We like to pin important comments to address issues or clarifications in our videos. We promise the read is worth expanding! :) We greatly appreciate a commenter who revealed to us that there is an inconsistency in introductory biology sources for non-competitive inhibition. The peer-reviewed source we like to use as our main factual reference is Openstax where they have "In noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than the active site, called an allosteric site, but still manages to *prevent substrate binding* to the active site." Direct Link: openstax.org/books/biology-ap-courses/pages/6-5-enzymes However, in the popular Biology "Campbell" book used by introductory biology courses, the 11th edition states that the substrate can *still bind* but the "active site functions much less effectively." So which is it? After looking at more sources and conversing with some science communicators online and in a biology group Pinky is in, what we are hearing is that while the non-competitive inhibitor alters the enzyme's conformation, sometimes the substrate *can* still bind - and sometimes the substrate *cannot* bind - it depends on the non-competitive inhibitor type and enzyme. Thus, focusing on the binding can be problematic since substrates may still bind so we have now included this sentence *"if the substrate still binds, the enzyme's active site might not function well. Or at all."*
Hello @AmeobaSisters! Your videos helped me alot during my home-education. I watched most of your videos and I understand the topics better. I know that you both have you own children and you are still working hard to making these videos. Are you going to continue to make videos on Advanced biology (College Level), or do you think you might need to have a break before coming back to making videos? I don't want to push you to much, but if you could, it would be great :)
uni student here, my bio professor got fired since he was kind of awful so my in-person class got switched to online, & now i learn everything through your videos. it all makes 200x more sense than anything my old professor said. amazing videos!
I'm always curious now because of you. I'm watching this at 03:00 AM (South Africa). Thank you, amoeba sisters I wouldn't be able to pass my science class without you guys. I'm now majoring in biology because you made me love science thank you guys ; )
So, nobody's going to mention about how they rickrolled us by the last part 🤣🤣🤣 You got us there Amoeba Sisters! How entertaining yet informative at the same time! Very great job! 💯✨
The fact that I've been watching your videos since grade 9 and now I've graduated and am in University. Truly shows how good your videos are, can be watched by all age groups
i'm starting 9th grade, and it's so hard to get over that hill. I just want to say you guys have helped so many people and you NEED to understand that, without you, people could have not even passed there own grades! Your videos are the ONLY videos I can understand, so thank you! TYSMMMMMMMMMMMM
i love you guys fr doing this. i went to a public school that didn't teach biology and i am now an adult falling in love with the topic. videos like yours are what's helping me with some huge gaps i have in my knowledge. thank you thank you thank you!
Hi sisters, I just wanted to let you know that your videos have helped me so much. You have made me realize that learning really can be fun. My grades have improved and so has my love for you guys. Thanks so much for your help!!
Just wanted to come on and say, thank you for these videos!! My biology teacher used your videos to help us understand the topics she thought us and you two have really helped me pass my biology class 💜
I wanted to thank both of you from the core of my heart! Since, the time I came across your channel - I began to fall in love with Biology! It helped me a lot in my junior years and currently the videos are helping me as a middle schooler as well! The videos has inspired me to go beyond the books and my curriculum! Thanks a lot - I am from Japan (13 years :) )
I waited along for this video only from amoeba sisters animation make me easier to study the basic concepts , Thank you so much ....it's too helpful for making short notes.
Wow! This is the first video I've watched that is very recent (just 1 month ago). All of the videos I've watched from this channel were way back 3-5 years ago and I'm very happy that until now, this channel is still active! ✨ Keep it up Amoeba Sisters! You have helped me get through this online/modular class amidst pandemic. I'm currently in the 12th Grade and by next year, I'm going to graduate from my Senior High and take another step further into College! I will still go back here to your channel because I will take a Biology Course! 🦋 If I graduate from my college and become a doctor of any type, I promise that I will again comment here or any of your videos! I'm reaching my dreams and you're one of the stepping stones that will help me through it! God Bless 💖
A GREAT video for helping to explain regulation of cell processes. This is Advanced Placement Biology content all the way, but it is also still very useful for general bio. Outstanding explanations! This helps my students a lot! Sincere Thanks!
just in time !!! i have my final on 12 september and was really confused about coenzymes and cofactors,now i understand them more clearly,thank you so much
I know this too late, but im in semester 4 n college and amoeba sister always in my search engine whenever its final exam, Thank you for your hard work in making this video
Amoeba Sisters+ Freesciencelessons+ Biological Science+ Functional Approach =🥳🥳🥳🥳🥳🥳. Tbh, amoeba sisters should be called interesting biology. thank you so much😭😭😭😭😭
Literally watching your videos is the only way i can make information stick. I sometimes watch the videos outside of learning just for the illustrations and jokes
Finally! It's another late-time production, for another biological science subject! I hope you've done a great job there... Also, I gratefully wish to acknowledge you for enhancing my biological science experience!
Oh! I just found your channel, my highschool biology teacher shows us your vidoes about membranes and plant cells,animal cell, all that stuff that I will forget in my adulthood
i´m a med student and these videos help me A LOT finally a funny way of learning... i´ve get an F from the feedback inhibition, cause I had no idea what it was, I thought it´s complicated as hell, but thanks to you I discoverd it´s not that bad.. I owe you my future degree :DD
These videos are going to put me and all other biology teachers out of a job! Or rather, competitively inhibit our usefulness. Still though, they're incredible and I would do my students a disservice by not sharing them! Thanks, Amoeba Sisters!
I just realized,,, I got rickrolled at the end 💀 but anyway, thx you for your videos!! I have the bio EOC in a few days and your videos are better than out crusty textbooks. 💚💙💚💙
We like to pin important comments to address issues or clarifications in our videos. We promise the read is worth expanding! :) We greatly appreciate a commenter who revealed to us that there is an inconsistency in introductory biology sources for non-competitive inhibition. The peer-reviewed source we like to use as our main factual reference is Openstax where they have "In noncompetitive inhibition, an inhibitor molecule binds to the enzyme in a location other than the active site, called an allosteric site, but still manages to *prevent substrate binding* to the active site." Direct Link: openstax.org/books/biology-ap-courses/pages/6-5-enzymes However, in the popular Biology "Campbell" book used by introductory biology courses, the 11th edition states that the substrate can *still bind* but the "active site functions much less effectively." So which is it? After looking at more sources and conversing with some science communicators online and in a biology group Pinky is in, what we are hearing is that while the non-competitive inhibitor alters the enzyme's conformation, sometimes the substrate *can* still bind - and sometimes the substrate *cannot* bind - it depends on the non-competitive inhibitor type and enzyme. Thus, focusing on the binding can be problematic since substrates may still bind so we have now included this sentence *"if the substrate still binds, the enzyme's active site might not function well. Or at all."*
Can you please recommend a book in Biology (zoology to be precise). I have taken the Campbell bio 7th edition and it was quite interesting !
Hello @AmeobaSisters! Your videos helped me alot during my home-education. I watched most of your videos and I understand the topics better. I know that you both have you own children and you are still working hard to making these videos. Are you going to continue to make videos on Advanced biology (College Level), or do you think you might need to have a break before coming back to making videos? I don't want to push you to much, but if you could, it would be great :)
Ok you are a good channel but why is it that its called amoeba sisters when it is only one talking and not two
Just take out purple
besties, please make a video on centrioles and microtubules, its so confusing pls
Can y’all make videos more often please
Imagine taking Biology in college and the Amoeba sister is more useful than a college book.
It is ….
@@jeannettemeyer3093 me rn
Me rn😥
@@TOP4K175 same 😭😭
Freshmen in college taking anatomy 😅😅
I wouldn't be able to pass my science class without you guys! 💖
You “girls”
@@Sh1nsoul it’s a gender neutral response, it’s just like ‘oh what’s up guys?’
uni student here, my bio professor got fired since he was kind of awful so my in-person class got switched to online, & now i learn everything through your videos. it all makes 200x more sense than anything my old professor said. amazing videos!
how was he awful
I'm always curious now because of you. I'm watching this at 03:00 AM (South Africa). Thank you, amoeba sisters I wouldn't be able to pass my science class without you guys. I'm now majoring in biology because you made me love science thank you guys ; )
So, nobody's going to mention about how they rickrolled us by the last part 🤣🤣🤣 You got us there Amoeba Sisters! How entertaining yet informative at the same time! Very great job! 💯✨
Me looking for this comment!!! 🤣🤣🤣
don't ruin it for those who haven't seen it yet
Nice
The fact that I've been watching your videos since grade 9 and now I've graduated and am in University. Truly shows how good your videos are, can be watched by all age groups
😭😭 it's my first time her and i like the channel
i'm starting 9th grade, and it's so hard to get over that hill. I just want to say you guys have helped so many people and you NEED to understand that, without you, people could have not even passed there own grades! Your videos are the ONLY videos I can understand, so thank you! TYSMMMMMMMMMMMM
It was much needed before my medical entrance exam on 12 September
Lot's of love ❤️❤️❤️
Neet aspirant spotted
@@deekesh7321 😂
howd it go
I've learned more by watching your videos than a whole week of biology class
i started watching these for school stuff and now i genuinely enjoy it! biology is my favorite subject now too!!
I’m taking AP bio this year! I’m really scared, but I know that with you guys I’m gonna pass the exam!
good luck on the exam its in a couple days
how did it go I need ur help I'm taking it this year
@@sabinalkhalil2733 Excellent! I got a 5
@@josemiguelkuri2405any advice?
@@josemiguelkuri2405 omgg i'm in ap bio right now and I'm failing do you have any tips? 😢😢
i love you guys fr doing this. i went to a public school that didn't teach biology and i am now an adult falling in love with the topic. videos like yours are what's helping me with some huge gaps i have in my knowledge. thank you thank you thank you!
Biochem teacher here! This week we will see this in class so I’m definitely recommending this. Great work, love it! 💯
recommendations for somebody going into biochem?
you made such complex concepts easy and fun. it's natural that we'll stay curious. and thanks for spreading knowledge..♥
Cartoons+Studies=Awesomeness....you guys are just amazing.
I love your videos! I always watch them the morning of my tests because you have videos on all the things I'm learning!
Hi sisters, I just wanted to let you know that your videos have helped me so much. You have made me realize that learning really can be fun. My grades have improved and so has my love for you guys. Thanks so much for your help!!
Just wanted to come on and say, thank you for these videos!! My biology teacher used your videos to help us understand the topics she thought us and you two have really helped me pass my biology class 💜
Another concept clearing video. Thank you so much sisters 🥰🥰🥰
The Amoeba sisters have made learning biology so much more fun for me. Thank you!!!
I wanted to thank both of you from the core of my heart! Since, the time I came across your channel - I began to fall in love with Biology! It helped me a lot in my junior years and currently the videos are helping me as a middle schooler as well! The videos has inspired me to go beyond the books and my curriculum!
Thanks a lot - I am from Japan (13 years :) )
you have taught me way more than what my bio teacher could have taught me in the past 1 year!
I'm watching this not for school but for how fun you guys make science. Keep doing what your doing! ❤❤
Thanks for all of the effort and time you spent into the making of this video! I truly appreciate it : )
your way of explaining is very good and it makes the complicated topics more easy to understand
I was really confused about what feedback inhibitors are until I watched this video. Now it makes sense. Thank you!!
Today i started reading enzymes, and you uploaded this video 😁What a timing 😎
I waited along for this video only from amoeba sisters animation make me easier to study the basic concepts
, Thank you so much ....it's too helpful for making short notes.
Wow! This is the first video I've watched that is very recent (just 1 month ago). All of the videos I've watched from this channel were way back 3-5 years ago and I'm very happy that until now, this channel is still active! ✨ Keep it up Amoeba Sisters! You have helped me get through this online/modular class amidst pandemic. I'm currently in the 12th Grade and by next year, I'm going to graduate from my Senior High and take another step further into College! I will still go back here to your channel because I will take a Biology Course! 🦋 If I graduate from my college and become a doctor of any type, I promise that I will again comment here or any of your videos! I'm reaching my dreams and you're one of the stepping stones that will help me through it! God Bless 💖
I love these videos, and LOL alone in my room!!
u know what, if i ever want to watch cartoons, i watch your videos, informative and interactive . cant get enough of it. u r amazing
Found out about your channel in school love y’all for helping me pass 6th grade
Im so happy that i can educate my mind with ya'll
A GREAT video for helping to explain regulation of cell processes. This is Advanced Placement Biology content all the way, but it is also still very useful for general bio. Outstanding explanations! This helps my students a lot! Sincere Thanks!
you're literally my saviour yt channel
I was wondering about enzymes since I saw your other enzyme video so thank you for the elaboration
I love the Amoeba sisters. Thank you for making my college life easier
This really helps me! Thx Amoeba Sisters!!😀
just in time !!! i have my final on 12 september and was really confused about coenzymes and cofactors,now i understand them more clearly,thank you so much
My interest in Biology Is because of You, Thank You!!!
This is the best animated science teaching account I’ve seen
I love it when you guys put out a new video.
Thank you ! I would not be able to pass the exam without you ! Always stay curious 💕💕
I know this too late, but im in semester 4 n college and amoeba sister always in my search engine whenever its final exam, Thank you for your hard work in making this video
Amazing video! I have learnt so much from your RUclips channel. Thank you 💕
Amoeba Sisters+ Freesciencelessons+ Biological Science+ Functional Approach
=🥳🥳🥳🥳🥳🥳. Tbh, amoeba sisters should be called interesting biology. thank you so much😭😭😭😭😭
Literally watching your videos is the only way i can make information stick. I sometimes watch the videos outside of learning just for the illustrations and jokes
Finally! It's another late-time production, for another biological science subject! I hope you've done a great job there...
Also, I gratefully wish to acknowledge you for enhancing my biological science experience!
Your animations were cool which makes even a kid to understand like this complicated topics
hi i rlly love ur channel it brings me joy! thank u mrs fireball for bringing me here 💕💕💗💗
Nice to see you again with another great and Informative video AMOEBA SISTERS 👌👌
This has actually made me enjoy biology thank you!!! ❤️
Amoeba sisters teaches me more in their few minute videos more than a semester of class has taught me
ive never heard of u guys until my science teacher used ur videos for my assignments!
Why is this so funny and helpful at the same time 😂
Yay new ameboa sister's video, love your content, best channel.
thanks, this channel is very effective to Bio students
POV your Bio teacher can’t teach you this in a hour and a half class period, but this video can in 8 minutes
thank you amoeba sisters...you guys upload sooo interesting topics and ofcourse help in academics
I have a final at 8 am and it’s currently almost 1 am and I’ve been binging your videos to help me prepare for my bio exam
I LOVE YOUR GUY'S VIDEOSSSSSSSS!!!! I LOVE YOU BOTH!!!!!!!! Y'ALL ARE AMAZING!!!!!!!!❤❤❤
Nothing related just a random biological pickup line - If I'm Adenine, will THYbeMINE?
@Anchal Vijayan haha good one
Oh! I just found your channel, my highschool biology teacher shows us your vidoes about membranes and plant cells,animal cell, all that stuff that I will forget in my adulthood
i´m a med student and these videos help me A LOT
finally a funny way of learning... i´ve get an F from the feedback inhibition, cause I had no idea what it was, I thought it´s complicated as hell, but thanks to you I discoverd it´s not that bad.. I owe you my future degree :DD
My science teacher loves your videos and your videos really hep me with my science class
Thank you so much, you helped me understand it more clearly than in textbooks.
lmao i have an exam tomorrow and i wasted my whole day trying to cover a chapter, wish i saw this vid earlier, itd help save my time
I love Amoeba sisters!!
Really appreciate your explanation
Thanku amoeba sister's
Tysm! This vid is gonna help me on my AP Bio quiz on enzymes tomorrow!
Im spanish, and even tho that i am, i understood everything with a english video. Amazing
Nice explanations are relatable
Thanks for your help so much
I have an exam tomorrow and now I finally understand allosteric reactions and feedback inhibitors
Thank you SO much for this incredibly helpful videos!
This is the only way i can focus and study❤
you two sisters are perfect 😍💕!
Thanx for the great video and the info on ACE inhibitors!
These videos are going to put me and all other biology teachers out of a job! Or rather, competitively inhibit our usefulness. Still though, they're incredible and I would do my students a disservice by not sharing them! Thanks, Amoeba Sisters!
I just realized,,, I got rickrolled at the end 💀
but anyway, thx you for your videos!! I have the bio EOC in a few days and your videos are better than out crusty textbooks.
💚💙💚💙
It would MAKE MY LIFE if you made videos on Vitamins and Minerals!!!
This video was sooo helpful for understanding inhibitors.
Thank you! You guys make chemistry fun and interesting to learn!
If possible, post a video about the tissues as well
👌👌
Plz make a video on osmoregulation in plants and animals and balance of water and solute in the body ☺☺☺☺thankyou
A conversational tone helps to teach very well sometimes in tandem with literary, detailed level textbooks 😄
Y’all teach so clearly
Like I can understand really good
I agree ATP synthase is my favorite enzyme. I like to think about it working in my body while I'm jogging.
Sisters can you please make a video about what is chemistry and why is it important, please
We really want Amoeba Sisters Hindi
Thank you for making this awesome videos
Thanku so 💓 💗 much,, you both are amazing 👏 💖
Superb channel 😄 please make more and more and more videos
Can you give more of feedback inhibitions and Immobilization of enzymes it would help a lot. Thank you
this videos are helping me allot for tests!!
Thank yo so much. The video was perfect.
Informative 👍
Thank you so much for this video. ❤️❤️
Is no one going to mention the fact we got rickrolled by a group of cofactors, coenzymes, and 2 ameobas?
woah, no words the graphic were so helpful
Please make a video on characteristics of all five kingdoms from monera to animilia ❤❤ love from India 🇮🇳 ❤ ♥