Biochemistry | Michaelis Menten Equation
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- Опубликовано: 25 апр 2017
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will present on the Michaelis Menten Equation. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #MichaelisMentenEquation #Biochemistry
Watched this video for my undergraduate biochem class and got an A+ in the class. Watching again to study for the MCAT. You’re a great teacher brother
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I'm a first year mbbs student ..i really like the way you explain anatomy biochem and physiology..really appreciate your work ..Thanks alot for clearing all my concepts
Could you please enable subtitles on this video and the other biochemistry videos? I'm deaf and would really like to watch.
I wasnt looking forward to studying this topic because biochem is not my strength but then I realized Ninja Nerd made a video and now I am pumped! Thanks for making engaging and easy-to-follow videos.
My brain has officially been fried from Biochem.. You did such an amazing job to explain such heavy contents. Much respect and love from Australia, thanks for saving me from failing !!
I am first year medical student and I just want you to know that your lectures are amazing and useful. I appreciate the way you teaching complicate lesson in easier way to understand . Big thanks
Which uni?
Which uni?
I tried reading this on my own and it felt like my head was being pounded in. Thank you so much, I understood it perfectly!
Really helpful. When my professor tried to derive it, everyone was confused lol kudos to you and thank you :)
God bless you man...been running about trying to figure out this equation for like two days, you finally linked up everything in a way that makes sense
Why didn’t I find your channel sooner? Thank you sooo much for explaining these concepts so clearly!!
Among all the videos in youtube regarding enzyme kinetics your one is the best, great teacher😊
This dude really said "that's a big mofo to derive" 😂😂😂 I love him for that. 👏
One of the best teachers I’ve ever seen
Great 👏🏼
By far the best explanation I've seen on this topic. Awesome
This guy made me to love biochemistry and now I'm doing my Master's in biochemistry 😍
Ninja Nerd Nation all the way from Perú. All I get is A's because of you. Thank God I speak english; you are legit top 10 best youtube teachers. Salute my boy
I just cited this in my thesis. Excellent video amazing explannation better than anything I have seen before
I am an old IMG with a full-time job and mother of two little girls to take care of. I finally did my Step 1 test on Jan 11. I haven't got my score yet, maybe not good enough :) It's okay. I can't thank enough to Ninja nerd lectures. Very deep insights and so well-organized, too good to be free. I particularly like neuro, cardio and bicochem, and more. My biochem UW 1st pass is 91% correct overall. I'd like to give full credit to these lectures. Thank you again for sharing these high-quality lectures!!
Congrats on your success! ❤️
May I ask how you're doing now? Hope you got a good score
@@dhishansivadas8227 244, not very good... Will try to make it better for CK
@@linahan1634 Lots and lots of luck to you Lina ❤❤🤞🤞
That was a very good revision for biochemistry. You just helped me remember many points I forgot during my 12th class
I don't know how to thank you you really did a great job I wish you all the best.
If the life would have been in my hand, you would have lived on earth for the next generation.
I really don't know how I could explain my heart felt for your lecture which isn't merely this Bio(chemistry) but also the rest of the medical courses.
Thanks you alot.
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Best teacher I've seen so far. Thanks a lot sir.
Followed this channel for my undergrad Biochem and got an A+ . Thanks
Thank you so so much. You’re an extraordinary teacher.
Thank you very much Sir... amazing job to explain it ....
It’s just like the movies we ignore the random equations in the background
And ninja nerd would be the one to focus on it other then
Watching.
this is probably the best explanation video ive ever watched in my life
Km does not equal 1/2Vmax
- units for KM is concentration (moles)
- units for 1/2Vmax is concentration/per time
Km equals "concentration [S] at which Vo=1/Vmax"
How can v max ever be half of initial velocity pls exaplin
Excellent explanation!!! Thank you very much.
You made me feel like a genius. Now I'm going to watch every other video about this on your channel. Tysm!!!
thank you so much sir .very helpful video 🙏🙏🙏
Please make more videos about Genetics and medicine. I'm Health science student and you are really helping me!
You're literally a life saver!! I've watched so many of your biochem videos, you are an amazing teacher!!
Explained really well. thank u sir
i literally lost hope to even pass the biopharmaceutics exam...
thanks to ur videos got my hopes up ans started studying
GOD BLESS U KIND SIR❤❤
Thanks to you doctor okey here in Algeria the place where I live we study in french language but my last solution to understand what the lessons looks like is to watch your videos 💙💙💙so thank you I appreciate your work 👏👏👏👏👏👏
You are amazing thank you for a great explanation
Love you man!!!! You are the best!
Thankyou for your efforts sir these videos are very very helpful
Thanks alot.
I got my point clear which i was trying to clear through many videos.
But your's 👍
Super helpful! However, how would we find the Vmax without using the Lineweaver equation or plot?
Enjoyed learning it. Thank you
Incredible video. Thanks!
You’re literally an angel ! THANK YOU !
Guyy. Your explanations are on a whole different level 🫡🫡
So helpful. Thanks :) Will you also do The eyring-polyani equation??
Hello! This video was very helpful, thank you so much!! I had one question though, in my textbook they refer to kcat, which measures the # of substrate molecules turned over/converted to product, per enzyme per molecule per second. They give the following equation: Vmax=kcat[E]. Going of off this lecture I can see that we used k2 instead, but I'm confused as to why they used the reactant concentration, because what I took from this video was that at Vmax we only have the [ES] for the total amount of our enzyme. I can see them using Vmax=kcat[ES], but I think I am probably misunderstanding something. If you could please explain it would be greatly appreciated! Thank again (:
Thank you a lot. You made me understood the Michaelis Menten equation with ease
man you supper great
thanks so much for this. i got to subscribe before even finishing the video
o my god it helped even after 5 years thank u so much ..very easy to understand ..
Very helpful in clearing doubt ....love from India ❤️
Thank you so much. Great job 👍
greetings sir . we thanks you for your teaching. please I have a question to ask.
please can u make a video on the differences between the Michaelis menten approach and the Brigg Haldane approach of enzyme kinetics. I can't really see a difference btw this two approaches
U killed it bro.. great explanation.. thnks
Thanks brother , really helpful
Thank you very nice explication
I wish this man was my professor, great explanation!
this guy is a rockstar of biochemistry thumbs up for ur knowledge and presentation
I haven’t started watching this video, but I can tell it would be 💣🤩
very good sir , please create video on different plots in enzymology
Thanks for the very useful lecture and you have very nice teaching method.
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Im a master student in medicinal chemistry and im glad i came across this
this vedio was of great help...many thanks🙌
Hi I really appreciate all your lectures and well thought out explanations and illustrations. Could you make a video on vitamines?
Thanks for this great lecture❤ , I wanna ask : do you recommend a biochemistry book which is well-organized and straightforward to the information
In 3:58, you said you were assuming that it was a first order reaction, but if it includes the concentrations of both reactants isn't it second order?
very very well done thank you
Thanks, this video has helped a lot.
u r amazing Sir Really great
I WATCHED THIS VIDEO AND I LIKED IT VERY VERY MUCH THANK YOU
Great video, little bit different from my book but really helped me understand the topic.
Wonderful...thanks a lot
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The best video for Michael menten equation all over the internet 😶🌫️
Great explanation🎉
Thanks ❤️
Thanks sir you are great 😍❤
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Thank you!
Thank you
Thanks a lot...u save my day
+Aditi Barman You’re welcome! Happy studies!
Why distribute k1 only to factor out to get km?
I have a question! Why does steady state assumption only apply to enzymes, not to inorganic catalyst?
I understood this that inorganic catalyst has rate-determining step, but enzymes don't.
Why do enzymes don't have a slow step? Is it because of the structure of enzymes?
It would be really helpful if you could answer me!
jh, enzymes absolutely have a rate-limiting step most of the time. It can either be the binding of the substrate (k1) or the conversion from the ES complex to E+P (k2) if we assume a classical enzyme.
20:35
theorising here any experts correct me
going back to the definition of Km = K-1 + K2 / K1
where Km essentially is the rate of dissociation over association
a low Km = high affinity
a low Km means that either the rate of association is higher and/or the rate of dissociation is lower, so more ES is formed high affinity
high Km = low affinity
vice versa, rate of dissociation is higher while association is lower
in the context of affinity referring to how much substrate an enzyme can take on, I'm guessing that k2 is higher rather than the effects of k-1 being higher or K1 being smaller (though i thought that affinity would refer to how fast K1 would be)
so low Km means higher affinity, K2 is lower, less substrate can be taken on as ES complexes take longer to form into E + P
while high Km means lower affinity, K2 is higher, more substrate can be taken on as ES complexes are freed up quicker
thank you dude x
Can you explain the pH and temperature effect variation of the enzyme please🥺
this guy gonna get me through first year med
Thanks so much!!
you are gifted! your videos are very the best
thank you so much!
i think there are few mistakes.. one of which is mathematical around min 9:15 when u divided the equation by k1 - you didn't divided the subtraction as well..
This was something really terrific
Thanks you so much... Love from INDIA
Could you please add subtitles, for people from other countries who don’t know english very well(and also for me)
This is the impactt of a gud teacher ...they can make anything easier ...evrything was prct..bt can anyone tell me ..from which country he belongs to,,?????
I'm a bit confused about the end...how is an enzyme with LOW substrate affinity able to take up MORE substrate??
Need it for my Pharmacokinetics finals tomorrow
I have a doubt when you add [ES][S] to both the side but in next step where did it go