Cholesterol Synthesis Pathway || Cholesterol Metabolism || Biochemistry

Cholesterol Metabolism - This video is on the Structure of Cholesterol, Cholesterol synthesis, regulation of cholesterol metanolism and metabolic fates cholesterol along with NEET PG MCQs.
1. Cholesterol Structure -2:00 minutes
2. Cholesterol Synthesis-3:18minutes
3. Mechanism of Statins-6:50minutes
4. Energy requirement of Cholesterol Synthesis-8:50minutes
5. Regulation of Cholesterol Synthesis-10:00 minutes
6. Metabolic fates of cholesterol - 13:10 minutes\
7. NEET PG MCQs - 14:27 minutes
Cholesterol is the major sterol in human
Cholesterol is an amphipathic lipid which can be synthesized by most cells of the body and it is obtained from the diet in foods of animal origin.
It is not synthesized in plants.
The major source of dietary cholesterol is egg yolk and meat, particularly liver.
Normal Level Total Cholesterol in Blood is 120-200mg/dl
An abnormality in either cholesterol metabolism or transport through the plasma appears to be related to the development of atherosclerosis that can lead to myocardial infarction or stroke.
Cholesterol is synthesized by most cells of the body. Liver and intestine are major site of cholesterol synthesis.
All 27-carbon atoms of cholesterol are derived from the acetyl-CoA.
The reactions of cholesterol biosynthesis occurs into 5 stages
Condensation of three molecules of acetyl-CoA to mevalonate
2. Conversion of mevalonate to activated isoprene units
3. Polymerization of six isoprene units to form squalene
4. Cyclization of squalene to form parent steroid
nucleus lanosterol
5. Formation of cholesterol from lanosterol.

[@gulfwarveteran8528]

Much needed I was waiting . Biochem is now sounding logical to me thank u doctor

[@Biochemistrybasics]

🙏 Thanks garav. Medicine is incomplete without biochemistry.

[@ShreeyaSirulu5]

Thank you so much Dr Amit
You made Biochemistry easy to remember
Can't thank you enough
Your work is Awesome

[@Biochemistrybasics]

Most welcome dear. Please spread the word about the channel among your friends and help me to reach my work to it's potential audience

[@akashbiswas.8225]

It's easy to understand the way you explained ..... Keep teaching us sir.... Thanks a lot ....😊😊😊

[@Biochemistrybasics]

Thanks आकाश. Keep loving biochemistry and do spread the word about the channel 😊

[@ritika9725]

Best ever explanation sir 👍🥰🥰

[@Biochemistrybasics]

Thanks dear ritika 🙏🙂

[@prashanthegde6461]

Very well Explained. I love the way you teach sir.

[@Biochemistrybasics]

Thanks Prashant.

[@hamedeghbali3501]

it s good way for lerning

[@Biochemistrybasics]

Thanks dear

[@aceo_o2295]

the BEST ever

[@Biochemistrybasics]

Thanks a lot

[@sudhu4ever]

Nice doctor

[@Biochemistrybasics]

🙏

[@Oyester221]

Sir Your lecture was helpful please do a lecture on INTERACTION between DNA & PROTEIN , RNA & PROTEIN

[@Biochemistrybasics]

Glad to hear that. Sure I will keep it in mind

[@pratishthanidhi9749]

Sir, your videos are amazing . Can you please post a video on transport cholestrol.

[@Biochemistrybasics]

Hey प्रतिष्ठा. Thanks. Please check lipid metabolism and lipoprotein playlist all the videos are there.

[@tanyabansal4570]

Sir endogenous cholesterol is esterified by which enzyme?

[@Biochemistrybasics]

Lipoprotein lipase

[@Pooja_g16]

Literally i I found this gem today thank u so much sir🙏🏼

[@Biochemistrybasics]

Most welcome dear. Please spare a few minutes and do spread the word about the channel among your batchmates and friends

[@Pooja_g16]

@@Biochemistrybasics sure sir it’s my pleasure 😇

[@Pooja_g16]

One thing I would like to ask you sir , is your vedios are enough to fetch good marks or else i have to refer some other book

[@Biochemistrybasics]

@@Pooja_g16 definitely yes. No need to read anything apart from making notes from my videos as all my videos are combination of standard textbooks

[@ss13_]

Sir
Video is awesome...
But small doubt sir
Ipp, isopentenyl pyrophosphate and isoprenoid units are same?
And the number of NADPH utilized in the cholesterol synthesis sir?

[@Biochemistrybasics]

Thank you. Two NADPH are utilized and yes they are same.

[@ss13_]

@@Biochemistrybasics tq sir
In entire cholesterol synthesis, how many nadph utilised sir?

[@nehasuthar5500]

Finely explained sir👍 sir how I find LDL & VLDL normal reference range? Is this found in friedwald's formula?

[@Biochemistrybasics]

Thanks Neha. LDL can be calculated by FF (total cholesterol (TC) minus high-density lipoprotein (HDL)- minus triglycerides (TGs)/5 in mg/dl) or measured directly in the laboratory.

[@Biochemistrybasics]

To estimate VLDL-C, divide the triglyceride value by 5 if the value is in mg/dL or divide by 2.2 if the value is in mmol/L. In most cases, this formula provides a good estimate of VLDL-C

[@Biochemistrybasics]

LDL normal value is less than 100mg/dl and Normal VLDL levels are from 2 to 30 mg/dL

[@nehasuthar5500]

@@Biochemistrybasics thankuuu soo much sir I don't know the calculation in mmol/L, thanks for telling me this important knowledge about lipid profile.....,and sir I want to know these ranges bibliography...if u use textbook of biochemistry than who is the author?

[@nehasuthar5500]

@@Biochemistrybasics we measured directly in backman Coulter sir....but this is also very useful 😊

[@priyanshuchouhan1848]

Sir notes kha pe milega

[@Biochemistrybasics]

On the website

[@priyanshuchouhan1848]

@@Biochemistrybasics website name?

[@Biochemistrybasics]

@@priyanshuchouhan1848 www.biochemistrybasics.com