Heparin-Induced Thrombocytopenia (HIT) | A Comprehensive Explanation

Heparin-Induced Thrombocytopenia (HIT) | A Comprehensive Explanation...There are two types of HIT: HIT-type I and HIT-II.
Heparin is an anticoagulant that stimulates antithrombin III (ATIII) which then inhibits coagulation factors VII, IX, X, XI, XII, as well as thrombin. This leads to prevention of thrombus formation (anticoagulation)...Heparin is used for ICU anticoagulation...Adverse effects of heparin includes bleeding, Heparin-induced thrombocytopenia (HIT), and osteoporosis.
Heparin | The blood 🩸 thinner | The Anticoagulant | Pharmacology | Hematology.
Anticoaulants are chemicals that inhibit blood coagulation (secondary hemostasis).
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Vitamin K Deficiency | Hemorrhagic Disease of the Newborn or Vitamin K dependent bleeding (VKDB) is a bleeding disorder that occurs due to deficiency of vitamin K.
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Coagulation Tests (PT, aPTT, TT, Fibrinogen, Mixing Studies,..etc).
The coagulation factors are divided into 3 coagulation groups | Fibrinogen group, Prothrombin group, and Contact Group..
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Platelet count is one of the lab tests used by a doctor or a hematologist to assess whether your platelet number is normal, low (thrombocytopenia) or high (thrombocytosis).
Bleeding 🩸 time (BT) is another test for platelet function.
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[@MedicosisPerfectionalis]

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[@mirnas.1692]

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[@MedicosisPerfectionalis]

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That well drawn out Messi in the cascade 🙌

[@MedicosisPerfectionalis]

☺️😊😊

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You're the reason for my survival in medical school.❤️

[@MedicosisPerfectionalis]

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[@sumayyarehman99]

It is the first video of this channel that I've watched and God do I love these! I am taking the oath to watch most of its content if not all. God, so smart!

[@MedicosisPerfectionalis]

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[@nora5230]

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Very educational and entertaining
Thank you

[@MedicosisPerfectionalis]

My pleasure 😇

[@waytoallah9977]

Underrated Channel.... Great work.You deserve million subscribes 👍🏻

[@MedicosisPerfectionalis]

Thank you so much 😊

[@jacobcolombo3158]

I wish i found this channel in 1st year instead of 4th year. Fantastic stuff and love your personality that you inject into the video to make it fun!

[@MedicosisPerfectionalis]

Thank you so much,Jacob!
I appreciate you!
Would you please help me by sharing?

[@rahimdawar6290]

What A superb methodology, Mind blowing felt Immense pleasure 😊 to watch.....May God give me strength to learn it for thousands years 😀🙏🏻😊

[@MedicosisPerfectionalis]

Thank you so much!

[@sagar5267]

No words"..immense hardwork n made insanely easy for us...stay forever

[@MedicosisPerfectionalis]

Thank you so much 😊

[@oderadee169]

Your voice and humor. Thank you Dr.

[@MedicosisPerfectionalis]

My pleasure 😇

[@scarecrowzero84]

this helps me understand HIT I and HIT II way better.

[@MedicosisPerfectionalis]

Awesome 👏

[@eil9663]

I dont know why i found you channel JUST NOW.
can’t believe it, my academic life would be so much easier if i found it earlier.
Anyways, thank you so much!!!! This was very helpful

[@MedicosisPerfectionalis]

My pleasure 😇
Welcome to the family!

[@TooMuchTigerero]

Favorite videos thank you! I have a topic discussion on the topic and your lectures really help make things click! Keep it up!

[@MedicosisPerfectionalis]

Thank you 😊

[@zachsbabe2013]

what a great video, loved the commentary but very helpful, information was presented in a great way!

[@MedicosisPerfectionalis]

Thank you 😊

[@Maryam2825]

This author is hilarious, I love his teaching approach!

[@MedicosisPerfectionalis]

Thank you 🙏

[@parvathi9999]

You're simply amazing!!!! Loved it!!! ❤️❤️

[@MedicosisPerfectionalis]

Thank you 🙏

[@leviathaen]

Thank you! I had HIT type 2 years back and my doctors did a poor job explaining its effects and cause. Thankful to finally have a better understanding of what happened to me.

[@MedicosisPerfectionalis]

Thank you 🙏
How is your health today?

[@leviathaen]

@@MedicosisPerfectionalis I am much better, thank you! It took quite some time to fully recover from the PEs, but I am doing well.

[@kathmandunepal9547]

Thank you soo much for your videos!! Have MRCP in 1 month, your videos are soo helpful! You make studying fun! Laughing in humour white studying at 11 pm in my bedroom, something I had never imagined!

[@MedicosisPerfectionalis]

I am honored! Thank you so much for watching my videos!
Would you please help me by sharing my videos with others?

[@MrNetyzen]

Fantastic work. Thanks!

[@lydao8292]

You explained HIT very well. Thank you very very much!

[@MedicosisPerfectionalis]

Thank you 🙏

[@rishidas2479]

Watching this with Robbins pathology just cleared my whole concept
Thanks bro
Love from india

[@MedicosisPerfectionalis]

Thank you 🙏

[@underxk8640]

اسأل الله في هذا الشهر الكريم انه يفرج همك ويرزقك من حيث لاتحتسب ياارب والله يادكتور بسطت اشياء دكتوري معقدها ومخليها مملة. مصر مفروض تكون فخوووورة فيك 😔❤️❤️❤️❤️❤️❤️🇪🇬🇸🇦

[@MedicosisPerfectionalis]

Thank you so much 😊

[@pavanbevoor8636]

Ur angel in disguise. Tq doc.

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@abensteve132]

Great video as usual.Life saver!!

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@Lerolero_candelero]

Thank you so much for that explanation, that was really awesome

[@MedicosisPerfectionalis]

My pleasure 😇
Thank you so much for watching!

[@abduls.h4385]

Sir your tutorial is excellent and I couldn't stop laughing at your sense of humour too, made the tutorial more interesting, stay blessed and hope to see more 🙏 😊 ❤

[@MedicosisPerfectionalis]

Thank you so much 😊

[@challotteawasum2375]

love your videos, you really deserved million follows. just one request if you will slow down when explaining, it will help a lot

[@MedicosisPerfectionalis]

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A complex theme made very simple and in nice presentation

[@MedicosisPerfectionalis]

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[@muneeraabushukur3498]

Best tutorial ever 👏👏thank you so much

[@MedicosisPerfectionalis]

My pleasure 😇

[@keyurr_27]

Thank u for your superb teaching master accept my salute 🙌 le second year mbbs student from India 😅

[@MedicosisPerfectionalis]

Thank you!

[@luna.kashyap1313]

Just loved it

[@MedicosisPerfectionalis]

Thank you 😊

[@hkohlanyy]

awesome explanation, and great sense of humor gentle doctor.
those 3 dislikes must be from the aforementioned medical students

[@MedicosisPerfectionalis]

Haha 😂

[@zjengle6878]

As a lab tech who works with a Sysmex XN CBC instrument on a regular basis, I can confirm that it is, in fact, a stupid-butt machine.😆
Thanks for these videos! They're helping me a lot while I'm studying for my hematology final this week.

[@MedicosisPerfectionalis]

You’re very welcome 😊
Good luck 🍀

[@lianallado1616]

you are hilarious! love your videos, thanks so much for making them!

[@MedicosisPerfectionalis]

My pleasure 😇

[@dailydoseofmedicinee]

What are the signs and symptoms of HIT?
Pain, redness, and swelling of an arm or leg.
Bruise-like discoloration of your skin.
A rash or sore where a heparin shot was given.
Weakness, numbness, or problems moving your arms or legs.

[@linkkraft]

Are you fucking kidding me? 1 min into the video and i already learned some amazing things

[@MedicosisPerfectionalis]

Happy to hear that!
Thank you 😊

[@noonijo1997]

Thank you so much!

[@MedicosisPerfectionalis]

My pleasure 😇

[@Music-xp5wg]

Warfarin can be given for HIT according to my textbook that's a copy
Warfarin (goal INR 2-3) for all patients with confirmed HIT diagnosis once the platelet count is above
150,000/mm3
a.Duration depends on the presence of thrombus.
i.No detected thrombus - 30 days
ii.Thrombus - Continue for appropriate duration depending on thrombus type (typically 3-6
months).
b.Start with doses of 5 mg/day or less, and overlap with injectable anticoagulant for at least 5 days.
c.Will need to account for elevation in INR caused by both argatroban and bivalirudin during
transition

[@user-zr4gq3hp3i]

great work, keep going!

[@MedicosisPerfectionalis]

Thank you 🙏

[@evankim2158]

Just, just superb

[@MedicosisPerfectionalis]

Thank you so much 😊

[@alpr1864]

Dear Medicosis
Thank you so much for your lectures. It has helped me a lot with my study. I can only wish that no medical student would live in restricted-resources areas (like middle eastern countries) to not afford your brilliant lectures.
Best regards.

[@AbidKhan-qn7wt]

that '' SHUTUP'' was personal hehehe

[@MedicosisPerfectionalis]

:)

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You are Amazing!! 🙌🏻

[@MedicosisPerfectionalis]

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[@narandetagenblirtillluft1419]

Cool as usual 🌷

[@MedicosisPerfectionalis]

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[@arunmehta8234]

You are awesome !

[@MedicosisPerfectionalis]

Thank you 😊

[@toniencheff4046]

Thank you for your amazing video. A lot for me, and a bit above my head, but I will listen several times.
You could have a second career as a stand-up comic. Maybe at a destressinv conference for medical people? ❤️❤️❤️

[@MedicosisPerfectionalis]

Thank you 😊

[@asmaalamin6245]

Amazing

[@theresia115]

Thanks!

[@MedicosisPerfectionalis]

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[@peregrimus]

Dude you’re awesome greetings from cardiology resident

[@MedicosisPerfectionalis]

Thank you 🙏

[@sadixarg5508]

amazing!!

[@MedicosisPerfectionalis]

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[@aboutfarvardin]

Thank youuuu sooo much...

[@MedicosisPerfectionalis]

My pleasure 😇

[@abukhalidrussian9561]

Great lecturer
Amazing lecture ☺️

[@MedicosisPerfectionalis]

Thank you 🙏

[@shaikyasmeenbegum7295]

Wow believe me I had fun watching this💝

[@MedicosisPerfectionalis]

Thank you so much 😊

[@deyandimov9589]

I think im not dropping out after all.. thanks dude

[@MedicosisPerfectionalis]

My pleasure 😇

[@dr_marwabekheet7387]

Good job👍👍

[@MedicosisPerfectionalis]

Thank you 🙏

[@nagatsatti8426]

Thank you so much sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@rayanefilali934]

awesome!

[@MedicosisPerfectionalis]

Thank you 🙏

[@k4kingkiran]

You are awesome.

[@MedicosisPerfectionalis]

Thank you 🙏

[@chiranthiem.k.h.1597]

As a medical student, I'm living for the undisguised medical student hate ♥ Thanks for the clear lecture doc

[@MedicosisPerfectionalis]

My pleasure 😇

[@amuletangelamuletangel6229]

Sir, Instead of using direct thrombin inhibitors, can we use fondaparinux in HIT2 after stopping heparin?

[@dexterdexter402]

My brother has developed hit type 2. Platelets is down 60 and now 45. Hematoma in glutes (12-17 centimeter). Dr is now giving him platelets and fondaparinux. But not argitroban. What should they be doing? Administer platelets or not? Thanks

[@anastasiaaa4094]

I was studying from Harrison and understood nothing and came here . Thankyou 🌟

[@tanvirizaz8665]

Hi Doc...
Can I get VITT after get vaccinated by Astrazeneca vaccine...
After getting the vaccine, I'm having persistent abdominal pain from last 5 days...

[@thiagodinizcoelho]

WOW!

[@MedicosisPerfectionalis]

Thank you 🙏

[@OOOOOOOKKKKKKK69]

Hahaha...
O man, you make studying so much fun.
Thanks again.

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@maryangelicaj624]

😂😂😂😂😂😂😂😂😂 love the comedy that you add to your videos

[@MedicosisPerfectionalis]

I am grateful! Thank you!

[@hannahrosa5485]

Kermit was right. It's the greet top. Thank you for yet another valuable lesson.

[@MedicosisPerfectionalis]

Haha 😂
You’re very welcome 😊
I remember your comment on the last video...You’re so smart!

[@hannahrosa5485]

@@MedicosisPerfectionalis But you are so much smarter than I lol

[@MedicosisPerfectionalis]

Nope...You’re smarter!

[@davidwu3247]

So funny!! thank you!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@kelseyechoharbiyeci209]

I’m studying for a critical care exam right now and I can’t stop laughing.

[@MedicosisPerfectionalis]

Haha 😂
Laughter is a cheap medicine…Even cheaper than Heparin 😉

[@esraaabdel_shakoor6609]

رهيييييب 😂😂😂😂😂😂😂😂😂

[@MedicosisPerfectionalis]

Thank you 🙏

[@sadiyaafreen1308]

This vdo🥰♥♥

[@MedicosisPerfectionalis]

Thank you 😊

[@elizabethjaco8144]

What other anticoagulants could you use other than argatroban?

[@MedicosisPerfectionalis]

Have you watched the video?

[@mourisarker6872]

Wow this is so cool. So funny. "Who named these things?"
Really I also think so...why so difficult to remember drug names

[@MedicosisPerfectionalis]

Thank you 😊

[@rimshasiddique1255]

Fity munh!

[@WhyNot-si4pj]

02:43 You mentioned that LMWH inhibits factor X alone & NOT the rest of the upstream clotting factors of the intrinsic pathway ; that's why the aPTT is NOT prolonged !!!!!
As you know ; both intrinsic & extrinsic coagulation pathways converge towards factor X to activate it in order to proceed down the coagulation cascade !
So how comes an inhibited factor X alone does NOT prolong the aPTT ?

[@Apratim98]

Why would we use ELISA and not Coombs test?

[@MedicosisPerfectionalis]

Coombs is for RBCs, not the best for platelets!

[@saralissali1090]

Please make us a video about antiphospholipid syndrome dr

[@MedicosisPerfectionalis]

OK 👍

[@saralissali1090]

@@MedicosisPerfectionalis thank u u r the best

[@trickster1030]

why does the thrombocytopenia cause clotting? Shouldnt it bleed more?

[@trickster1030]

ah i think you explained it at around the 12 minute mark

[@lynjohnson2778]

I have a blast watching your videos! But why does the doctor sprinkle dust on his head when type II HIT is confirmed? You are a smart funny and confusing man

[@MedicosisPerfectionalis]

I was just joking 🙃
I meant to say: “it’s a tragedy.”

[@himanshuambilkar4160]

Argatroban
Lepirudin
IgG
Platelet factor4

[@MedicosisPerfectionalis]

I don’t understand

[@himanshuambilkar4160]

Sir I have written important key words so that when I come again I know the overview

[@ahmedalhafid9272]

"shut up, If a student says that in real life I will kick him in the nuts" xD

[@MedicosisPerfectionalis]

Just joking 🙃

[@poojapujari2502]

Plzz make a video menustrl cycrcls

[@MedicosisPerfectionalis]

Ok

[@poojapujari2502]

@@MedicosisPerfectionalis tunku soooooo much sir

[@zangetsu949]

All i wanted to know was HOW
But we are soo stressed on just mugging up that when asked how it happens we tell them well those who can cause coagulation can also cause anti coagulation
It would have taken just extra 1-3 min to tell how the fuck is it causing thrombosis BUT NOoooo.

[@elhamsamo6755]

ما تبطل بضان يسطا واشرح زي الناس وبطل تشد في بضاني انا تعبت
بس شرح جامد الله ينور

[@AmandaJPChin]

Proves smart people can be funny too

[@MedicosisPerfectionalis]

Haha 😂

[@hanifyousuf5880]

dudeeee i love u ,,,, hahahahhah

[@MedicosisPerfectionalis]

Thank you 😊

[@tyuu901]

Vedio starts at 11:28 robbins dude 🤫🤫😂😂

[@jimazing1]

As a lab tech I take offense at you calling our machines stupid LOL. Most platelet problems come from preanalytical errors!!

[@MedicosisPerfectionalis]

I was joking 🙃
I can only imagine how much stress lab techs have to work under!
I appreciate you 😊

[@matthewreddick9334]

The platelets go crazy? That’s the explanation?

[@MedicosisPerfectionalis]

Yup 🤪

[@amaardoc8148]

You filipino 😮

[@drfadumaibrahim9402]

HIT tpye1 medical student😁😁😁 doctor dancing

[@MedicosisPerfectionalis]

Haha 😂

[@dorantebrutus5188]

LOL….

[@MedicosisPerfectionalis]

😊😊

[@Pedro-hk9ng]

Horrible presentation but good information.

[@MedicosisPerfectionalis]

Ok

[@noamikhan7771]

Slow down. You're talking too fast. Someone who doesn't have much knowledge of the subject will find it difficult to follow u.

[@MedicosisPerfectionalis]

Thank you for letting me know!