T cell development in the Thymus

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  • Опубликовано: 8 сен 2019
  • This video gives a quick overview about the development process of T cell inside the thumus

Комментарии • 179

  • @tarunkant95
    @tarunkant95 4 года назад +17

    I listen to your video more than I watch it. Great content but just a friendly suggestion, some words because of the accent are very hard to grasp in one go, try to minimize it and keep up the good work.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +5

      Tarun Parihar thanks for the feedback ....it would help me to improve in future

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +6

      Please share among your friends and help me to reach big audience

    • @tiffanyhoward9935
      @tiffanyhoward9935 4 года назад +7

      Animated biology With arpan I appreciate your willingness to teach. Oddly, I appreciate the accent because it encourages me to truly pay attention rather than multitasking as I do with other videos.

    • @tarunkant95
      @tarunkant95 3 года назад

      @@animatedbiologywitharpan you're most welcome. I wish you success.

  • @usmanamini1871
    @usmanamini1871 3 года назад +8

    Medical student at germany. This video made it so easy for me to learn this topic. thank you.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please my friend share my channel link with your classmates. I am unable to reach big audience

  • @missesCarmenB
    @missesCarmenB 3 года назад +8

    This makes learning biochemistry so much easier, I wish this was available when I was a student, many years ago. Thank you

  • @phoenixkepo2743
    @phoenixkepo2743 2 года назад +5

    Lucid, clear and to the point. Love your presentation

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @olinko2849
    @olinko2849 Год назад +4

    Thank you so much!! I was stuck so long on this because I couldn't visualize it right. Keep up the good work :)

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Год назад +1

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Small contribution like $5 means a lot for us.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Год назад +1

      Don't forget to check out my entire immunology playlist. Please share my youtube channel link with your friends

  • @nidhishukla8095
    @nidhishukla8095 2 года назад +3

    your videos are genuinely very helpful for me tomorrow I have a test and I am crying for not covered anything and don't have a time for reference reading but your video is going to helping me out of this situation thank you , thank you for this favorable explanation ...........👌👌👌👌👌👏👏👏👏👏

  • @priyadarshinighosh6461
    @priyadarshinighosh6461 4 года назад +4

    Your channel deserves a lot more subscribers !

  • @gladysudoka193
    @gladysudoka193 Год назад +1

    This is good , very simplied and enhances the understanding of difficult subjects as this. well done

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Год назад

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.

  • @jeffreykennedy3707
    @jeffreykennedy3707 2 года назад +1

    Your video is well structured and very easy to understand. GREAT JOB!!! You should create more content.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
      I'm on Instagram as @animatedbiologywitharpan. Install the app to follow my photos and videos. instagram.com/invites/contact/?i=1p41h314q3fv8&

  • @hariigaire
    @hariigaire 3 года назад +2

    Your explanation is very beautiful.
    Keep on posting more videos.
    Love from Kathmandu

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад +1

      Thanks and keep on supporting.......please share among friends and help me to reach big audience

  • @tusharsarve6586
    @tusharsarve6586 4 года назад +2

    Recent one!.. liked it bro. Animation is good and description as well. Really nice and helpful

  • @user-mo4cc6hr7b
    @user-mo4cc6hr7b 4 года назад +2

    Beautiful and easy explanation! thank you

  • @sanroopramesh7620
    @sanroopramesh7620 Год назад +1

    Very useful. I like the comparison at the beginning

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Год назад

      Please support my channel via super thanks. Your small contribution like 1$ means a lot for us. The super thanks option is present at the lower right corner of any video, a heart sign with $ in it.

  • @iambliscanna1592
    @iambliscanna1592 Год назад +1

    Brilliantly explained! Thank You!
    SUBSCRIBED! 😀

  • @nil7425
    @nil7425 3 года назад +1

    Arpan da! Just another masterpiece. ❤️

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      ruclips.net/channel/UC4IpyopsGWSjaPACNTZLuqg please subscribe to my other channel

  • @hxdcm
    @hxdcm 2 года назад +2

    Such an interesting video, thanks for making it

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @abhibittu16
    @abhibittu16 4 года назад +2

    Very simple and easy explanation. Thanks👍

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +1

      Abhishek Anand please share with your friends and help me to reach big audience

  • @RayyannAlqadry
    @RayyannAlqadry 4 года назад +1

    According to a research paper in the Journal of Experimental Medicine, T Cell training takes only 4 days. Just a sharing. Everything else is amazing, exactly what I was looking for

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +1

      Rayyann Alqadry thanks for your detailed feed back it would help me to improve my content..... also I am a learner and the audiance like you would help me to learn

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад

      Rayyann Alqadry please share my channel link with your friends and help me to reach big audience

    • @RayyannAlqadry
      @RayyannAlqadry 4 года назад

      @@animatedbiologywitharpan Oh, I wanted to know, where did you find the information that only 10% of the T Cells pass through Positive Selection? Thank you in advance

  • @tanmayatripathy3944
    @tanmayatripathy3944 3 года назад

    superb sir....your context and describing style is mindblowing

  • @zainabjummah7383
    @zainabjummah7383 3 года назад +1

    Thanks you help me to understand this complicated process... go on

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @phoenixkepo2743
    @phoenixkepo2743 2 года назад +2

    Special forces selection training @ the cellular level. Amazing!

  • @nedunchezhian9914
    @nedunchezhian9914 2 года назад +1

    Nicely demonstrated

  • @youhani9459
    @youhani9459 Год назад +1

    amazing video! Very well explained :D

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Год назад

      In order to make high quality content consistently, we need support from you. Please support us by using super thanks option. Super thanks icon is present below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for us.

  • @Mchc167
    @Mchc167 3 года назад +1

    This was very helpful thank you

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @mindspaceinvaderskibinhhon4465
    @mindspaceinvaderskibinhhon4465 2 года назад +2

    Sorry but can someone please explain me more about the positve and negative selection when
    T cells are trained by the thymic epithelial cells? what is "MHC restriction" like? I need it for the coming test at school. If you know, guide me as soon as possible. Thank you so much

  • @hibakaleed387
    @hibakaleed387 3 года назад +1

    Amazing video thank you so much

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      please share my channel link with your friends and help me to reach out big audiance

  • @gurunathvenugopal4642
    @gurunathvenugopal4642 2 года назад +2

    Very well explained. Thank you for teaching

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Please share my channel link with your friends and help me to reach big audience .

    • @lurker7522
      @lurker7522 2 года назад

      @@animatedbiologywitharpan Hi, I have a question. Do regulatory T cells go through the same training process as other T cells?

  • @shakir1325
    @shakir1325 Год назад +1

    This is osm ❤❤
    I understood very well
    Thank you

  • @HarryPotter-vl3pc
    @HarryPotter-vl3pc 3 года назад +2

    Woww... this really is awesome

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @ToniDJohns
    @ToniDJohns 4 года назад +2

    wow ! Thank you !

  • @africkinamerican
    @africkinamerican 3 года назад +1

    Fascinating. How do the T cells know when /how to enter the bloodstream to travel to "school"?

    • @aaquib608
      @aaquib608 2 года назад

      Thymic epithelial releases certain chemokines which attracts immature T cells towards Thymus.

  • @sherbetstraw8605
    @sherbetstraw8605 2 года назад +2

    sensational thank you

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @vascofachada9774
    @vascofachada9774 4 месяца назад +1

    good job, thanks!

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 месяца назад

      Please share my channel link with your friends and help me to reach big audiance

  • @GauravKumar-fc7sr
    @GauravKumar-fc7sr 4 года назад +2

    Awesome sir,,,, all basic concepts clear 😘😘😘

  • @paulchang8743
    @paulchang8743 4 года назад +1

    whether negative selection happens in the thymic medullary region?
    by interacting with medullary thymic epithelial cell (mTEC)

    • @johnnielee5618
      @johnnielee5618 4 года назад

      Please see wiki "thymus". Positive in cortex; negative in medulla. Knowledge should be shared. Good luck.

  • @gaurishah9086
    @gaurishah9086 3 года назад +1

    Easy explanation, thank you

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @sobis6670
    @sobis6670 3 года назад +1

    Thank you very helpful 👍

  • @partibhapanchal7030
    @partibhapanchal7030 2 года назад +1

    Insightful video.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад +1

      Please share my channel link with your friends and help me to reach big audience

    • @partibhapanchal7030
      @partibhapanchal7030 2 года назад +1

      @@animatedbiologywitharpan I'm on to it. Content might be available on sites but the way u delivered it making ur videos superb 👌.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад +1

      Thanks for the kind words

  • @muntakaalhassan959
    @muntakaalhassan959 4 года назад +1

    Thank you very much

  • @biotechstudent8658
    @biotechstudent8658 2 года назад +1

    First of all thank you for this video, but I should ask for one concept, the hematopoietic stem cells are multipotent stem cells as I read from the other articles and from my stem cell lessons, Can I ask that where is it available the information of the HSC cells are pluripotent stem cells ?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Kuby immunology 7th ed (not 6th ) chapter 2 or you can refer to revire article. Pdf of the book is there in pdfdrive

  • @halima2953
    @halima2953 3 года назад +1

    For one Tcell and after TCR genes rearrangement will there be MANY types of TCRs or a single type of it which could be ( Alpha, Beta )or (gamma, Delta)

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад +1

      One tcr type should be found in a particular T cell.. because after tcr vdj recombination one particular type is formed. But in a population of T cell we can find diversity of TCR

    • @halima2953
      @halima2953 3 года назад

      @@animatedbiologywitharpan ok I got it now thanks for replying

  • @azkaarshad4773
    @azkaarshad4773 4 года назад +1

    Thank u and may god bless u

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +1

      Azka Arshad please share among your friends

    • @azkaarshad4773
      @azkaarshad4773 4 года назад +1

      @@animatedbiologywitharpan OKAY and stay safe ,lots of respect from pakistan

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад

      @@azkaarshad4773 You also stay safe my brother . Love from India

    • @azkaarshad4773
      @azkaarshad4773 4 года назад +1

      @@animatedbiologywitharpan Thank you so much umm i am a medical student and i am a girl.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +1

      Ups sorry ....I called you brother....my bad... please share my channel link among your friends and help me to reach big audience

  • @customking8467
    @customking8467 Месяц назад +1

    Some much better than my lecturer

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  Месяц назад

      here is immunology playlist for complete revision ruclips.net/p/PLKtiwIJ8Q7rq77W7r4cXPrbhi_VpLWw8c&si=eafq-0lBBzfGLrAt

  • @avantikachauhan1837
    @avantikachauhan1837 3 года назад +1

    Thanku for explaining this well

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me reach out big audience

  • @roselinkitherik6972
    @roselinkitherik6972 2 года назад +1

    Superb bro

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @pranav6143
    @pranav6143 2 года назад +2

    @Animated biology With arpan sir as it says the thymus will be inactive on adulthood,then how is the t lymphocytes matures in the adulthood time?
    Bcz the TCR(t cell receptors)forming on the T cell membrane are said to be specific to the pathogenic antigen(by the response of related specific genes like TAG 1 or TAG 2 genes).Isnt this process of new pathogen encounter to be happened in furthur phase of ones life,so then isnt the thymus need to be active for those specific kind of functioning related to T Lymphocyte development?
    So again,my qstn is is thymus active in adulthood,if not ,how the t cells are developed in adults?

    • @pranav6143
      @pranav6143 2 года назад

      I got the answer sir,
      Bcz on t cell production itself diff types of TCR having diff t cells are produced.So during an infection ,the t cells having the tcr, ie compactable to those pathogen will get activated and do their function
      Isn't it sir?

    • @lunam7249
      @lunam7249 Год назад

      HIV attacts the thymus....the thymus is "said" to contract and shrink normally with age, however this is not as significant as the common medical knowedge believes

  • @awestphal9602
    @awestphal9602 8 месяцев назад +1

    The regeneration of the Thymus is a current topic. Particularly, the use of Russian bioregulators such as Vladonix (A-6) and Thymic Protein A. Teach us how we can regenerate the Thymus and overcome future illnesses. Apparently, there are scientific studies and experts supporting the regeneration of the Thymus.

  • @zzzsss00
    @zzzsss00 3 года назад +2

    Can u please make a video what happens if u remove thymus gland and how would effect people after?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад +1

      Adaptive 8mmune response would be compromised in short...i will make a video on that

    • @zzzsss00
      @zzzsss00 3 года назад

      @@animatedbiologywitharpan thank you very much! Waiting for your video👍

    • @amandaczymbor281
      @amandaczymbor281 Год назад

      Was a video made on this?

  • @arindampaul5256
    @arindampaul5256 3 года назад

    Best understood this topic

  • @chtatarrachid2443
    @chtatarrachid2443 Год назад +1

    Thanks

  • @triggerednj2709
    @triggerednj2709 2 года назад +1

    Superb presentation

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance
      I'm on facebook & Instagram as @animatedbiologywitharpan. Install the app to download notes and flash cards. instagram.com/invites/contact/?i=1p41h314q3fv8&
      You can support the channel by clicking on the super like icon below the video ( a heart sign with $ in it ) . You can support using paytm/ phone pe/ gPay / paypal. Your small contribution means a lot for me

  • @joesteinwold5782
    @joesteinwold5782 2 года назад +1

    Can the t-cells from the bone marrow grow the thymus?

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      The mature in the thymus but are born in bone marrow. They can't be born in the thymus because thymus don't have the stem cells that produce t cells

  • @backbenchersbio3688
    @backbenchersbio3688 4 года назад

    Thank u sr
    My immuno is not so strong but after watching this vdo t cell maturation is totally cleared
    Sr make vdos on b cell maturation also

  • @biologylover1565
    @biologylover1565 3 года назад +1

    Hematopoietic multipotent stem cell found in bone marrow.
    So it is multipotent stem cell able to give all cell of same linage of blood cell.

    • @millbankowusuemmanuel4572
      @millbankowusuemmanuel4572 3 года назад

      Yes, it's the basic pluripotent cell that differentiates depending on the chemical signal received from the body for specific demands

  • @madhurabanerjee1965
    @madhurabanerjee1965 3 года назад +1

    Owo u aktually made my doubt clear

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @s.papadatos6711
    @s.papadatos6711 2 года назад +1

    Well explained, however the β chain is the one that has D genes, not the α.

  • @getitdone0010
    @getitdone0010 9 месяцев назад

    Hi Sir,
    I think at 6:00 you indicated the alpha vs. Beta chain captions wrong to their respective pictures... wont B-chain will have VDJ-C and alpha chain will have VJ-C recombination pattern for genes. Please correct me if I am wrong.

  • @RaviKumar-sb4bp
    @RaviKumar-sb4bp 3 года назад +2

    Helpfull

  • @mdshahjahan618
    @mdshahjahan618 Год назад +1

    How to easily improve our body T- cell,plz suggested me.?

  • @gilbertgrejp
    @gilbertgrejp 2 года назад +1

    Sorry, my Histology book says no HEV in the thymus. Only in lymph nodes and MALT/GALT/BALT

  • @biancaelena6675
    @biancaelena6675 3 года назад +1

    Nice explanation

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @bidhisingh9982
    @bidhisingh9982 4 года назад +1

    great exp sir

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +1

      Good.... glad to hear that you guys are liking it... please share among your friends and help me to reach big audience

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад +1

      And I am not sir .... I am one of you guys

  • @immadisarojini2775
    @immadisarojini2775 3 года назад +1

    Nice

  • @HatiKeseorangan
    @HatiKeseorangan 2 года назад +1

    Like ... Wow !!! What happen on this earth... WBC not the one who stop the symbiosis, but thymus....

  • @ritahtezra1386
    @ritahtezra1386 3 года назад +1

    At what point are the RAG genes involved

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад

      ruclips.net/video/yc3uW6rr9lM/видео.html rag Gene's are essential for tcr receptor vdj recombination. Watch this video to know more

  • @knowledgejunction1643
    @knowledgejunction1643 4 года назад +2

    Dear brother arpan yr content r amazing and also teaching but if u want more and more subc , share and populality then pls make video in also hindi language; next as u wish

  • @bio366geethasankar7
    @bio366geethasankar7 3 месяца назад +2

    🙏🏻🙏💖

  • @somid7777
    @somid7777 Год назад +1

    I loved this video! However i thought VDJ was for B chain and VJ was alpha chain

  • @xianjia9372
    @xianjia9372 2 года назад +1

    Pretty slides

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Please share my channel link with your friends and help me to reach big audience

  • @meghashreeguha99
    @meghashreeguha99 11 месяцев назад +1

    ❤❤

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  11 месяцев назад +1

      Please share my channel link with your friends and help me to reach big audiance

    • @meghashreeguha99
      @meghashreeguha99 11 месяцев назад

      ​@@animatedbiologywitharpansure

  • @snowy2875
    @snowy2875 2 года назад +1

    I think you should tell us, how to increase the amount of t cell in my body that would be more practical.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  2 года назад

      Diet is the most important thing for that. You can watch the following video to get an idea ruclips.net/video/wf20Gu1y1_o/видео.html

    • @snowy2875
      @snowy2875 2 года назад +1

      @@animatedbiologywitharpan Thanks buddy!!!!!

  • @MehediHasan-gy8uz
    @MehediHasan-gy8uz Год назад +1

    Book reference??????

  • @missesCarmenB
    @missesCarmenB 3 года назад +1

    The living cell, the True God's creation in my opinion. So wonderfully intelligent in ALL living beings. The rest is all about Evolution.

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  3 года назад +1

      I agree with your point

    • @missesCarmenB
      @missesCarmenB 3 года назад +1

      @@animatedbiologywitharpan I was 19 in my first year studying biochemistry, this has been my "religion" ever since as it is the only thing that makes sense to me. I've never cared if anyone agrees with me or not, I avoided talking about it realizing that most friends or relatives will not understand. Thank you so much for agreeing with me.

  • @kvnkvn9191
    @kvnkvn9191 3 года назад +1

    I can see you learnd this from kuby

  • @kunalgaurav5181
    @kunalgaurav5181 4 года назад +1

    U r teaching is 👍!! But why u are faking your accent?🙄

    • @animatedbiologywitharpan
      @animatedbiologywitharpan  4 года назад

      As I have spent a long time abroad I have developed this accent ..... cant help it ...any way thanks for the feed back ..please share among friends

  • @youtubeyoutube5887
    @youtubeyoutube5887 3 года назад +1

    Why you are using fake accent otherwise it is good

  • @teleportvalorant7658
    @teleportvalorant7658 3 года назад +15

    Hi everyone.If you read this message please read the Holy Quran the direct words and the final message from Almighty God.Ut will guide you to peace truth and happiness in this world and the afterworld with my lovely wishes