Just thought I should let you know you are genuinely the only reason I know any haematology. On behalf of every medical student on the planet: thank you SO much.
Thank you. I’m a retired female physician. My HCT is 55. Platelets 552. WBC 12K. And I just tested positive for JAK2 mutation. Thanks for the brief yet thorough explanation.
I’m afraid I feel awful. Multiple vague symptoms. I’m also healing from parathyroidectomy surgery. I was hoping that would fix most of my symptoms but it looks like that won’t be the case. The burning feet, night sweats, fatigue and joint pain are especially bothersome. I quit practicing due to these symptoms.
I’m not a student, I suffer from PV and this instruction really helped me understand this better despite a couple years of previous research. Also, sadly, I’m not an old guy! Great job and thank you.
My last exam in medical school is in less than 3 weeks and I just came over your videos. Wanted to let you know that YOU ARE AWESOME!!! Thank you, thank you, thank you! #Gratitude
It took a years and years to get diagnosed with PV. So this is great maybe it can help educate doctors on what to watch for so patients don't suffer as I did.
I Diagnosis Polycythemia Rubra Vera PRV/PV from ealy 2014 and I know I have PV In 2012... In May 2015, I have experienced in Transients Ischemic Attack symptoms TIA with MRA scan showing severe stenosis in L proximal M1 it's means Blood clot in brain... I have to keep Red Blood Count *Hemoglobin* in 14g to 16g with 2 or 3 monthly Venesection... Apa yg aku Nak share Kat sini, betapa bernilai nya hidup di waktu sihat tapi di saat ini AKU Belajar lebih menghargai segalanya yang ada di SEKELILINGKU... Thank you Allah atas segala pengalaman ni...
@@mmns2910 I am feeling absolutely 💯 percent doesn't have much of a impact on my daily life now and again I feel tired 😴 . But as long as I get a good 8 hours sleep a night it's fine .hope you're mum is OK and if you need a chat I am here don't mind 😉 answering any questions .
@@georgehotham1312 Thank you for the kind response, much appreciated. My mum is feeling very tired and has swelling in her legs with some bruises but going every 3 weeks on check ups. It's nice to know that she is not the only one and it means a lot to have a community that are supportive with one another. Thank you.
@@mmns2910 Your welcome as long as she is been seen by hematology team she be well looked after took me about a year to settle into my treatment plan and only going every 3 months now . And like I said feeling OK now 🙂 Tell your mum she be fine and much love to you all
Stay Happy Prof ❤❤❤ for ur lectures. # High blood viscosity is due to: High Cellular Count Or *** Reduced Plasma Volume not Increase Plasma Volume (I THINK SO) 14:09 #Case Answer: C.
I found out I had ET after a neck injury and clot in my vertebral artery developed. 5 strokes before I found out. I was 43 at the time. I have no difficulties related to those strokes (strokes of luck). I recently started itching like crazy after a shower. I tried everything I could think of to fix what I thought was my dry skin. I changed my skin and hair products. I just learned from your videos that I probably have converted to PV!! All the labs were so different and that dang itching. Tried Benedryl today and it helped a little. Thank you!
I just found this video. My husband has polycythemia vera for about 9 years now. We never know how he gets it. I hope to get the answer here. I'll watch the video when I get home later.
I'd like to add a correction: Major WHO criteria are as follows: Hemoglobin >16.5 g/dL in men and >16 g/dL in women, or hematocrit >49% in men and >48% in women, or red cell mass >25% above mean normal predicted value Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic, and megakaryocytic proliferation with pleomorphic, mature megakaryocytes (differences in size) Presence of JAK2V617F or JAK2 exon 12 mutation The minor WHO criterion is as follows: Serum erythropoietin level below the reference range for normal So i actually don't know if this is a correction or maybe you're using different criteria than the WHO but in my uni we use WHO so whatever :) Thanks for the video! Reference: ashpublications.org/blood/article/127/20/2391/35255/The-2016-revision-to-the-World-Health-Organization emedicine.medscape.com/article/205114-workup#c1
Ur way of teaching is best Kindly add new treatment options of topic Like prv now adays jak 2 inhitirs withbname ruxolitinib , peg alfa interferon. R also treatment options.. Anywz quite helpful
Thank you so much, your lectures are perfect . the major and minor criteria are different from what i have learned that was the only confusing part of this lecture . ALL LOVE FROM REPUBLIC OF TURKEY
U r saving my life literally!!! missed a few lectures and feel like i am gonna die in the next exam keep up the good work!!! Thank you sooooooo much T.T
Great video as always. Just needed to mention that JAK2 mutation doesn’t cause JAK 2 to stimulate EPO or TPO receptors. It’s a signal transducing protein hence the mutation causes it to be constitutively active without EPO or TPO stimulation.
I think you need to update this. It may be primarily diagnosed of the elderly--but you are incorrect in calling it a disease of the elderly. But there are many people who are diagnosed with PV and have the JAK 2 gene mutation.
My brother aged 71 died two days ago. He had Polycythemia Vera and Myelofibrosis. He had multiple strokes and blood clots over the last few years. He fell and cracked his ribs and nicked his liver. Within a couple of weeks his body couldn’t fight any more. Rectal bleeding, inability to eat, cirrhosis of the liver, infection from IV and severe pain.
The hydroxyurea stopped having an effect about a year and a half in. They started giving something called jackify and that has been holding steady for the last couple of years
@aregahailu2487 1. Getting diagnosed with pv is an extremely time consuming, intensive and expensive process. So I find it very hard to believe that the doctors you have there were willing and able to do all of that just to not treat you for the disease. 2. Hydroxyurea is a chemotherapy drug. You can get it through any Dr who treats cancer. 3. Jackafy is $20,000 for one months supply.
I am one of whom I Watch most of your videos for a while and I find them them very enjoyable and informative But I want to note something, there are 3 Major criteria to diagnose PV and bone marrow is one of them. For diagnosis it is required to have 3 major and 1 minor. Thank you
Thank you for the great videos. I am 63, female, fit, active, nonsmoker, 2 glasses of wine per week, no other issues except removal of half my thyroid and take 88 mg per day. I cook everything from scratch, Mediterranean diet. I noticed my ferritin levels raising over the last two years, now at 390 and then in the last eight months my platelet counts were going up, now at 600, I was diagnosed with ET JAK2. Bone Marrow biopsy taken waiting for results. Do you think that there is any correlation to the ferritin? My doctors just kept saying I had Covid or I was fighting a cold. Thanks so much!
thank you for the great lecture . i have a question please mentioned in your lecture in time 1:39 . when PV converted PM so the patient will have anemia in PM after having high hemoglobin in PV ?
very interesting lecture.your way of teaching is very good.i entirely depend on your videos for indian pg medical entrance.sir please post videos on pharmacology also
My 39 year old son has PV. When he was diagnosed, we were asked if he had ever been exposed to anything? I recently wondered if the chemicals found in the Round Up weed killer may be a cause as he played baseball (no weeds on a baseball field) and has been exposed to it. Thanks for your video. Lorie
🦠Antibiotics Lectures: www.medicosisperfectionalis.com/
📝 Download Notes: www.medicosisperfectionalis.com/
The answer is C??
Just thought I should let you know you are genuinely the only reason I know any haematology. On behalf of every medical student on the planet: thank you SO much.
My pleasure 😇
That’s why I wake up every morning...to help students 😊
@@MedicosisPerfectionalis thanku so much for ur hardwork❤❤❤
Unique presentation. You dissect the subject. And simplify it. Proud Egyptian
As I watch this I realize other lecturers make this work seem so difficult when it's actually easier with u
I am a lecturer of hematology, but really I am learning the the excited way of lecturing from you, thank you
Thanks a ton, dear! I am honored!
He is very smart and intelligent . I love Dr. Medicosis
Watching your videos before the respective lectures in class is making a real difference. Much more retained knowledge afterwards.
I appreciate you so much, Eylül!
Thank you so much for supporting my channel!
Am a medical student but i can really say you have widened my hematology understanding through your lectures thanks much 🙏🙏
My pleasure 😇
I was diagnosed with PRV and I found this super interesting and informative! Thankyou
You are bloody good. Your videos are literally carrying me through hematology in my clinical classes
Thank you. I’m a retired female physician. My HCT is 55. Platelets 552. WBC 12K. And I just tested positive for JAK2 mutation. Thanks for the brief yet thorough explanation.
You’re very welcome!
How is your health, doctor?
I’m afraid I feel awful. Multiple vague symptoms. I’m also healing from parathyroidectomy surgery. I was hoping that would fix most of my symptoms but it looks like that won’t be the case. The burning feet, night sweats, fatigue and joint pain are especially bothersome. I quit practicing due to these symptoms.
I’m not a student, I suffer from PV and this instruction really helped me understand this better despite a couple years of previous research. Also, sadly, I’m not an old guy! Great job and thank you.
I felt the same! More information than I have found or that my doctors have explained to me in a year. And I don’t think I’m that old either. Lol
Joe d...what kind of test have done for pv confirmation
I feel the same way bro, I’m only 26
I am diagnose with PV and right now taking. Ascal en hydroxyurea. I suffer from itchiness mostly back of my body. Thanks for this info
Is this a fatal sickness or shall I say. cancer?
My last exam in medical school is in less than 3 weeks and I just came over your videos. Wanted to let you know that YOU ARE AWESOME!!! Thank you, thank you, thank you! #Gratitude
Grateful people are the best...I am honored! Keep at it, you will pass if you stay focused 👏
Same.. mine is in a week. N i just wanted to finish heamat so bad
Study hard...You can do it 👏
It took a years and years to get diagnosed with PV. So this is great maybe it can help educate doctors on what to watch for so patients don't suffer as I did.
I am so sorry to hear that you went through this!
I can't prescribe how amazing are these lectures.. Thank u so much for your help
Glad you like them! Thank you!
Would you please help me by sharing?
I Diagnosis Polycythemia Rubra Vera PRV/PV from ealy 2014 and I know I have PV In 2012...
In May 2015, I have experienced in Transients Ischemic Attack symptoms TIA with MRA scan showing severe stenosis in L proximal M1 it's means Blood clot in brain...
I have to keep Red Blood Count *Hemoglobin* in 14g to 16g with 2 or 3 monthly Venesection...
Apa yg aku Nak share Kat sini, betapa bernilai nya hidup di waktu sihat tapi di saat ini AKU Belajar lebih menghargai segalanya yang ada di SEKELILINGKU... Thank you Allah atas segala pengalaman ni...
Answer C is correct in my opinion.
Thanks now I no more about my PV in the last 9 minutes then I have in the last 2 years since been diagnosed . Big thanks my friend
You’re very welcome!
This condition is treatable. Please follow up with a good oncologist...You can get through this.
Good luck to you!
How are you filling now, my mum has been diagnosed with PV last January and just wanted to know how other patients are? Thank you.
@@mmns2910 I am feeling absolutely 💯 percent doesn't have much of a impact on my daily life now and again I feel tired 😴 . But as long as I get a good 8 hours sleep a night it's fine .hope you're mum is OK and if you need a chat I am here don't mind 😉 answering any questions .
@@georgehotham1312 Thank you for the kind response, much appreciated. My mum is feeling very tired and has swelling in her legs with some bruises but going every 3 weeks on check ups. It's nice to know that she is not the only one and it means a lot to have a community that are supportive with one another. Thank you.
@@mmns2910 Your welcome as long as she is been seen by hematology team she be well looked after took me about a year to settle into my treatment plan and only going every 3 months now . And like I said feeling OK now 🙂 Tell your mum she be fine and much love to you all
Stay Happy Prof ❤❤❤ for ur lectures.
# High blood viscosity is due to:
High Cellular Count Or *** Reduced Plasma Volume not Increase Plasma Volume (I THINK SO) 14:09
#Case Answer: C.
I wish my instructors can explain the way you do. Awesome job! Keep it up ✌️
I am so honored and humbled...So happy to hear that...You made my day!
I found out I had ET after a neck injury and clot in my vertebral artery developed. 5 strokes before I found out. I was 43 at the time. I have no difficulties related to those strokes (strokes of luck). I recently started itching like crazy after a shower. I tried everything I could think of to fix what I thought was my dry skin. I changed my skin and hair products. I just learned from your videos that I probably have converted to PV!! All the labs were so different and that dang itching. Tried Benedryl today and it helped a little. Thank you!
My pleasure...Please talk to your doctor, because I am not one...I wish you the best of luck!
@@MedicosisPerfectionalis oh I have talked and talked and will talk some more... thanks
I just found this video. My husband has polycythemia vera for about 9 years now. We never know how he gets it. I hope to get the answer here. I'll watch the video when I get home later.
Not all hero's wear capes. Gon' pass my boards just because of you🙇🏻♂️
Haha 😂
Thank you so much 😊
Good luck to you!
I'd like to add a correction:
Major WHO criteria are as follows:
Hemoglobin >16.5 g/dL in men and >16 g/dL in women, or hematocrit >49% in men and >48% in women, or red cell mass >25% above mean normal predicted value
Bone marrow biopsy showing hypercellularity for age with trilineage growth (panmyelosis) including prominent erythroid, granulocytic, and megakaryocytic proliferation with pleomorphic, mature megakaryocytes (differences in size)
Presence of JAK2V617F or JAK2 exon 12 mutation
The minor WHO criterion is as follows:
Serum erythropoietin level below the reference range for normal
So i actually don't know if this is a correction or maybe you're using different criteria than the WHO but in my uni we use WHO so whatever :)
Thanks for the video!
Reference:
ashpublications.org/blood/article/127/20/2391/35255/The-2016-revision-to-the-World-Health-Organization
emedicine.medscape.com/article/205114-workup#c1
Same❤
this was an amazing lecture on PV. I am an NP student about to take my boards. Thanks :)
My pleasure 😇
Good luck 🍀
Mutated JAK2 does not stimulate, but simulate EPO and TPO receptor activation.
Ans is C. Hypercellular bonemarrow with panmyelosis
"It's called gravity" 😂
That made me laugh for some reason, thank you so much ! 😂❤
😅😂...My pleasure! Take care 😊
Thanks a lot
I study my exams with your videos
Wonderful...Keep slaying it!
I can tell that this guy is a nerd, but he's kinda like the stud among the nerds😎🤣🤣
Haha 😂
Wallahi i really dunno how to thank you you do more than you even expect urself ur foing💜💜💜
Thank you 🙏
Option c is correct
Hyper cellular marrow with pan myelosis.
WHO 2016 criteria modified FOR PV changed sir…Hb more than 16.5gm/dl for male .16gm/do for female.Thank you for your nice presentation ❤
I am learning from you more than my DR. I have pv and Mastocytosis. SM-AHN
Thank you so much for watching!
I am so sorry you’re going through this...It must’ve been hard!
Please do you take drugs . I am PV patient living in third world with no drugs available
I love you pro 💙 I am from Yemen.
Best doctor 🔥
Thank you!
Ur way of teaching is best
Kindly add new treatment options of topic
Like prv now adays jak 2 inhitirs withbname ruxolitinib , peg alfa interferon. R also treatment options..
Anywz quite helpful
Thank you so much for your honest and valuable feedback
Funny + educated = amazing person!
Thanks man!
Thanks for your continuous encouragement!
Thank you so much, your lectures are perfect . the major and minor criteria are different from what i have learned that was the only confusing part of this lecture . ALL LOVE FROM REPUBLIC OF TURKEY
Thank you 🙏
I think the guidelines have changed.
The answer is C baby 😂💕
😁 Correct!
yep
Your way of teaching very good
I truly appreciate it
Great video
Answer is C.
Myeloproliferative baby. Haha loving your videos
Happy to hear that 😎
Answer of case study is C
I thank sooooo much you really help me in studying pathology i ammmmmmmm sooooooo thankful
U r saving my life literally!!! missed a few lectures and feel like i am gonna die in the next exam
keep up the good work!!! Thank you sooooooo much T.T
You will do great...Keep it up 👍👍
I made a mistake in this video...In CML, there is actually increased basophils (not neutrophils, which was a mistake)
Thank you 🙏
The answer is c
These videos saved me and my marks thank you
Thank you so much 😊
Can you please help me by sharing?
Answer is C
Btw great video
Excellent...and thanks 🙏
Great video as always. Just needed to mention that JAK2 mutation doesn’t cause JAK 2 to stimulate EPO or TPO receptors. It’s a signal transducing protein hence the mutation causes it to be constitutively active without EPO or TPO stimulation.
You’re correct!
I think you need to update this. It may be primarily diagnosed of the elderly--but you are incorrect in calling it a disease of the elderly. But there are many people who are diagnosed with PV and have the JAK 2 gene mutation.
Go ahead..up more and more..it will be a blessing fr us..thanks
this dude is a genious
Wow 🤩
Thank you ☺️
this video is so well done, i am amazed.Thank you, you're awesome !
Thank you so much, dear, for your encouraging words.
Can you please help me by sharing?
Great job it is not just informative it's funny too 👏👏👏👏
Thank you so much 😊
Can you please help me by sharing?
The explanation was too good but I have a small doubt-Why is splenomegaly present in polycythemia vera but not in secondary polycythemia?
What was your inspiration behind this channel?....Great work Sir.....huge respect
Seeing medical students in the library losing it! 😂
So, I decided to help!
@@MedicosisPerfectionalis 😅So you're a doctor? actually im curious for a while
My brother aged 71 died two days ago. He had Polycythemia Vera and Myelofibrosis. He had multiple strokes and blood clots over the last few years. He fell and cracked his ribs and nicked his liver. Within a couple of weeks his body couldn’t fight any more. Rectal bleeding, inability to eat, cirrhosis of the liver, infection from IV and severe pain.
Oh! I am so sorry!
My condolences!
Thank you. May God be with all those with chronic illness.
Amen 🙏
I study my exam with your videos♥️😍 my medical life saver ♥️Thanks sir🙌🏻🙏🏻
My pleasure 😇...That’s an honor...so happy to have you at “Medicosis”...Good luck with your exam 😃
Amazing videos.. im ur new fan now! 😊😊😊 thank u so much.. God bless u
God bless you too
Crystal Clear
Great job !
Cool! I am glad you liked it!
Ans - C hypercellular marrow with panmyelosis baby 😀😀
Excellent
Great info, but the amount ads you have is rediculous.
Thanks for your honest feedback!
Thank you for all you do❤
The hydroxyurea stopped having an effect about a year and a half in. They started giving something called jackify and that has been holding steady for the last couple of years
My dear I am PV patient living in third world .doctors have no drugs to prescribe so please send me these two drugs .thank you
@aregahailu2487 1. Getting diagnosed with pv is an extremely time consuming, intensive and expensive process. So I find it very hard to believe that the doctors you have there were willing and able to do all of that just to not treat you for the disease.
2. Hydroxyurea is a chemotherapy drug. You can get it through any Dr who treats cancer.
3. Jackafy is $20,000 for one months supply.
I am one of whom I Watch most of your videos for a while and I find them them very enjoyable and informative
But I want to note something, there are 3 Major criteria to diagnose PV and bone marrow is one of them. For diagnosis it is required to have 3 major and 1 minor.
Thank you
They updated the guidelines
Lectures good
By the way Hb in RBCs carry oxygen not the platelets. Please correct at 6minute and 14 seconds.
What's the answer to the question at the end? I can't find his "next video "
I like your style of teaching. Mostly that "baby" thing
Everything is covered from your lecture
Thanks 🙏
i'm 24 and recently i was diagnosed with polycythemia vera, hope they will find the cure soon, just hope :(
how are you doing now
Me tooo
Ans hypercellular with panmyelosis
Omg… fantastic Job man you r creative 😍😍😍
Thanks 🙏
The answer is c hypercellular marrow with Panmyelosis?
one of the best medical channels on RUclips, Thank you so much you made my life much easier and you draw a laugh on my face Baby :p
Hehehe! Thank you ☺️
You are amazing. Hats off!
Thanks 😊
The answer is (C) dear
Ans is C.
I liked your imformation in a more interesting way ,can you made a video how is treated this cancer to the blood .please
Thank you
Thank you so much 😊
Thank you for the great videos. I am 63, female, fit, active, nonsmoker, 2 glasses of wine per week, no other issues except removal of half my thyroid and take 88 mg per day. I cook everything from scratch, Mediterranean diet. I noticed my ferritin levels raising over the last two years, now at 390 and then in the last eight months my platelet counts were going up, now at 600, I was diagnosed with ET JAK2. Bone Marrow biopsy taken waiting for results. Do you think that there is any correlation to the ferritin? My doctors just kept saying I had Covid or I was fighting a cold. Thanks so much!
thank you for the great lecture .
i have a question please mentioned in your lecture in time 1:39 . when PV converted PM so the patient will have anemia in PM after having high hemoglobin in PV ?
very interesting lecture.your way of teaching is very good.i entirely depend on your videos for indian pg medical entrance.sir please post videos on pharmacology also
That’s amazing! Thanks a lot for your continuous support and encouragement...I wish you the best! And yes, I will consider doing pharmacology.
answer is C
Creative ! Thank you so much 😍
My pleasure 😇
Why B12 is increased in Polycythemia vera?
Primary Myelofibrosis (PMF). Polycythemia Vera (PV), and Essential Thrombocythemia (ET)
???
Very well explained 👏 Cheers.
Thank you so much 😊
since theres an increase in cell turnover, shouldn't we have jaundice too?
Well, I'm here to study about PV because someone I really cared about has it, and I wanna be educated about this disease.
Best of luck to you and to that person.
@@MedicosisPerfectionalis please I am PV patient no drug here in Africa for it like hydro something
The best
My rbc are high but i don't have itching after shower so what is that
Answer is C
C is correct answer
Great explanation.🙏🙏🙏keep it up.....thank you....
My pleasure 😇
You are the best👏👌💙
Thank you :)
C is the answer! And osm video!! 😄
My 39 year old son has PV. When he was diagnosed, we were asked if he had ever been exposed to anything? I recently wondered if the chemicals found in the Round Up weed killer may be a cause as he played baseball (no weeds on a baseball field) and has been exposed to it. Thanks for your video. Lorie
I’ve never heard of that.
Please don’t confuse legal precedent with medical evidence!
@@MedicosisPerfectionalis When he was diagnosed in 2014 a doctor in Minnesota asked the question about exposure. Thank you for your reply.
@@loriedavis7839 how is he doing now ?
Thanks Alot ❤❤
Your videos are just amazing ❤👍 please make more videos
Absolutely...I will never stop!
It's the alot of "baby" that regain my attention when I go daydreaming 😂❤
:)
Answer is c
The answer is C, right?
Is JAK-2 is negative in PV patients sometimes?
You are the best, thank you!
My pleasure...Thanks, dear!