T cell maturation and differentiation - thymic selection | T cell development 2

This T cell development lecture explains about the T cell maturation and differentiation pathway. It explains the mechanism of how T cell is trained in thymus after the activation and the chemical activation and differentiation of T cells in Thymus. This video also explains the thymic selection and clonal propagation of T cells.
Learn more about the T cell development with this immunology lecture here-
In addition to cell cycle proteins, cytokines and their receptors are produced following antigen activation of T cells. These are involved in the expansion and further differentiation of the T cells into memory and effector cells. IL-2 is an autocrine factor which leads to T cell proliferation. Other surface molecules induced following activation include CD40L (CD154) which interacts with CD40 on dendritic cells inducing them to produce cytokines (e.g. IL-12) required for T cell proliferation and differentiation into Th1 cells. This leads to the specific T cell priming and clonal expansion necessary for their effector function and the development of memory.
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Very well explained. Kindly teach this part before tcell activation process for proper sequence. And do segregate positive and negative selection events (which u already explained in a diffused way) .
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[@hardz2110]

Just to confirm, when the thymocyte comes in through the HEV it will be CD4-CD8-, the t-cell receptor will begin to form via VDJ recombination, and then they will interact with the thymic epithelial cells to become CD4 or CD8 in the inner cortex and this is where positive selection happens (with MHC I or MHC II) becoming CD8 and CD4 respectively --> then in the medulla they'll undergo negative selection with dendritic cells or medullary thymic cells (these cells have peripheral antigens which induce the negative expression) --> then they go on to the lymph nodes or in the blood as naive T-cells awaiting to differentiate in T-helper or cytotoxic T-cells
I hope this is right?

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[@isha7202]

Sir after the degradation of thymus gland how's the development of the T- cells occur pls reply

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[@subhankarsinha448]

Why DN cells,c-kit,cd44 are not told in this lecture?

[@ManishYadav-id7wl]

Sir please tell me answer I am confused so muchPositive selection in the thymus is mediated by:a Thymic epithelial cells
B Macrophages
C Dendritic cells
D T-cells
E B-cells

[@hanaanansari8067]

Sir plz make video on ABO incompatibility and Rh incompatibility

[@clashofpubg8789]

When IL-2 is secreated by one T-cell in a peripheral lymphoid organ, do all the T-cells in the vicinity proliferate in response to IL-2 or only some of them preferentially respond to it? Explain??

[@aes-thete_143.]

In this first one positive and second one is negative selection??

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Can you explain what happens at eat DN stage? (DN1-DN4)?

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i have a doubt.... in the video he says that the thymocytes undergo apoptosis if they dont recognize the protein present on the the self cell, so how odes the thymus recognize if the thymocyte has previously bound to it or not and subject it towards apoptosis

[@kiranbheemeshwar]

exactly.

[@priyankamanuja1617]

Once they have bind to any of the receptor they are transferred to blood or lymph by venules

[@AnisurRahman-hf8mw]

You are right. If TCR receptor recognise our own antigen, those type of T cell must be destroyed.

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