INFLAMMATION Part 5: Chemical Mediators: ARACHIDONIC ACID METABOLITES

Inflammation Part 5: ARACHIDONIC ACID METABOLITES
click to watch the earlier videos of inflammation
Inflammation 1: ruclips.net/user/edit?o=U&vide...
Inflammation 2: ruclips.net/user/edit?o=U&vide...
Inflammation 3: ruclips.net/user/edit?o=U&vide...
Inflammation 4: • INFLAMMATION Part 4: C...
ARACHIDONIC ACID METABOLITES In Inflammation
3. Overview • What are Arachidonic acid metabolites • How are they synthesized • The roles of these metabolites in inflammation • Applied Aspects ( Very Important!)
4. Tissue injury Injury to Neutrophils , Mast cells, platelets, endothelial cells, Macrophages Influx of Calcium into these cells Activation of Phospholipase A2Arachidonic acid in membrane phospholipids of the above cells Free Arachidonic acid
5. Once arachidonic acid is freed from the membrane, it is rapidly converted to bioactive mediators. These mediators are referred to as Eicosanoids ( derived from 20-carbon fatty acids) Eicosa is a greek word - Meaning 20 Prostaglandins, Thromboxane, Leukotrienes and lipoxins are the eicosanoids formed
6. ARACHIDONIC ACID Cyclooxygenase Pathway 5- Lipooxygenase Pathway 5HPETE Prostaglandin G2 (PGG2) Prostaglandin H2 (PGH2) Tissue specific synthesases PGD2 PGE2 PGF2α PGI2 TXA2 Prostacyclin Thromboxane A2 COX-1 / COX-2 Leukotriene A4 Leukotriene C4 Leukotriene E4 Leukotriene D4 Leukotriene B4 5HETE Lipoxin B4Lipoxin A4 12- Lipoxy genase Hydroperoxyeicosatetraenoic acid
7. Prostaglandins Leukotrienes & Lipoxins Produced by mast cells, macrophages, endothelial cells and other cells Produced by Leukocytes and mast cells
8. Effects of These mediators in inflammation
9. VASODILATION VASOCONSTRICTION VASODILATION BRONCHOCONSTRICTIONBRONCHODILATION PLATELET AGGREGATION +_ CHEMOATTRACTANT INHIBITS CHEMOTAXIS
10. In addition, Prostaglandins also mediate Pain and fever which are the important systemic manifestation of inflammation
11. What did we understand so far?? • The metabolites of arachidonic acid i.e prostaglandins, leukotrienes and lipoxins mediates • Vasodilation • Vasoconstriction • Bronchodilatation • Bronchoconstriction • Platelet aggregation and inhibition • Chemoattraction • Inhibition of chemotaxis! CAN MEDIATE POSSIBLY EVERY STEP OF INFLAMMATION
12. Applied Aspects! Since , these mediators can mediate possibly every step of inflammation Inhibition of the production of these mediators SUPRESS INFLAMMATION SO WHAT??
13. Inhibition Non Steroidal Anti inflammatory drugs (NSAIDS) Aspirin Ibuprofen Diclofenac Suppress Inflammation Reduce Pain & Fever
14. InhibitionZileuton 5-lipoxygenase inhibitor Bronchoconstriction Treatment of Bronchial Asthma

[@RohitSharma-ni7mq]

i need to search a new word from dictionary to praise u, may god bless u, now i am having hope to pass the exam...
thank you very much for making it so simple

[@ilovepathologyVijayPatho]

Rohit Sharma thanks 😊 glad you liked it

[@nehasinghal4851]

These videos are so good and beneficial ....plz make some more videos of other chapter so that we get more benefit....🙂🙂🙂

[@notadonna5983]

Doctor, Your clear models could prompt a revolutionary medical paradigm-- from symptom suppression to integration. What if medicine focussed on understanding genetic and epigenetic factors and used those to complement the brilliant, complex and often-unknown natural processes? With teachings such as this, doctors can have the ability to educate the patient who, understandably, has even less appreciation of symptoms versus quick cures. I hope for a collaborative, enlightened, exciting paradigm for practicing physicians. Gosh! I love Pathology, too! Thank you so much!!!!!
Notadoctor😙

[@bushramansoor1969]

Thank you sir! I always watch your videos before opening Robbins! Please continue demonstrating such confusing concepts in a clear simplified way.

[@usernamesolomon]

Just want to say Thank You Sir. What you are contributing is priceless.

[@soniababu7193]

This video was a godsend, idk how to thank you. You made this so simple and easy and that diagram is invaluable. Thank you so SO much!!!

[@sarw6649]

Your videos have been so helpful to me in unpacking some Patho concepts! Thank you very much!

[@namratachakravorty9750]

Thank you so much sir,
It's a great video tutorial,🙏

[@Mary.mj4]

Thank u , you make these subjects easy to study . I usually hate pathology but u help me get better understanding it ❤️❤️

[@SurajSingh-bo8fl]

Loved this Explanation. You Explained so Beautifully , Simply, in a Easy to understand manner in short time!
Great🔥🔥🔥

[@dr.sukhmanikaur]

Dear sir, you teach in an amazing way. I am actually preparing for my exams in pathology, and I would love it if you could cover more topics like this.

[@priyaeduplus9785]

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[@ravinachoudhary4457]

Best teaching style 🥰🥰👍👍👍

[@BoneConnector]

thanks to ur channel..
it really helps..
your tutorials are good enough to understand the concepts..
Please keep posting such tutorials.. 😃

[@oceanwaves657]

A Big thank you for such an awesome informative presentation.

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Im from Zimbabwe, man this the best lectures i have attended. This is so great. May the Lord Jesus bless you abundantly

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Thank you so much! 💖

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Concise and understandable. Thank you

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Please keep making these videos.👍👍

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Ur videos are awesome... God bless you

[@nurdanorgun6152]

So good, thanks a lot

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One of the best videos in this topic🙂🙂

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Thanks a lot

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thank you sir, keep going

[@leeanncharles4523]

AMAZING VIDEO!!!

[@vaishnaviramakrishna265]

Just amazing Sir! Thank you sooooooooooooo much

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Your videos are so informative & good..I just love this videos.please make more videos 😊

[@vickiijunior2631]

Perfect and detailed explanation:)

[@evancepolin1403]

Very helpful teaching using moving picture video make it easier and appreciable

[@anmarraheem3824]

great illustration! thanks

[@Fyi5700]

Thank you so much sir!

[@kalsoomzahra9021]

Nice explanation.A bundle of thanks

[@SHUBHAMKUMAR-rz6kk]

I am preparing for my final exams with your videos and Ramdas book - perfect combination ❤️

[@oyocobm9067]

Thank you sir!

[@parthshahani3071]

Very nice , clear cut explanation!

[@dadsdoctor6656]

Thank you ❤️ sir do more videos✨🌟🔥,I'm also recommending ur videos to my frnds @ilove pathology

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Thanks sir..Do more videos ..It will be helpful !👍

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excellent videos.,, continue the good work!

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Best video🙌🏻

[@lemisteward5849]

Very understandable and enjoyable 😊

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U r legend sir explained in simple way

[@biotopper5390]

Thank you very much sir ... I like your simplified explaining way ...💖

[@i.ashish_official]

Hats off to u sir ... Great way of explanation ❤❤

[@sciencevalley2429]

Loved it❤

[@wahib786]

Thank-you

[@englishshala8686]

Thank you so much sir you are a great help 🙏

[@dr.omarelham9714]

Thanks for making it simple Sir

[@13.ummesalamahussain55]

Thank you sir😇

[@hafsazi9688]

Plz keep making...it's really helpful

[@shrenjal9268]

Amazing ❤

[@rashmikalyan3407]

Thankyou so much sir , u make this subject so easy

[@thesarkargirl3237]

Thank you so much sir

[@sofixzma716]

sir you are best teacher may God grant you all happiness and please do make videos on allergy

[@aartikapil6711]

very nice explanation sir keep making videos like this🤟

[@shreyasingh7205]

Thank you sir this video is very helpful☺

[@jaydeepchauhan7712]

superb,,......awesome.................explanation sir....fantastic.............

[@baliyogeswari1527]

Simply superb 🤩🤩 sir please make more videos on patho...it's helps students a lot

[@parvathymohan4629]

Thank u soo much sir 💖...u r a gem 💎

[@abrarkhan2374]

great to wtch .was quiet informative,and explained in very easy way.keep up the good work sir.God Bless

[@priyaeduplus9785]

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[@riyanarang3566]

👌👌👌👌❤️❤️❤️❤️
Your videos are really amazing Sir..

[@disalachanduli1496]

Amazing❤

[@houshangy]

Enjoyed the presentation.Reviews could benefit further, if you can add and apply the electrostatic interactions at the molecular level when O-antigen come to make bonding with the target tissue at the level of , for example, enzyme-stoicheometry and conformational changes that occure to ultimately cause increased metabolic rate, hence, increased temprature .

[@n-acetylcysteine8093]

I love pathology after watching your all videos, plz upload more videos.

[@priyaeduplus9785]

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[@01.bhetariyadivya4]

Osm explain 😁👍,keep it up

[@pankeshbh7614]

thnx a lot sir

[@hafsazi9688]

Tq...

[@daniellaarisa905]

Thank you so much, God bless you.

[@ilovepathologyVijayPatho]

You are so welcome

[@shubhamyadav9956]

Plzz continue sir..😍

[@user-qg6ri7pj7f]

Good and calm way of teaching....clear concepts and integrates things well....

[@ilovepathologyVijayPatho]

Thank you 😊

[@muskanmishra5385]

Thank you so much sir.. this sildes are very helpful.... but i have some doubts regaring pathway of arachidonic acid pathway

[@Newszabardast-__]

Sir aur video banaoo awsm hay sb videos aapke

[@sankeerthanayadavalli6060]

very helpful... your videos seriously makes me to say #ilovepathology .... thank you sir . please keep making such videos .

[@ilovepathologyVijayPatho]

Thanks for the encouraging words. Glad you liked it 😊

[@chandaniyadav6720]

Sir pls upload more and more videos they r awesome

[@amandalal4854]

plz make a tutorial on COMPLEMENT system too !!

[@LeMasterYi]

Great video thanks,though PGD2 its a bronchoconstrictor,

[@Thenewz163]

thanks sir

[@cholwepatel6088]

Thank you so much for making inflammation so easy for me ,can you please do apotosis ,cell regeneration

[@ilovepathologyVijayPatho]

Thank you :-)
Both Apoptosis an Regenerations videos are already available in the playlist:-) Hope you enjoy them too:-)

[@shimlangshylla4343]

i like n subcribe

[@tiaras.a.7984]

Sir, thank you so much for this video. I really do thank you, Sir. God bless you.

[@ilovepathologyVijayPatho]

You are most welcome

[@javeriasattar1118]

Ur. Videoa are literally life saving.... Thank u soo much sir . U make a tough subject easy👏👏👏👏❣️❣️❣️

[@ilovepathologyVijayPatho]

thanks :-)

[@shreegandhachannel8433]

Sir u r simply Amazing sir 🙏🏻🙏🏻bcz of ur videos I'm getting intresting to read pathology...........Tqsm sir 🙏🏻 keep making videos ❤️😍

[@ilovepathologyVijayPatho]

So nice of you

[@asgancorea]

Thank you for information! I’m nutrition chef, can I know how we can improve our Arachidonic acid level by natural food?
Regards

[@javeriasattar1118]

Make video on tissue repar

[@sharma8642]

👏👏👏
Pls upload videos on genetics pathology

[@renusrigangisetty5159]

Thank u so much sir. Your vedios are really amazing .u made it easy thank u so much ❤

[@ilovepathologyVijayPatho]

Thanks 😊 glad you liked it 😊

[@ashagorasiya4996]

Nice videos, See videos then read Robbins.. Thank you sir!

[@happychinki6851]

Great video my all dbout clear .....only improved voice quality

[@rahmamohamed3049]

This is was so helpful ❤️❤️ thank you sir I don’t know how to pay you back❤️❤️❤️

[@priyaeduplus9785]

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[@hinanabom3657]

Finally..i found th right one..thnku so much for saving me

[@ilovepathologyVijayPatho]

Happy to help

[@dawnkesteloot5377]

How do you repair these processes? I have a problem converting these. Look up the pathology of AERD. What could I do to fix this? I’m very sick because of this. I have asthma, can’t smell, and have inflammation so bad I feel sick all day. Any help would be great

[@Dr.RamaDevi7788]

Thank u sir ur videos are bringing us some interest to study or else reading text is so boring sir.

[@rohantalandi2374]

Pls make about cancer too.....

[@sofixzma716]

sir dnt look for subscribers but think how many students love you work please do make more videos god will inshallah grant you with all what you desire💞

[@ilovepathologyVijayPatho]

Sofi Xzma thanks 😊

[@asifishtiyaq1599]

Arifs representation on Pathology and Hematology..
Joy Bongal

[@riyachoudhary2634]

Sir please make all videos on pathology. We request you.

[@ilovepathologyVijayPatho]

Thanks:-)/ Have plans to cover most topics

[@muskanpoddar829]

Can u please help me by uploading vedio for chronic inflammation

[@shimlangshylla4343]

nice

[@rohantalandi2374]

Abou hypersensitivity also

[@asiyafs7309]

🙏

[@javeriasattar1118]

Plxx make videos on chronic inflmmation nd repair.... Nd hemodynamics unit

[@ilovepathologyVijayPatho]

Thanks:-) Glad you liked them . Please do share if you feel its useful :-)

[@ilovepathologyVijayPatho]

will surely plan to cover few more topics. Thanks :-)

[@rafeequeahmed7282]

Make a tutorial on COMPLEMENT system too!