Central T cell Tolerance - Positive and Negative Selection (FL-Immuno/77)

This video lecture explains mechanisms of Central T cell Tolerance
Non-Selection
Positive-Selection
Negative-Selection

[@kemberlieadolphe6439]

You did such a great job! It was so clear!

[@gabriels2395]

Wonderful job, I would have added that T cells going thru maturation in the thymus are, initially, both CD4+ and CD8+. This is important to make sense of the fact that they can be presented antigens by both the MHC2 and MHC1, respectively.

[@morganharaeb2768]

Great video but doesn't include all fates of the CD4+ T cell such as change in receptors and Development of regulatory T lymphocytes.

[@belldushair]

new subie! :) ive been following your videos and they have really been helpful. keep up the good work.

[@FrankLectures]

Glad to know this. Thank you your feedback.

[@reem4912]

Amazing videos! Thank you so much.

[@FrankLectures]

Thank you for your valuable feedback.

[@luvsingin6]

awesome lecture, very clear! thank you!

[@TheFarahzz]

Thank you this was immensely helpful!

[@taddeasefa5050]

Thankyou for such good work! love much from Ethiopia !!!!!!!

[@mohammedal-hammadi5085]

Thank you so much, it's so clear

[@xgeneproteinx2889]

Highly appreciated.

[@menna6144]

Beautifully explained

[@apekshalad4926]

Thank u so much for this concept.

[@nichobelle8543]

Thankyou so so much for making this video

[@kasraakbari229]

wow, thanks a lot, it was great, your powerpoint was also great

[@FrankLectures]

Thanks

[@hoydaadel3689]

keep up the good work i love your channell

[@FrankLectures]

Thanks

[@shafiakhan5023]

Thank u so much for the video it helps alot

[@mahireddy2533]

Excellent explanation

[@kathyc3005]

Great video lectures. Thank you so much!

[@FrankLectures]

Thank you for your feedback

[@toyasinahmed3782]

This video is very very useful and knowledgeable for me

[@lucigo1852]

Love you bud

[@leixiao169]

what's the name of the nice music in the end?

[@madman5710]

I can't take this video seriously with the Brian TTS voice lmao

[@Joeythegoats]

Ur real for this

[@jogeshkumarsharma2969]

Thankyou so much man🙏🙏may god bless u🤙

[@FrankLectures]

Thanks

[@KA-ig6qy]

Pls add the assay to description so I can go through it any time

[@sakhaty1794]

Thank you that was helpful ♥️

[@dashapulkova581]

Thank you! 💗

[@RanaAbdelhamied]

What is the evolutionary point of the
recognising by T cells of microbe-derived
peptides, which had been processed and
displayed on the antigen-presenting cell
membranes, in-stead of recognising microbial
antigens itself?

[@doktorazoe]

Thanks for helping a med student out! I was reading robbins and I just needed it simplified so thank you!

[@thaniabremer7255]

Thank you

[@sonalev2583]

Thank you 😊

[@456fazi]

Would it be possible for an actual voice recording? Great lecture though. Thank you

[@FrankLectures]

Thanks

[@familyplan2742]

@@FrankLectures You didn't answer the question lmfao.

[@harshadarathod228]

You can convert this video to MP3 format

[@user-vh8sd3un4w]

Excellent

[@user-gt6qh5be7o]

Thank you so much

[@sahirajaafar1470]

Thank you sir! Xoxo

[@michaelkhuvung981]

The music at the end is banger just like the lecture. Anyone knows the name of the music?

[@MolecularMedicine327]

Amazing

[@FrankLectures]

Thanks

[@lubainansari16]

owsum 💯👍

[@peachmin2557]

thank uuuuu so muchhh

[@m.waheed6016]

fantastic sir

[@FrankLectures]

Thanks

[@xxnajdxxful]

My heroes

[@moonlight-do7wt]

Why does autoreactive b cells or autoreactive t cells get develop ??? If these cells have to get killed by negative deletion.?? These autoreactive tcell or autoreactive b cell escape from negative deletion, then they remain in dormant state in the blood , then conditions make them active e.g when foreign antigen act like self antigen then these autoreactive cell can become active. Please answer

[@FrankLectures]

Please go through these videos on immune tolerance once again.
I have explained it already in detail.

[@world5841]

Thank uuuu

[@namariq1952]

كلش حلو الشرح والصوت يعني بسيط ومفيد
ومحد راح يفهم اللهجة مالتي

[@manwithoutborders2343]

😂😂😂😂

[@subinbyclema]

Screening process: Non, POSITIVE, NEGATIVE selection

[@toyasinahmed3782]

👌❤️❤️❤️😍

[@aynazchan2771]

Topic starts at 3:00

[@amruthamavily]

Nyz

[@FrankLectures]

Thank you:)

[@subinbyclema]

Maturation thymus origin bone marrow thymocytes TVR generate specificity

[@subinbyclema]

Central T Cell Tolerance precursor T cells enter the thymus T cell development starts

[@subinbyclema]

Thymic epithelial cells MHC1 immature T cell self-peptide: self-MHC

[@subinbyclema]

No interaction apoptosis non functional TCR, non-selection

[@subinbyclema]

Positive selection strength of biniding moderate Survival self MHC molecule MHC restriction

[@subinbyclema]

Apoptosis very strong affinity negative selection

[@subinbyclema]

Immature T cells non- positive negative selection

[@abdel2264]

why the robotic voice though

[@pedroh4778]

great video but weird voice.. does not sounds natural. After watching 2 or 3 videos of this channel it really gets annoying. please don't take me badly. The content is fine and helps a lot. thanks

[@DestinedFX]

nice video, but what is this non-selection bullshit? that's just positive selection

[@familyplan2742]

Get a voice recording