated it is ? So do not mention it's basic concept.
@@nhanquang8884 meh, pretty basic stuff to me. But everyone's different.
10:54 , 20:24 , 24:04
Thank you so much sir😊
Pleas if you can make the sound better ,thank you
Por favor con subtitulos en Español
My head hurts 🤕
TLR- 7&8 responds to ssRNA
Hi, Why subtitles aren't available?
Is TLR4 a homodimer?
OMG! How does he know so much? I can barely understand Double Stranded RNA hahahahaha
❤️
bro, ily
Thank you so much for the wonderful explanation! I just wanted to point out that I believe TLR-11 is technically not in humans but in rats.
❤❤❤❤