Arachidonic Acid Pathway (Prostaglandins, Prostacyclins, Thromboxanes, & Leukotrienes)

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00:00 Intro
0:55 Pathway
6:44 Physiological Products
10:34 Pharmacology

[@DirtyMedicine]

Note: NSAIDs inhibit both COX-1 and COX-2. Celecoxib selectively inhibits COX-2, which relatively maintains the gastric mucosa. Wanted to make that clear. Also, the drugs in blue are analogs (not inhibitors per se).

[@davidsc4680]

Hey, is ACSL4 involved in AA recycling back to the membrane?

[@Sam_1964]

Thank you for the presentation. For the medications in Blue color you meant to say Analogues to Prostaglandins and Not inhibitors. Thank you for excellent teaching.

[@gideon_k]

@DirtyMedicine Hey! Thanks for this video. It's very helpful. I wanna clarify something though, is carboprost a PGF2 inhibitor or PGF2aplha analogue? You mentioned in the video that carboprost inhibits PGF2 @11:37.

[@Sam_1964]

Carboprost is PGF2 analogue

[@Dr.SheepDO]

Here's an advance for my future support when I'm in residency!🧠 If I pass my first board exam next week, it will be because of Dirty.

[@victoriazaid]

Hi Dr.SheepDO, I'm from CT. I want to do it but don't know how. Please, please help me

[@Dr.SheepDO]

I passed, FYI

[@Sam_1964]

Thank you for the presentation. For the medications in Blue color you meant to say Analogues to Prostaglandins and Not inhibitors. Thank you for excellent teaching.

[@mahnoorgohar997]

It makes my day whenever I see that Dirty Medicine uploaded a new video! 😍✊

[@briank9354]

Hey Dirty Just wanted to make note the meds you have in Blue are all analogs and do not inhibit the meds but Mimic them. Epoprostenol prevents coag is used in pulmonary HTN as it vasodilates and prevents platelet aggregation. Carboplast increase uterine contractions. Alprostadil is a vasodialator which is the function of E2 and Dinoprostone is used to prepare the cervix for birth again a contractor. I unfortunately got a Uworld question wrong on this detail and i'm sure u didnt mean to say inhibit but just wanted to let you know

[@cihanergul1115]

I LOVE YOU KEEP UP THE GREAT WORK. YOUR LEGACY WILL ALWAYS BE REMEMBERED.

[@_Simplychristie_]

Came at the perfect time. Thank you!

[@johntower2005]

why?

[@abdu_jilani]

Bro plz make a video on Important cytokines to remember!! Hot T Bone stEAK is just not cutting it!

[@Dr.SheepDO]

If I had used DM during MS1&2 instead of dedicated, I'd have been golden right now instead of struggling. Dirty Medicine Medical School ftw! Also you have my support pledge in residency.

[@MadaymRoyalty]

I'll be back on this vid for my finals!

[@isaiahpinkerton3445]

PGE2 also helps keep a PDA open which is important for congenital cyanotic heart diseases, too.

[@rosatwinkleblossom]

Thank you! Could you maybe do a video on drug reactions and antidotes? These are in the general pharm section of FA but can’t seem to find a resource that talks about them specifically

[@yacerdido5824]

thank u bro u are the best

[@girmachewakalewold6286]

Thank u

[@dayronpadron4572]

Thank u 🙏

[@faizanalvi3932]

kindly make a video on the renal tubular defects

[@briangoli1092]

thanks for the video dirty can you do a video on epidemiology formula questions and all that non-sense?

[@emmanuelgordon6127]

Please where can we get your slides?

[@LivinOnTheEdge1001]

❤

[@dantesbiacrate8800]

i am afraid that i am getting used to your voice so much that i will be watching your videos even if i dont have an exam to pass. I am not an US Student who studies for USMLE or sum. I am from Turkey and preparing for my university finals. So much love from Türkiye 🙌

[@shenba810]

Put more videos

[@muzzamilsamad5711]

2nd comment 🤩🤩