Inflammation: Immune Response to Tissue Injury or Infection

MEDICAL ANIMATION TRANSCRIPT: Inflammation is a local immune response to tissue injury or infection, experienced as heat, redness, edema, pain, and loss of function. Immediately after injury, inflammation begins with brief vasoconstriction of the local blood vessels to reduce blood loss and formation of a clot to stop the bleeding. Then, stimulated by cell injury and death, local cells release vasoactive chemicals, such as prostaglandins and histamine to dilate local blood vessels leading to increased blood flow to the area. These chemicals also cause endothelial cells in small blood vessels to contract, opening spaces between them. This increased capillary permeability allows fluids and proteins to pass from the blood into the tissue. Next, during a multi-stage process called chemotaxis, circulating immune cells called neutrophils move out of the blood vessels to the site of injury and destroy pathogens and damaged cells. Chemotaxis begins when cells at the injury site release messenger molecules called chemoattractants, which cause local endothelial cells and circulating neutrophils to stick together. Next, in a process called diapedesis, neutrophils squeeze through the endothelial gaps. The neutrophils migrate to the injury site by following a chemotactic gradient. Upon arrival, the neutrophils encounter bacteria, engulf them and digest them in a process called phagocytosis. After destruction of the bacteria and removal of cellular waste, tissue repair begins when locally produced growth factors cause local fibroblasts to begin dividing rapidly and secreting large quantities of collagen to reinforce the wound. Anti-inflammatory drugs inhibit inflammation by blocking production of inflammatory chemicals. The most common drugs for inflammation are non-steroidal anti-inflammatory drugs, or NSAIDS, such as aspirin and ibuprofen. They contain an enzyme called cyclooxygenase or COX, that inhibits the production of prostaglandins and several other inflammatory chemicals. Thus, reducing vasodilation, edema, and pain associated with inflammation.
#inflammation #ImmuneResponse #chemotaxis
ANM11028

[@bishalsen6850]

Please Make more videos on Immune system and how they fight infections

[@smitvirani5791]

whenever you feel alone remember that your immune system is always there for you

[@cameron6538]

2:57
"the most common drugs for inflammation are non steroidal anti-inflammatory drugs... such as aspirin or ibuprofen"
"They *contain* an enzyme known as cyclooxygenase...."
just wanted to clarify that this information as presented about the function of nsaids is misleading and incorrect. They do not contain cyclooxygenase, but inhibit the enzyme which is present within cells already, preventing it from producing prostaglandin and other immunogenic molecules.

[@abeliever7301]

Yes, thats that's why you can easily draw nsaid (drugs) in Lewis structure etc , because it's relatively simple structures

[@pinky9410]

Please Make video on thyroid inflammation (thyroiditis)

[@maverick.404]

We need more videos on Immune system. The most fascinating system.

[@jackkenny4194]

Always appreciate these videos. Thankyou :)

[@nadapenny8592]

Wildly fascinating with beautiful animation

[@KeandellClydeArcenalPineda416]

Can’t stop watching these videos 😊

[@user-si7zr4wv2y]

Please make a video about ' Near Death Experience '.

[@sergioparodivazquez4284]

Masterful video. I love it!

[@ahmedmustafashanbani3134]

This channel is best for health cares.

[@lauragadille3384]

Great video

[@birhatyouns2004]

Thanks

[@horuscurcino]

Really calm narrator

[@Tanaboy]

Thank you so much for sharing the information.

[@nucleusmedicalmedia]

Glad it was helpful!

[@anuragsahu1437]

If release of chemoattractants & vasodilation decrease then how the immune cells reach to the infection site and how to they prevent infection ?

[@denisanedelcu6614]

Just my opinion here (i don't know many informations about this, so if i say something wrong, please correct me). So, i think that medications like this are meant to reduce inflammation by blocking the release of these chemo attracts and so they won't spread and damage other cells anymore. Basically, i think they prevent the spreading of the inflammation, while some white cells are still coming in the way to help (because you can't just reduce it to zero). Did you know that penicillin doesn't actually kill the bacteria, but rather it prevents it from dividing by damaging their cell wall? I believe is similar in this case.
- from the perspective of a future medical student

[@diepoan5459]

đây chính xác là những video tôi đang cần👍🏻👍🏻

[@Angelen]

wow, beautiful!

[@jzluzzy123]

You can’t tell me God ain’t real when there are trillions of cells fighting to keep you alive at all hours of the day, nonstop, and when you get hurt they come running to save tf otta you . When they say your body is your temple, they mean that. God is amazing and there is no greater love. There are intense battles going on that we don’t even know about, and your cells don’t have any other thought than “I AM GOING TO SACRAFISE EVERYTHING I CAN TO HELP HIM!’ Amen, if you think nobody loves you, there are trillions, TRILLIONS of little creatures in you, that love you. How can scientists study this and question whether God is real? What more proof would anyone need?

[@user-fl6ob7bd6c]

❤❤❤

[@icecold8974]

Well said!

[@CaramidaMen]

Right. God bless and have mercy upon everyone.

[@luciferthe2nd]

“I dont understand science therefore god did it”. Thats pretty much what you said. Why don’t you educate yourself instead of filling it in with your god.

[@ceneblock]

Dang this is interesting!

[@nehasaroj4264]

Thanks 🎉for explaining such complex processes in simple ways
and also I appreciate your hardwork 😊you are the best teacher guys

[@nucleusmedicalmedia]

Thanks a lot 😊

[@dionysuswife]

In this case, if the wound still exists and haven't recovered fully, why would we have an anti-inflammatory drugs?

[@jeswithapranith9046]

8 comment
Knowledge..........

[@Puppies_Are_Forever..Sia.]

Sia..🩸😍!

[@sentientfetus3894]

Do the blood vessel wall ever used the oxygen before it gets to the other tissues. I mean if red blood cells had their own power they'd use up the oxygen but would we need these arteries muscles in in arteries

[@youngking0704]

the body God created is an astounding piece of machinery!

[@bio366geethasankar7]

🙏😊🙏🏻

[@shardasmitha3003]

You can send about light

[@yaduvanshianurag2017]

Cleared many concepts about immune system
Sadly few people are watching these kind of video
Love from India

[@neonthefox8518]

First

[@deepakfarswan8840]

If it prevents vasodilation, decreased blood flow so how our body gonna encounter foreign pathogen that entered our body ??

[@TrueInvisible]

our bodies are an endless war zone

[@shoka3167]

My immunity has become very weak due to Corona, TB and Allergy 😢

[@mahfujalam6688]

Same here it's like I will eternally coughing and few time fever and fatigue

[@gruiz3762]

In Spanish?