Platelet Plug - Primary Hemostasis - How The Clot Forms!
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- Опубликовано: 4 мар 2019
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Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).
Platelets are called thrombocytes "cells of thrombus".
The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.
When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).
After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.
Hemostasis is defined as “cessation of blood bleeding”.
There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).
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To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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i really like your videos you are doing a great job pleaae can i have notes
Please use darker coloured pens as I can't see light colours that much.I have to focus my eyes too much and I get eye strain.Also if u can write a little bigger words , that will be great ! Thanks a lot and blessed ramadan to everyone.
Yes sir I have maintained absolute confidentiality about that wrist cutting thing
Your way of explanation is so sassy and I love it!!!!
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My pharmacology lecturer recommended a couple of your videos for easier understanding of haemostasis. I have to say, you're explanations are really concise and more importantly, relatable. Really well done job!
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The University of the West Indies. It’s not your Harvard or Yale but it’s the major university of the Caribbean region with multiple campuses across the islands. My campus is the largest one situated in a city called “Mona”. I hope it’s nice to hear that your lecture has made its way across seas! I have already recommended the series to my mates in preparation of our exams.
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Medicosis Perfectionalis your praises and recommendations are deserved.
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📗 Get my notes in pdf files that are downloadable at www.patreon.com/medicosis/
Test your knowledge by answering these FREE cases about platelets and bleeding disorders, written by me: goo.gl/APUimj
This whole series is aweome! I love the re-visiting of prior concepts and building on top of them...just like a coagualtion cascde. And now its stuck in my brain and I wont forget. Not ths week anyway :-)
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Know I’m gonna makes it a habit of studying from this channel before and after any lectures not only when I’m having exams stay bless #medicineisfun
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I appreciate you so much!
My school includes your videos in discussions. You are our favorite substitute teacher
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I hope you liked my videos!
So, what do you study?
@@MedicosisPerfectionalis I study 1st year medicine :)
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Enjoy the journey!
this is best channel, your humor injects life in my caffeine riddled husk. Cheers to my hopefully passing scores!
Thank you 🙏
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you explain this so well... beats my textbook any day. thank you!
Yeah! Textbooks are now history 😂😂...Thank you, dear :)
Beautifully explained, as always!
Thanks 🙏
I just found out about you today and you just helped me in the basis of haematology. Thank you
Thank you, medicosis perfectionalis, i will keep the wrist cutting technique in mind whenever my life goes south
Ur way of expaining the things is really fabulous.thanks a lot🙂
You’re always welcome 🙏
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even from the start ur voice makes me smile, knowing i will learn nd laugh as well
Thank you!
You wildin out with the wrist cutting comment LMAO 🤣🤣 but thank you that info is now stuck to me lol
Thank you so much for watching!
Great explanation !!
this is the most fun videos of medicine out there. thank you
My pleasure 😇
Man You are a life saviour!!♥️
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"And baby, it's on" ;)
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I died xD
Beautifully explained.....Thankuu once again.......🤗🤗🤗
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Thank you!
إبداع منقطع النظير
Thank you so much 😊
love love love your explanation like wow how come you know that much better than phd prof!! #mashallah
Thank you so much!
Thanks again 👍🥰
Thank you for it is more informative to watch 😊
My pleasure 😇
U r out of this world.. brilliant
Thank you so much 😊
Can you please help me by sharing?
Of course
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Enjoying every bit of ur explanation. Don't stop saying "Baby" coz it brings smile to my face apart frm jst gaining knowledge ❤
So nice of you!
Hey, thank you so much. I also like to explain things my way on yt. My pharmacology doctor also seems to like your video.
Thanks 🙏
@@MedicosisPerfectionalis I'm glad you replied. Keep up the great work. BTW are you a medical student?
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Would you please help me by sharing?
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I hope there will come a day when I graduate I will be able to contribute to your patreon.
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A new subscriber here.....I appreciate sir!!!
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Sir do you have any video on anticoagulant and antiplatelet
OMG I LOVE YOUR VIDEOS
Thank you 😊
I lost it at "brain scan." That's brutal lol
Hehe 😉
I was joking 🙃
Just FYI @ 10:58 the receptor changed from GP1a to GP1b. Thanks a lot for making this video. :)
I did some research and I think GP1a doesnt exist lol. I think the're both supposed to be GP1B
@@indiabiologyexplains5013 I agree that in the video it probably should have been GP-1b but GP-1a does exist :) its a receptor that allows platelets to weakly bind to collagen directly without the need of vWF, platelet receptor GP-IV does the same thing
@@BMOfficial1114 thank you. Do you know if it is the reason platelets spontaneously aggregate in a given test tube?
4:20 i spat out my drink haha thats one way to make learning memorable!!
Thank you ☺️
Ohh man!!! You are awesome..
Thank you so much 😊
Why can’t my professors explain things like you
I don’t know 🤷♂️
Thank you so much for your kind words that I don’t deserve ☺️
I Love watching your videos. They are way better than Pathoma videos and more interesting.
I just had a small question, at 5:47 you wrote GP1b and while showing the process of hemostasis you wrote GP1a, so which one is correct?
Thank you.
Forever your fan.
Thank you so much for your kind words...and yes, I made a mistake...The correct fact is that it’s GP1b
Please tell me anytime you have a question 😊
With a great teacher, you are a great human being too 😊🙌💯
Sure if any doubts will let you know😄
Thank you 😊
You’re always welcome 🙏
very helpful, thankyou
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Can you please help me by sharing?
@@MedicosisPerfectionalis of course I already shared it to my friends
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Thanks a million
up to present 12 yrs ago after my delivered ceasarian my platelets is so high almost 1000 ,pls help me sir I need your advice,from Philippines
4:25 is when I stopped the video liked it and subscribed haha
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Excellent
Thank you so much ☺️
Can science get any more fun? Guess not...Literally saving lives.
Thanks for simple lovely explain ❤️❤️
My pleasure 😇
and baby...it's on. #dead. I shared these videos with my advanced Patho class.
So how fast would platelets seal a paper cut ? How fast in the process ?
It takes about 2-7 minutes
Thank you so much
You bet!
@@MedicosisPerfectionalis 😂
Magnificent ...
Thanks, dear 😊
Fibrinogen it convert to fibren by thrombine will break down polypeptide of fibrinogen
awesome
Hi your videos are really great do you have notes of these
Awesome 👏
Yes! I do! Please go to www.patreon.com/medicosis/ and subscribe to tier 4 , I will send you all the slides that are in all of my videos... Thanks in advance!
@@MedicosisPerfectionalis thanks lot
My pleasure 😇
I have a question VWF that take part in coagulation comes in plasma from endothelial cells or platelets?
Both
@@MedicosisPerfectionalis thank u so much.... I love all ur videos ❤️... Plz make more...
Sure!
thank you for inspiring lecture~ I get a membership today~ How can I get post_notes??
Thank you so much for supporting my channel! Please email me at: medicosisperfectionalis@gmail.com
You're too fast to talk hahaha still
I learned so much!! Thank you
I laugh so hard in cutting wrist hahahaha.
Thank you...Good luck with your studies!
You are the best 😂😂😂❤
Thank you so much ☺️
i laughed so hard at your c*tt*ng wr*sts joke HAHAHAHHAHAHHAHAHA
يا الله الطب شگد صعب 💔
You can do it!
You’re just early in the process.
Hello, What stops excessive uterus bleeding ?
It depends on what the cause is.
@@MedicosisPerfectionalisI believe its fibroids
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Sure!
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The real egyptian king wallah
Thank you 🙏
You drive very fast 🚗
Prostacyclin keeps the blood cyclin, damn😂
so sideways really are for attention and longways for results
Please Sir try to took a little beat slowly, I can't run withe you
He speaks at normal speed. You'd rather need to train your English hearing.
I have 1 million of platelets, because of the errors of DNA, how can I do?
Talk to your doctor to assess your risk factors!
I love you
Thank you 😊
love u
Thanks:)
This video is super helpful for me, but please do not joke about su1cide and s3lf harm, it may be triggering for people with issues. Thank you sir!
#and_baby_it's_on
Hehe 🙃
I think you are dr naji but in English !!!!
Ano ne ano ne
Why do all lecturers think doctors/medical students are machines and have no feelings! talking about suicide like if it’s not possible for us to have depression and suicidal thoughts! Because I have them and tried to kms several times! It’s NOT okay to joke or even talk about suicide because it’s a really sensitive topic and can easily trigger some people
As someone who’s been suicidal, stop whining❤
@@mirunaradu8860 babe, if you’re not triggered by these then I’m happy for you but some people does ♥️ so stfu and stop being so ignorant
Cut it longitudinally ok? 😉
It's not that serious
Baby is on
you talked too fast in this video
I'm from Psychology/psychoanalysis background, had a bit of concern when you mentioned on the suicide method: When you say "don't", people surely want to do it. So please don't bring the audience's attention to the matter. I appreciate your well explained lectures. Thank you for making them and helping us out.
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Thank you so much 😊
Thank you so much 😊
You are foolish thats why you injure yourself hahahaah me and my sister laughed out loud at this and my sister who is not a doctor but she said medicosis is right...🤣🤣🤣lots of love from Pakistan🇵🇰♥️
Thank you 🙏
Please say Hi to your sister!
But at least stick to a point