Hematology | Leukopoiesis: White Blood Cell Formation
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- Опубликовано: 1 окт 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about leukopoiesis. We will be discussing how stem cells are involved in the formation of white blood cells, the chemical factors necessary to drive leukopoiesis, and each individual white blood cell along with their function. We hope you enjoy this lecture and be sure to support us below!
References:
● Deborah Weatherperson. (2020) Medical News Today [digital image] www.medicalnew...
● Teresa Winslow. (2007) WBCs formation [digital image] slidetodoc.com...
● Granulocyte development [digital image] link.springer....
● Agranulocyte vs granulocyte [digital image] www.shuttersto...
● Monocyte pathway. ReasearchGate [digital image] www.researchga...
● OncohemaKey. Macrophages in different organs [digital image] oncohemakey.co... 6 of 6 HEMATOLOGY: Note #1. Leukopoiesis (White blood cell formation)
● Proprofs Hematology (2013) [Quiz] www.proprofs.c...
● Wikivet. Thrombopoiesis Pathway. 2008 [digital image] en.wikivet.net...
● Markus Peck. The action of TPO. Wiley Online Library. 2016. [digital image] onlinelibrary....
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● Sabatine MS. Pocket Medicine: the Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia: Wolters Kluwer; 2020.
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#ninjanerd #Leukopoiesis #Hematology
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This dude deserves a noble price as a best teacher in medical science . Those who are struggle to understand how should read medical sceince I highly recommend watch his video .You definitly will fall in love his teaching method .Best explanation ever.
Totally agree 👍🏻
You purely deserve a Nobel prize for Physiology
Agreed
Yesss! Absolutely! 👏🏼👏🏼
Prize *
YOURE SO SMART, ITS WHEN SOMEONE KNOWS SOMETHING SO GOOD, THEY CAN TEACH IT SIMPLE ENOUGH FOR OTHERS TO EASILY UNDERSTAND IT! THANKS SO MUCH! YOU ARE AMAZING!
Kinda cute how cells are upgrading like Pokémon levelling up to myloids then monocytes etc 😂❤
Haha! 😝💕
You retain an incredible amount of information young man, very gifted. Your understanding of the processes and linkage through out the systems is remarkable. Your drawings are so helpful along with your explanation. I hope you use your talent as a Physician. Please cover Endocrine System if you haven't already.
6 dislikes? The hell is wrong with you people? This segment is high yield!
support this guy and buy a t-shirt, I will do
those who dislikes this video are my science teachers
After promyelocyte is myelocyte and then metamyelocyte and then band and then to either neutro, eos or baso depending on the grnaules
The dislikes are because the information is only partially correct. He doesn't have the WBC lines correct nor does he have the nucleus description correct either. I wonder if he's a student trying to teach. Also the interleukins are not correct, especially for the lymphoid cells
@@binslabajo3152 LOVE IT LOL!!!!!!
This was AMAZING! Can’t thank you enough. Reading my hematology book doesn’t hold a candle to what you just taught in this video.
God, I can't believe how i actualy understood a whole year of physiology and biochemistry in 2 weeks and almost covered the study for my internal medicine exam next week. I told all my friends about this channel. Keep it up! It's amazing job!
P.S - If you could make more pathophisiology viedos it would be awesome!
this guy helped me so much , that i even want to give him my firstborn
I agree 100% to the comment as BEST teacher in medical science. These videos are truly great blessings for me. Excellent presentations, great examples, easy to follow along, never boring, etc. Glad I found this site. Thank you GREAT NINJA!
I'm going to study for my Master degree in Medical science and your lecture videos are really helpful for a non-English speaking person like me. Thanks a lot for your informative videos!
Thank you. I was diagnosed with myelofibrosis which has become chronic. I've been trying to understand the RBC and WBC and how I might be able to help in my situation. Your presentation helps me calm down. It's too much science for me. Thank you.
Thank you so much. I never understood hematology that well. After your lacture everything is so clear. Do you teach in the school ?
may i ask your book preferance. i read several books like haffbrand's essential haematology, William's haematology, Hariison clinical Haematology, and Lange (for pathophysiology); but those book always says different way of leukopoiesis. at hafbrand they are using the code like CFU-GEMM, CFU-GMEo, and many others. on the other hand some books said using the name of the cell and when i want to cross check, it just did not match (i tried to match haffbrand's table in different chapter but with the same topic, yet they are different). so may i know what source are you using. i want to use it for my study too. thanks btw
+clifford eltin hello, I used marieb and hoehn human anatomy and physiology. I hope it helps. I also use guyton and hall physiology!!!
Ninja Nerd Science thanks for the reply bro. I have checked and read the book. It helps me more to understand about haematology. Thanks man
Simply excellent!
Btw, can you do videos on reading a complete blood test results? Thank you.🙏🙏
Why WBC ratio higher in bone marrow then circulation.??
Assalamalikum
Im from maharashtra india and I like yr lecture too much❤
Thanks a lot🎉
Doubt : i hv studied pluripotent hematopoietic stem cell divide into forming colony forming unit-spleen(CFU-S) which further divide into CFU-GM, CFU-M
How can I relate that with myelocytes ?!
Anyone reply
I love this one he is different from all
Monocyte is for the second line of defense especially in chroni and parasitic
Your fingernail is black and your neck....Is it cupping?
are you okay body?
sorry , but I'm just a little worried cuz u r awesome , like really awesome.
58 dislikes? You guys disliking his video can try teaching this topic ,let's see how you do it.mtchw!
Why didnt you mention Metamyelocyte after myelocyte ?
was wondering the same
Metamylocyte is the same thing with band cell. metamylocyte is also called band cell.
Not to my knowlege.... It is usually seen as left shifted with primary and secondary granules. With bands, this is literally before it form to be a N, E or B.. They look very much different.
Dude, you're awesome!!!! I watch u so much my daughter calls ME Ninja Nerd!!! HAAAA!!!!
Love your enthusiasm ! Making learning FUN … been out of medical school since ‘87 … it’s so great to listen ,refresh and learn new material …
Thanks alot i really appreciate your hard work i was having real hard time understanding it now i got it really well thank you alot 🙏 💜
My A&P 2 teacher introduced me to your fantastic videos. Thank goodness! I actually think there is hope for me now :)
Best teacher ❤️ ♥️ 💙 💖 💕 💓 ❤️
I am so glad I found this channel. This is going to help so much in my clinicals. Cheers!
I really wanted to thank you for pausing and asking questions, I found it incredibly helpful. I usually pause the video and try to answer your question as best I can before I continue and I've found it really helps my learning
thank you brittany & where are you from ?
Very informative and excellent visualized lecture 👍👍 I am a kind of person who does not like to read a 📚. I like to listen to lectures and visualization of them. And you made it👍👍👌✌️✌️
This really helps me to understand leukopoiesis. Thank you so very much! And keep the good work!
Lend me your brain
I'm amazed with every video I watch of his. He gives long lasting understanding to every subject and for that I'm truly grateful.
Sir, you are doing awesome work for us by Ninja Nerd Science Channel on RUclips, content of every topic and method of your teaching all are very very good.... I'm very grateful of you.
"Megakaryocyte. And this cell is huge. His very very very very big. Like HUGE." I love you Zach! Thank you for being such an amazing teacher!
Thanks for explanation. From India 🙏
Dude keep it up,👍 please avoid abbreviations. Thanks
This was so helpful. I'm taking the chemo course from ONS and this is actually better explained than their charts and vidoes.
What more can I say? Thankyou so very much for this powerful presentation. Its really helpful
The how question...been asking myself and other people that question for years ...thanks now I know hormones "control everything " in our body.
Your incredible Dr. Professor hope and wish you have a book to read . I have this problem of my WBC . Congratulation good luck and more power . This kind of person must have an award .
You are amazing bro...I understand it easily by your simple explanation ....love from india 🥰
Your videos are so incredibly helpful! Thank you!!
This helped me alot For My Red and White blood cells Test! Thank you!!!! This made it much more easier for me to practice and learn! Btw Am i the only one thats watching this in 2020?!?!?!? Again Thanks!
Awesome
Hi. As English is not my first language, would it be possible to add subtitles please?
I somehow feel tamil actor Madhavan is teaching . Really excellent dedication towards teaching.
Great video. Why did he skip over metamyelocyes?
You have been an amazing teacher! You make learning so fun and interesting. I really understand the material better because of you. Thank you thank you thank you!!!!!! I deeply appreciate your videos❤
This is awsome, you are literally explaining what is on my book, and is more easy for me to see your videos and understand the whole concept.
Very legendary lecture 👌 thank you sir love 💘 from India
I like your videos and they easy and graphic way you use to explain su complex process in human body. I'm studying for my ASCP exam and I commonly come back to your videos to refresh what I've learned. Thank you so much for help us.
Sir, clearly understood. Great help. Thanks a lot
My white blood cells are always high, but no infection is ever found, but I'll break out on my chest when my white blood cell count is high. I've been to a dermatologist. I'm hitting walls with these doctors, I've got thick blood, polycythemia, but they aren't helping me, well I live in Kentucky no wonder
your videos are amazing and so helpful at helping me refresh my knowledge. going from a research job back to clinical job felt a bit like culture shock
Zach you rock, best teacher of all time 100%! You give me hope in humanity!
thanks for the picturesque explanation, very helpful for systematic diseases or for medical students, good very good job, nobelprize nomination from me
pls tell me what my 14 yr olds diagnosis means, her complete blood work up says she has thrombosis disorder with neutropenia disorder..her dr referred us to hemo / oncologist..her appt is at the end of march but i'm on pins and needles worrying what that means..pls reply, you seem very good at what you do..pls reply sir..
I have no word to describe how helped this man has been to me all I can say is God bless you nerd🎉🎉❤
Babby
High hematocrit w low white cells. 5 centimeter right kidney cyst and intermittent pain on right side. What could this mean and how is it diagnosed/ studied at the cellular level?
great video overall! very helpful. but I'm also sort of confused on the aG-CSF, since all the sources i've been reading from just says that it uses GM-CSF for all the cells the myeloid precursor cell are going to turn into. I can understand that it's only because that they don't show up when they are colored, but are possibly still there, but are there a large difference between aG-CSF and GM-CSF? Thanks :3 Keep up the cool videos!
+mutia23mp hello great questions!!! Yes there is many types of colony stimulating factors such as stem cell colony stimulating factor, monocyte colony stimulating factor and these factors can cause the production of many cells. These factors can be so overwhelming sometimes, so for simplicity sake I just said colony stimulating factors for agranulocyte growth and granulocyte growth. I should have taken the time to explain them in more detail. I'm sorry for that!! I hope that helps!!!
Ahhh i see. So I guess it would still all be the same hahaha. Thank you so much for the reply and the video. will be waiting for more videos. :)
Granulocyte cell line have both primary and secondary granules. Monocytes are still considered along the myeloid line and they can have the very fine (ground glass appearance) granules. The monocyte granules aren't defined in appearance like the baso and eos granulocytes in the other lines. Lymphocytes are on a separate line and have no granules at all.
Good day teacher, please i would like to know if there is a video on the increase or decrease in DWC with relation to pathology like there is for RBC?
Thankyou very much sir.. handwriting explanation language presentation all are super cool
These guys are phenomenal, sir have too much respect for you, watching from Pakistan.
Wowwwww! This is the only word I can say😭 thank you.
God bless you sir may i have a permanent account for the videos sir
If yes how can i create that sir please
I have really enjoyed these videos. Wish I had something like this in NURSING SCHOOL, It would have made working on the ONCOLOGY UNIT easier to understand Blood groups & development of Cells. 0800 7-15'23. How many years did it take you to remember all these chemicals & hormones?
Would you please translate it into English? Therefore, we need to know the terms spelling
As a misdiagnosed patient, I am learning way more here than by my doctors. I have been studying my blood work for the last 3 years trying to put it all together.
Thompson Paul Garcia Michelle Rodriguez Angela
He's lowkey hot and highkey cute. When he said the minions thing I was like give me a baby
Was searching baseball vids and this popped up.
So basically, stem cells need the correct hormones in order to make your blood. The kidneys and liver make the hormones needed to make said blood. Did not know that.
Damn, so diabetics get hit with a double whammy when they resort to dialysis.. They stop making the hormones needed to keep your blood in tip top shape.
That was vary informative, even though i didn't understand the lingo.
Thank you.
Good talk. Just curious: what are those red circles on the back of your neck?
I doubt after so long he'll be replying to comments, so can anyone tell me exactly how eosinophils kill parasites? Do they engulf them? Are they antigen presenting? How do they do it please.
The release proteins called major basic proteins or cationic peptides that causes destructive effects on pathogens by way of parasitic aggregation. It also signals mast cells to release histamine causing increased flux of neutrophils and macrophages to site of infection to clear pathogens. Hope that helps!!
Very good, just one thing, myelocytes have more rounded appearence then U shape starts with metamyelocytes and after that band forms is next and ending with segmented forms.
Who the fuck are the dislikers ?
Dude u r amazing.Love from INDIA 🇮🇳
you are an Angel- only found u in 2020... still thanks
Raise your hand if you liked the video even before it started playing...... this man is soo good....👍
Love to watch your explanation Sir👍👍👍
Thanks sir your lecture is outstanding 👌 and it's Make me to understand very easy
Please can you upload this video again, but with subtitles please. For people from Latin America it is a bit complicated without English subtitles. Please please please.
This helped. Keep up the Good Work!!
+Dejhano James Glad to hear it!!!
Thank you sir for your brilliant lecture. Your lecture have made my hematology easy.
You know how much i like you?
I forced all of my 6 family members including my grandparents to support you bro🤣
Can u please tell me how myelopoiesis and leucopoiesis are different
I m confused
Thank you so much for this video. This helped me in so many ways
You only missed out 1 thing. B cells go to the spleen to further mature.
Jarrett Springs
Hi sir what a great teacher you are. Want to say can you add leukemia in your lecture thank you.... It will be great I will be waiting
You are one of the most intelligent people I've ever seen. Damn...my brain is fried and all i did was watched.
ده س خوش زور جوانا
Simply wow,, well explained..
ur voice resembles Salman khan's voice(indian film actor) ..
taken me years to realy apreciate these systems and how they function. tones of iformation made simple for easy understanding and recall
i wish i had watched it when i firstly learned that .it should have been easier.
What's on the back your neck🤔
Ringworm
Please is hematopoietic stem cell pluripotent or multipotent?? Am sooo confused... could you please explain??
Thanks you!! It was easier to understand that reading a whole F**%^% book.. 😊👍🏼
Nice one can you do gout arthritis and haematological malignancies
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