I cant believe you have a whole video on this exact topic! i was so lazy to learn it from my book with all the crazy steps, you simplified it brilliantly
Ah ..isnt it like this ... Thromboxane A2 is made from COX 1 and PGI2 and PGE2 is made from COX 2 ..thats written in Lippincot ...and in the video its opposite... its confusing me ...do correct me if im wrong.
Thank you for this video. You wonderfully summarized the proStaglandin-leukotriene cascade in one page which makes it much more easier to understand. REALLY HELPFUL!!
Hello, thank you for an informative video, loved it. I had a question. In 4:15 you mentioned that PGI2 inhibits platelet activation and formation. Should it not be the opposite? As NSAIDs like Aspirin reduce platelet function.
What a coincidence! I recently helped correct the Pharmacology exams of 3rd year Pharmact students with my Professor. One of the questions was: "Why are prostaglandinE2 analogs often prescribed concomitantly with NSAIDS if patients are to use them rather long-term?" The answer is in the video of course ;)
Thats great! Hopefully not too many mistakes were made. Good job on your channel btw, keep it up! Its great to see graduates who are passionate in their field becoming active on RUclips! :)
@@AKLECTURES Wow, this means so much coming from you! Thanks a thousand! And if I could have only 50% of your passion I would already go further. You made almost 2000 videos, dude, you're an icon! (and a lifesaver for many!). You should become a professor!
You have wronged COX-1 and COX 2. Pg I2 and PG E2 are synthesized by COX-2 PATHWAY not COX 1 PATHWAY. similarly PG A2 is synthesized by COX 1 PATHWAY. Cited from LIPPINCOTT BIOCHEMISTRY BY DENSIE R FERRIER WOLTERS KLUWER
And we can identify processes that cause imbalance in prostaglandin sysnthesis and then Government can regulate or completely ban those processes to prevent cell growth imbalances.
Then if we can maintain balance of prostaglandins then we can prevent platelet cell imbalances and indirectly reduce incidence of cancer formation sites, isnt it
FIRST! We miss you! Come back!!
Indeed, finally a new video! I didn't put AK Lectures on #1 in my Top 10 Biomedical channels video for nothing. You're the best AK!
He is back ❤❤
COX 1 produces pgf2alpha and TXA2
COX 2 produces PGI2 and PGE2 .
According to lippon
The link of your videos is placed in official portal of the medical university. I got acquainted with your channel using these links .😊
The minister of biochemistry ❤️
Just a small correction on 1:15, linoleic acid is an omega 6 fatty acid but it's not a 6 carbon fatty acid, it's 18 carbons.
i literally have my biochem final in 6 hours and i was struggling with the arachidonic acid.... thank god i have his post notifications on
Talk about good timing! Good luck on your exam, let me know how it went!
where r u from
do u study in med shcool
Doesn’t TXA2 belong to COX1? Kinda confused
A random GOAT just popped up into my feed. Nice
Just saw this posted and I'm so STOKED YOU ARE BACK
Same here
Thanks! glad to be back! :)
Literally the most in depth and best Channel in terms of explaining/understanding
Thank you! Glad you think so :)
GOOD MORNING SIR
LIFE SCIENCE TIGER HAS BEEN ARRIVED AFTER SOOOOOO LONG TIME
WELCOME SIR
Just dropping by to drop a comment/thumbs up/contribute a view.
Appreciate it!
He’s back! I dont need to learn this but now i want to
:)
I cant believe you have a whole video on this exact topic! i was so lazy to learn it from my book with all the crazy steps, you simplified it brilliantly
Ah ..isnt it like this ...
Thromboxane A2 is made from COX 1 and PGI2 and PGE2 is made from COX 2 ..thats written in Lippincot ...and in the video its opposite...
its confusing me ...do correct me if im wrong.
i'm confused too
Replying late but did u get the answer??☹️
Welcome Home, we missed you.
:) Thanks Joshua!
You helped me during undergrad and now you're helping me in medical school. Thank you GOAT.
Ya ! Been a min!
Well, not even done with gen chem 2 and I’m scared already but glad I have you 😭
Take it one step at a time, this stuff is great! You'll love it :)
Yes!! You're back, greetings from Mexico 🇲🇽😁😁
Thank you!
Sir i want to know , isnt it opposite Cox 1 produces txa2 while cox2 produces pgI2?
Glad you’re back
Welcome back
I Miss your lectures
Greeting from china 🇨🇳
Thank you! :)
i think it don't has youtobe in china????🤔🤔🤔🤔
mac hoang yea but there is proxy
CANT THANK UUU ENOUGH, im a 1st year med student, and i couldnt understand what this is all about, u made it way clearer
We miss you 😍😍😍
Sir make a video on
NMR & CD plz
Ramchandra Suthar he has videos on NMR already.
@@KB-vd8wq ok
Happy to see you back😀😀😍
Sir please made more videos on heart related conditions. I am fan of your videos.
We miss u sir
😊😊😊
Sir 😊
Pls make the video on why AIDS can't be cure till now 😊
Thank you for this video. You wonderfully summarized the proStaglandin-leukotriene cascade in one page which makes it much more easier to understand. REALLY HELPFUL!!
Thank you!!
We miss you, thank you for your time.
Ommmmmmgggggg... welcome back. You don’t know how much my class miss your lecture :)
Okie study time now
Great video 🌟 One question, isn’t EPA and dihomo gamma linolenic acid are used too? Not exclusively AA in these pathways?
and i think its ltdA4 C4 D4 and E4
Thank you and welcome back！You are my best teacher!
欢迎回来，谢谢你做的一切！
Whoo welcome back!
Love the vid. I think you are saying "eiconasoids" as opposed to "eicosanoids"
Welcome back sir!!!!!!!
I can't believe it❕❕❕❕❕❕
Just to note; Linoleic acid is an 18C fatty acid with 2 double bonds, not a 6C FA as said at 1:16
I was about typing just exact the same thing but then had the great idea of scrolling through the comments firs ;-)
Hello, thank you for an informative video, loved it.
I had a question. In 4:15 you mentioned that PGI2 inhibits platelet activation and formation. Should it not be the opposite? As NSAIDs like Aspirin reduce platelet function.
Thank you sir for coming back ❤️❤️❤️👍👍
:)
You're back :)
Omg you're still active! We've missed you so much.
Great Video.
Hey man, are you in residency right now?
8:13 (correction) we block Cox 1 not 2 because u already said it cox 2 in 8:05
NSIAD block both Cox1&2
Econisoid ❌
Ecosinoid ✅
My Chemistry Crush >>>
What a coincidence! I recently helped correct the Pharmacology exams of 3rd year Pharmact students with my Professor. One of the questions was: "Why are prostaglandinE2 analogs often prescribed concomitantly with NSAIDS if patients are to use them rather long-term?" The answer is in the video of course ;)
Thats great! Hopefully not too many mistakes were made. Good job on your channel btw, keep it up! Its great to see graduates who are passionate in their field becoming active on RUclips! :)
@@AKLECTURES Wow, this means so much coming from you! Thanks a thousand! And if I could have only 50% of your passion I would already go further. You made almost 2000 videos, dude, you're an icon! (and a lifesaver for many!). You should become a professor!
This could be all made up and I wouldn’t know the difference
Thanks for your efforts but I had noticed that you didn’t mention the prostacyclin in cox2 ?
Excellent as always!
I'm becoming good at biochemistry,Thanks to you🥺
Linoleic acid is omega-6 btw
A small correction, linoleic acid is actually 18 carbon fatty acid, I guess Andrew wanted to say that it is Omega-6
Welcome back its really nice to see you again , how have u been?
Thanks! I've been great but a little busy :) hope all is well on your end too!
isnt COX1 responsible for TXA2 and COX2 for PGI2?? think it has gotten switched
hypertrophy canavarı olmuşsun andre
You have wronged COX-1 and COX 2. Pg I2 and PG E2 are synthesized by COX-2 PATHWAY not COX 1 PATHWAY. similarly PG A2 is synthesized by COX 1 PATHWAY.
Cited from
LIPPINCOTT BIOCHEMISTRY BY
DENSIE R FERRIER
WOLTERS KLUWER
The Leukotrienes have 4 double bonds making them LTA4, LTB4, LTC4, and LTD4 (not LTA2, LTB2, LTC2, and LTD2)
Boss, linoleic acid is an 18 carbon unsaturated fatty acid. You said 6. Please 🙏
I'm learning a lot from this channel.
Lippin says TXA2 is formed by COX-1 and PGI2 by COX-2 while you say the opposite. Kindly Reconsider ❤️
All Leukotrienes contain number (4) LTB4 etc. YOU HAVE MENTIONED IT 2?
So what is the best and safest way to block excess prostaglandin d2 production.
Does anybody know what could be a result of very high eicosanoid levels? How can these levels be reduced?
Welcome back, AK!
Great videos by the way :)
Thank you!
Very interesting exploitation 👍
I'm confused as to the pronunciation of eicosanoids.....as when you say it you mix up the 's' and the 'n'.
Didn’t know will be seeing your video posted two years before in my medical school. Loved it. You just explained it so beautifully ✌🏼
And we can identify processes that cause imbalance in prostaglandin sysnthesis and then Government can regulate or completely ban those processes to prevent cell growth imbalances.
Not ltb2, ltc2.... they are LTB4, LTC4 etc. but still great!
PgI2 produced by cox 2 according to lippincott book
Cool to see new uploads. I am just watching all of biochemistry. Cant wait to hear all the newly discovered things!
Then if we can maintain balance of prostaglandins then we can prevent platelet cell imbalances and indirectly reduce incidence of cancer formation sites, isnt it
Just subscribed. You're great!! 💜
The legend is back
I'm sorry I'm late to the party but why are people calling him a goat
Welcome back
So good videos, thank you! Could you make a 5-Lipoxygenase specific one?
Sir your hand writing is too much good and your teaching is very attractive thank you sir 🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🍓🍓🍓🍓🍓🍓🍓🍓🍓🍓🍓👍👍👍👍💖
so helpful!!!! thank you!!!
Prostaglandin makes my back ache terribly when I'm menstruating, specially if I consumed caffeine a few days before. Just, why? T_T
Do you know You are amazing..thank you from Iraq..
شكرا لك 🌹
Thank u so much
What a legend
You’re back :)
Thank you for your time and all you do. Your work is appreciated more than you can ever know
Thank you for your kind words!
u make learning interesting
Beautifully explained
Where can i get this notes
Thank you.
Your explanation is so comprehensive and wholesome
Great analysis of BIOCHEMISTRY
Thanks!
soltan khodeti
Thank you for making me a good doctor! I appreciate you a lot...
amazing lecture
Thnk u for help sir
❤️❤️❤️❤️❤️Love u Thanks
Also great lecture as a lay person I have a better understanding of what this is now 😊
U saved my life tnx
I have watched every single videos but this one was the only one who really helped 😊👏🙏