INFLAMMATION Part 1: General concepts, types , Vascular changes in Acute inflammation
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- Опубликовано: 18 дек 2024
- In this short tutorial i have described the the basic concepts of inflammation and described vascular changes in Acute inflammation.. Visit ilovepathology.... for more topics in Pathology!
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Inflammation : Definition Local response of living tissue To any injurious agent
Protective response needed for survival!Can Cause tissue damage by itself!
Historical Aspects
The word inflammation from the Latin inflammare (to set on fire).
Celsus , Roman Writer 1st century AD listed the four signs of inflammation.
He said “rubor et tumor cum calore et dolore” which meant “redness and swelling with heat and pain”
The 5th Sign “Functio leasa” Loss of function Was added by Rudolf Virchow In 19th Century
John Hunter, Scottish surgeon:1793: inflammation is not a disease but just a response!
Elie Metchinkoff: 1880s; A Russian zoologist, Discovered the process of Phagocytosis
The 5 “R”sSteps of inflammatory response
RECOGNITION of the injurious agent
RECRUITMENT of inflammatory cells ( leukocytes)
REMOVAL of the injurious agent
REGULATION ( control) of the inflammatory response
RESOLUTION/REPAIR
ACUTE INFLAMMATION
Vascular Changes
There will be increase in the blood flow
To bring cells and proteins to the site of injury
By vasodilatation & increased vascular permeability
Cellular events
Recruitment of leukocytes
Activation of leukocytes leading to the process of destruction of invaders and production of mediators.
By Phagocytosis
How these stimuli are recognized by the host?
The antigen presenting cells/epithelial cells have RECEPTORS that sense these stimuli
Toll like receptors
Microbial sensors
Present in plasma membrane & endosomes.
Recognize products of bacteria, virus and other pathogens ( almost all!!)
Results in production of mediators of inflammation
Inflammasome
Multiprotein cytoplasmic complex
Recognize products of dead cells
Activation of Caspase-1
Activation of IL-1 which is the mediator of leukocyte recruitment.
These leukocytes phagocytose & destroy dead cells.
Increased Vascular Permeability
Hallmark of Acute inflammation
There is escape of fluid, blood cells and proteins from the blood vessels into the interstitial tissue
Mechanisms of increased vascular permeability
Contraction of endothelial cells
Direct damage to endothelium/Endothelial injury
Endothelial injury due to leukocytes
Transcytosis
you can now solve practice sessions ( including multiple choice questions, questions to learn simple conceptg and case scenarios).
It is interactive and enjoy the process of active learning. CLICK BELOW
app.wisdolia.com/learning-journey-overview/i2xDA2Q4gqwOrZDtgGyg?r=wvsgLIh1lJQdSXHQYQLBj5FEfE51ma
This video did what my lecturers couldn't in hours.hats offf
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Robins seemed a headache but u made it all so easy😍 Thankyou
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@@ilovepathologyVijayPatho Thanks 🤝
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THankyou for this video, I'm studying inflammation right now for my Patology exham, and this si really clear and helpful.
Which book u r reading
Amazing video i learn a lot of things from this video and it helps us a lot when i study the book
This is explained in so simplified way that I understood about inflammation at once.... Great job bro.... Keep making these kind of stuff 👏👏
Spectacularly explained.
Your videos are a great help to a lot of students. Please upload more chapters..we're all waiting
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Thanks 😊 🙏
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Best video for inflammation. Thank u sir!!! Well explained
Thank you so much for your videos, sir! You are a life saviour! Pathology textbooks are easier cuz of crisp explanations, like yours.
Thank you very much😊
Ehich pathology text you are using
Thank you this was very helpful, I have CGD, and I want to understand the inflammatory aspect.
Sir your videos are very helpful..your lectures are very easy to understand..
Thanks for making these videos and helping the students:)
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This lecture is far more better than my clg lecture
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Thanks 😊
it helps a lot! actually i found it very hard but now its seems really easy...
This video was extremely helpful in understanding Inflammation. I am going directly to Part 2. Thank you!
Superr explaination sir 💫💥🙏🏻
Thank you sir
helpful sir u explained in such a easy manner please do keep uploading such videos
Thankyou so much sir .. after watching your lectures ( i literally have watched every lecture of yours in just 4 days 😭 offcourse it is last minute revision just to relieve my stressful mind which is constantly poking me and giving me flashbacks of supply exam in pathology) but now I'm totally satisfied that i will score a very very very good score 😤💪🏻 in pathology. Thanks a ton sir 🙇🙏
You are a saviour . Hats off to you 🙏🙏
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Thank you very much 😊.am really glad that it helped you..
All the very best for your exams 😊
thank u the concept was clear. it was delivered well. Good audio. it was not boring. thanks
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this one is better than book because it was simple and concept was easy to absorb
After watching this video robbins seems too easy. Thank you so much sir.
May God bless you bro🙌🏽
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Very well explained 👍👍.
Thankyou
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Thank you sir. This video gave that little boost and more understanding to my knowledge
ThaNkkkk u Sooo MuCh sir 💓✨✨✨💓💓✨✨ It Made my Anxiety Lowered about Inflammation chap..💓💯💯
Thanks for the tutorial!..I really liked it.. It's very helpful for understanding the subject.
Thank youu so much for creating this video!! This helps a lot! Hope to see much more video from this channel
Helpful . Thanks
thank you sir...I m pathology pg student..and your videos are really helping me..thank you
Thank you! Glad you like it.
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Thank you! I will be start estudy to step 1!
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Kinjal Shah
Good
Which test u are using.iam struggling with the subject.can u share some tips
great explanation sir
Thanku sir for your wonderful lecture
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Very helpful. Thank you Sir.
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Love from Pakistan
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Thank you
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Thanks 😊
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Nyc video sir!! Plz upload More videos on general and systemic pathology aswell!!
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Make videos on genetic disorders and diagnosis, if possible as I know it will take lots of time and efforts
بہت عمدہ
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Thanks 😊
Sir this video is really helpful for us but can I ask for the reference books
Please upload more videos on other topics of pathology...
Thank you doctor,
Can you tell me a good book resource for simple explanation
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Super sir
it was very easy to understand thankyou sir
Vascular events @9:19