I got through Pre Med because of you. Sometimes your lectures were too advanced for me and I thought "I will probably need these when I'm in medical school." 5 years later and I will get through medical school because of you. Thanks man. I hope someone is paying you very well out there.
It's a homeostatic master mechanism too. The more we understand it, the more it becomes apparent that killing invaders is just what it does in its spare time.
Fragment b is always kept and Fragment a is thrown into the plasma, but there is one exception, it's for C2. So instead of keeping C2b , you keep C2a instead.
In respect to the C4bC2b complex, for about 5 years or so in the recent past, immunology textbook writers wanted to make the process more uniform since C2a is the only large factor which remains associated with the cell surface and renamed it C2b to be more inline with C4b. So C4bC2b was published for a couple of years but it never really stuck as C4bC2a was already widely accepted and established.
You helped me to pass the oral exam in Biochemistry in Step1. My professor asked me the questions you underlined in your videos and it would normally required me to read thick text books to understand. Now you are helping me to pass Immunology. I can't thank you enough.
I just want to say ive watched this guys videos since grad school immunology. I am now in medical school, and still use his videos on all go his topics. 10/10 would reccomend AK Lectures!!
You are the best and i guess the only one on youtube who really deeply understand the scientific material and introduce it with no side talk and in a very simple and informative method Best regards to your efforts
Master of all, i almost use half of time before exam watching your so organized precise articulately presented lectures. Love and pray for you from bangladesh.
Hello AK lecture, according to my professor, C4bC2a is the C3 convertase that cleaves C3 to C3a and C3b. And also C4bC2aC3b is the C5 convertase and C3 convertase cannot cleave C5. Please keep on making video. thank you very much.
I like how you started with the big picture first and then went into the nitty gritty details. My immunology prof doesn't do that enough, hence why I'm here. She will drill the process steps, but doesn't really get at the purpose of why these things happen. Thanks for this. :)
you're absolutely great and talented, thank you for these insightful videos, really help me to understand the materials in my college :) may God bless and keep you
i hope you know that till this time while im in training for speciality i still return to your videos to remember things 🙏 may God bless you wherever you are 🙏
Hi AK. Could you please check out this source: www.complement-genetics.uni-mainz.de/cp.htm I was reading Kuby's Immunology 6th edition (internation).. And the lecture notes supplied by university in UK also say it should be C4b2a.. really confused now..
en.wikipedia.org/wiki/C3-convertase#/media/File:Complement-pathways.png users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html Here are two separate sources that describe the C3 convertase as having C4b-C2b structure.Your lecture notes are probably based on the book you're using. Perhaps its an error in the book. Double check with your professor and let me know what he or she tells you.
I am really grateful for these lessons that you are lecturing, but I've got a small note which I hope you will consider, you're speaking with such loud tone and keep speaking without any pause to take a breath. anyway your lectures are very useful for me, thanks
There is Super man, there is Batman, there are the X man, there are all kind of super heroes and then there is you... the one who saves me every single time since I started Biomedical sciences.
C4b2b is correct and it's the new form of formerly known C4b2a complex aka C3 convertase. Anyways, the name changed cause of some wrong nomenclature of complement proteins. The 'b' in these complexes stand for binding and 'a' stands for anaphylotoxins, so that should be it.
My textbook describes the C3 convertase as C4b2a not C4b2b. it mentions when C2 is cleaved, fragment C2b leaves into the fluid phase and C2a joins with fragment C4b to form the C4b2a complex.
+tkanes17 You are correct the C3 convertase is composed of C4b and C2a, not C2b. I think this was a small mistake in the video as C2 is an exception to the general rule that the b fragment always is kept.
Great one👌👌👌...n thanks to A K Lecturers fo adding new stuff in C3 convertase part(c2b c4b)...it is nt at all mentiond in books till now, thnks again...😊😊😊
Great video! Very clear, thank you so much for posting. I do have one question though. When mentioning the C3 convertase you said that it is formed by a C4b and C2b molecule. However, in my text, as well as from my professor, I have been told that it is composed of a C4b and C2a, instead of C2b, molecule. I was wondering if there are any discrepancies in naming of the subpart of complement molecules after they are cleaved, or if this was just a small mistake? I apologize for the specificity and detail of my question, I just want to ensure I am understanding this process correctly. Thank you kindly, Kat
+Niiinjaaa Its not a mistake. As I said in a comment below this one, its currently known as C4bC2a but for a while people were pushing to change it to the C4bC2b to make it more logical. But people were simply not using it enough so I guess were stuck with C4bC2a for now.
I'm so greatful for ur lectures I was abt to complain the same thing abt c3 convertase but I can see that it has already been done.I'm ur big fan... I appreciate ur metabolism videos on biochemistry.I'm hoping that immunology videos will help too. Pls prepare lectin pathway and also transplantation. If possible also prepare lectures on the other types of immunoglobins. I sincerely hope u would consider my pleas cos my exams is soon approaching... Thanks in anticipation.keep up with the good work AK..
There are 2 groups of people. Those who call the larger active C2 fragment C3a and those who call it C2b. The larger active fragment of C2 was originally called C2a for some god awful reason and now there are people who want to switch around the names to go in line with the other complement proteins. Which makes sense, but it kinda just causes confusion.
I got through Pre Med because of you. Sometimes your lectures were too advanced for me and I thought "I will probably need these when I'm in medical school." 5 years later and I will get through medical school because of you. Thanks man. I hope someone is paying you very well out there.
Should be called the complicated system
Definitely.
Exactly what crossed my mind as I was watching this
It's a homeostatic master mechanism too. The more we understand it, the more it becomes apparent that killing invaders is just what it does in its spare time.
B zabet 😂
5osousan eza kent 3am te5od hede l mede b jem3a lebneniye 💔😂
🤣💀
i love the way you stress on words it helps me stay focused.. ;)
you are born a teacher ,keep up the good work
Yup! He kept my attention the entire time and I understood everything !
Fragment b is always kept and Fragment a is thrown into the plasma, but there is one exception, it's for C2. So instead of keeping C2b , you keep C2a instead.
Correct bro I also think that C3 convertase is C4bC2a
If you known so much why are you here¿¿ Just watch the damn video and then go to a book. Damn whites ruining everything
I think that this correction help lot of students......my opinion....
I think it s only C4b2b
It's actually debatable, I observe, some of the older editions have it C4bC2b, even wikipedia says so. In my textbook it's C4bC2b.
clearest explanations on youtube. Much better than a certain "academy"
In respect to the C4bC2b complex, for about 5 years or so in the recent past, immunology textbook writers wanted to make the process more uniform since C2a is the only large factor which remains associated with the cell surface and renamed it C2b to be more inline with C4b. So C4bC2b was published for a couple of years but it never really stuck as C4bC2a was already widely accepted and established.
Mind blowing no words!!!!!
Made the topic crystal clear to understand!!!!
Thank you so much
You helped me to pass the oral exam in Biochemistry in Step1. My professor asked me the questions you underlined in your videos and it would normally required me to read thick text books to understand. Now you are helping me to pass Immunology. I can't thank you enough.
Hi! I'm from Brazil, I'm Pharmacy student, and I must say u r an incredible teacher! Your classes help me a lot! Thanks for Everything!
hi Luiza Aguiar . am also a pharmacy student. hope it does help
This was SO helpful - You are making such a difference for me. I am almost crying of hapiness
Thank you. You saved my life today!! I needed to teach the Complement System to my students and this explained it so well. THANK YOU!!!!
you made me understand in less than 15 minutes what my professor couldn't make me understand in more than 2 hours. thanks a lot :)
I just want to say ive watched this guys videos since grad school immunology. I am now in medical school, and still use his videos on all go his topics. 10/10 would reccomend AK Lectures!!
He’s so good at explaining. I can’t do this even if I have perfect understanding of something.
You are the best and i guess the only one on youtube who really deeply understand the scientific material and introduce it with no side talk and in a very simple and informative method
Best regards to your efforts
Everything is simplified and understandable. I am so thankful for your style and form of lectures.
love your accent 😍😍😍 ,the way you speak 😘😘 understandable
I love u man u are the best lecturer i have seen ❤️❤️❤️❤️❤️
Excellent Video! Clarity is second to none. Brilliant
I love this man so much right now
Your lectures are amazingly easy to understand. I'm so grateful for your effort.
What a Man,Good stuff..Life saver
this was honestly so helpful! thank you for being so clear in you explanation
Amazing summarized lecture on the classical complement pathway and its significant immunological functions! Thank you so much for this, sir!
your youtube channel is the 1st one that helps me a lot in my studies....solute you
Hi I noticed that the C3 convertase should be C4bC2a ☺️ I looked it up in Immunology 7th Ed David Male page 90 fig. 4.4 ☺️
I think he did great explanation for classical but he missed to explain more how C3 convertase formed instead to explain formation of C4bC2b complex
Yes me too
Actually, it was historically called C4bC2a. These days, scientists call it C4bC2b for the sake of uniformity. AK lectures is right.
Master of all, i almost use half of time before exam watching your so organized precise articulately presented lectures. Love and pray for you from bangladesh.
Hello AK lecture, according to my professor, C4bC2a is the C3 convertase that cleaves C3 to C3a and C3b. And also C4bC2aC3b is the C5 convertase and C3 convertase cannot cleave C5. Please keep on making video. thank you very much.
Hats off sir, you are better than my lecturer. Remain blessed.
I like how you started with the big picture first and then went into the nitty gritty details. My immunology prof doesn't do that enough, hence why I'm here. She will drill the process steps, but doesn't really get at the purpose of why these things happen. Thanks for this. :)
Your lectures are worth to be acknowledged on my final dessertation
you're absolutely great and talented, thank you for these insightful videos, really help me to understand the materials in my college :) may God bless and keep you
i hope you know that till this time while im in training for speciality i still return to your videos to remember things 🙏 may God bless you wherever you are 🙏
AMAZING!!!!! You are the best explainer
You helped me a lot. Inmunology final tomorrow. Wish me luck.
Good luck!
"Clocked" couldn't figure this shit out for months!
i love this man makes every make sense
More thanks again for your help sir keep it up ,by abel kakinda from Tanzania at CUHAS.
Many Thanks from the UK🎖️🎖️🎖️
I love your recaps at the end of your videos. Great video!
+Andres De Avila Thanks Andres!
Somehow you can make me understand those topics so easily. Thank you
Love how you make everything easy, you’re the best 👌🏻keep up the good work.
I had difficulty in understanding complement system but with this video I will teach complement system to my friends. thanks as much as sea :-)
best video ive ever seen on this
quality of this video cured my cancer via my innate immunity boost
Love from Indian occupied kashmir..... awesome way of reaching
Thanks so much for this... You are appreciated.
Thank you so much! This video really helped me understand the classical pathway of the complement system.
glad that many realise whats in c3. overall, this video is helpful in my Immunology subject. worth the subscription.
Shouldn't the C3 Convertase be C4b2a, instead of C4b2b?
Siddharth Saxena Look it up and link me to your source. Ill take a look and let you know.
Hi AK. Could you please check out this source: www.complement-genetics.uni-mainz.de/cp.htm
I was reading Kuby's Immunology 6th edition (internation).. And the lecture notes supplied by university in UK also say it should be C4b2a.. really confused now..
en.wikipedia.org/wiki/C3-convertase#/media/File:Complement-pathways.png
users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html
Here are two separate sources that describe the C3 convertase as having C4b-C2b structure.Your lecture notes are probably based on the book you're using. Perhaps its an error in the book. Double check with your professor and let me know what he or she tells you.
Siddharth Saxena Yep. My teacher also said "C3 convertase is C4b2a too"
Phạm Thị Quế Như thanks for the feedback! I will look into it.
You're helping me so much in my Immunology and Clinical Chemistry subjects. Thanks a lot! :)
classical pathway made simple and sweet..... great video
Thank you for this video! You explained this way better than my patho book.
I am really grateful for these lessons that you are lecturing, but I've got a small note which I hope you will consider, you're speaking with such loud tone and keep speaking without any pause to take a breath. anyway your lectures are very useful for me, thanks
Great teacher, great explanations!
10:03 shows just the info. Fairly simple to follow what he's written.
Much better explanation than my books.
Thank you so much for making this video, I found your explanations really clear and helpful!
There is Super man, there is Batman, there are the X man, there are all kind of super heroes and then there is you... the one who saves me every single time since I started Biomedical sciences.
Woowoo.. you make it so easy and helped me with my exam..thank you alot.
Really, I appreciate these courses
Thanks a lot for this lecture sir..... Your notes and explaining is legendary..... Keep up the good work sir
Amazing, very easy to follow. Thank you for sharing
C4b2b is correct and it's the new form of formerly known C4b2a complex aka C3 convertase. Anyways, the name changed cause of some wrong nomenclature of complement proteins. The 'b' in these complexes stand for binding and 'a' stands for anaphylotoxins, so that should be it.
This guy helped me pass my doctoral exams 🤲🤲
Thanks a lot for your explanation
it will be C4b-C2a complx. because of historical reason here C2a is larger fragment which is an exception.
Hi, This is amazing! Great Job! I use this to teach my students and it is really really really good!
Thanks for the video....greetings from Brazil
What a way of teaching.. Superb #AK
these notes are wonderful
Very well explained! thank you very much 😊
I'm so thankful for your efforts ☺️☺️☺️
My textbook describes the C3 convertase as C4b2a not C4b2b. it mentions when C2 is cleaved, fragment C2b leaves into the fluid phase and C2a joins with fragment C4b to form the C4b2a complex.
+tkanes17 You are correct the C3 convertase is composed of C4b and C2a, not C2b. I think this was a small mistake in the video as C2 is an exception to the general rule that the b fragment always is kept.
Great one👌👌👌...n thanks to A K Lecturers fo adding new stuff in C3 convertase part(c2b c4b)...it is nt at all mentiond in books till now, thnks again...😊😊😊
beautifully explained 👌
Very helpful!
Sir, great explanation, I'm grateful 👏
Thank you sir it was very helpful.
thank you for the helpful videos much appreciated.
thank you for teaching online
Very useful!! Thank you :)
Great video! Very clear, thank you so much for posting. I do have one question though. When mentioning the C3 convertase you said that it is formed by a C4b and C2b molecule. However, in my text, as well as from my professor, I have been told that it is composed of a C4b and C2a, instead of C2b, molecule.
I was wondering if there are any discrepancies in naming of the subpart of complement molecules after they are cleaved, or if this was just a small mistake?
I apologize for the specificity and detail of my question, I just want to ensure I am understanding this process correctly.
Thank you kindly,
Kat
+Katherine Williams I confirm, it's a small mistake that I didn't even notice before I read your question ^^
It's indeed C4b and C2a, well spotted ;)
+Niiinjaaa Its not a mistake. As I said in a comment below this one, its currently known as C4bC2a but for a while people were pushing to change it to the C4bC2b to make it more logical. But people were simply not using it enough so I guess were stuck with C4bC2a for now.
C4b-C2a is the C3 convertase.
Amazing. Thank you!
Couln't help my self to finish the video ... I had to pause and put like and comment first ... Thank you so much 😊
thank U man thank U
that was so efficient for me
really well explained
you got me confused there for a moment. But thanks, you helped me out a lot;)
Thank you so much 🙏🙏🙏
Thank you so much
Amazing... ty!!
Awesome! Thank you!
great video, definitely worth the subscription :)
Ahmed Kamal thank you Ahmed! :)
I'm so greatful for ur lectures
I was abt to complain the same thing abt c3 convertase but I can see that it has already been done.I'm ur big fan... I appreciate ur metabolism videos on biochemistry.I'm hoping that immunology videos will help too. Pls prepare lectin pathway and also transplantation. If possible also prepare lectures on the other types of immunoglobins. I sincerely hope u would consider my pleas cos my exams is soon approaching... Thanks in anticipation.keep up with the good work AK..
Thank you doctor 💙💙
U r so one kind keep going
God's work it is😢, so clear. I got this on 1.25x ,tysm
thank your sir very informative lecture ,immunology section be giving me headache for days...
There are 2 groups of people. Those who call the larger active C2 fragment C3a and those who call it C2b. The larger active fragment of C2 was originally called C2a for some god awful reason and now there are people who want to switch around the names to go in line with the other complement proteins. Which makes sense, but it kinda just causes confusion.
Holy fuck you are so good man, sorry for swearing, but you are amazing.