INFLAMMATION Part 4: Chemical Mediators- HISTAMINE & SEROTONIN

1. Inflammation Part 4
click to watch the earlier videos of inflammation
Inflammation 1: ruclips.net/user/edit?o=U&vide...
Inflammation 2: ruclips.net/user/edit?o=U&vide...
Inflammation 3: ruclips.net/user/edit?o=U&vide...
3. MEDIATORS OF INFLAMMATION
4. Overview • General Properties • Types of mediators • Histamine and Serotonin
5. Mediators of inflammation These are the substances that INITIATE REGULATE& Inflammatory reactions
6. General properties These mediators can be produced Locally, by the CELLS Derived from inactive precursors present in plasma CELL- DERIVED PLASMA -DERIVED Preformed/ Ready made! Synthesised de novo/ made if needed! 1
7. They can be produced only in response to agents that stimulate inflammation They can stimulate the release of another mediator They have short lifespan! They can act on wide variety of cells 2 3 4 5
8. Preformed Synthesised de novo • Histamine • Serotonin • Arachidonic acid metabolites • Platelet activating factor • NO • Reactive oxygen species • Cytokines • Chemokines Compliment activation Factor XII activation • C3a • C3b • C5a • Coagulation system • Kinin system Cell - Derived Plasma - Derived CHEMICAL MEDIATORS OF INFLAMMATION
9. HISTAMINE & SERATONIN Vasoactive amines Are the first mediators to be released during inflammation Once formed it can be either stored or rapidly inactivated Derived from the decarboxylation of the amino acid histidine
10. Sources Mast cells Basophils Platelets Stimulus Substances inducing inflammation like heat,cold, irradiation,trauma etc C3a & C5a: Anaphylatoxins IL-1 & IL8. Histamine releasing factors from cells like neutrophils, monocytes and Platelets.
11. ACTIONS Increase in Vascular permeability Vasodilatation It is responsible for the Wheal & Flare reaction in the skin. Responsible for itching and pain Also mediates bronchial Asthma and anaphylactic shock By Increasing Blood Flow and Endothelial Barrier Disruption
12. ACTIONS Increase in Vascular permeability By Increasing Blood Flow and Endothelial Barrier Disruption Vasodilatation It is responsible for the Wheal & Flare reaction in the skin. Responsible for itching and pain Also mediates bronchial Asthma and anaphylactic shock Resulting from nitric oxide release Contraction of extravascular smooth muscles eg:bronchus By the excitation of a subset of unmyelinated C-fibers which are pruriceptive.
13. SEROTONIN 5- Hydroxytryptamine Stored in platelets and mast cells Also in chromaffin cells of GIT, spleen and nervous tissue Actions are similar to Histamine but less potent.
14. Summary • General Properties • Types of mediators • Histamine and Serotonin

[@nayakmeet12]

Glad to know that this excellent video is by our indian professor ❣️

[@misBugzHere]

Sir, we can never pay u back for what a great job u've done for us,bhttt saari duaaen aap k lye❤❤❤

[@ilovepathologyVijayPatho]

Thank you 😊😊

[@sohelsaheen]

Fantastic to learn Pathology and to have a clear conception after reading the Text Books and listening the Lectures in the class room.

[@sidbloom1995]

Your videos are very helpful, i have a final exam coming up in two days and your videos really helped clear this topic for me ^^
thank you and i hope to see more videos in the future

[@shaileshrao8694]

life saviour!! this topic was hands down the hardest i ever felt in general pathology and your videos just cleared all my concepts! thank youu ❤

[@harshitaiyer2283]

YOU ARE DOING A GREAT JOB..ITS MY EXAM TIME NOE AND UR VIDEOS ARE A BOON FOR ME...LOTS OF BLESSINGS FOR U 😊😊👏👏

[@abdallarohi5429]

Sir i just want to say your videos are really helpful...thank you so much Sir

[@Alwayspositive786]

Dr Vijay Shanker, great video.
Can I have more information on the role and influence of cAMP on resolution-phase macrophages.

[@nabeelkhan9547]

assalamualaikum Sir1! JAzakallah for these videos ... you try to give good concept in a short time. masha ALLAH

[@hillarybassey1072]

You really make pathology so easy pls more of your work.... thanks so much

[@abdulyesriff7414]

Sir the way u teach is awesome
Please do upload more videos it will be very helpful for us
Plz continue uploading Sir
Thanks a lot

[@RohitSharma-ni7mq]

its simple easy to understand and u clear the concepts very well but add some more videos on other pathology topics

[@manahilharoon1702]

Love the short and accurate information explained very well. Thankyou sir!

[@waheedurrehman3743]

Thank you Sir
You make it easy great
LOVE YOU

[@nousheenkhan5369]

I've got an exam and these videos are such a big help!!!! Thankyou soo much

[@vinayakhadagali3060]

Fantastic video concepts will be soo clearly understood

[@bongekamandisamthembu9439]

Fantastic thank you Pro🙏🙏 lecturers we pay in our institutions would never

[@misBugzHere]

ye Jo Robbin se Ishq,ye aap ki vaja se h sir
bs regret is baat ka h k zra late pta chla is channel ka,
More power to u sir💞✨✨

[@ilovepathologyVijayPatho]

Thank you 😊
Do share among your friends and juniors 😊

[@misBugzHere]

@@ilovepathologyVijayPatho ya sure sir,I'll definitely recommend yr channel to my fellows right now nd even to my juniors(next yr 😂)

[@ilovepathologyVijayPatho]

@@misBugzHere That's so very nice of you :-) God Bless . Good Luck :-)

[@misBugzHere]

@@ilovepathologyVijayPatho thank U sir

[@penchalaiahnallipogu9774]

Sir ur teaching is superb and easily understandable...thanks for this all video...I have subscribed too...

[@rosechemutaikoech8441]

I like it easy to understand... can I get the same for pathophysiology of granuloma formation

[@emmanuelmokgosi2628]

so helpful, keep on doing that advanced offers

[@sachindharan9845]

Sir ur vedio is really useful and easy to grasp

[@erraticananya]

The videos are really helpful

[@prashantranjan2539]

Well explained and simplified👏.... Sir please upload more lecture videos🙏

[@lizafriends6476]

Awesome work.keep it up sir.n make more videos.very useful for mbbs students

[@rinkuprajapati2]

This video really helps in studying
Thank you sir

[@dadsdoctor6656]

Sir the way u explained was🙏🙏🙏🙏🙏🙏thank u sir thank uuuúuúú soooooo much u are god of patho🙇🙇🙇🙇🙇🙇🙇🙇🙇

[@Hassankhiyal]

Thank you sir ❤️

[@rebeccahowley1355]

excellent video thank you

[@mohanadalassiri8641]

very helpful ..thanx

[@mdmahosin3751]

really helpful !!

[@dr.sukhmanikaur]

Sir kindly upload more videos on other topics as well

[@SaraKhan-jt8ty]

Clear concept thanks Sir .. plz make more videos

[@shubhamyadav9956]

Very helpful sir..!

[@manishk.1818]

Why couldn't it load the previous videos part 1,2,3 of the chapter inflammation .
Why doesn't you tube directly open the link ??😕

[@vstutorials2764]

And your video are very helpful too

[@giulio.pluchino]

Good video doc

[@abdelrahimhajelnour7682]

Thanks a lot, SIR.

[@n.a.creation9662]

It is very helpful sir thank you so much

[@mohammedkaleemkhan9585]

Awesome

[@musebibs]

You explain well! ❤️

[@ashishkori7535]

Thank u sir, it was helpful

[@anandankushvlogs6042]

Very very helpful sir ji

[@joseliberato9625]

is there any video where you talk about chronic inflammation? like definition, general features, causes, cells and mediators involved. As well as Granulomatous inflammation, types of granulomas etc.

[@farahazizsawal7959]

Thankkk Youu...

[@himariyabelayneh1937]

Dear sir these vids are amazing
But the logo in the corner is covering a bit of the content

[@musafiz6164]

Legendary. Thank you sir. Your videos are very helpful

[@ilovepathologyVijayPatho]

Thanks 😊

[@ikramshehzad6936]

Sir.. plz can you tell us from which one book u prepared these slide??

[@vstutorials2764]

Sir ye Jo Aap video banate ho ye kis app ki madad se banate ho Bina dikhe
Please tell

[@01.bhetariyadivya4]

Well explained 👍

[@Aspiring_healer]

Thnqq sir ❤

[@faiza1118]

Plz make a vedio on diabeties mellitus

[@areebajavaid1498]

tomorrow is my sendup and I'm just going to listen these lectures....

[@kondayugandhar9748]

Expecting many more lectures from you SIR🔥🔥

[@lizafriends6476]

All functions of seratonin are not exactly similar to histamine.histamine causes vasodilation whereas seratonin vasoconstriction.

[@dr.kuldeepojhavlog6514]

tq sir

[@ManishYadav-fr4to]

Sir more videos make for us

[@nikitaronge5953]

Thank u sir

[@hafsazi9688]

Sir i need ur lecture on edema plz....plzzz

[@ashishsinghal6190]

thank you , pls upload some videos on another pathological topics

[@vijayalakshmirabba5447]

Sir plsss add some more vedios on another topics

[@kidisitketema8783]

It is so 👍👍👍👍👍👍👍👍👍

[@tseganewaddisu3115]

I found your vedio. Very helpful

[@ilovepathologyVijayPatho]

Thanks:-)

[@tamizhatamizha9266]

Is Serotonin a vasoconstrictor?

[@robbyg9938]

I'd like to ask if serotonin can help breathing through the nose getting unclogged to breath better, just wondering.

[@beckiwildeman600]

An Anti-histamine or called a DAO like a natural Stinging Nettle or ButterBur & FeverFew. There are others just research for Natural Anti-Histamines

[@robbyg9938]

@@beckiwildeman600 thanks 😊

[@afsin2688]

👍👍👍

[@user-qk4hn5ce9x]

really appreciated

[@pheonixheart5534]

💜💜💜💜🏌️‍♀️

[@rosechemutaikoech8441]

I like it easy to understand... can I get the same for pathophysiology of granuloma formation

[@SaraKhan-jt8ty]

Clear concept thanks Sir .. plz make more videos