Phospholipase C - IP3, DAG Pathway || Gq protein pathway

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Video Summary:
Binding of a ligand with Gq protein-coupled receptor causes release of GDP and binding of GTP. The α subunit then dissociates and activates phospholipase C. Phospholipase C degrades PIP2 into IP3 and DAG. IP3 goes to the endoplasmic reticulum and opens the Ca channel. Released Ca binds with calmodulin. Ca-CaM complex alters the activity of downstream enzymes for example MLCK. DAG activates PKC which modulates the activity of other proteins like MARCKS proteins and transcription factors.
🎞 More videos on Signaling:
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• Adenylyl Cyclase - cAMP Pathway: • Adenylyl Cyclase - cAM...
• Cell to Cell Communication: • Cell to Cell Communica...
• Receptor - Types & Functions: • Receptors: Types & Fun...
• Intracellular Signaling / Second Messenger System: • Intracellular Signalin...
• Receptor Tyrosine Kinase: • Receptor Tyrosine Kina...
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Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

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[@codeblue3228]

Great and simplest explanation i have come with so far, More videos on cell signalling and molecular biology please 🙏🙏🙏

[@NonstopNeuron]

there already are videos on cell signaling. I have completed the topic fully. Please search with channel name. You should see the video. I guess I have also created a playlist. Please check.

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[@seldomvlogger]

What a great explaination with the animations , thanks a lot. Understood the processes very well

[@NonstopNeuron]

Thank you 😊

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Thank you so much for this video. This made really easy to understand. I felt like gaining knowledge while watching caartoons. 💛💛
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At last again thank you so much......

[@NonstopNeuron]

yes I am regularly uploading videos. Meanwhile you can check other videos. Thank you.

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Nice explanation 😊

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Thanks my friend

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[@NonstopNeuron]

You are welcome ☺️

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U made this concept very easy and in understandable manner..we really wait for ur next videos👌👍 and really thnku very much 😊

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Great video

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That helps ,been trying to understand it for far too long and finally I got it !
Hope you have more for other stuff like genetics 🧬

[@NonstopNeuron]

Sure. Meanwhile please share the videos with your friends and colleagues. It helps them as well as me. Thank you so much 😊

[@Alrashed.]

Thank you so much for this video is very helpful 💗

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Thank you .

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Thanks a lot for this informative session

[@MohamedMahmoud-ui4fg]

amazing! thank you for this beautiful explanation

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Best explanation.

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best explanation
it helped me through my presentation a lot .
thank you ♥️

[@NonstopNeuron]

Glad to hear that

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This is trully a masterpiece! Thank you for explaning it so well!

[@NonstopNeuron]

You're very welcome!

[@AK-jt7cc]

this is the mechanism of action for norepinephrine on the alpha 1 receptor,.. correct?

[@Efu67883]

Really great! Thanks!!

[@boazie1237]

Great video! Isnt it true that DAG also needs a calcium ion to activate Protein kinase C?

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Yes it does

[@karl_fischer]

thanks for the summary at the end

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Next level 🙌🙌 explanation ❤️

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Explain cgmp pathway

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Thank u this helped a lotttt❤

[@mraman2633]

Gq means what sir?

[@jayarajshekarats9197]

Sir which app you use for this graphic abstract

[@NonstopNeuron]

I used to use InkScape and concepts but now I am learning Affinity designer to create graphics

[@snivellus15814]

What happens to the beta-gamma subunit when they get abandoned by alpha subunit?

[@NonstopNeuron]

They act on some downstream molecules like channels. Then they re-associate with alpha subunits. Watch video on G protein coupled receptors and on Adenyl cyclase cAMP pathway.

[@snivellus15814]

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[@Vitorschroeder12Gmail.ComSchro]

how did you do it can you share with me , thank you

[@NonstopNeuron]

I am using standard workflow for creating animations. Reading, script writing, storyboarding, audio recording and editing, creating graphics, animations, rendering etc.

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[@sebastianosaccon5976]

what is the initial ligand?

[@NonstopNeuron]

time?

[@sebastianosaccon5976]

@@NonstopNeuron 0:35

[@NonstopNeuron]

Ohh... It can be anything that stimulates Gq protein coupled receptor.

[@NonstopNeuron]

This video is general explanation for all of them.

[@sebastianosaccon5976]

@@NonstopNeuron Ok thank you

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