Immunology | Inflammation: Complement Proteins: Part 3

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  • Опубликовано: 30 мар 2017
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    Join Professor Zach Murphy as we continue our discussion on the physiology of inflammation. During part 3 of this lecture series, we discuss complement proteins. This will include the classical, alternative, and lectin pathways. We hope you enjoy this lecture and be sure to support us below!
    Inflammatory Response Video Series:
    Part 1: • Immunology | Inflammat...
    Part 2: • Immunology | Inflammat...
    Part 3: • Immunology | Inflammat...
    Part 4: • Immunology | Inflammat...
    References:
    ● Hduman Galician. Complement Pathway [Digital image] en.m.wikipedia.org/wiki/Compl...
    ● Srijana Khanal. Complemetn pathway; Types, Functions, Regulations. [Digital image] microbeonline.com/complement-...
    ● Medicalbiochemist [Quiz] www.medicalbiochemist.com/201...
    ● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
    ● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
    ● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
    ● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
    ● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
    ● lberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Science; 2002
    ● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
    ● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
    ● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012
    Join this channel to get access to perks:
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    #ninjanerd #Inflammation #Immunology

Комментарии • 329

  • @suje8032
    @suje8032 3 года назад +313

    I’m a 56 year old woman who knows nothing about immunology. I’m fascinated by you. Your mom must be very proud of you.

  • @ibreathexcellence
    @ibreathexcellence 6 лет назад +567

    Just a heads up guys, your stuff is being noticed and talked about in a lot of places. Reddit med school and SDN for example have nothing but good things to say about you, and a lot of my classmates are watching your vids now. Great explanations as always, and keep them coming

    • @IAmTheEggMan111
      @IAmTheEggMan111 4 года назад

      Man Kev what are you studying to become?

    • @Cannabisqualityengineering
      @Cannabisqualityengineering 3 года назад +3

      I came here from r/medlabprofessionals recommendation. Not disappointed, will watch again.

    • @burcuyener7421
      @burcuyener7421 2 года назад

      @@Cannabisqualityengineering what is this? I try to find it out but couldnt success. Can you clarify me? Thank you

    • @andrewgonzales1359
      @andrewgonzales1359 2 года назад

      I think that this material is really accessible.

    • @sultankhan6407
      @sultankhan6407 2 года назад

      Agghjmmmnn. MmmggghhhbbbbbbbbbbbbbnnnAaaa

  • @sudiparoy9302
    @sudiparoy9302 6 лет назад +231

    I am a first year Medical student and yup all these explanations that u gave are so damn helpful.... i am more a visual learner and found it quite difficult to understand these topics when the professor taught this in class. your explanations made it quiet easy for me .... thank you ninja nerd science

    • @NinjaNerdOfficial
      @NinjaNerdOfficial  6 лет назад +111

      +SUDIPA ROY I will quote Zach here... He said “the immune content was one of my favorite areas to research/present on, and I really hope students get a lot out of it.” The ninja nerd science team is thrilled we are able to make these videos to supplement visual learners like yourself!
      Happy studying!
      -Rob

    • @osamazeidan
      @osamazeidan Год назад +5

      Are u in year 4 now?

    • @amirabenaissa1343
      @amirabenaissa1343 9 месяцев назад +1

      @@osamazeidanyear 5 now time flies 😅

    • @bilalurrehamankhan1052
      @bilalurrehamankhan1052 4 месяца назад

      And now what are you
      I am in 1st year ❤

  • @popoolatosin1204
    @popoolatosin1204 4 года назад +109

    I wonder how he cracks those jokes and still keeps a straight face 😂

    • @ahmadalkaabneh7475
      @ahmadalkaabneh7475 3 года назад +3

      bro yes i really die when he makes these jokes LMFAO
      but honestly his way of teaching is hilarious i love it.

    • @Cass_i
      @Cass_i 3 года назад

      Ikr!

  • @katiel8725
    @katiel8725 Год назад +7

    Amazing. When I read my textbook, it all sounds like gibberish. Then you explain it so well and thoroughly, it all clicks into place. Thank you.

  • @Habulcool1999
    @Habulcool1999 2 года назад +3

    Zach I don't know how much all these positive comments pay u off hope u all are being paid pretty well off for your service to mankind too but I have lost words how beautiful a teacher can be , your teaching skills ,simplied diagrams and their explanations not many can do it

  • @nourmohisen1472
    @nourmohisen1472 4 года назад +60

    This channel should have millions of views
    You should start making tours around world universities 😂

  • @FooDanger
    @FooDanger 3 года назад +105

    This guy is such a huge lifesaver during Covid. My lecturers prerecorded classes are really useless in comparison to The one and only Ninja Nerd.

  • @Mani-hs8dd
    @Mani-hs8dd 4 года назад +12

    l lost hope on understanding and passing immunology with good grades but
    i found this vid and i cannot express enough how much you saved me from 1- a mental break down which will lead me to 2- wasting study time on crying
    keep going i love every single vidow you’ve ever posted 🤍

  • @erinoyama1788
    @erinoyama1788 2 года назад +14

    I'm taking an advanced pathophysiology class for my AGACNP program and your lectures have been a God send!! I haven't taken a pathophysiology class in almost 20 years, and you explained everything in a way that was user friendly and made a subject that I was always terrified of a bit more manageable! THANK YOU!!

  • @megimcme9610
    @megimcme9610 5 лет назад +59

    This is the best educational video i have seen in my life. MASSIVE respect and thank you for posting such beautiful content. Your way of teaching complex topics is beyond stunning. Very visual, very memorable and really fun to watch. Lots of love

  • @mayurakshisarma33
    @mayurakshisarma33 Год назад +8

    God give you all the happiness in the world sir. You might not know what good and kind things you have been doing bye helping all the clueless students like me. So so so thankful towards you for such high quality content, free of cost. 🙏🏻🙏🏻🙏🏻

  • @lucelence6312
    @lucelence6312 3 года назад +14

    Thank you so much for this. I could understand this perfectly now. The professors in our college just read a bunch of presentations and left. I have been postponing learning this thinking it was so hard. But you made it quite simple with your white board and explanations. You and your team are earning worldwide reputation for you passion sir And thank you again for making these free for us.

  • @liridonadonna3189
    @liridonadonna3189 2 года назад +3

    You sir deserve a noble price. You have conferred the greatest benefit to Mankind. Very much appreciated, you make my studying so much easier.

  • @ssims373
    @ssims373 2 года назад +7

    SIMPLY BRILLIANT, OUTSTANDING, AMAZING and JAW DROPPING lecture. You Sir and your team deserve a standing ovation!!!

  • @annaudvari
    @annaudvari Месяц назад

    I am a biotechnology master student and just found you channel...damn, if I had known about you earlier... You are saving me right now!

  • @Magicboogaloo
    @Magicboogaloo 6 лет назад +43

    You just saved me from failing my immunology module!!

  • @AllysonRR
    @AllysonRR Год назад +1

    This guy never ceases to amaze me.. I can't tell you how many times I'd studied the complement ad for the first time I can FINALLY say I understand it

  • @user-kg3go4fh5o
    @user-kg3go4fh5o 7 месяцев назад +2

    you are literally a legend how did I not come across your channel sooner tysm bro I'm going to avoid complete and utter failure thanks to you

  • @giuliabrahimaj7296
    @giuliabrahimaj7296 3 месяца назад

    God bless you! Thank you so much for your job! Not everyone share his knowledge as you and also open for all! You are the angel of medical students. Please keep going, we need you!!

  • @fani.p.9
    @fani.p.9 Год назад +2

    I just wanna say. You help vet students too ,thank you so so much.

  • @PasanJayaweeraYashoda
    @PasanJayaweeraYashoda 3 года назад +5

    Your lectures are so helpful for us biomedical engineering students. we don't know as much about human body like people with science majors but the way you explain stuff, makes it easy to grasp these concepts for us. thank you!

  • @melpinhattischisler994
    @melpinhattischisler994 Год назад +1

    For over a week, I have been reviewing my immunology lectures, books, notes for an exam this week. I have been a diligent student all semester, but still managed to be confused and frusturated with this course. Then came this series, that made everything clear and fall into place

  • @reditamiru6651
    @reditamiru6651 2 года назад +5

    In my medical school, there is 3 hours long lecture on immunology for two days( all systems in innate and adaptive immunity) and we are allowed to use the left hours in these two days to learn and to review what we learnt in the lectures. The 6 hours long lecture was totally confusing to me; and by having that great fear for immunology course, I was worrying how I can read and finish the huge reference books just in some hours. I tried to use some short videos to save my time...still they did not work out. Finally I came here....Ohh, so amazing!...since the ninja lectures have sequences and have clarity to follow , I even do not know how much long they last and I never feel bored and confused...at the end of each lectures, I smile and thank this person...and will be motivated to read more and more. After listening to the lectures, I always feel that how much we are created being magnificent and I feel like I can go and answer each of my exam questions.
    Now I have already decided to be a member for this academy through out my medical life and thinking how I can save some money to be a full member.
    Thank you Ninja!

  • @vihaansinghdhami908
    @vihaansinghdhami908 Год назад +1

    How can u make each and every concept so easy to understand!!!! U r a pure genius .. a teacher in pure sense !!

  • @amyhoover7613
    @amyhoover7613 2 года назад +2

    Thank you for all you do to educate people!! I would never be able make it through these textbooks without your amazing ability to make these things make sense. THANK YOU

  • @charlesakhimienmhonan2175
    @charlesakhimienmhonan2175 3 года назад +1

    Anaphalatoxins : C3a, C4a, C5a; Chemoattractant: C5a; MAC: C5b6789. Another interesting one from Ninja Nerd

  • @overduejoyful
    @overduejoyful 8 месяцев назад +1

    professor zach you are a lifesaver. if i ever get my mpharm degree i owe it to you.

  • @shivanishivani4705
    @shivanishivani4705 2 года назад +1

    i have no words to explain....how beautiful and conceptually u explain everything.

  • @aufa2119
    @aufa2119 3 года назад +5

    really amazed by how he is so passionate about teaching the concept, making me feel passionate and eager to learn too :)

  • @DrOscarPacheco
    @DrOscarPacheco 5 лет назад +2

    I think that part of your succesful explanation is the liveliness you put on it... Thank you!

  • @christinapeck3573
    @christinapeck3573 2 года назад +1

    You. Are. Loved. Thank you for your time and dedication, you help millions of students around the world!

  • @kyralidiss.3361
    @kyralidiss.3361 9 месяцев назад +1

    My beloved NINJA, I would love to see more immunology and oncology material in your channel! Best regards!

  • @JCgo119
    @JCgo119 2 года назад +1

    Watched bunch of Jack's lectures and really AMAZED how this guy knows all these things. I have watch multiple times to remember all the names and terms.
    Anyways I just wanna say THANK YOU for Jack and his team for the detailed clips. It helped me a lot to get the overviews.

  • @tamarjasmin6989
    @tamarjasmin6989 Год назад +2

    It’s Amazing how you make this information come alive for us visual learners. Thank you Ninja Nerd!❤️

  • @funsizedtwinkie
    @funsizedtwinkie 2 года назад +1

    May you be blessed with abundance!! You have no idea what a blessing your content is!

  • @bre1263
    @bre1263 2 года назад +1

    Some text books are useless right now....this guy is the best

  • @josoborn6417
    @josoborn6417 Год назад +3

    You're a born teacher Zach ! Thank you so much for your work ! You save every semester !
    Sending love to the whole Ninja Nerd Team from Germany !

  • @caraeisert4660
    @caraeisert4660 Год назад +1

    Thank you for your amazing work! I love watching your videos and you are a better teacher than all of my professors at med school together. You inspired me to tutor some of my class mates in med school during the neurology semester. All I did was implementing your style of explaining, repeating, visualising and permanently trying to find out how the person understands the subject of matter in the best way! I got lots of thankful comments for my tutoring but it was really you and the understanding you gave me that helped me to help others! Greeting from Germany with a thankful heart.

  • @irismalon1694
    @irismalon1694 4 года назад +53

    I asked the bacteria what was that red thing on his head,
    The bacteria replied: "its manose"

  • @mariamgeldiashvili155
    @mariamgeldiashvili155 4 года назад +5

    You are awesome. Thank you so much for doing this! You make studying in Med school a lot easier.

  • @nichole7617
    @nichole7617 3 года назад +1

    You do such a kick ass job of breaking down complicated topics. You are my life saver! Thank you.

  • @elielielizabeth
    @elielielizabeth 4 года назад +11

    you draw the cutest 'mean' bacteria hahaha I love it!

  • @lanasallaey2101
    @lanasallaey2101 3 года назад +6

    Ninja nerd : so easy right !! 🤓
    Me : saying yes when am almost crying 😭😂

  • @tariksebbah393
    @tariksebbah393 2 года назад +3

    I just watched 2 of your videos and I already apprecite the experience, I mean it feels like we are attending a class from home and that's wonderful, you're doing a great job mat

  • @santibise
    @santibise 3 года назад +1

    El mejor maestro que he tenido. The best teacher i've had.

  • @persidematigi3192
    @persidematigi3192 6 лет назад +3

    I am so happy that I found your videos, they are so helpful.

  • @andreasepulveda8203
    @andreasepulveda8203 5 лет назад

    You're just amazing! I love your videos and I love your energy. Plus, you're keeping me and my friends from totally failing.
    Love you.

  • @elenaderisio5947
    @elenaderisio5947 5 месяцев назад +1

    you are my hero. Sending lot of support from Italy

  • @nadiasneedle8639
    @nadiasneedle8639 4 года назад +1

    You are my favorite online teacher so far. Thank you.

  • @puneetvyas5466
    @puneetvyas5466 4 года назад +3

    Lots of love and appreciation.. seriously.. you make our lives so much easier and happier... Thanks. -Med students

  • @rangerdownfishing
    @rangerdownfishing 5 лет назад +3

    "This guy is going to get all fricked up" 8:40. I appreciate your down to earth demeanor! Keep up the great work, love watching your channel and I send as many people here as I can. As a Bio Major and a Paramedic, this channel really helps to understand the basics and many of my colleagues and fellow students have enjoyed as well.

    • @alaa2581
      @alaa2581 2 года назад

      what is the meaning of going to get all fricked Up ?
      iam Egyption so i didnt get that

  • @TamingTheJump
    @TamingTheJump 5 лет назад +20

    Nice vid! Although, you are wrong about MAC. It is only C9 which penetrates the cell membrane and builds the pore that allows the flow of water and ions. (It is several C9-structures that make up the pore).

    • @vicentecuba3707
      @vicentecuba3707 4 года назад +2

      I agree. The pore is only C9

    • @ForYouPH
      @ForYouPH 4 года назад +5

      Well I learned that C5b to C9 are all building mac. Probably it`s different in different books!

    • @illidan124825634
      @illidan124825634 3 года назад +2

      @@ForYouPH The pore itself is polymerized C9, but it still requires C5b to C8 to initiate the process, so it's not wrong wrong, just depend on whether you're talking about only the pore or the entire complex.

    • @nikeshs3231
      @nikeshs3231 3 года назад +3

      C5b678(9)n is called the MAC.....he is right.

  • @luvstarryskies
    @luvstarryskies 2 года назад

    Thank you so much! You have made this information very clear and digestible for comprehension instead of regurgitation! You are amazing and I am going to keep watching these videos on repeat until I can verbally teach it like you do 💖

  • @a199719971997
    @a199719971997 Год назад +6

    ay yo good stuff!! I am in graduate level chem courses but need to know this stuff for some projects. Straight up awesome resource that is somehow free.
    Keep it up!!!!!

  • @jessicamckinney9367
    @jessicamckinney9367 Год назад

    This in incredible! So knowledgeable with such helpful and clear illustrations! Thank you for the time and thought you put into this.

  • @sirinesaleh5398
    @sirinesaleh5398 3 года назад +1

    Hello ninja nerd, first thank you so much for your videos they saved my life.
    Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse).
    Thank you deserve so much more recognition.

  • @elizabethsadley2368
    @elizabethsadley2368 5 лет назад +1

    this dude rocks it easy to understand, super interesting, fun to watch

  • @shangakonaporshibergqvist4454
    @shangakonaporshibergqvist4454 6 лет назад +4

    Extremely helpful. Thank you!

  • @gurpreet244
    @gurpreet244 10 месяцев назад +1

    This has been so helpful and is really preparing me well for an upcoming quiz, thank you guys so much!

  • @GeasreenEgar
    @GeasreenEgar 4 года назад +2

    Hello Ninja Nerd, all we have left in this time of pandemic are online platforms to continue our discussion and just so you know we use your videos as our resource. Incredible explanation, you are like my Guyton Jr. Good job as always. Stay safe😊

  • @nodoubtli
    @nodoubtli 5 лет назад

    So helpful and the description of opsonin was great! Thank god for your videos!!!

  • @SERKO0TURKO
    @SERKO0TURKO 3 года назад

    he is explaining realy complex things while making fun it is so easier to learn this way thank you man

  • @rhajneystephenson4669
    @rhajneystephenson4669 5 лет назад +18

    This kills me!! 😂 Man look at the bacteria's legs, it's so weird. I love this

  • @GurpreetKaur-mo8hh
    @GurpreetKaur-mo8hh 4 года назад

    I am learning from all of your videos they are best. I hope our professors should have taught this way.

  • @Justmevishnu
    @Justmevishnu 8 месяцев назад +1

    I have no idea why the teachers in my uni make these topics so complicated with their "sophisticated " ppt's..... hope they watch the videos of this legend at least once for goodness sake😢

  • @faezehabbasi9151
    @faezehabbasi9151 6 месяцев назад

    I wonder how I could pass my exams in nursing school without u ❤.

  • @ailem2707
    @ailem2707 4 года назад +1

    THANK YOU!! I couldn’t get the compliment mechanism in my head. If I do well in my exam tomorrow, I’ll say that grade’s for you

  • @camilasousa5853
    @camilasousa5853 3 года назад

    You make it so simple to understand. It`s amazing!! Thankkkkk you so much!!!

  • @fatimazafar5614
    @fatimazafar5614 Год назад

    absolutely amazing sir... I have never read this topic before but now I think It couldn't be more understanding than this.

  • @user-qv6gt7px5k
    @user-qv6gt7px5k 5 лет назад

    You're videos are just crazy!!! Thanks a lot

  • @sama_albairmani
    @sama_albairmani 3 года назад

    You are ABSOLUTELY the best of the best! thanks a lot

  • @monicasantos8233
    @monicasantos8233 Год назад

    In Acupuncture school and we have to learn the things about the things I never wanted to know about!! But LORDY these videos are so hugely helpful. No joke, Acupuncturists have to learn this stuff too :)

  • @nosotress4744
    @nosotress4744 6 лет назад +4

    You're so good! Wish you would use the right keywords to get more views. You're lectures need to get our there for the world to see.

  • @dr.anitaqamarzamanshah4643
    @dr.anitaqamarzamanshah4643 Год назад

    Ninja… bro u r purely a blessing for med students…🙏

  • @charliethomas9326
    @charliethomas9326 3 года назад

    Best teacher i have ever had.

  • @sakimiakoto8786
    @sakimiakoto8786 3 года назад

    Brilliant. I was given a sequence of Cs with 0 meaning to memorize, came here and understood the thing in 2x speed. 3 30am exam at 9, feeling more positively about it knowing that things have an actual meaning

  • @stepup5338
    @stepup5338 2 месяца назад

    Thankyou Dr Zach!

  • @kabouch
    @kabouch 2 года назад +1

    9:55 phospholipid membranes of both host cells (such as immune cells) and pathogen cells carry -ve charges so, they naturally repel unless a positively-charged protein such as antibody and a complement protein help them get in contact for further phagocytosis.

  • @fiyaraza6337
    @fiyaraza6337 2 года назад

    Your videos are very helpful! Thank you so much!!

  • @josephdrinkard
    @josephdrinkard 5 лет назад

    This is amazing. Thank you so much!

  • @egs8545
    @egs8545 4 года назад +1

    Fabulous videos, I can’t thank you enough!

  • @madeline8968
    @madeline8968 3 года назад

    Sir, you are a wonderful teacher. Thank you.

  • @kirtigupta1349
    @kirtigupta1349 Год назад +1

    Thank you for such an interesting and detailed explanation. Helps a lot! 😍

  • @risperkaronei5100
    @risperkaronei5100 4 года назад

    Thank you for these lectures.

  • @hinanabom3657
    @hinanabom3657 4 года назад

    Thnku man..i was struggling with these system..but now aftr watching ur video everything cleared,..god bless you

  • @ranazohaib2389
    @ranazohaib2389 3 года назад

    you are such an amazing teacher i can’t describe in my words❣️❣️❣️

  • @immaabdirzakmoh5077
    @immaabdirzakmoh5077 2 года назад

    Thank you alot, you're best teacher I never seen in my life ❤ ,thanks alot ❤ you're help many chapters...😘

  • @martayihun1884
    @martayihun1884 2 года назад

    Doctor Thanks I always see it and it has helped me a lot🙏🙏

  • @raiffarosso3393
    @raiffarosso3393 Год назад

    I LOVE NINJA NERD! THANK YOU.

  • @pedromaciel3058
    @pedromaciel3058 6 лет назад

    Do you know how the MAC binds and fuse in the bacteria membrane?

  • @laura18700
    @laura18700 5 дней назад

    Thanks for keeping up my will to finish uni

  • @pattiekrohn4853
    @pattiekrohn4853 Год назад

    Amazing. You are such a gifted teacher.

  • @disappointedbutnotsurprised17
    @disappointedbutnotsurprised17 17 дней назад +1

    8:36 😂😂 how can he just do that with a straight face i'm wheezing-

  • @bububuvu6349
    @bububuvu6349 2 года назад

    I know my lect tomorrow gonna be complicated so i watch ur vid firsttt ….so helpfull

  • @MariaLuiza-tz1kv
    @MariaLuiza-tz1kv 9 месяцев назад

    You are awesome, I cant quite explain how u changed my view of how I learn and how is supposed to be fun and always interesting, thank you so much, kisses from Brazil ❤
    Note: binge-watching all the playlists... physiology, biochemistry, and now immunology 😂

  • @charlespc8855
    @charlespc8855 4 года назад +2

    Zack a fan as always. I had a small request for pharmacology videos would you be able to perhaps do some on pharmacokinetics, pharmacodynamics and neuropharmacology?
    Your biggest fan
    Charlie, your biggest fan from Edinburgh

  • @eminaanime4477
    @eminaanime4477 5 лет назад

    I love you Ninja Nerd. Thank you ♥

  • @hasantinwala8879
    @hasantinwala8879 7 месяцев назад

    You dropped this 👑

  • @isaac_6530
    @isaac_6530 Год назад

    You are the best ninja nerd ! Arigato 🙇‍♂️