Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, LOX,Prostaglandin, LTNs

Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, Prostaglandin,Leukotrienes - Physiology, Pharmacology, Biochemistry
Arachidonic Acid (Ara. A) is one of the major inflammatory mediators in your body...It's liberated from the plasma membrane phospholipid by the phospholipase A2 enzyme. By cyclooxygenase (COX), arachidonic acid can be converted into prostaglandins (e.g. thromboxane A2, prostacyclin "Prostaglandin I2 or PGI2", PGE2, PGF2-alpha, and others.
By 5-lipooxygenase enzyme (LOX), the arachidonic acid can be converted into leukotrienes (e.g. LTB4, LTC4, LTD4, LTE4) which act as chemotactic agent "to recruit neutrophils for inflammation" and bronchoconstrictors "bad for asthma patients.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
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[@joshdudeguy2830]

Me *comes to video knowing absolutely NOTHING about the arichidonic acid pathway*
MP *makes 18 minute video full of freaking magic*
Me *leaves at end of video feeling like a subject matter expert*
I know this is a 4 year old video but still. You do incredibly important work here, man! Thank you!

[@MedicosisPerfectionalis]

Thank you!

[@moonprincess1992]

My professor didn't even attempt to teach this, just gave us a chart to memorize. So thank you for explaining everything so well!!

[@MedicosisPerfectionalis]

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Let me know if you have any questions!

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From the arachidonic acid pathway, can you mention some side effects of Acetyl-Salicylic Acid (ASA)?

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Bleeding, peptic ulcer (decreases production of mucus)

[@MedicosisPerfectionalis]

Good...and why does it decrease production of mucus?

[@ricardobaroni1714]

@@MedicosisPerfectionalis Because ASA inhibits the COX pathway, consequentely inhibits the production of prostaglandins, wich are responsable for the production of mucus. Sorry for my english, I am still learning haha

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