Drugs for Heart Failure
HTML-код
- Опубликовано: 2 июн 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/dru...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Drugs for Heart Failure. During this lecture we will begin by discussing the pathophysiology of heart failure. After we have provided a solid foundation to build upon, we will move into the various categories of drugs used to treat heart failure. These will include Beta Blockers, RAAS Inhibitors, Angiotensin Receptor-Neprilysin Inhibitors (ARNI's), Direct Vasodilators, Diuretics, Ivabradine, and Positive Inotropic Agents. We will then review the NYHA Chronic Heart Failure Management Classification and how we manage Acute Heart Failure. As always, at the conclusion of this lecture we will have 10 practice problems to help you truly master this important topic. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Drugs for Heart Failure Introduction
0:45 Pathophysiology of Heart Failure
32:41 Beta Blockers
43:10 RAAS Inhibitors
57:00 Angiotensin Receptor-Neprilysin Inhibitors (ARNI's)
1:07:51 Direct Vasodilators
1:17:26 Diuretics
1:27:41 Ivabradine
1:41:19 Positive Inotropic Agents
2:08:53 NYHA Chronic Heart Failure Management
2:17:57 Acute Heart Failure Management
2:41:54 Drugs for Heart Failure Practice Problems
2:51:50 Comment, Like, SUBSCRIBE!
Join this channel to get access to perks:
/ @ninjanerdofficial
Pharmacology Source:
Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology (Lippincott Illustrated Reviews Series). Wolters Kluwer Health. Kindle Edition.
APPAREL |
shop.ninjanerd.org
www.amazon.com/s?k=ninja+nerd...
PODCAST |
Apple Podcast: podcasts.apple.com/us/podcast...
Spotify: open.spotify.com/show/2ZDXoak...
Google Podcast: podcasts.google.com/feed/aHR0...
DONATE
PAYPAL | www.paypal.com/paypalme/ninja...
SOCIAL MEDIA
FACEBOOK | / ninjanerdlectures
INSTAGRAM | / ninjanerdlectures
TWITTER | / ninjanerdsci
@NinjaNerdSci
DISCORD | / discord
#ninjanerd #heartfailure #chf
Not only students, but also pensioners when we are lonely and have nobody to talk to we listen your lectures to know our illnesses to live longer. 60 yo. Thank you that you are. 💐
😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊😊
❤
❤😊
Teaching cardiology better than any cardiologist we've seen in med school... thank you for making this available to train doctors and healthcare workers around the world! This channel is a gift to humanity!
Real life and models are very different
for sure
couldn’t agree more 💯
I'm a very busy family medicine doctor with 28 years of ER and urgent care as well as hospitalist service experience and I have to say these Ninja Nerd videos are the BEST teaching videos I have seen. Lot's of deep dive detail that I wish I would have had in medical school, but the internet was just getting up and started in the early 90's when I was in training and residency. This would have been fantastic to have "back in the day." GREAT stuff here.
I had heart failure with a LVEF below 40%. With Entresto and after a year on it and then discontinuing it, my LVEF was 65%. I've been without the drug for more than a year now and my heart is still perfect. In other words, I've been cured of heart failure thanks to Entresto!
On behalf of the entire medical students in Sierra Leone, we want to thank you for all you have done for us…Thank you Prof Ninja Nerd ❤
I'm dealing with stage 3 heart failure and taking several meds...I learned enough to talk to my doctor thank you❤
In the name of all the romanian medical students i would like to thank you. We have our residency exam in two weeks and this topic is a very big one in our bibliography and a very troublesome one, may I add. This will come in real handy. Thank you!
Indians too
Scottish too❣
Iraqi too
serbian too
Greek too
I can't listen to any other person having 3 hours of lectures but it's only youuuuuu to whom I can listen 😭
This dude have taught me not only medicine but also, what commitment actually means. Huge and massive respect buddy for your time and commendable efforts.🙌 Can't imagine how you gather all the information from various literatures and put them altogether within just a week that too in a 3-hour video ✌ Tons of love and appreciation to you and your team 🙌❤ please keep doing 🌠
I AM HABTAMU TEKALIGN FROM ETHIOPIA I AM CLINICAL PHARMACY STUDENT SINCE FIRST YEAR I AM USING YOUR TUTORIAL VIDEO ITS SO SUPPORTIVE NOW I AM ONE OF TOP SCORER THANK YOU BIG BRO NINJA
bro, mad respect and props. seriously your videos are great, well researched and I can tell you have spent a lot of time gathering all this info together. from the bottom of my heart. thank you fam!
You are really Ninja bro, you make the difficult easy😉.
From someone who found Dr Ninja
looking for just this subject, your other video on this topic helped me know that my husband was on the correct drugs for his possible class 2 of heart failure.
(He had a quintuple bi -pass just just 3 1/2 years before.)
Which then lead to the three scheduled tests US of abdomen, CT, and an Echo!
All waiting to take place, to help find the cause of his now (some 70 lbs )of Water weight gain in 4 weeks time!
You are the best lecturer ever! You are very smart nerd ninja! I adore your ability to share your enormous knowledge!!!
This guy does such an AMAZING job of explaining these concepts!! I hope he continues to teach bc many are not able to explain complex mechanisms this well, making it easy to hold our attention in my opinion!! His pace of speaking is just perfect!, easy to keep up with & definitely not dull & boring!! Thank you!!
You are the best person ever who can discuss anything you’re asked to do. You have a unique way of explaining everything so we can understand. Pls keep doing your education videos. Plenty of medical staffs are benefiting out of them like me. I love you!!!
you, your team, your spouse, your dog, your mailman and your mama....IS THE MAN. Thank You for helping out the little guy !!!!!
Medical lectures owe you a lot..You are a boss man..
This as a phenomenal lecture. I listened to some of your stuff during nursing school and am now studying for PCCN and wow, so helpful. Thank you!
wow this is helping me drastically. I am an ICU new grad and this is very helpful! THANK YOU!!!
Your videos are so good that I always hit the like before watching. Congratulations on your dedication and knowledge!
EMT-b and nursing student here. Thank you. I believe I have a better and more in depth understanding of the material than any of my peers now.
so impressed by the depth of your knowledge and how well you are able to explain it. You're a tru master of your craft.
hey, I'm not a medical student or anything but I love genuinely learning about how the body functions, thank you so much for making this knowledge available for free, actually would cost thousands of dollars of books to learn this stuff otherwise. actual chad
One of the best teachers in the world 🌎 ❤ I'm learning a lot from your lectures. Keep it up guys, your work is highly appreciated
All the way from South 🇿🇦 ❤
I am not even a physian but in another medical field and enjoy the courses.
Thanks for you bro from my heart, your the the best lecturer in the world. Keep going
Greating from sudan 🇸🇩🇸🇩
My exam is on the 5th of January
And I'm so thankful cos I'm studying pharma from your wonderful channel
It's so entertaining to learn it from you zach
Thank you so much for your magnificent effort 💗
I am starting a cardiology posting and all I can say is thank you very much for what you do.
Great work. Doctors can easily make their right approach towards patients and diseases. You make it too easy. God bless you for your great work.
You just dymystified heart failure with low EF. Thank you so very much for this presentation
I wish this was published prior to my ICU rotation in PA school, but it's still a great review now. Thanks!
Amazing video Zack! You have an amazing talent to teach! You make all these concepts so easy to understand!
LOVE his energy for teaching!!!
This is one of the best educative sites ever visited
I’m a med tech entrepreneur and you are the reason my company exists ❤
I never knew medicine could be this interesting!! BRAVO!
From all different countries, we support you, love you, and wish all best for you
I am a 74 year old male with a pacemaker and use anti hypertension drugs. I did not want to use metaprolol because I am still a racing cyclist and I want a high cardiac output for that reason.
You told that metaprolol initially lowers the heartrate (and therfore the Cardiac output) but after some time it even increases the cardiac output. That is nice to hear and I wished I knew that earlier. Thank you! Today I use Perindopril, Nifedipine, Xarelto and Jardiance and I feel fine.
Thank you for this awesome lecture. Your knowledge and commitment is remarkable.
Thank you very much for your time and effort producing this learning material. It will help me in my practice and benefit hundreds of my patients.
Great content as always. Easy to understand, easy to revise and learn from. Your videos are a lifeline!
Awesome video, I have heart failure and like to review what my meds are doing for me every now and then haha. Losartan, Carvedilol, Warfarin, spironolactone, and a few others in the past. Thanks everyone in the medical field!
That " Bro please , stop filling me up , I've got too much in my ventricles " caught me off guard.
I'm male, 78 (almost) and I was diagnosed with heart failure 4 months ago with an ejection fraction of 25% to 35%. I'm now taking a cocktail of drugs: Entresto, Apixaban, Rosuvastatin, Furosemide, Bisoprolol, Eplerenone, Dapagliflozin and Aspirin. 11 years ago I had a triple CABG and made a full recovery. Three months after the operation I had a follow-up with a cardiologist and had an echocardiogram. The result of that, however, was an EF of 60%, no noticeable valve disease and the heart was pronounced good. In the intervening years I lost a lot of weight by counting calories and I modified my diet considerably with grains, wholemeal bread, lots of fish, including oily fish. What I want to know is how the EF can sink from 60% to as low as 25% in 11 years.
thank u this is the best lection
You are so intelligent, You have such a cool way of explaining things and I absolutely love your board and marker pens. Keep up the good work.
Thank you Ninja Nerd very much!
Thank you so much for sharing in more in-depth information on these drugs. I am HFrEF
I'm watching again. The signals from the heart to the medulla obligata is by the IXth (9th) cranial nerve, or the glossopharangeal nerve. The Xth (10th) is the vagus never.
I had to look it up to be sure, as it had been a while, but hopefully, that's helpful for someone.
The carotid sinus baroreceptors are innervated by the carotid sinus nerve branch of the glossopharyngeal nerve. Their stimulation results in heart rate reduction mediated by the vagus nerve.
Thanks for your lectures!
No matter how much i try .. i can't thank u enough
Due respect 🙏 .....!!bow down to u dr Zack🙌🙌🙌🙌
a lot of info presented very well.
thank you so much for your lecture and your passionate teaching. it really really helps
literally was asked to do this by my professor today - let''s go ! Cant wait for this video :) Love you ninja nerds
Thank you for this detailed explanation. You are a fantastic teacher.
Zach is a such amazing human being- lovely and talented. ❤️
Thank you so much for educating patients with their diseases CHF.
Thank you Dr., for this awesome video
Thank you for this detailed explanation. It is truly a fantastic video.
This is amazing! Thank you so much!
This is so awesome. I have a child with chd and its sooooooooo helpful to hear what these meds are doing
can you please continue on the cell biology videos, for example, the techniques for monitoring and manipulating cells and genetic material? you are the best teacher ever:)
Just want to say you have gotten me through nursing school. Used you last semester and got an A when the previous semester I got a C.
Thanks man , you are a great help to medical students
Bro...I have no words for these masterpiece.. Greetings fm 🇮🇳
You are doing really great job ❤️ thanks for your effort ❤️
Thank you so much ❤
Best 3 hours ive ever invested in
Can't imagine studying medicine without your videos! :')❤❤❤
1:04:15 Actually, the 2022 AHA/ACC Guideline on heart failure now suggests that ARNi are now first-line RASi in HFrEF, *ahead* of ACEIs and ARBs. ARNi first, then ACEI if ARNi can't be tolerated (or afforded), then ARB if ACEI can't be tolerated (e.g., angioedema, bradykinin cough). This recommendation is different than what you say in here regarding order of priority.
Nitpicking aside, this is a *fabulous* teaching video.
Ah yes coz that was what I was given which is the Entresto when I was diagnosed with CHF last year with reduced EF.
NOT ONLY YOU ARE AN AMAZING TEACHER, YOU ARE SO FUNNY TOO
So insightful thank you so much and much appreciated
You may be in residency or fellowship training now as I have noticed the decreased number of recent videos BUT I PRAY MY FRIEND that you are working toward a specialty where you will be able to teach at least a large percentage of the time in a medical school, and a medical school that will allow you to continue this work with these videos and on your website because YOU HAVE A SPECIAL GIFT and are helping so many health care professionals and others be better practitioners and better people. YOU HAVE HELPED RESTORE MY LOVE FOR MEDICINE WHICH I HAD GOTTEN AWAY FROM. GOD BLESS YOU MY FRIEND. I know you would be a phenomenonal researcher and clinical practitionerand I PRAY ( selfishly I readily admit 😂) THAT YOU LEAN TOWARD TEACHING ( along w some clinical care to keep you FRESH, of course )
Excellent tutorial!
Love love love your videos. Please keep posting on more and more new topics
I enjoy all your videos I think I'm ready for medical school now after watching your videos and the way you teach the lecture
Thanks!
Im so grateful for you prof
Thank you for your lectures
Your video to this topic is impressive, Brilliant, thank you
THANKYOU so much!
In Australia we've added SGLT2 inhibitors like dapagliflozin to our first line therapy along with the beta blockers and ARNI + valsartan. It's unknown why but seems to be cardioprotective and improve outcomes, likely due to the diuretic effect.
We also learned about the role of SGLT2-i in my PA program in the US. Seems especially useful given the frequent comorbidity of HF and DM.
In NHS too we add DAPA 10 along with others
Thank you so much for saving my semester! ❤
Just in time!
Thank you
Professor-
Please do a similar exposé on how SGLT2 inhibitors work for non-diabetic heart failure patients with low EF (
thank you so much great effort
You are the bomb!
Better lectures than during med school
The why’s of pharm!
I just found you. You're an excellent instructor/professor. I'm having to take this in a bit at a time, but excellent teaching, excellent content, and to the point.
I hope and pray that you are teaching as many students as possible, as we need tons of clones of you who can learn, and then they can teach others as well, and so on.
You have a great voice, you cover the subject matter in an organized manner, you are clear, you have drawings and printing that is great and readable.
Can you do a video on Alpha-1 antitrypsin deficiency MZ phenotype, and treatments for lung, liver and eye inflammation, drugs to avoid (such as Tamiflu, NSAIDS, Tylenol, etc.), risks for heart, lung, liver, kidneys, brain, retinas (especially in children), etc.?
It seems MZs are more at risk for both lung and liver problems, as well as other problems that have very little research, it seems.
This would be greatly appreciated, both from a personal and professional standpoint. Thanks for at least considering this.
I agree that Ivabrdine is a strange bird... Wouldn't the ion transfer create a delay in and/or prolongation of ST waves? And all that entails? (Early repolarization, aneurysms, pancreatitis, etc.)???
I'm asking, as it seems that could be a problem, and without other meds, a possible increase in stroke risks???
I can see why they'd need to ideally be maxed on a beta blocker when using Ivabradine. And a
Respect,luv and bundle of thnx
thank you for everything
Just amazing! he is like the Bob Ross of medical teaching!
Yes. Exactly. 🤣😂🤣😂 It is funny because it is true.
Excellent, don't forget you.
Thank you
Very beneficial. Thank you!
thank you bro like really we are all grateful you exist ,
Zach Murphy the great 🖤🇸🇸
Made it easy for me, I really really enjoyed it ❤❤
Aldosterone antagonists arent an add-on therapy, its a GDMT which means all HFref patients should take this medication with an acei or an arb because it reduces heart fibrosis and hypertrophy
Dude you are a blessing!
Thanks you Dr ninjanerd you are best lectural for medical department, we hope next video for pharmacology will be Diabetes mellitus drugs and their classification in best teaching and memory way