Vitamin B6 Alert for all Vitamin Takers.
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- Опубликовано: 11 сен 2024
- You may be unwittingly overdosing on Vitamin B6 and risking toxicity and the possibility of irreversible nerve damage. The Therapeutic Goods Administration has acknowledged reports of peripheral neuropathy in people taking doses previously considered safe. Check your supplements and fortified foods for content.
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Energy drink companies should be held accountable for their products containing extreme amounts of the synthetic version of B6 because that's what caused my neuropathy in my feet.
Hi Brian, My B 6 toxicitycame from the combo of multivitamins and b complex. Have you recovered from your foot neuropathy. Thank you.
if it has that much it's bad although energy drinks usually have a miniscule amount if at all
b1 is more helpful for neuropathy
I have had B6 toxicity for over a year and a half and no one knows why or how to help me. I used to take the occasional B complex and i drank Liquid Iv electrolyte drinks which contain added synthetic Bs. I literally thought i was dying... cardiac symptoms, arrhythmia, stroke-like symptoms, neuropathy, severe sleep disturbance, bruxism, hyperreflexia, severe fatigue, etc. I stopped all synthetic Bs 6 months ago and started eating healthy, eating mostly meat and veggies and taking beef liver supplements. I finally began feeling better, but still had some tingling and bruxism, but it not nearly as bad. I was finally healing... but then had my B6 rechecked, and was shocked to find it is even higher than it was before when i felt my worst. If i back off the beef liver i start to feel horrible again, so i tend to agree with the theory that some of us who are toxic are actually deficienct at the cellular level. Our bodies cannot effectively convert the b6 into its usable form so it accumulates in the blood. I also believe the worst symptoms were due to the synthetic B in my body. I also discovered i have an MTHFR gene mutation as well as a mutation that keeps me from properly absorbing B6. I also have hashimotos and found that many others with B6 toxicity also have it. I'm 45 and also going thru perimenopause. There may be a perfect storm for some of us of gene mutations and uncontrolled inflammation (which could be caused by any variety of things). My current course of action is to address the inflammation caused by hashimoto's and see where that leads. I just can't believe our Healthcare professionals have NO IDEA about any of this. It's been an absolute nightmare. I hope science catches up soon.
Souns like you have another gene mutation, hypophosphatasia, or HPP. You can get gene tested but if your alkaline phosphatase is low, as indicated in your typical CMP bloodwork, you have it.
@gilly8876 Thanks for the info! I just had a CMP, and it was all normal.
As some research sites claim, the in active form of B6 called Pyridoxine is usually in plant based food.
The active B6 form is in animal based proteins. That may be why you feel better after consuming beef liver.
There is an active form of B6 in the market called P5P tablets and liquids.
Since you are in the UK, there is a metabolic unit at St. Thomas Hospital in London that does the blood test of P5P. It is called the nutristatis unit if you wish to google it.
If you do decide to take P5P supplements then begin on a low dose and don’t do this high dosage stuff. Low dosage means 2.5 mg to 10 mg daily. I would begin at 2.5 and see if the brand you are taking is okay with your digestive system. Begin gradually and see where it takes you.
Your blood test should cover, P5P, Active B12 , Homocysteine. I believe this lab performs them all.
I hope this helps.
@daronnemis3812 thanks for the info, that's very interesting. I am not in the UK though... but I appreciate the reply.
Your story sounds just like mine. I haven’t been able to take prenatals because of the b6 so I started taking beef liver and it makes me feel great!
Tingling in the feet could be due to B1 and B12 deficiencies. At advanced age, Pernicious Anemia can result from inability to make 'intrinsic factor' that absorps B12 from food in the stomach. A sublingual 1-5,000 mcg is a good solution.
Fat-soluble Benfotiamine B1 absorbs 5-8 times better than Thiamine mononitrate/HCl and crosses the blood-brain-barrier and myelin sheath.
P-5-P B6 is safe upto 7 grams, according to Nerve Doctor Dr Valerie Monteiro
Cyanocobalamin B12 is also toxic to the cells, as it releases cyanide-group during conversion to the active Methylcobalamine.
Folic Acid B9 can also be toxic for those without MTHFR- genes to convert it to active methylfolate. Residues can cause kidney-stones and even cancer.
Most people opt for cheap, toxic-component Multivitamins since respectable brands are way overpriced. Try Life Extension two-per-day multis.
Had megavitamin-b6 syndrome back in mid-2019. Thank you for spreading awareness. I say the NHS recommendation of no more than 10mg/day is the most reasonable guideline.
I take 100 mg a day.
@@domenikschmitz334 You're playing with fire. It may take several years, but you can't comprehend the level of risk you're taking.
Which type are you taking? The P-5-P or the pyridoxine hcl? I have vitamin B6 toxicity now from way less than you are taking but mine was the pyridoxine which stores in the body.@@domenikschmitz334
@@domenikschmitz334 I got toxic from 50mg. I urge you to reduce what you are taking.
@@CraigTalbertIn the EU they have set a limit of 21mg B6
I developed Brachial Pruitis, severe radiating itch down the arm. I resolved it twice by stopping my supplements that contain B6. It’s so sad that most people do not realize that neuropathic pain or numbness can easily be prevented.
Hello. I heard the Pyridoxal 5-Phosphate version of B6 is not toxic.
I hear this from time to time, but have seen no scientific support. I believe it’s a theory put forth but not actually tested.
I so disagree!!! This is an active forum natural. HCL is synthetic. Tbofy recognizes natural much much better. WE MUST DO OUR OWN RESEARCH. And several sources. Medicine is NOT Healthcare! Doctors don't get nutritional education.
That's the general understanding but some people develop toxicity from this as well.
Dr.Monteiro, Nerve Doctor, said P-5-P is safe upto 7 grams per day. In contrast, Pyridoxine HCl is safe under 8-10 mg per day.
I take 50 mg P-5-P for years without any problem.
ruclips.net/video/KIM_J93ycvA/видео.htmlsi=5_RC9vAD3PWEqFq7
@@pramuanchutham7355 I don't believe there is any safe level of Pyridoxine HCL based on people I know who have developed peripheral neuropathy from as little as 2mg. I think most people can tolerate P5P, but some people develop the toxicity symptoms from this product as well. I've just had a sleepness night because my tingling and burning from my neuropathy was so great. All I am trying to do is warn potential sufferers about how bad this vitamin is in supplement form. I am pleased you are not affected, but I feel it is my civic duty to raise awareness so that no-one else goes through this toxicity hell.
Thank you. I got toxic from taking MegaMagnesium produced by Ethical Nutrients. Did not realise it contained 50mg of B6. I am hoping the TGA acts soon to drastically reduce the upper limit. I never saw the warning on my product. The levels will probably flush out within three months of stopping supplements but it will take on average two years to heal nerves damaged by peripheral neuropathy.
Thankyou for your comment, yes I saw a client yesterday who has been taking this. I think most people ignore the warning.
In May 2023, the EFSA (European Food Safety Authority) set a new maximum permitted intake of vitamin B6 of 12.5 mg/day for adults (including pregnant and breastfeeding women); the previous UL value of 30 mg/day from 2000 was thus lowered.
Yes. The EU is way ahead of Australia and the USA on this topic.
What type of vitamin B6 did your patient Jane take? You didn't mention that. Was it pyridoxal 5-phosphate or pyridoxine HCL? I heard the latter is harmful like you said. But allegedly P5P can be taken safely in high doses. Is that true?
P5P can also cause issues. It may be a different method though. The bottom line is that if you have disrupted aldehyde detoxification then if you take B6 or even vitamin A I think, then you could get toxicity. I just took 4 capsules of 50mg P5P and now a few days later I have paresthesias all over my body. I never thought it could happen so fast. If there was a way to test for that then you would know if it was safe to take B6.
They are equally horrible.
@@gilly8876
Not at all!
P5P widens the safe range upwards. It's pretty tight with the HCL form.
And it probably reduses the number of genetic traps which can cause trouble for you.k
B6 does a lot of good things in the body, and more of them at higher levels. Until it gets too much, of course.
P5P can absolutely cause toxicity as well. Why there is a rumor going around that it is safe is just another thing on the internet that is false.
From the research paper:
"The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function"
"In conclusion, the present study strongly indicates that the neuropathy observed after taking a relatively high dose of vitamin B6 supplements is due to the vitamer that is used in the supplements, namely pyridoxine. The inactive form pyridoxine competitively inhibits the active pyridoxal-phosphate. As a consequence, the paradox arises that the symptoms of vitamin B6 supplementation are similar to those of vitamin B6 deficiency. Vitamin B6 supplements are used by a large number of people. The safety of vitamin B6 is debated and recently EFSA has lowered the upper limit for vitamin B6. The question is whether lowering the safe dose for vitamin B6 is the solution. Remarkably, even at relatively low dose, vitamin B6 supplementation has given rise to complaints. Our study indicates that the toxicity of vitamin B6 is not only determined by the dose, but by the vitamer in which it is taken. Perhaps it might be better to replace pyridoxine by pyridoxal or pyridoxal-phosphate as vitamin B6 supplements, which are much less toxic. In this way, the vitamin B6 paradox may potentially be prevented."
From another research paper:
The B6 metabolites stays in the body for a number of days. So if you take a high dose daily, it can accumulate. One research paper recommended to take 100 mg once a week to avoid that accumulation.
In conclusion. I don't think pyrodoxin and P5P are the same. Don't take the pyrodoxin form, which is used in most multivitamins! With that form you can get toxicity at the dose of B6 you require!
And don't overdose on P5P either. And you don't need it daily.
It’s very hard to hear the affected lady. But I was three times over the B6 limit from supplements. Plus I was toxic on other vitamins. Had no clue. Then my body started doing crazy things. I’ve never been the same since. I’m not sure if the toxicity messed me up or something else. But, it sucks!
Hi Julia, sorry to hear this. Regulation of supplementation is important as many people don't read the warnings or assume that anything on the market is safe.
I feel ya. My body is doing strange things as well. I will stop multi vitamins and just eat real food.
You can turn on closed captions, Julia. 😊
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Nutritional yeast is very common ingredient in vegan cooking. So disappointed to learn that it has added Pyridoxine Hcl especially as recent blood test shows I have B6 toxicity (602 nmol/L). I have never seen this listed in the ingredients of Australian supermarket brands of nutritional yeast.
How you fix it same
B6 accumulates in muscles and nerves tissues even in small doses
Absolutely it does. Now try educating a Dr on that. They refuse to hear it.😒
Unfortunately GPs get very little nutritional training. I think it is thought that all B Vitamins just pass through. Hopefully bringing attention to this current problem will raise awareness.
Hence the reason that you must cycle your vitamins, for example 8 weeks on then 4 weeks off
Morton's Toe (Greek Foot) is meant to be associated with inability to metabolise B6. This can be addressed by consuming P5P, the activated form of B6.
B6 can build up in people with this condition, without taking any or much supplementation. How do you reduce serum B6 if you are not supplementing?
You have to eliminate it from you diet. And P5P is equally horrible. It's safety is a myth.
So scary. 100 mg P5P is what I've been taking for past 6 months. Why do they make it at that level if its that toxic?
P5P is not a toxic form of vitamin B6
You must cycle all your vitamins intake, 8 weeks on then 4 weeks off
I took 200mg of P5P total in a week and now I have paresthesias. I've been told it is aldehyde toxicity because some people have that detox blocked. That is why others are find with B6. This is horrible. I can't deal with another health problem now.
I just stopped it 3 days ago and feeling horrible my brain feels tension all the time.
Thanks, this is valuable information.
Glad it was helpful!
It can even start being an issue at like 20mg+ daily.
Most the other B-Vitamins are more safe and generally helpful
For Neuropathy and Energy take B2 individually
For skin and general circulation B3 Niacin
B2 for energy ?
After thorough testing from a neurologist and being cleared of MS and ALS, I've been found to have b6 toxicity. The problem is that I do not take b6 at all in any form other than what naturally occurs in food. I'm told this is impossible but I've searched everything I've consumed for the last year and I can assure you there's no b6. Any thoughts on how I can be toxic? My symptoms have been so severe, drs have put me on 2 rounds of steroids.
I am sorry for this
Is ur alkaline phosphate low
@@hawk28912 yes
@Andrew Dimick yes, mine is low too. You thinking hypophosphatasia? I just came across this. I can't seem to get my dr to move on it because 1 of my tests came back normal. 8/10 of my alk phos tests are all below normal. Is there a specialist or regular GP who treats this?
@@gilly8876 ya its gene related
I have tingling in the toes of my feet, and I have a Vitamin B6 deficiency. How to explain this?
Both B6 deficiency and B6 excess cause the neuropathy in your feet. Need to change your diet to add more B6 foods.
La neuropathie peripherique …c est un manque de b1 benfothiamine liposoluble…non?
Peut-ètre. Généralement en excès B6
do u kno if b1 or b2 can raise b6 to toxic or cause similar symptoms
B1 is safe even in high doses and known to help with neuropathy
idk about b2
@@BitZapple well wat happened i developed a b2 deficiency from b1 and for that reason my b6 went up for some reason even though i was taking b2
@@BitZapple hm idk b1 depleted my b2 hence i got a b6 toxicty since b2 deficiency inhibits b6 and creates toxicity
So now you're going to see this more lies we can't believe
Vitamins ate NOT toxic, they have other problems and blame it on vitamins. Paid trolls
Nope. I got toxic from my magnesium supplement which had very high levels of B6 included. Anything in excess is bad for the body and vitamins are no different.
@@carokat1111I’ve been taking a methylated B-complex for years containing 50mg B6 P5P and never had any problems. If your body is unable to get rid of the access vitamins and you get a buildup you probably have an underlying problem. Being deficient in B1 is a really common problem that can cause functional deficiency meaning a high serum vitamin buildup.
@@nameofthegame9664 Not everyone gets toxic. I am just sharing what I know about B6 so that others don't go through what I have done. It took fours years before my toxicity became evident. No underlying health problems in my case but I was taking (unknowlingly) the most toxic form of B6, pyridoxine HCL. I was taking 50mg in my magnesium tablet. The Australian government now has a warning label on pharmaceutical products which carry more than 10mg because of its links to peripheral neuropathy. It's bad stuff.
As someone with normal health who has developed peripheral neuropathy and other symptoms because of excessive B6 leading to toxicity, I can confirm you are 100% wrong. Not a paid troll - just someone wanting to help others avoid the same fate.
@@nameofthegame9664 No. I have had every single test and blood test possible and I am in complete good health. I was unadvertently taking 50mg daily, sometimes twice daily, of a magnesium supplement which contained 50mg of B6 as pyridoxine HCL. That product and others like it, even carries a warning label now from the Australian regulatory authority, the Therapeutic Goods Administration, to avoid it's use if symptoms of neuropathy develop. Any product with more than 10mg is now required to carry this warning. This stuff is TOXIC and the scientific world is slowly awakening to this knowledge.
I'm having a hard time following this. You're not delineating the difference between synthetic B6 pyridoxine hydrochloride, which is toxic, and natural B6 pyridoxal 5' phosphate. Understand that most of the vitamins in the supplement industry are synthetic vitamins, often made from toxic compounds, and that's where the side effects and toxicity are. The synthetic form of B6 is particularly awful.
The rule of thumb is do some research. Understand what the body actually uses, and what's natural, and don't buy any cheap supplement labeled something. These companies ought to face charges for synthetic B6, pyridoxine hydrochloride (HCl).
🪷🙏
Why do THEY make this hard? HCL is synthetic! Cheap to put in supplements PERIOD. P-5-P Is NATURAL. The body RRCOGNIZES natural. Don't ask a doctor... the are too restricted, drug and medicine are driven by greed/money. Chiropractors, Naturepaths, some in HEALTHCARE. NOT medicine. Good luck. I got my PN from them and poor diet (B vit). PN you can relieve, repair & restore.
Unfortunately they can both be toxic, though it may be through different means. I took 200mg P5P total over a few days and now I have paresthesias. This is bad. I've been told it is the aldehyde toxicity which is the problem because some people can't detox that well due to a blocked metabolic pathway from immune / infection.
P5P also causes toxicity for some people despite the medical profession spruiking it at every opportunity. Best to avoid both. I appreciate that she's made this video.
@@MrApplewine so wat can be done for that blocked pathway anything
@@hawk28912 The paresthesia went away after a few weeks and I took sulfur compounds like NAC and taurine. There is a protocol trying to remove the block at a website called born free dot life, but I don't know about that working. I think the problem could be microbiome damage so I got my gut microbiome sequenced from Biomesight and am taking things to fix that. I have IBS-D, so I know mine is messed up.