INFLAMMATION Part 2: Cellular Events- Leukocyte Recruitment.

In this short tutorial i have described the the basic concepts of inflammation and described cellular events in inflammation.. Visit ilovepathology.... for more topics in Pathology!
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Cellular events in Inflammation
Recruitment of Leukocytes
In the lumen
Magination , rolling, Adhesion
Across the vessel wall
Outside the vessel wall
Chemotaxis
Cellular events in Inflammation
The influx of the leukocytes ( neutrophils & Monocytes) to the site of injury
These leukocytes ingest and destroy the injurious agents ( microbes/necrotic tissue/foreign bodies) [PHAGOCYTOSIS]
Also these leukocytes secrete growth factors needed for repair.
How does leukocytes travel from vessel lumen to the site of injury??
Multistep process
Mediated and controlled by ADHESION MOLECULES and CHEMOKINES
Why neutrophils predominate early ??
They are more in number
Respond more rapidly to chemokines than others
Attach more firmly to adhesion molecules
BUT, They are short lived!! Undergo apoptosis and disappear in 24-48 hrs
Replaced by monocytes, as they survive longer and can proliferate in tissues
Exceptions
Pseudomonas infections : neutrophils continues to be recruited for several days
Viral infections: lymphocytes predominate
Allergic infections: eosinophils predominate
What is the therapeutic implication of understanding this whole process??
Helped in finding the therapeutic targets for controlling harmful inflammation
Eg: TNF blockers
Integrin antagonists: Approved.. And in clinical trials.
What NEXT? After recruitment of leukocytes
To recognize the microbes/necrotic cells/foreign bodies
Activation of Leukocytes
Phagocytosis & intracellular Killing

[@adamprabowo4556]

Alhamdulillah finally i found the best video for teaching me based on the Robbin Basic Pathology book. Good job sir, I'm really big appreciated!

[@anjalijog837]

I've understood these cellular events so well that if it wouldn't be asked in my exam, I'd be highly disappointed 😅
thanks a ton for your effort.

[@chideraokolie222]

lol

[@olivialiang7054]

omg you're the best, my lecturer has failed to teach me inflammation immunology through 2 lectures (an hour each) and you've done so in 12 minutes.

[@sinyingkueh]

Everything is clearly explained !! love the style of the slides, not complicated and easily to understand !!! Thanks sir u're my life saver! ^^

[@xT..]

These videos are just perfect. Thank you so much. I'm using them as a revision but they're so good that Im even learning more than when I first studied this.

[@rahamatanangterle2567]

This is the best channel of pathology I found until now. Thanks for your helpful videos!

[@intimounika9428]

Sir ,please do a video on immunopathology especially hypersensitivity and pathological changes in circulation like thrombosis and embolism

[@dr.shabrishgowda1309]

Please continue making more videos . 😭 This is one of the best channels so far .
Please keep continuing . I wish to see you back wit( more videos
This definitely has helped me a lot

[@mwangalamusialelaamwalana3689]

SIr, you are the best pathology tutor I have ever come across! Thank you soooooooooooooooooooooooooooooooooooooooooooooooooooooooo much!!! your efforts are very much appreciated!

[@akathiyarvarmailanchezhiaa7588]

Sir it was awesome... just like in harsh mohan textbook.. Useful for MBBS 2nd year examination preparation..🙂😊

[@ronypraneethkumar9633]

Best video for understanding inflammation topic
U saved me from wasting approx 3-4 hrs 😁😁😁😁

[@user-on5uh4tu2t]

Best channel for pathology robbins.. i think slides are from big robbins ...there are more points than medium robins

[@saniyakm5315]

😇Thank you soo much sir
Finally patho topic's is going to understand in this channel.... ❤️

[@samantariq5261]

this is so helpful.All the important points are covered in it.best way to grab concepts to a topic is just open your book and start watching this video along highlighting the imp.points.definately it will helpful..great video ,huge thumbs up👌👍👍👍😍

[@wobbyyy]

such a good teacher. God bless you!

[@zenithpotter8797]

You're one outstanding teacher there!

[@dr.shyamalprakash1656]

Best thing is you explain the basic ,and it's become so easy to understand,once again thank you

[@racshana1348]

I might pass my internal assessment because of your video, thank you so much!

[@zunairamaniar4588]

You made it seem so easy. Keep up the good work!

[@siddheshrahate4351]

Concise and clear. This is best channel for pathology.

[@67.junedashaik84]

Thank you so much sir......I understood easily because of you.....it may be difficult for me without your classes thanks a lot sir ❤️❤️❤️

[@sakaleshhippalagemath6984]

Thank u Sir for ur clear and crisp explanation..
Waiting for many other topics 😍😍

[@mishkapathak]

Sir ,after watching your videos I felt Robbins is very very easy and addicting
......It helps a lot also understanding pathology has become much more simpler

[@sarojchaudhary9387]

Your all videos are too good 💓... complete covers Robbins....do make on all topics😅... really appreciate it....very helpful!!

[@Carlovers343]

the best video on inflammaion

[@anithanandvhanumanthu]

Sir it was an awesome lecture u made it easy jst loved the explanation🙂 it is easy during xams if we see this vedio👍

[@intimounika9428]

Ur videos are simply memorizing the subject for life long
tqsm sir 😊

[@MehwishCookingInKorea]

Jazakallah sir 😍 bhht bhht achi tara se sb smjh agya 😃

[@muhammadshanzaib8802]

Ks medical college se ho?

[@misBugzHere]

Sir u r amazing,the way u teach,ur slides,ur efforts all are just beyond praise♥️♥️😭
"Thank You" is Soo small before ur hard work sir,many prayers for ya♥️♥️♥️🙏🏽

[@ilovepathologyVijayPatho]

Thank you 😊

[@reneerocksify]

THIS IS SO GOOOOODD!!!! I understood everything. It was clear and concise

[@VishnuGupta-id9cp]

Really awesome its complete Robins and I just wanted the same... thanks thanks a lot

[@pavisiva5822]

Amazing video
Thank you so much for this🎉

[@zainabeid294]

Thank you so much,that was very helpful

[@zakirzak1494]

Great videos and animations.., thank you so much

[@adityashetty217]

please upload more videos sir these videos are very helpful while studying

[@AanchalsArtGallery]

Best ❤️ loved the way you explained i was so confused and u just made it so damn simple i can't thank u enough 💯✌️

[@Sallabhavana-ct2tb]

Thank you sir....very helpful 😇

[@eiranicoletan1068]

this was so informative thank you!!

[@blagojaleksovski2567]

Sir thank you for this video and many more, you have helped us so much,but please please if possible please enhance the audio so we can hear you better

[@dhayalansureshkumar3343]

Thank you so much sir...clearly explained each steps ...you just nailed it ...I am forever grateful for your videos...the real teacher 🥹💥💯

[@starrynight3009]

Thank you so much for these videos on inflammation... it helps a lot in understanding the topic

[@lekshmirs4860]

Thank you sir .U r doing a great job

[@annathjuzaina7103]

You are the best lecture 🥺👍🏻

[@shiddrajshirigeri11]

Very nicely explained sir.Very Simple and clearly explained .Thank you

[@meditationarena.879]

Thank you very much.You saved my day.

[@39-manuskumar92]

Thankyou , sir
I understood every point .

[@Utube049]

Thank you so much....😢❤ . Clearly explained
🙏🙏

[@easudj6876]

Thank you sir thank you so 😇much

[@shammafarhathp3808]

U r the reason y I luv pathology 😍👍

[@kosaisharfi1671]

Thank you very much
Excellent lecture !! Very USEFUL
💓💜💛💖💗💙💚💙💗💖💓💜💛💜💖💗💙💚💟💞💝💓💓
Your video make it very clear
You explained it much better than our professor !!!. Continue the excellent work

[@yenibera.priscillaJCD]

Thank you sir, 🤗🤩 v.nice explanation sir

[@sarakhader729]

Thank you so much for these videos. Please keep posting soon. This is very helpful

[@chrischrist1378]

Sara Khader excellent

[@hiralpatel6147]

great work... keep it up.. no one could have taught me better than this..

[@vaishnavi2175]

Beautifully and shortly explained sir...thankuu

[@RahulKumar-wo7oq]

Sir please cover other topics of Robin's pathology....humble request hoping positive response

[@ashishsinghal6190]

Nice and excellent . please put some more videos on pathology topics and some review questions

[@priyanshisharma8011]

Please sir we want more videos.You explain soo well . Thanks a lot .

[@nitzartzcraze8939]

Superb class sir thank you so much

[@sharjeeldreshak9157]

Awsome Sir g very helpful video

[@amirhatami7736]

Simple and digestible thanks for the good job 🌷🌷🌷🌷

[@adlesal24]

Greaàaaaat
Fabulous lecturer
I couldn't find the hemodynamic lectures.
Is it still not included in the channel!

[@ilovepathologyVijayPatho]

Thank you 😊
Few hemodynamics topics here ruclips.net/p/PL6fcSX6gqoFBYnTBvU_INZjsauEhcCdLw

[@ilovepathologyVijayPatho]

Infarction topic is covered too..its not shown in playlist though

[@adlesal24]

@@ilovepathologyVijayPatho
Yes Infarction and thrombosis was the ones I looking for

[@adlesal24]

@@ilovepathologyVijayPatho I will check them

[@adlesal24]

Your prompt response is highly appreciated, doctor 💝

[@misthisinha3157]

Best video

[@ravinachoudhary4457]

Best video 🥰🥰

[@sneakepete5570]

Really loved this video, very easily and beautifully explained❤️🔥

[@banshalrinki7284]

Sirr I love the way u teach ..U clarify my concept ..Tqsm sir..sir one request plz uplaod more video on pathology....

[@186rojapitla7]

Highly superb ❤️🥳

[@abhisheka4379]

Awesome video , nice animations , understood to the fullest

[@user-jq4rv3we7l]

Just wow!!!!
Thanks a lots

[@rashidjavaid6099]

Thanku for these videos, sir please add more pictures which helps out understanding the things more clearly,thank u

[@sumitvarat6378]

fab explanation .....u really talented .....

[@prajwalareddy2603]

Thank u so much Sir such a wonderful explaination

[@dr_auspicious]

Excellent explanation...love it....best for revision...

[@kamransunny5463]

Alhamdulillah
sir go for the systemic also. will be more beneficial to students

[@rutujamorje6609]

Thank u so much for this video 🤗💗

[@eMedSchool]

very nice explanation

[@yashparikh4326]

Sir this information is which I want, so thankyou very much sir .

[@_a_butterflyy376]

so far so good.. thank you so much for the wonderful explanation.. :)

[@muhammadkashif1481]

Thanku sir ...u discussed it in an facinating way . sir plzzzz upload more vidoes .

[@poojabohra15_]

Thanks a lot sir 🙏🙇

[@toufiqenam9516]

Excellent. Mind blowing

[@Einstein010]

Nice explanation ❤️

[@adelinejoseph128]

Thankyou really helped me 🙏

[@anuragjaiswal8241]

Sir you are great

[@tahseenshaikh5582]

Thank you sir now
Cellular events are easy for me

[@ilovepathologyVijayPatho]

All the best

[@medabhishek]

Supeb explanation 👍🙌

[@rashidjavaid6099]

THANKS A LOT SIR!
Understood it so well!

[@syedsabirbiology4710]

nice work 'concptual thanks for delivering such lectures

[@aviator5875]

Very well explained.Thank you so much sir💙💙💙

[@virtualworld6365]

Good presentation....without lag👍🏻

[@shabanakhan8342]

Thank you sir!

[@kidsvlog1191]

Oh Thank you so much such a nice video really appreciated👍👍

[@anthonysamson7293]

thanks a lot it is awesome it makes pathology easy

[@joguprashanth5834]

nice explaination

[@priyankasarkar7596]

Sir but according to harsh mohan, receptors for integrins are stimulated on neutrophils Nd not on endothelial membrane

[@ShaleharkyShalesafin]

Brilliant

[@dee..o]

THANK YOU SO MUCH

[@happiestus9530]

Very helpful sir. Please make more such videos.

[@sabreen3052]

Thank you

[@yomarie09]

Amazing explanation! Thank you

[@karishmadash2284]

Wow sir plssssss post more video , excellent work🙏