Essential Thrombocytosis (ET) | Myeloproliferative Neoplasm (JAK2 Kinase)
HTML-код
- Опубликовано: 14 дек 2018
- 😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/me...
- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
Disclaimer: I use affiliate links....
►👨🏫💊Antibiotics Lectures: www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Myeloproliferative disorders are a group of disorders when your bone marrow is OVERproducing cells...All cell lines "red blood cells, platelets, and white blood cells" are increased in number.
Essential thrombocytosis is one of the myeloproliferative disorders.
All cell lines are increased especially platelets.
Get all of my notes here: / medicosis
Check my full playlist on "bleeding and coagulation" here: goo.gl/Dt41Bg
Books that I use for this series:
► Guyton and Hall Medical Physiology Textbook goo.gl/yZoeS9
► Goljan Rapid Review Pathology, amzn.to/2MufTPw
► Harrison’s Internal Medicine amzn.to/2OJiVNf
► Goldman-Cecil Medicine amzn.to/2N0v93u
► Davidson’s Principles and Practice of Medicine amzn.to/2vTmf1p
► If you love MNEMONICS, check out this amazing website www.picmonic.com/referrals/JK...
► If you need some flashcards to memorize better, try firecracker: mbsy.co/gcHHP They have many flashcards that appear in your feed based on how well you remember the answer…Check them out…They are really good.
*** As a small gift for my viewers, here are 2 FREE audiobooks from Audible amzn.to/2FQurW0 Learning has never been easier.
*** Also, try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. amzn.to/2UceoG2
Don't forget to watch my video on polycythemia vera • Polycythemia Vera (PV)...
Also, I have discussed secondary thrombocytosis in this video • Thrombocytosis (Primar... If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
► Visit my website: www.medicosisperfectionalis.com/ My Favorite Productivity App: airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: fbuy.me/q6bMj 🏦 Qbank (TrueLearn): truelearn.referralrock.com/l/...
🦠Antibiotics Lectures: www.medicosisperfectionalis.com/
📝 Download Notes: www.medicosisperfectionalis.com/
"If you haven't subscribed, there is no hope for you" LMAO
Please, help me reach 35,000 subscribers and I will start uploading videos on “bleeding and coagulation disorders” instantaneously.
Thanks 🙏
You are amazing.
Thank you, dear :)
I shared your channel with my classmates on WhatsApp group . You are amazing 💕💕
Thanks a bunch...I am really grateful!
Medicosis Perfectionalis
I was diagnosed at 15 with an average platelet count over 4 million with terrible headaches, after three years of low dose oral chemo and just baby aspirin after, my platelet count 8 years later is just over 500,000. Have you heard of someone so young having ET?
Love your channel still lol. And I’m not even a med student. Your humour and honesty compliment pathology really well and help make medicine meaningful. Thanks!😊👍🇨🇦
My pleasure...Thanks a lot for your kind words.
Your videos are so helpful. Please! don't stop doing the amazing work. ❤️
Sure! Thanks for your encouragement ❤️
so glad i found your channel....my hemato module is saved!
Wonderful 😃
Yes ur correct. Best channel ever
Thanks 🙏
Thanks for producing a very informative video. You are appreciated.
My pleasure 😇
if im gonna pass my tmrws hematology exam its thanks to u !!!!!!!!!!!
Go get them 👏
GREAT HUMOR!!!!!👍🏼👍🏼
Thanks 🙏
Thanks a ton..
i love your work💖
Thank you so much 😊
Yeah! This channel is awesome 😂😊💕.
Thank you for your continuous support!
Hi
Please note in the case study the last option was >20% myeloblasts .. your interpretation was CML.. that is not the case, i think you meant AML
.. thanks for your nice useful videos
Yep
Or it could have been blast crisis of CML
Thank you 😍
My pleasure 😇
My exam is the next week so you save, thanks!
Thank you so much 😊
thanks alot for these videos❤❤
My pleasure 😇
Thanks a lot!!❤❤🌹
My pleasure 😇
Thank you very much 🎉
My pleasure 😇
Excellent
Thank you 🙏
Thanks alot
Hmm you didn't include anything about the CALR mutation that is found in ET patients.
Why INF - alpha is given in PCV or ET?
And could you pls 🙏🙏🙏make videos on cardiology also it would be really helpful ☺☺
Blood test results came back with insertion 30bp, deletion 52BP. Couldn’t help but to do a bit of research and came to this. Also “PV” and “ME” were written multiple times on my test in some spots for test results on the right. Any ideas? I’m Only 20 and not much I’m hearing right now back.
hello awesome channel. I'm looking for the history of tyrosin kinase and all the genetic related to jak2 kinase. what make the jak2 mutation. why it changes, what genetic and dna cause this. thank you.
Friend please make a video on leukoerythroblastosis if possible.
Study hard🔥🔥🔥
Hey, one thing that isn't clear to me if you could elaborate.
You're saying ET is an "exclusion diagnostic" which means you have it when all other possible causes don't fit.
However, what about Jak2 (or calreticulin) mutation? Isn't that an explicit diagnostic and not an exclusion diagnostic? 🤔
Or maybe jak2 can "go back to normal" after the first cause (infection or inflammation or anyone you listed) vanishes??
Thank you
Great Q
I'm undergoing this testing
Best of luck!
I am going to comment hope I get an answer...I have had high platelets and high wbc since 2010,two bone marrow biopsies showing same as blood work anemia. I have recently had some problems namely the H-pylori bacteria hopefully after treatment and recheck it will be gone,but I am still being sent back to hematologist oncologist he already did bloodwork everything came back except for the JAK2 could the H-pylori been causing the high platelets and high wbc all these years????
All I know is having the jak2 mutation will produce high platelet count. Have you got ET or PV? My platlets were at 700 when I was first diagnosed a few years ago. I'm now 55 and my platelets are 1200. Currently on 75mg of aspirin only.
my mother has double of normal platelets counts and had jack 2 mutation,after had operation at carotid and the day after had big stroke in brain .now is completely paralized for 1 year already .why did they operate carotid when they knew she had to much platelets just before operation ? they had to remove exess platelets before operation but didnt do that ,why ???
I'm so sorry! Although I know any amount of apologies won't fix it 😢 I can't stand it when people fall victim to medical malpractise, it makes me so angry!
thanks. can you explain about topics in surgery ?
Sure! I will...After finishing internal medicine! Thanks
Another great video
Thanks a lot!
Can a asymptomatic person can still have ET if jak2 and calr is negative but ONLY platelets are persistent 4 months high ranging 550-800 ??
Having no symptoms ESR and CRP all inflamations normal??
How are you?
I got ET when I was 32, am now 43. It is now becoming common in children as well. Very interesting that you show little symptoms until about 40 and then haematologists start with medications. Luckily I am on aspirin but I do definitely notice a change in symptoms. You almost feel like a fraud when you first get it as you don't have any visible symptoms except high platelets and tiredness. Took me a long while to get to grips with mentally.
So sorry to hear that...How is your health now?
@@MedicosisPerfectionalis My health is ok now, take it on a day to day basis. Some days I feel awful other days fine. I find exercise helps incredibly with the tiredness and also mentally. I am taking Clopidogrel 75mg every other day. Better than aspirin because that just made me feel sick. I like to find as much information out there regarding this so I know what I am up against when visiting dr's as sometimes they are so pushed for time. Thanks for asking and your channel is very informative.
Me too I have ET
@@mohamedsahal9123 this disorder cause itching? Sudden itching?
@@siafathima6343 nope, just headaches and dizziness sometimes. When I stopped smoking I felt better.
Im a 23 year old male and I've been diagnosed with Essential Thrombocythemia. I'm JAK2 negative, but CALR GENE is present. I had a good laugh when you said it's a disease of the elderly and more common in women since I'm a young man 🤣🤣🤣🤣
I have it too Jak2 positive.
@@nuclearstevex4516 me three!! Makes me feel a little bit better knowing I am not the only one.
@@millr9916 Me four? Had it when I was 21years old :( JAK2 positive also
Me five. 38 year old male. So far so good with just a baby aspirin and regular monitoring. JAK 2 positive and platelets typically in th 750 range.
@@21zimm I am on aspirin and a small dose of Hydrea (Oral chemo, 3 tablets a week) My platelets have settled at 880... going to up the does to try get it down to 600-700 as I have had a couple of clots (that healed themselves). So far no side effects from Hydrea.
my doubt is related to von willebrand factor. how does it help in platelet aggregation
Good question...Platelets have an outer coat, outside of the lipid bilayer plasma membrane, called glycocalyx...This glycocalyx contain receptors that bind the subendothelial collagen and the vWF (which is part of factor 8)...That’s how the platelets recognize trauma and start to bind to the collagen, activate, release, aggregate, start the coagulation cascade and fuse together...We will discuss all of that in future lectures.
I (F45, now) was diagnosed with ET @29yo, jak+ and feel like there’s nothing there for people like me. It’s all about old people and nothing for younger patients like myself. Medical professionals don’t know what to do with me. I’m not healing well and I was told it’s because I’m aging and I’m basically old and therefore nothing to do with my et. I’m in a process of changing my medical team as I’ve been gaslit by this clinic way too many times and above is just one example. Also medication to treat et cause to many side effects for younger patients to function at full capacity but I’m forced to work full time and all my complaints about any side effects from any of the meds above (and I was on all of them already), are treated as I’m saying lies. Doctors don’t know how to help me effectively so I can live my life and stop comparing me to their elderly day to day patients.
Could bloodletting help ?
Hi currently 19 and just got diagnosed with this and the Jak2 mutation. Is that abnormal?
ET is way more common in old people, but it can happen at any age. Only a doctor (hematologist) can confirm the diagnosis.
It is awesome ..indeed
Thanks 🙏
Why increase in platelets leads to increased risk of bleeding?
I'm 29 and thrombocytes 414. Is this very abnormal? I have higher than normal leukocytes and positive leukocytes in my urine. I only know because I was having a blood test for lithium and over the past weeks I've had a huge amount of migraines and random sudden nosebleed
That is in the normal range as far as I am aware 250-450(*1k). Above that you can be considered as having thrombocytosis, if you had much lower numbers a doctor might want to check it out tho. But you are having symptoms that bother you so I'd get checked out.
Is this treatable ?
Still watching in 2024…for my exams😂 Live savior ❤
I wish you all the best!
What is the difference between pt and ptt and the bleeding time
Bleeding time measures platelet function.
PT measures extrinsic coagulation pathway (as well as the common pathway).
PTT measures intrinsic coagulation pathway (as well as the common pathway)
I don't know if I would classify it as something only the elderly are diagnosed with. I'm 27 and was diagnosed a couple months ago, and I am in a couple FB groups that have a good amount of young people in there. I think due to the improvement in technology, maybe we are able to diagnose sooner? I'm no expert, of course, and I am still learning a lot about this disease.
It’s not “only”, but generally.
I am sure there are young people who has it, but you will find that the overwhelming majority are old. You can even ask your physician to confirm.
I really wish you speedy recovery.
Take care!
@@MedicosisPerfectionalis makes sense! I will. There’s so much out there! Lots to learn. Thank you. I appreciate that!
@@MedicosisPerfectionalis I'm 27years old too.
My Platelets count is 697 and my JAK2 test positive. I have MPN ..
I going to do biopsy soon
Same. I was diagnosed at 33 with JAK2 positive. ✨🤗 Wishing you both health and happiness!
@@lenamichellejames thank you!! Healing and positivity sent right back to you! ✨🤍
❤️❤️❤️❤️
Thank you ☺️
Platelets have no cell nucleus, so there is not going to be increased Uric acid as a final nuclei degradation product , thrombocytosis have no risk for gout
Good point, but remember that essential thrombocytosis is a myeloproliferative neoplasm where all cell lines are increased including WBCs which have nucleus...I hope it helps.
انت رائع
Thank you 🙏
👌 ☘️
👍😊
I am confused about the JAK2 EPO receptor part.
Isn't it like this: EPO binds on the EPO receptor, conformational change, JAK kicks in, intracellular signaling, etc.?
So basically in PV/ ET the EPO receptor part is just skipped and the JAK remains active, right? Or why is the JAK "activating the EPO receptor"? Thank you!
xDomglmao yes I think that’s what he meant. I was a little confused too.
My partner has just been diagnosed with ET. She is 33.
😳😳😳
How is her health?
@@MedicosisPerfectionalis she is in great shape in general, eats well, goes to the gym, etc. At around 18 she got put on medication for hypertension but after the initial investigation the cause was put down to 'one of those things'. In 2014 after a healthy pregnancy (but with mild anemia controlled by iron supplements) at 30 weeks we lost our boy to a sudden placental abruption which again was just chalked up to 'one of those things'.
Since losing our little boy we have gone on to have a health little girl, but with constant monitoring through the pregnancy and she was delivered at 34 +6 weeks. Both children were delivered by cesarean.
Two/three years ago she had some bloods done which showed high platelets but when she called for the results she was told that everything was OK. Then about three months ago she had a weekend away abroad and when she came back she had a very tender and swollen ankle. I pushed her to seeing a doctor and they treated her for cellulitis and took bloods which is when they then saw she still had a high platelet count in the high 700's. They have had her under a hematologist who has run several bloods tests to rule out other causes and then run tests to look for genetic mutations. It has tested positive for a JAK2 mutation.
As a treatment they have put her on a low dose of aspirin, 75mg daily, and she will go for blood screening now every three months for the rest of her life. Also unless she has a stroke or hematoma they will not give her any further treatment until she reaches 60.
After reading about ET now she has a diagnosis we are starting to notice certain symptoms that have gone unchecked. She is tired all the time even though she gets 8-10 hours sleep every night, she's always scratching her thighs and she sweats a lot in bed ever since losing our little boy. I don't know if it has any bearing on anything but she has a black Caribbean heritage but there is no history of health issues with either side of her family. The women have lived good long healthy lives as far as we know.
My partner is completely unshaken by this, feels fine and will just take it in her stride. It is me who is looking in to the disease and worrying. I'm insisting that we spend some money to go and get a private consultation. I still think the NHS is a great thing but they don't have the time or resources anymore. The hematologist didn't explain anything properly to us and it was in the car on the way home, reading a leaflet he had given to her, that cancer was first mentioned. It has left us both rather confused and looking for answers.. More me than her I have to admit.
Although I have no medical background I found your video very informative and easy to follow. I will watch it a few more times I am sure. Are there any other you recommend i watch to help build my understanding of this disease?
@@MedicosisPerfectionalis apologies for the essay 😬
I have been diagnosed with it and I am 23
@@jontython hello...how is your partner? What type of itching she had? Sudden or chronic?
Is AML a myeloproliferative disorder?
And please why if not
essential thrombocytosis How it can cause bleeding, i don't understand plz if any one knows
Because these platelets are abnormal.
I'm a male, 20 years old. What were the odds? :(
Do you have ET? I do
@@nuclearstevex4516 high platelet cause sudden itching ?
❤❤❤
:)
Quiero esta información en Español
Please send for this vedio of the papers can be reader a easy
I am afraid I don't understand!
You don't have videos for platelet and coagulation disorders :((((
They’re here: Bleeding & Coagulation ruclips.net/p/PLYcLrRDaR8_cAqUviH6nWUwYttoVhsyQf
@@MedicosisPerfectionalis Hemophilia, vWD, ITP, TTP, Are they present in the playlist? Thank you.
ITP was uploaded today
polycythemia and pv same or not
Polycythemia has many causes. One of them is polycythemia vera.
Your lectures are great ,but sometimes you speak very fast.
Thank you so much for your honest feedback!
Elderly????? I’m 44 got diagnosed last week
Im on 25 got diagnosed with ET😂
Español x favor
I have ET
I am so sorry 😐
Medicosis Perfectionalis I’m fine with it. I have a great hematologist, and the hydroxyurea seems to be helping lower the platelet count. Only downside is the side effect of being immunocompromised from the chemo. Aside from that, all good
Thanks for the concern!
I am happy to hear that you’re doing fine!
Take care!
My mother's plt rate has risen to 1,300. She has constant headaches and fatigue. They started taking medication yesterday. I don't know if her plt rate will decrease.
if you haven't subscribed then there is no hope for you😂😂🤦🏻
Spanish, please
please slower ur speaking 😂😂🙏🙏im sorry but the way u speak is too fast for me.. anw thanks for ur videos
Thanks for your feedback 👍
you can change the playback speed in the settings of your youtube player
Right near the start you say it is a disease of the elderly - it might be more prevalent but is certainly affects younger people too. Rubbish!
Same holds true for saying: “seat belts save lives”...There are exceptions to every rule.
At least half the people on a couple of FB groups that I see are under 60. Possibly because in the UK there is a reluctance to start chemo. drugs below that age and they are struggling with symptoms.
I am 23 with Jak2 ET and have had it for about 2 years!
@@helenobrien1241 this disorder cause itching?
@@siafathima6343 some say so. I have no symptoms and so I am lucky! Diagnosed from rising platelets + BMB
Yeah! This channel is awesome 😂😊💕.
Thank you 😊