Positive and Negative Selection for the USMLE Step 1

Immunology made ridiculously simple.
Covered in this video: T cell differentiation and maturation, positive selection, thymic cortex, self-MHC, T cells, thymic epithelial cells, apoptosis, negative selection, CD4, CD8, T cell receptor (TCR), antigen presenting cell (APC), thymic medulla, self antigens, regulatory T cells (Treg), autoimmune regulator (AIRE) gene, autoimmune endocrine diseases, autoimmune polyendocrinopathy Candidiasis ectodermal dystrophy (APECED), candida, hypoparathyroidism, adrenal failure
Check out our website for the most comprehensive video resource available for the USMLE Step 1: physeo.com/

[@freedaboyoung3722]

Hands down best video ever. After 4 years of med school, never understood this but you guys have made this concept so so clear

[@princessz5087]

Great work covering the hot/hard topic. Thank you very much. Looking forward to more video of immunology.

[@s.u.k.k.u8765]

Mindblowing video. Thank you.

[@shalemram4471]

quick and very helpful lecture for understanding negative selection concept, thank you so much sir.

[@sinigdhabiswas8144]

Most helpful video ever. Thanks!

[@weirdways7966]

Keep up the great content man you're going to heaven for this believe me

[@rachelhaley1909]

succinct and great refresher, thanks!

[@sarahmina1442]

I really wish I was taught these concept with ease in medical school. Now, going back on my own to review it

[@CORPSE77]

best video ever. thank you

[@Shadow_4040]

This video just cleared all my doubts. Thankyou❤❤❤❤

[@shahedelnadjar3144]

Best video i’ve found on this topic :)

[@oumchansopheak5450]

I can't really thank you enough

[@user-fy4yk8vi9i]

Amazing and very simple thaaanks

[@mishkatnoor7501]

Best explanation thank you

[@breNdizSxD]

So nice, thanks!

[@mokshsurya1681]

Good explanation. Keep making videos. 👍

[@tiimm0002]

Great video, really helpful! Thanks for sharing :)

[@Be1smaht]

I love these videos

[@freedaboyoung3722]

Bravo to you guys

[@TachyTutorials]

Great video!!!

[@TilleTheo]

This was very helpful!! Thanks a lot!

[@gulanzafar7636]

Was Really helpful,
Thank you ✨

[@user-uc7fi7fu2c]

Thank you

[@ShaunCharkowick]

incredible

[@meadhikari]

thank you

[@karthiksadanand3350]

love you so much

[@dina3630]

Thanks ✨

[@joannadaniel9396]

Thank youu

[@user-pq7yj2gh2u]

Thanks ❤❤❤❤❤

[@yakubuzainab6497]

Thank yiu Sooo much. New active subscriber

[@headoverclouds]

T cell binds to self antigen in medulla.
Medulla APC: So you've chosen death.

[@Unstoppable1001]

T cell doesn't bind to self antigen in thymic cortex
Mr Apoptosis: I have a special gift for you baby

[@mccoymedlog]

I'm a bit confused. So in positive selection we need the T-Cells to bind to MHC, but in negative we don't want them to?
I understand that in negative selection we want to eliminate cells that would cause an autoinmune response because they bind too tightly, but don't we need them to recognize our own MHC? Shouldn't the diagram say "binds to MHC --> no apoptosis", "binds AND responds to MHC --> apoptosis"?

[@Nono-sl4ff]

guys you are so expensive ! I wish you could put this in consideration

[@jeetthakkar8505]

Thankssss

[@Ali_en]

thank uuuuuuuu

[@talaiscomingafteru]

What type of cells undergo negative selection? DP cells or SP cells ?

[@medicalscience1528]

Hello, can you please clear. In positive selection , where do those MHC molecules come from?
Are they part of T cells? Do they present on membrane of T Cells?

[@omarnaasan3536]

Present on the type of stromal cells found in thymus cortex called the thymic cortical epithelial cells

[@akashn4420]

❤

[@chocolatykirthi]

Wow