The way you teach makes me feel like I can understand this with practice. I think its because you don’t let it intimidate you, but you like treat it like its easy. Gives me the confidence to learn it. I hope that makes sense. So I just wanted to say thanks, and I have been watching all the biochem videos.
Please never stop uploading, u r literally a saviour, when i am about to leave youtube bcz of not being able to understand the topic, u r the one who protects my emotions for that topic, now u have, i swear become one of my top most priorities in case of lectures Thankyou so much 😭😭
Whenever I get sick and tired of studying for the medical school entrance exam, I watch your videos. They help me regain my motivation to keep studying XD Thank you so much! Your knowledge inspires me a lot. I wish I could be like you in the future. (From South Korea)
You are the best and I do mean the BEST! The way you explain things just sticks. You are literally my number 1 resource for leaning new material! Thank you so much!
OMG! THANK YOU SO MUCH FOR ALL OF THESE VIDEOS! YOU ARE TRULY HELPING ME WITH UNDERSTANDING ALL OF THESE!! IM ALMOST GIVE UP ON BIOCHEM THANK YOU SO MUCH!!
Happy to hear that! I wish you all the success in the world! Make sure to watch My MCAT Playlists: 🚗 Organic Chemistry: ruclips.net/p/PLYcLrRDaR8_f_-vdA2r_z4Ie-CFAPV2sK 🔥 General Chemistry: ruclips.net/p/PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w 🧪 Biochemistry: ruclips.net/p/PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N 🧬 Biology: ruclips.net/p/PLYcLrRDaR8_f10hjfgWdBzaZ9PuIut-y7 🚗 Physics: ruclips.net/p/PLYcLrRDaR8_cnnwn5YP6EAfXoAYknzVI3&si=vsCtVfJHk5Upum1F ⁉️ MCAT Questions: ruclips.net/p/PLYcLrRDaR8_fOmzTb2f8L96D_LkLhPw0X
Thank you. THANK YOU for posting this video in the first place. Once, I was absolutely fucking confused with the whole Michaelis-Menten Equation thingy that only a few of my peers got it. But now, after watching this video, I'm now enlightened. Thank you!
Great Michaelis-Menten graph explanation also a good reminder of enzymology. Good to know in the upcoming one we'll be talking about the 3 types of enzyme inhibition which also drives students nuts 😅 but of course no more, thanks to your comprehensive lectures.
So basically if there is a lot of Km meaning a lot of substrate the enzymes will have lower (less affinity) because there are too many substrates and enzymes are very specific?
No!!! Km measures enzyme affinity for a substrate, remember Km is half Vmax. Meaning if an enzyme has high Km, it means an enzyme requires high concretration of a substrate to reach Vmax. The increase in substrate has no effect on Vmax, as the Vmax remains the same
Why do enzymes or protein get saturated? Saturation: What Does That Mean? Does that imply fatigue? Is it comparable to a man who works extremely hard all day being exhausted (saturated) and losing all energy? please shed some light on this comment
Saturation means that all the available receptors are busy, and therefore can’t bind more substrate (think of it as a call center where all the customer service representative are busy with other clients, i.e. saturated).
Hey, Thank you so much for the video! I have a question about the affinity. Leninger 8th edition (page 785) says "The term (Km) used (often inappropriately) as an indicator of the affinity of an enzyme for its substrate. The actual meaning of Km depends on specific aspects of the reaction mechanism, such as the number and relative rates of the individual steps. When k2 is rate-limiting, k2 ≪ k−1, and Km reduces to k−1/k1, which is defined as the dissociation constant, Kd, of the ES complex. Where these conditions hold, Km does represent a measure of the affinity of the enzyme for its substrate in the ES complex. However, this scenario does not apply for most enzymes" As I understand it, Km represents affinity only when k2 is wery low, and Km=Kd. I just can't understand why is it so. Also, I googled it and mostly everyone says that Km is an indicator of affinity. I hope you'll have a look at this, maybe you will be able to put it in simple words, as you do. Thanks again for your amazing content!
![Lineweaver-Burk plot (Enzyme Kinetics) - Vmax, Km & [S] - Biochemistry 🧪](http://i.ytimg.com/vi/nivkBZkmu14/mqdefault.jpg)
![Lineweaver-Burk plot (Enzyme Kinetics) - Vmax, Km & [S] - Biochemistry 🧪](/img/tr.png)
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The way you teach makes me feel like I can understand this with practice. I think its because you don’t let it intimidate you, but you like treat it like its easy. Gives me the confidence to learn it. I hope that makes sense. So I just wanted to say thanks, and I have been watching all the biochem videos.
I am so delighted to hear that! You made my day! I wish you all the success in the world!
I just stopped in the middle of the video to thank the creator for this amazing explanation.
This channel deserves to have so much success ❤
Thank you!
Please never stop uploading, u r literally a saviour, when i am about to leave youtube bcz of not being able to understand the topic, u r the one who protects my emotions for that topic, now u have, i swear become one of my top most priorities in case of lectures
Thankyou so much 😭😭
I am honored!
Thank you so much for your kind words!
Pretty sure 99% people whatching this aren't actually med students but chem majors
med student here
@@LocuraAndante ok you are 1%
Med student here😂🤝
@@ageedmohammed8300 ok i was wrong
remember about biotechnologists
I'm actually like literally impressed, I mean I can't express how fun it was and yeah just amazing man keep it up
Thank you so much! I hope you enjoy the entire Biochemistry playlist!
@@MedicosisPerfectionalis I'm new to this channel and you don't know how good you are at this job ...... Hats off to you man. Huge respect
Thank you so much I can not express how much I appreciate your help! I also love the jokes you make learning fun!!!
You are so welcome!
"Why do you call it Km, why not FU?" HAHAHA I love these entertaining and educational videos
Thank you so much!
“Shut up and calm your butt down it’s easy” ok my bad💀
Whenever I get sick and tired of studying for the medical school entrance exam, I watch your videos. They help me regain my motivation to keep studying XD Thank you so much! Your knowledge inspires me a lot. I wish I could be like you in the future. (From South Korea)
I am honored! Thank you!
You are the best and I do mean the BEST! The way you explain things just sticks. You are literally my number 1 resource for leaning new material! Thank you so much!
You’re very welcome, Ashley!
Would you please help me by sharing?
@@MedicosisPerfectionalis of course!
You have no idea how much you saved me here today! Thank you so so much!
My MCAT Playlists:
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🔥 General Chemistry: ruclips.net/p/PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w
🧪 Biochemistry: ruclips.net/p/PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N
🧬 Biology: ruclips.net/p/PLYcLrRDaR8_f10hjfgWdBzaZ9PuIut-y7
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this channel is juste P E R F E C T! thank you, ur jokes made me feel way better abt all this stuff
Thank you!
OMG! THANK YOU SO MUCH FOR ALL OF THESE VIDEOS! YOU ARE TRULY HELPING ME WITH UNDERSTANDING ALL OF THESE!! IM ALMOST GIVE UP ON BIOCHEM THANK YOU SO MUCH!!
You are so welcome! I hope you enjoy the rest of this Biochemistry Playlist!
not only a high yield video but also an entertaining one..indeed it makes perfect sense..
Thank you!
Your content made mcat studying so much easier!!!!!
Happy to hear that! I wish you all the success in the world!
Make sure to watch My MCAT Playlists:
🚗 Organic Chemistry: ruclips.net/p/PLYcLrRDaR8_f_-vdA2r_z4Ie-CFAPV2sK
🔥 General Chemistry: ruclips.net/p/PLYcLrRDaR8_e4MrgwcOjbt3mS4nUbSs8w
🧪 Biochemistry: ruclips.net/p/PLYcLrRDaR8_c2LBpF_OYvwijOok7ae96N
🧬 Biology: ruclips.net/p/PLYcLrRDaR8_f10hjfgWdBzaZ9PuIut-y7
🚗 Physics: ruclips.net/p/PLYcLrRDaR8_cnnwn5YP6EAfXoAYknzVI3&si=vsCtVfJHk5Upum1F
⁉️ MCAT Questions: ruclips.net/p/PLYcLrRDaR8_fOmzTb2f8L96D_LkLhPw0X
That "why do you call it Km why not FU" cracked me up 😂😂😂😂
:)
Thank you. THANK YOU for posting this video in the first place. Once, I was absolutely fucking confused with the whole Michaelis-Menten Equation thingy that only a few of my peers got it. But now, after watching this video, I'm now enlightened. Thank you!
Thank you so much for watching!
Great Michaelis-Menten graph explanation also a good reminder of enzymology. Good to know in the upcoming one we'll be talking about the 3 types of enzyme inhibition which also drives students nuts 😅 but of course no more, thanks to your comprehensive lectures.
Thank you 🙏
U r just amazing as u were earlier love u so much medicosis🥺🥺❤️
ok, this is the first time I understand the equation, thank you.
Happy to help!
Thank you so much, I have never enjoyed a learning video this much.
Happy to hear that!
Thanks sir you made the concept crystal clear 👍
You're a lifesaver! Thanks a lot!!
I just found this channel and I am soo in love ❤. Thank you very much for this.
My pleasure!
you are an absolute angel!!!!!
Thank you!
almost fall asleep after the mid term exam, but jerk up by " why it is Km constant not a fu? " hahhaha woke me up!
:)
Hey Medicosiss!! Been a long time. Thanks,you do an amazing job!
Thank you 😊
Glad to see your comments again!
Thank you.
This video made my day
Thank you!
Crystal clear concept thanks
My pleasure!
Finally I enjoyed biochemistry
Wow!
I like medicosis like enzyme love thier substrates
Best comment ever!
Thank you!
you made me laugh and helped me study! thanks!
I'm so glad!
omg thank you i watched a long ass fourty minute video and didnt understand shit except from you thank you!
Thank you!
Thank you for this video.. highly appreciated
I appreciate you too!
that “mechaelis FREAKING menten” 🤣🤣🤣🤣😭😭😭😭🤣🤣🤣🤣
Indeed :)
You just made me smile, thank you 😂
I'm glad!
Oh my god it simply attracted meeeee 😂😂❤️❤️❤️❤️
You are amazing person
Thank you so much!
Medicosis 🤝My will to pass biochem
I wish you success!
Never stop bro please ! i owe u my degree!
Thank you 🙏
More videos are coming!
4:29 why not
_b
Thank you for this amazing explaination!!!!!!
My pleasure!
Sir you are great ❤❤
Thank you so much!
thank you so needed!
You're so welcome!
You are freaking amazing. Thank you so much!
Thank you so much!
this was fun tyyyy!
omg...! you are the best
Thank you!
So basically if there is a lot of Km meaning a lot of substrate the enzymes will have lower (less affinity) because there are too many substrates and enzymes are very specific?
No!!! Km measures enzyme affinity for a substrate, remember Km is half Vmax. Meaning if an enzyme has high Km, it means an enzyme requires high concretration of a substrate to reach Vmax. The increase in substrate has no effect on Vmax, as the Vmax remains the same
bruhh you the best i am going to destory the exam now
Thank you so much!
Would you please help me by sharing?
Please make a video on the 10 step proof for the Michaelis-Mentin Equation.
Thank you for letting me know!
You saved me tq so much and i love u your jokes ❤
You're welcome!
hi medicosis thank you so match could you please explain why km have inverse relation with affinity ?
Thank you, But i lowkey didn’t get the affinity point what does it mean?
thank you so much! you are my hero
Thank you ☺️
Why do enzymes or protein get saturated?
Saturation: What Does That Mean? Does that imply fatigue? Is it comparable to a man who works extremely hard all day being exhausted (saturated) and losing all energy? please shed some light on this comment
Saturation means that all the available receptors are busy, and therefore can’t bind more substrate (think of it as a call center where all the customer service representative are busy with other clients, i.e. saturated).
@@MedicosisPerfectionalis thanks a bunch medicosis perfectionalis
this video saved me
Great!
Thank you 😭😭😭😭😭😭♥️
My pleasure!
Got a question: I saw Kcat on my text book, what is Kcat?
Hey, Thank you so much for the video! I have a question about the affinity. Leninger 8th edition (page 785) says "The term (Km) used (often inappropriately) as an indicator of the affinity of an enzyme for its substrate. The actual meaning of Km
depends on specific aspects of the reaction mechanism, such as the number and relative rates of the individual steps. When k2 is rate-limiting, k2 ≪ k−1, and Km reduces to k−1/k1, which is defined as the dissociation constant, Kd, of the ES complex. Where these conditions hold, Km does represent a measure of the affinity of the enzyme for its substrate in the ES complex. However, this scenario does not apply for most enzymes"
As I understand it, Km represents affinity only when k2 is wery low, and Km=Kd. I just can't understand why is it so. Also, I googled it and mostly everyone says that Km is an indicator of affinity.
I hope you'll have a look at this, maybe you will be able to put it in simple words, as you do.
Thanks again for your amazing content!
Hii thank you so much, l wanted to ask if rate of enzyme reaction is the same as rate/velocity of reaction
This dude funny af
Thank you!
Do you have any examples i really need to work on this i have exam day after tomorrow 😢
Examples of what?
@@MedicosisPerfectionalis like problems? English isn't my mother language. I mean something to solve
I want this notes pdf howw??
They’re available on my website: www.medicosisperfectionalis.com/
@@MedicosisPerfectionalis the link does not open!
The line 'Biochemistry suck at physics' 😂
I love u brother❤❤❤❤
Thanks!
ok but I don't understand why knowing the 1/2 Vmax/Km is relevant. What can you use it for?
Hi
Good video
Thank you so much 😊
Genious!!
Thank you!
Ty
My pleasure!
Most of the time, the substrate concentration is well below Km
The way fun as i wait for me cat in two hours with zero knowledge😂😂😂
I wish you all the best!
Greatttttt
Thank you 😊
Love you
Thank you 😊
“Why not F U “😭😭😭
:)
I love you
Thank you!
* Why do you call it Km , Why not FU *
LMAO , he did it on purpose
Km why not Fu😅😅😅😅
:)
3:12 😅😅😂🤣
Hi, first :)
Thank you 😊
I'm not watching your video because in between video some middle voice irritating me
Why Km and not Fu😂😂😂😂
Stop unnecessary talk and come to the point straight
I didn't understand Km 🥹
Please watch my biochemistry videos in order in my Biochemistry playlist!