Hematology | Polycythemias

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  • Опубликовано: 24 ноя 2024

Комментарии • 176

  • @jeimycastellanos7743
    @jeimycastellanos7743 5 лет назад +168

    You're a gift to humankind

  • @keithwalker3890
    @keithwalker3890 Год назад +16

    As someone facing the prospect of a dx of PV (just had blood work including JAK2 drawn today) and a recently retired ICU RN, your presentation was outstanding. It puts it all in perspective. You're an outstanding teacher!

  • @cca8244
    @cca8244 2 года назад +24

    Why does this video has so many clicks but much less thumbs up? Guys PLEASE give the videos thumbs up, this channel deserves it by far more than any other!

    • @sonyam8
      @sonyam8 8 месяцев назад +1

      People watch the video multiple times but can only like it once...

  • @wolfie5470
    @wolfie5470 4 года назад +44

    Zach, you are the BEST!!!

  • @TheAznCrazy95
    @TheAznCrazy95 Месяц назад

    I passed my ASCP mlt exam thanks to your videos 3 years ago... am now in a CLS program and here I am once again :') Bless this channel so much.

  • @robertshrewsbury2891
    @robertshrewsbury2891 3 года назад +17

    I had Polycythemia and had to get a phlebotomy about once a month, because my Hemoglobin was around 55 g/dl and my Doctor ordered it.
    Finally I wondered about people with Anemia that were short of red-blood-cells analogously like an opposite to Polycythemia!
    Then I looked up the foods that people with Anemia do not eat because they are iron blockers.
    Many of these foods are called Oxalate's and absorb Iron. So then I started eating these foods (with Oxalate s) abundantly and after a
    few weeks I had my Hemoglobin checked by my Doctor and my Hemoglobin was down to 16 g/dl and now over a year later my Hemoglobin is still 16 g/dl. That is a drop of 39 g/dl’s in a very short time and it held good. Sometimes just a simple procedures are workable.
    Of course I believe that my mental procedures, meditations & thoughts had something added to this procedure that was synergy related that made it more effective.
    Make it clear that I am not prescribing
    anything to anyone, but expressing my own thoughts and experience.
    However I would recommend that medical personnel investigate this.
    Cordially, Robert Shrewsbury

    • @mangeshgadhave6791
      @mangeshgadhave6791 3 года назад +1

      Thanks for the information.. May I know if your RBC was also on higher side and reduced with hemoglobin too?
      Also may I know which Oxalate foods did you take up like beans or nuts?

    • @robertshrewsbury9344
      @robertshrewsbury9344 3 года назад +1

      @@mangeshgadhave6791 My hard-drive went bad and I lost some of the data on the particular oxalates, but I used a lot of them.
      I suspect that oxalic acid diluted to a Ph of say 6 may also work? I used to use oxalic acid in the assay laboratory to absorb iron from my ore, so it would assay better. However I would never do any such a thing without having my hemoglobin checked by a competent medical person, because this could be dangerous if one goes too fat and become anemic!?

    • @mangeshgadhave6791
      @mangeshgadhave6791 3 года назад +1

      @@robertshrewsbury9344 Thanks for the quick reply. Definitely I'm relying on food only and not laboratory things but just curious to know does it help in lowering RBC's too as my RBC's are still bit on higher side 6.05 even after phlebotomy every 3 months?
      My rest of the medical reports are normal so just trying to fix this with diet.

    • @CapricornStories
      @CapricornStories 7 месяцев назад

      ​@@mangeshgadhave6791 hi how are you now

  • @jituchowdhury1744
    @jituchowdhury1744 4 года назад +14

    I never bored to your lecture ..how much long it would...

  • @Maddie-xk5pf
    @Maddie-xk5pf 4 года назад +16

    I'm a fan of your channel since my undergrad days and now, I plan on binge watching your videos before I start medical school to give me a headstart on the basics cuz you give the most detailed yet concise explanations. Thank you for this. You really are a blessing 🥰

  • @davissheffield1531
    @davissheffield1531 6 лет назад +18

    Great video! You have all the specific videos I can't find anywhere else. Good quality and great explanation! Thank you ninja nerds. I found your videos right before my first hematology test. The coagulation cascade and anemia videos saved me! Keep up the great work.

  • @jrtjohnson1974
    @jrtjohnson1974 6 месяцев назад

    I was just diagnosed with PV and this is the most informative explanation I've found. Thanks!

  • @benjaminhlithapi4291
    @benjaminhlithapi4291 5 лет назад +21

    Thank you. Your lectures are my absolute favorite..

  • @IsmailAdamu-y8b
    @IsmailAdamu-y8b Месяц назад +1

    Thanks for the Lecture,
    Additionally; Apart from an increase in the number of red blood cells ("absolute polycythemia")
    It can also be due to a decrease in the volume of plasma ("relative polycythemia")

  • @christianedwards4071
    @christianedwards4071 4 года назад +24

    Indeed so great,,,, you are a blessing to medical students

  • @reemosama5934
    @reemosama5934 16 дней назад

    The video was very beneficial ❤
    I wanted to add something: Another cause to secondary polycythemia is increased thyroid hormone which leads to an increase in oxygen consumption and a decrease in oxygen supply to tissues wich leads to hypoxia that stimulates increased secretion of erythropoieten

  • @mycah1993
    @mycah1993 2 года назад +12

    You are getting me through nursing school! Thank you so much!

  • @OnlyADownstat
    @OnlyADownstat Год назад

    as someone who had a stroke 2yrs ago due to polycythemia (so diagnosed at time of stroke) this gives me new avenues of cause to explore.. Underwent bone marrow tests that proved -ve (so not primera).. have been told ever since it was "transient", despite 5 tablets a day not reducing BP.. will be back at my GP next week.... Thankyou very much

  • @patwatson7038
    @patwatson7038 Год назад

    You have me hooked on these videos. Brings med back to ANATOMY & PHSILOLGY in NURSING CLASSES. THANK YOU. YOU HAVE MADE IS TEALLY SO EASY TO LEARN. 9:23. 7-14'2023

  • @sandywong5473
    @sandywong5473 4 года назад +13

    Thank you. I’ve learned a lots from every lecture you shared. You’re the best 👍

  • @gulzarwani1179
    @gulzarwani1179 3 года назад +5

    Awesome, concise, precise and productive!

  • @rrahmanferizi9829
    @rrahmanferizi9829 Год назад

    Grateful and very empathetic and attractive explanation
    Prof., Rrahman FERIZI

  • @architasaha8917
    @architasaha8917 4 года назад +1

    Good gifted human. I am overwhelmed with your concept. Big thanks.

  • @artlovelily8144
    @artlovelily8144 2 года назад +1

    I owe so much to u.... U are a blessing for medical students.... God bless u and may u get aalll the happiness ....💗💗💞💞

  • @Jupiterian26
    @Jupiterian26 2 года назад +1

    This was Zack's pathway.. amazingly explained 👏 👌 👍

  • @SamwelPkemoi-k8t
    @SamwelPkemoi-k8t 9 месяцев назад

    Thank you very much, may God bless. You really make me understood through your well elaborated lecture. Thank you🙏

  • @musttoknow3469
    @musttoknow3469 Год назад +1

    i hope there will be a subtitle that was made by you guys, not just by the youtube cause some words are not right, and its make me confuse. thank you. i love ninja nerd

  • @JerryFlanaganOD
    @JerryFlanaganOD 2 года назад +4

    Been battling secondary polycythemia for 2 years now and this video really helped my understanding. I think my best solution is focusing on hydration now and your other "Approach to Polycythemis" helped me with that. Thank you!!

    • @АлексейЛесуков-ч3ь
      @АлексейЛесуков-ч3ь 2 года назад

      Yeah keep yourself hydrated , take one to two 80 mg aspirin daily and donate blood every 2 months and you will be fine.
      He forgot to mention other causes an increase of red blood cells or secondary polycitemia Vera like the use of Anabolic steroids, smoking reduces the oxigen capacity and so is sleep Apnea.

    • @chrisoliver9442
      @chrisoliver9442 Год назад

      I've been fighting this for almost 2 years now it's still unclear on how I got this my hematologist still will not give me any answers why is that ? I have been experiencing hip and joint pain ! It really irritates me that he won't give me any answers on my condition he just suggests I speak to my PCP ! Why can't he answery questions ? Just saying

    • @Secondaryihr
      @Secondaryihr 10 месяцев назад

      ​@@chrisoliver9442 What are those actual symptoms of this? I'm researching on it because my rbc is slightly higher ( Only 0.4 than normal range) & I feel extreme cold sensitivity which seems intolerant to me with breathing problem like chest pain while taking deep breath.

    • @CapricornStories
      @CapricornStories 7 месяцев назад

      ​@@chrisoliver9442 hey how are you now did you find out anything

  • @swatisinha4763
    @swatisinha4763 4 года назад +1

    Your lectures saves lives. .trust me 👍👍

  • @navaneeth_us
    @navaneeth_us 2 года назад +1

    Top-notch conceptual correlation and beautifully crafted and articulated video.
    Thank you so much.
    14/JAN/2022, Friday, 12:20pm IST

  • @maivezonk
    @maivezonk 9 месяцев назад

    Actually in PV, the WHO criteria requires seeing "panmyelosis" in the bone marrow - an increase in all three lineages made by the myeloid stem cell. So someone with PV will have high red blood cells and/or high platelets and/or high hemoglobin and/or high granulocytes. High leukocytes in PV confers a higher risk of thrombosis per the WHO MIPPS-PV risk stratification algorithm. Btw, I really appreciate you talking about Secondary Polycythemia. I'm trying hard to find something to educate patients who have this - but patient guides or videos for secondary are sorely lacking.

  • @rayzuc3
    @rayzuc3 3 года назад

    This topic made no sense to me until now! Thank you!

  • @Jenny420ky
    @Jenny420ky 2 года назад +23

    I've had 2 cancer doctors. One said we will blame it on your mild sleep apnea, the other doctor said, is not a cancer, I'm on 81mg aspirin. When I checked my patient portal, one said polycythemia vera and then one said secondary but I'm in stage 2 kidney disease and my family doctor didn't tell me. So now I'm going to another cancer doctor for 3rd opinion. I itch after a shower, I burn up, shortness of breath sometimes, I'll sweat at nights sometimes. Heat about takes me out in the summer. I can tell when I have way to much blood and I'm thinking about just donating blood to get those levels down.

    • @rlove3222
      @rlove3222 2 года назад +4

      Have you had a bone marrow biopsy or have you been tested for the mutations?
      Why are they not doing regular CBCs for you?
      Polycythemia Vera is considered a blood cancer or chronic leukemia.
      Find someone who will test you for those things and monitor your blood counts as all of your symptoms are saying PV.

    • @Jenny420ky
      @Jenny420ky 2 года назад +5

      @@rlove3222thanks for your concern, around here, it's hard to find good doctors that will listen to you. I've been on top of oncologist after oncologist. My hubby has a great oncologist that recently came back to work after breaking his leg, he's going to look over every blood panel I've had going back 1 yr. And to the recent blood work I've had, but he will repeat every blood panel, he will probably do a bone marrow biopsy. If he does a run around with me, I'll just stop going to a doctor all together. I've been dealing with this problem for a long time, my CBC will be elevated sometimes and I rarely get infections. But it's showing my red blood cell count will go up and down. I'm all over the place and I'm becoming more frustrated cause of how I'm being tossed around. I want to have high hopes for this oncologist but when you have been done so shitty, you don't know what to expect. Hopefully I'll have answers soon.

    • @chetanrs
      @chetanrs Год назад

      Looking at the description of your symptoms you MAY have polycythemia ( elevated RBC) so for your peace of mind, pls, get CBC blood test -- the hemoglobin, hematocrit and RBC count must be elevated all the time then your doctor may evaluate you for further testing, for diagnosis.
      He may order a jak2 mutation blood test, if this test turns out negative then you don't have polycythemia vera if it's positive the you have it.
      If a jak2 mutation test is negative then you won't need a bone marrow test, BUT if you've had any blood clots with a negative jak2, then the doctor may order a bone marrow test.

    • @Jenny420ky
      @Jenny420ky Год назад +2

      I've had all testing including a bone marrow. I've got Polycythemia Vera. My jak2 is positive.

    • @chetanrs
      @chetanrs Год назад +1

      @@Jenny420ky oh I see, I'm sorry. Hope you're managing it well.

  • @akkilicoguzkagan
    @akkilicoguzkagan 5 лет назад +5

    Excellent video as always! Thank you very much for your content!

  • @iqra4397
    @iqra4397 4 года назад +4

    Ur teaching skills are just perfect ❤

    • @АлексейЛесуков-ч3ь
      @АлексейЛесуков-ч3ь 2 года назад

      He forgot to mention other causes an increase of red blood cells or secondary polycitemia Vera like the use of Anabolic steroids, smoking reduces the oxigen capacity and so is sleep Apnea.

  • @Aviation_Professional
    @Aviation_Professional 3 года назад +1

    As a PA-C now you will routinely see elevated counts in RBC from your men on TRT. Teach all providers the difference between PCV and erythrocytosis.

  • @hafsaahmed5759
    @hafsaahmed5759 2 года назад +2

    polycythemia can result from excessive intake in which of the following?cobalt,copper,iron,phosphate or manganese

  • @stephanies524
    @stephanies524 5 лет назад +4

    thank you for your excellent explanations!

  • @norenelaggart2477
    @norenelaggart2477 3 года назад +2

    Great job! Do one on Essential Thrombocythemia please

  • @robertshrewsbury4241
    @robertshrewsbury4241 2 года назад +3

    I had Polycythemia/cancer and my g/dl's was 62 g/dl's instead of 16 and I had to get a pint of blood (Phlebotomy) drained out of me a lot. So I started taking oxalate foods until my hemoglobin was back down to normal at 16 g/dl's Strawberries are good oxalated, but so is rhubarb, but I thought rhubarb was too much Oxalate, so I stuck with strawberries. I am aware that too much oxalic can also be harmful.

  • @theravipaswan7314
    @theravipaswan7314 8 месяцев назад

    Thank you sir❤
    From India (Bihar)❤❤
    A lot of love to you😘😍

  • @beerandbones614
    @beerandbones614 6 лет назад +4

    Great teacher SIr.. Excellent! If one has polcythemia (secondary) From trt , and does not get rid of some blood. How long will it take to get back to a normal hemoglobin and hematacrit if they get off of trt. Thanks

  • @fethiyahassen2404
    @fethiyahassen2404 4 года назад

    You are such a genius, God bless your brain!

  • @dannybau
    @dannybau 3 года назад

    I have secondary polycythemia and one of the probable causes given was my recently diagnosed severe sleep apnea and smoking.
    My Apnea Hypopnea Index (AHI) was 92 (average of 92 apneas/hr in sleep with a desat over 4% causing an arousal). This was most likely ongoing for years. After several phlebotomy sessions over 2 months (500 cc of blood removed each weekly session), the RBC count dropped into a safe level.

    • @mangeshgadhave6791
      @mangeshgadhave6791 3 года назад

      Hello @dannybau,
      May I know if you still need to do the phlebotomy? What was your highest count of your RBC's ?

    • @chetanrs
      @chetanrs Год назад

      How are you doing nowadays ? Are you still on a CPAP ?

  • @manir.moniri2055
    @manir.moniri2055 4 года назад +2

    you are amazing! thank you for all your wonderful vids!

  • @tgifford4
    @tgifford4 3 года назад +3

    What percentage of population with the JAK2V617F mutation do not go on to develop a myeloproliferative neoplasm?

  • @Mystic.Space.Queen01
    @Mystic.Space.Queen01 2 года назад

    This was helpful really I’m not a med student but I was just told I have Polycythemia secondary, but what happens if someone has both polycythemia and Antiphospholipid antibody syndrome?

  • @freedomfighter5269
    @freedomfighter5269 6 лет назад +1

    Just great, u just injected the topic in mind.

  • @SarahChicharro
    @SarahChicharro 3 года назад

    This is a great video, so happy I found you.

  • @rickyarzulfandalay9851
    @rickyarzulfandalay9851 5 лет назад

    thanks for the video, this help me for my study in turkeys hematology.

  • @sharanshah5446
    @sharanshah5446 3 года назад

    Best in the business💕

  • @drhamnaashrafmbbs8267
    @drhamnaashrafmbbs8267 4 года назад +4

    Thanks alot. May Allah bless u

  • @jeshmajenniferjoy4135
    @jeshmajenniferjoy4135 6 лет назад +2

    Perfect explanation sir 😊Thanku

  • @cindymanyasi8673
    @cindymanyasi8673 Год назад +1

    Hallo Ninja does excessive use of diuretics and inadequate fluid intake cause secondary polycythemia?

  • @cherylmartelli788
    @cherylmartelli788 5 лет назад

    Love how you explain things..great teacher

  • @user-cy5ol3xl5y
    @user-cy5ol3xl5y 4 года назад

    At one time i got really sick and had blood work done at the ER. O had high hematocrit and high bilirubin, still never found out why but i was drinking alcohol a whole lot

  • @stepup5338
    @stepup5338 6 месяцев назад

    You are special man!

  • @joshuasieradzki5231
    @joshuasieradzki5231 4 года назад

    I'm doing homework and one of the questions asked me to identify any assessment findings that indicate Hypoxia. One of the findings was a ruddy purplish color. I chose this as part of my answer and was marked wrong. The feedback said ruddy purplish color can indicate COPD or Congestive heart failure and is caused by Polycythemia. So I guess in a way I was still wrong because polycethemia can result from the body responding to hypoxia? Okay I think I just answered my own question. Basically patient can have normal oxygen saturation levels and have an off color. I need to look at pictures for a side by side comparison.

  • @pkde1347
    @pkde1347 8 месяцев назад

    If there is an increased propensity to clot then why should there be increased bleeding/an increased prothrombin time?? I am confused. Can you please reply to explain?

  • @lulamaroxar8589
    @lulamaroxar8589 3 года назад

    You are very good at what you doing

  • @unknownname8898
    @unknownname8898 2 года назад +1

    Sir can we say polycythemia also occur in anemia

  • @alanmundy1536
    @alanmundy1536 3 года назад

    Interesting lecture, but I would add as a contributor to secondary polycycthemia - testosterone, especially for those receiving testosterone replacement therapy.

  • @rubydheri3885
    @rubydheri3885 2 года назад

    Thank you 🙏🏻. Your the best 👍👍

  • @ankitapatel4893
    @ankitapatel4893 Год назад +1

    Thanks a lot sir 🙏

  • @agglyusr
    @agglyusr 4 года назад

    Now I get it! Thank you!

  • @مهجهمحمد-ب7ي
    @مهجهمحمد-ب7ي 3 года назад +1

    allways You r the best.. alot of thank🌹🌹🌹🌹🌹🌹🌹

  • @amanyalfaris3525
    @amanyalfaris3525 9 месяцев назад

    Could you confirm polycythemeia only by peripheral blood smear ?

  • @farhanishrak612
    @farhanishrak612 3 года назад

    sir bring video on leukemia ,lymphoma ! plz

  • @albarraaabdulla3753
    @albarraaabdulla3753 4 месяца назад

    Cool .
    Best Ninja in world

  • @iqra4397
    @iqra4397 4 года назад +1

    How it result in bleeding if viscosity is high??plz tell

  • @DrWhoIsHere
    @DrWhoIsHere 2 года назад

    You are like a scholarship to me🖤😄

  • @urmothwr
    @urmothwr 5 месяцев назад

    Polycythemia = increase in hematocrit and/or hemoglobin
    Erythrocytosis = increase in number of erythrocytes but not necessarily hemoglobin for example

  • @clarajonas3538
    @clarajonas3538 3 месяца назад

    Thank you ❤️

  • @shilpisaha8969
    @shilpisaha8969 3 года назад +1

    Great video, Thanks

  • @FlipMacz
    @FlipMacz Год назад +1

    What if JAK2 negative - ZERO underlying conditions - EPO normal...would this be a case for primary PV?

    • @yawargulzar6956
      @yawargulzar6956 Год назад

      MOST UNLIKELY PRIMARY

    • @chetanrs
      @chetanrs Год назад

      how is your hemoglobin, hematocrit and RBC count ? Are they elevated ?

  • @uptown1317
    @uptown1317 2 года назад +1

    I have recently been diagnosed with Secondary Polycythemia. I have been told to consult a Hematologist. I am scared. I hope I don't have kidney cancer. What should I do?

    • @LastTrump7
      @LastTrump7 Год назад

      How are you doing now and how are you treating it?

  • @tammywade3649
    @tammywade3649 7 месяцев назад

    Is it still polycythemia if it's the white cells and platelets that are high??

  • @kemalwoliye4491
    @kemalwoliye4491 3 года назад

    Extraordinary.

  • @josephnoonan5255
    @josephnoonan5255 2 года назад +1

    So mine is caused by taking testosterone for hypogonadism. Is that primary or secondary?

    • @rlove3222
      @rlove3222 2 года назад

      Secondary due to medications. I had to have a bone marrow biopsy and tests for the mutations. I had a TIA almost 9 years ago and am treated with phlebotomies and aspirin.

  • @jackblack4367
    @jackblack4367 4 месяца назад

    I know a person who told me they have cancer of the blood. They were producing too much red blood cells. They have this person taking meds. This will eventually lead to either kidney and or liver cancer. . After this video. I am frustrated at doctors for not evaluating and treating the issue

  • @park6768
    @park6768 2 года назад

    Perfect video!!

  • @putuganggapusphitadewi3402
    @putuganggapusphitadewi3402 4 года назад +1

    thank u so much sir

  • @raywalteroutdoors
    @raywalteroutdoors 4 года назад +1

    Testosterone causes an increase in red blood cells and more viscous blood leading to donating to bring values to normal

  • @en_zone19
    @en_zone19 11 месяцев назад

    Thank you 💚💚💚

  • @jgirish6549
    @jgirish6549 2 года назад

    Why bleeding occurs despite increase in megakaryocytes

  • @aajohnsoutube
    @aajohnsoutube 6 месяцев назад

    Can’t there also be secondary due to Spleen not removing RBC.

  • @rajbirajdar1630
    @rajbirajdar1630 4 года назад +1

    Thanks sir

  • @LastTrump7
    @LastTrump7 Год назад

    I didn’t hear anything about the possibility of sleep apnea causing this?

  • @NONAME-cf6qq
    @NONAME-cf6qq 2 года назад

    Just loved it

  • @jbh666
    @jbh666 4 года назад

    What is the increase of RBC with normal epo levels caused by?

  • @zuhaalkareem9502
    @zuhaalkareem9502 Год назад

    Wonderful 👍

  • @Isabella-d3r5h
    @Isabella-d3r5h 9 месяцев назад

    The one and only 🤟🏿

  • @gymbox4555
    @gymbox4555 5 лет назад +2

    Sir I honestly ask you to follow some kind of text book and add the total index in a video and I even want to pay you if u follow pathology (robbins), pharmacology (tripathi),micro(satyanarayana),and some kind of other books which u like,u want an index and I really love the way u do it.i want to buy your videos and host an app for you

  • @baraaka5376
    @baraaka5376 3 года назад

    Thanks so much

  • @bonitamayers1780
    @bonitamayers1780 2 года назад

    My all in all

  • @thebestinbiologyandmedicine
    @thebestinbiologyandmedicine 10 месяцев назад

    Why there is bleeding?

  • @monika246
    @monika246 4 года назад

    Sir cor pulmonale causes increase in epo?

  • @gc3800
    @gc3800 5 лет назад

    very good thank you

  • @mathewj-6563
    @mathewj-6563 8 месяцев назад

    Thankyou ❤

  • @jaimedpcaus1
    @jaimedpcaus1 5 лет назад +1

    What's the blood test that would show EPO in high levels? Thanks.

  • @baraaka5376
    @baraaka5376 3 года назад

    We need a video of how can you be that

  • @tqb43
    @tqb43 2 года назад

    So what does it mean if your RBCs are high and your EPO is normal? (And jak2 negative)

    • @babumanu895
      @babumanu895 Год назад

      Idiopathic erythrocytosis , also not just jak2 u must do a complete mpn reflex panel test and a bone marrow test … sometimes jak 2 is negative but bone marrow has features of mpn

    • @chetanrs
      @chetanrs Год назад

      ​@@babumanu895what if a bone marrow test in normal for Idopathic Erythrocytosis? Is mpn reflex panel still required ?

    • @CapricornStories
      @CapricornStories 7 месяцев назад

      Hey how are you now