Hemolytic Uremic Syndrome (HUS)

Hemolytic Uremic Syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure.
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Bernard-Soulier Syndrome (BSS) is an autosomal recessive (AR) disorder characterized by a defective GP1b platelet receptor leading to a problematic platelet adhesion process (primary hemostasis).
Glanzmann Thrombasthenia (GT) is an autosomal recessive defect in the GPIIb/IIIa (GP2b/3a) receptor on the platelet which leads to defective platelet aggregation.
Ristocetin Cofactor Assay (RIPA) is usually abnormal in cases of Bernard-Soulier Syndrome (BSS).
Bleeding time is prolonged, platelets are big in size, but few in number (Macrothrombocytopenia).
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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[@elizabirdiek2798]

Lab student here, I love your humor in these videos. I was hospitalized with HUS when I was 9 years old. Lots of blood transfusions and dialysis. This was a great explanation, I'm enjoying your coagulation playlist to help me study.

[@MedicosisPerfectionalis]

Thank you so much 😊
How is your health today?

[@elizabirdiek2798]

@@MedicosisPerfectionalis I am doing great. Just turned 40 and have 2 kids. No long term effects from the HUS, just a few years of follow-up to make sure of that. But- fun fact, I did have a transfusion reaction while I received blood after my C-section(I lost a lot of blood during the procedure). I must've acquired some antibodies with my multiple transfusions with HUS.

[@MedicosisPerfectionalis]

Wow 😯
I am glad you’re doing well now!
Please say Hi 👋 to your kids!

[@alibuknan193]

Knowledge is not power unless it is organized, thank you medicoses for your great videos being the most organized

[@MedicosisPerfectionalis]

You’re absolutely correct!

[@MedicosisPerfectionalis]

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[@missvampire803]

I wish I knew your channel during my med school, your way of explaining makes everything seems easy and understandable. Thank you for your great efforts.

[@MedicosisPerfectionalis]

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Thank you so much for these videos. I'm in school to be a lab tech and the lecture notes I was given were organized confusingly to me and lacked visuals...these videos are saving me right now!

[@MedicosisPerfectionalis]

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I like the video. I enjoyed it, it's so helpful and I like the fact that you left us with a question to think about in the end.

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@vishtostudy9316]

fibrinogen is an acute phase reactant. therefore the level is increased due to infection.
also, your videos are amazing! thank you so much for making medicine this fun !

[@mohammadabed4041]

✅

[@sanjulawickremasinghe3793]

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[@ayodejioshakuade799]

What now causes the renal injury?

[@stanleyigbinosa1952]

Hemoglobin. It's nephrotoxic

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

You’re very welcome, Maryam!
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May Allah rewards you for your efforts

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@anastasiaaa4094]

Check HUS by zero to final. Far much better and in 3 minutes

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@aseragalaly2540]

Hi thanks for explaining this❤
Was wondering what software are you using to draw and record?
Thanks

[@theafricanesther5795]

You should know you are getting me through med school and I'm grateful for that.

[@MedicosisPerfectionalis]

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I am honored!

[@alviyt6627]

There is a reason for all three actually.
Shiga toxin of E.Coli has receptors for attachment on blood vessels and kidney. When inside the cells of endothelium and kidney it works by removing adenine from 28S subunit of Ribosomal RNA , this halts the protein synthesis so cells die.
Microangiopathic hemolytic anemia is because RBC when pass through damaged endothelium they break down and get distorted. Same reason for kidney failure.

[@ibrahimyoussef2399]

From where did u get this explanation ?

[@wakylaugh]

It’s actually 60S

[@billionairetrillionaire2356]

The humour in your videos is great 😂😂
Marvelous explanation 🤝💪

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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[@alexandraxxxx]

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

Thank you 😊

[@weedali5368]

Thank you from Yemen

[@Ostsol]

Didn't understand everything (too much terminology for me), but this does help clear up a few things about this weird condition. I had HUS as a very young kid. Most of my earliest memories are from my time in hospital. I don't remember how I felt, except for the pain and frustration over frequent blood tests and the IVs that were hooked up to me. This was in the early 1980s, too, when the tainted blood scandal was happening in Canada. Fortunately, a blood test I had about a decade later showed that I was clean. Not sure about dialysis, but I was too young to really note much of anything outside of my bed except people: like doctors/nurses trying to stick more needles in me.

[@mikemccool7575]

Same exact thing here but early 90’s. Were you able to eat and drink? I remember begging for ice chips

[@Ostsol]

@@mikemccool7575 Unfortunately, I can't remember. These are my earliest memories, after all. The only thing I remember of food or drink was when I paged a nurse asking for some orange juice. She told me I could have some after my blood test, which naturally I wasn't exactly enthusiastic about. I don't remember if I ever got the juice, but I did page her again after I calmed down from the test.
I am told that the staff encountered some difficulty in finding something that I would eat. Apparently it was during my stay that I came to hate eggs, but also came to love lasagne. This may have been a matter of my tastes, rather than anything medical, though.

[@sajadesign6354]

You are GREAT .. Thank you so much 🌸

[@MedicosisPerfectionalis]

My pleasure 😇

[@leaaamarianne0508]

Fibrinogen is high because of tissue factor is released, right?
Many thanks!!! 🙏🏻

[@rubamaher9804]

Thanks a lot!

[@luisgiraldo9947]

This was beautiful

[@dr.dibbyajyotidutta8304]

Excellent doc .. U r awêsome ❤️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@gatthepmadingbol6088]

This guy is really teacher indeed and his teaching have facilitate my learning process since I joined his videos and may almighty father reward him
And thanks by medical laboratory student

[@MedicosisPerfectionalis]

You’re very welcome! I appreciate you!
Please help me by sharing my videos with others!

[@eimansaeed6232]

Hi, thank you so much for the amazing way of teaching 👌🏼.
I have a presentation after tomorrow and I have to present the topic of microangiopathic haemolytic anemia in our scientific meeting in the department of internal medicine. Will definitely benefit from your informative videos. Wish me luck.

[@MedicosisPerfectionalis]

Good luck 🍀

[@arturburzawa2388]

You are the best!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@rachend810]

Te amo! thanks for this!

[@tshifhiwaruthmudau9262]

good day. in a situation where there is diarrhea (persistent no blood stated) on adult with same symptoms of those of hus is it safe to say it is typical hus even if age indicate that the patient is an adult?

[@ttavakoli8776]

thank youuu so much
😀

[@MedicosisPerfectionalis]

My pleasure 😇

[@Abo-alod]

Amazing ...Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@chinawholesalefactory4621]

Thank you Medicosis..you've made my medical years much easier.💐💐

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@westwoodoralsurgerydentalgroup]

wild guess… but is it because your using the platelets to clot so that triggers an excess of the secondary clotting cascade system?

[@SSgamergmail]

Tq so much for perfect explanantion

[@phoebebalabag2885]

Do you have any citations for these information? Would love to read your reference books.

[@MedicosisPerfectionalis]

Harrison’s, Davidson’s, and Goldman-Cecil

[@renz6634]

wait how is the AKI formed???

[@thilinaalagiyawanna3680]

Thank you very much

[@MedicosisPerfectionalis]

My pleasure 😇

[@kipkipour4507]

Medicosis Perfectionalis, you save me everyday, the past 3months.
Thaaaaanks

[@MedicosisPerfectionalis]

Happy to help!

[@dianamandewo9798]

This was fun. Thank you😂👏

[@MedicosisPerfectionalis]

My pleasure 😇

[@dr.talhaakpolat6143]

You are better than our teachers.

[@user-rv9xw8sk1g]

شكرا ميديكوسيس 🌹

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I enjoy this guy so freaking much

[@MedicosisPerfectionalis]

Thank you 🙏

[@drchhetri1599]

you literally make medicine fun.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@viviliberton6196]

ANyone know why the fibrinogen is high? Can't see to figure it out... Is it purely because of inflammation?

[@stanleyigbinosa1952]

I'd like to meet you someday. Thank you very much Medicosis. God bless you🙏🏾🙌🏾

[@MedicosisPerfectionalis]

Thank you!

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Please upload videos of text books to use for both basic and clinical subjects .🙏🏽🙏🏽🙏🏽🙏🏽🙏🏽🙏🏽

[@ahmdooz]

thanks soooo much

[@MedicosisPerfectionalis]

My pleasure 😇

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I m so embrassed with your explanation that i wish i know before🤓

[@MedicosisPerfectionalis]

Please don’t be embarrassed!
All is good!

[@giomarim]

Thank you. What a fun way to learn 😁

[@MedicosisPerfectionalis]

My pleasure 😇

[@Vismayaize]

Thanks ❤️

[@MedicosisPerfectionalis]

My pleasure 😇

[@oyaatamaner2153]

I couldn’t understand the meaning of GT @15.35?

[@MedicosisPerfectionalis]

Glanzmann Thrombasthenia.

[@saraisa633]

At this point i am watching your videos twice (or 3 sometimes 😂)

[@MedicosisPerfectionalis]

Wow 🤩
Thank you 😊

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Bless you❤❤

[@MedicosisPerfectionalis]

Thank you 😊

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Darn... you're the best!

[@MedicosisPerfectionalis]

Thank you 🙏

[@ahmedashraf5814]

I think in this case the patient had developed DIC 2ry to the infection?

[@saudalamoudi8]

Wonderful really wonderful

[@samyan_saleem4252]

Thnx 1000x❤

[@MedicosisPerfectionalis]

My pleasure 😇

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Damn , you are awesome and mind blowing

[@MedicosisPerfectionalis]

Thank you 😊

[@broomandmoslem829]

fibrinogen is an acute phase reactant.

[@MedicosisPerfectionalis]

Excellent

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Not my phone number and area code. I was like well, I fucking know🤣

[@user-su9lp8ri9w]

Thank you so much
Very very helpful and beautiful picmonic
Your sound very nice😊😊 making information stored in our mind
My name is Maha from Iraq😊

[@MedicosisPerfectionalis]

Thank you 😊

[@dr.dharmendrayadav119]

Best thanks sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@kardohassan]

thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@immersgamers9730]

best teaching

[@MedicosisPerfectionalis]

Thank you 🙏

[@hamzehhabib475]

Could you make a video for neonatal jaundice please

[@MedicosisPerfectionalis]

Ok, I will try my best

[@hamzehhabib475]

Medicosis Perfectionalis thank you very much 👍🏻

[@Mazzawak]

i think fibrinogen is high because it is an acute phase reactant and is elevated in acute illnesses

[@MedicosisPerfectionalis]

Excellent

[@mohammedbaqermahdi3743]

Thank you from iraq

[@MedicosisPerfectionalis]

My pleasure 😇

[@ifrahakbar2878]

"thank you for supporting my work.. I'm joking," what even lol

[@MedicosisPerfectionalis]

???

[@ifrahakbar2878]

@@MedicosisPerfectionalis 8.45 to 8.55 that's where you said this, I found it funny lol

[@MedicosisPerfectionalis]

Haha 😂
Bad editing in the video 😬😬

[@mhuraic]

Definitely Rolls-Royce phantom VII of medicine for sure

[@vidhyavithu4352]

Hemolytic Uremic Syndrome (HUS) found after delivering my first child is that safe to plan another pregnancy?

[@aakankshapatel2192]

Wonderful 🌈🌈🌈🌈
Happy Belated Teacher's Day

[@MedicosisPerfectionalis]

Thank you so much!

[@rodella1555]

You are making it easier and funnier ❤️😂

[@MedicosisPerfectionalis]

Thank you 🙏

[@wasimmuhammad]

how the kidneys are infected after the GIT?

[@MedicosisPerfectionalis]

It’s not “infected”. It’s affected.

[@wasimmuhammad]

@@MedicosisPerfectionalis How kidney are affected? Please give a little bit explanation. Thank u

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I am starting to dislike my college profs. Lol😂

[@MedicosisPerfectionalis]

:)

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اجمد شرح في الدنيا ده ولا ايه

[@MedicosisPerfectionalis]

Thank you so much 😊

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I wish that was your phone number, not sure what the area code would help with

[@MedicosisPerfectionalis]

Haha 😂

[@youngmedlion8631]

Hahaha "hoarding toilet paper"! Spot on

[@MedicosisPerfectionalis]

😂😂

[@bashirkhan9886]

Plz share kidney videos as well

[@MedicosisPerfectionalis]

Ok

[@sharonbitto9178]

Hahahahahaha. Oh my God. 'That's why it boggles my mind when a bunch of adults are hoarding toilet paper'.

[@MedicosisPerfectionalis]

:)

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Great

[@MedicosisPerfectionalis]

Thanks 🙏

[@Nahs_0]

يالله كل ما بحضر فيديو لأفهم مرض بقول نص الحكي حكيناه قبل وين قبل لك عمي فهمني اللي قدامي بس مشان الله😭😭😭

[@patient3841]

U r gooooood

[@MedicosisPerfectionalis]

Thank you 🙏

[@zainabsami9249]

This is an amazing explanation, thnx for all the efforts - Although I had one problem :) YOU ARE TALKING WAY TOO FAST, DUDE CHILL :)

[@MedicosisPerfectionalis]

Ok 👍

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I luv u man

[@MedicosisPerfectionalis]

Thank you 🙏

[@sathakamara1324]

What's with the catholic nun at the end of the video?