Metabolism | Triglyceride Synthesis
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- Опубликовано: 6 сен 2024
- Official Ninja Nerd Website: ninjanerd.org
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In this lecture Professor Zach Murphy will present on the process of triglyceride synthesis and all of the associated enzymes involved. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #FattyAcidSynthesis #Metabolism
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sir please zoom out the camera in the end so that we could take a screenshot of the lectures.
thanks
Agreed
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+cupcakechip So happy to help! Glad we were able to make you enjoy it!
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The ⁻O-CO-(CH₂)ₙ-CH₃-CoA notation is a bit weird, I guess you mean H₃C-(CH₂)ₙ-CO-S-CoA or something like this? Usually, there is no 5-bond-carbon and the FA-synthesis should result in something like R-CO-S-CoA.
Yes.. the notation is not weird. I would call it wrong. It misleads. H₃C-(CH₂)ₙ-CO-S-CoA this one is correct.
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Questions: Is the second fatty acid in a TAG always an unsaturated fatty acid? Does this mean that fatty acids 1 and 2 will always be saturated? Furthermore, are the answers important in the context of nutritional ketosis?
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Great video as always. There are a few things I wish you'd mentioned. First of all I only learned later that Glycerol 3-phosphate is made directly from DHAP via Glycerol 3-phosphate dehydrogenase. I don't believe you mentioned that. Also a mention about glyceroneogenesis would have been great.
Anyway. Thanks for the video. Maybe I'll actually survive Biochem with this.
+SeptimusCreed thank you very much I hope the video was able to help. Best of luck in your future endeavors
Biochemistry become my favorite subject after watching your videos 😃❤️
One of the best doctors I have ever seen, Your videos have really helped me sir and keep it up
Very lovely video, thank you so much for you content Ninja Nerd. However I do think the 3 fatty acyl-CoA you have made in the beginning is a little bit misleading, since it should be CoA-SH bound to the carbonyl group with a thioester bond right? The CoA should be drawn in the other end and the Oxygen shouldn't be present right? Please correct me if I'm wrong.
When a phosphate group linked to a glycerol molecule its formula become C3H7O3PO3-2, you guys add an additional oxygen atom and a negative charge. The rest is awesome thank you :DD
pKa1=1.0, pKa2=8.0 for phosphatidic acids, so at physiological pH, almost all are singly-protonated, that is -HP04-1
@@johnpowell9174 I think the main issue he is pointing out is that it should be PO3 linked to the glycerol backbone (resulting in O-PO3), instead of the O-PO4 that is shown
@@seanluong6064 Agreed.. There a structural formula issue
I think we can call the lysophosphatidic acid MAG only if we get to dephosphorylate it and similarly phosphatidic acid once dephosphorylated is when we get DAG if not so they are different structures.However, the lecture is great.
this guys is serving me Medschool on a golden plate😂 thank you
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We cannot call MAG (Monoacylglycerol) and DAG (Diacylglycerol) without removing the phosphate group attached to the respective compounds.
and in Step #3 conversion of Phosphatidic acid to DAG should take place first using phosphatase enzyme and in the next step we add the last Fatty acyl CoA to make it TAG.
Anyways, Thank you for this amazing video. Love to revise through this.
It can be called a DAG phosphate or a MAG phosphate
Thank you !!!
i really like how you explaining the things which i can understand it clearly. thank you for the great videos!!!
OMG THANK YOU, you have made a subject I dread easy to learn and enjoyable
Thank you for making me pass my biochemistry exams with your lectures , i love you man 💜🙏
This video made it so so clear thank you !
You’re the king of biochem
So happy I watched the fatty acid synthesis and oxidation videos you advised!
Man,you're better than my lecturers, what am i paying my money for when i can study online with you
Loved this video! You explained this process very well and I was able to make sense of it all. Thank you :D
What chooses which types fats are added to the glyceride base. Fully saturated fats are flatter and the resulting try g is more dense.
You make it so simple ❤ thats awsome 🐼 thank you it really helped 💙
Thank you very much! It is a great help as I prepare for my comprehensive examination.
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thank you, best explanation of the situation !!!
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bc the O is already drawn in the Glyceral-3-phosphate shouldn't it be PO3 ^-2 instead? Anyways thank you for these videos, i have such a hard time with Biochemistry and these are a lifesaver
Preparing for CSIR... This person is great..!!
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Awesome videos! I felt like I'd never get metabolism. Thank God I found you💕.
Please male vid. About nucleotide metabolism and phospholipids.
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I am from algeria and u guys ?
Thankyou sir. This vedio is very easy to understand .Very nice explanation. 👍
Why should the second fatty acid necessarily be unsaturated??
My question is that if we have to remove phosphate at the last step to make bond of 3rd carbon with 3rd fatty acyl Co a then why we convert glycerol into glycerol 3 phosphate at almost first step
For the steps from DAG to TAG, not just phosphate isn’t H2O also be lost in this process am I right? Could you clarify this for me ?
What an excellent video, just like all others!
Best ever , love your concepts and how u make it easy ! Great job ✅❤
great lecture u made everything clear thanks sir
+zena said You’re welcome!
for each fatty acid, the end side of the long carbon chain should be -CH2CoA?
also, this is an esterification, the hydroxyl group should react with carboxyl group ,thus the oxygen minus should act as electron donor. Right？
these triglycerides are synthesized by glucose breakdown? Pyruvate? Meaning the initial process.
greetings, in this lecture, you said that the 2nd fatty acid that is to be added to the glycerol backbone has to be unsaturated, so what about the 1st fatty acid that is to be added? does the 1st fatty acid have to be saturated fatty acid??
thank you in advance.
You are a literal life saver amazing video!!
thank you very much Zack it was so helpful as everytime
Where does the O from fatty acyl coa and H from glycerol-3-P go when they form the bond?
that was absolutely fantastic explanation for that process
thank you so much 🧡🧡🌹
I’m watching this after five years and thaaanks❤ just a question.. you told the fatty acid chain that is gonna attach to carbon No. 2 in glycerol should be unsaturated but how simple saturated triglycerides are made? Or we don’t have simple saturated triglycerides naturally?
Most thankful from Jordan
Hello, thank you for making this useful videos for us, I have a question about this lesson:
at the beginning we added a phosphate to the Glycerol using Glycerol kinase then before adding fatty acid number 3, by means of Phosphatidic phosphatase we got rid out of that phosphate, so what is the function of that phosphate group?
Great work, thanks for every video
Omw this is so understandable ...please please please do a protein metabolism video series
Love from tamil nadu 😍thank you sir
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To the person who said their watching this for fun; Well,me too!
Really we owe you a lot sir
Thank you!
such a good video!! maybe you can explain also one for unsaturated FA or unodd FA :)
thank you so much!!
Many thanks to you! You are great! Keep up your good job!
So what’s the point of breaking down TAGs via lypolysis and then form TAGs again?
Same question
Usually the two process take place in s different time and nutritional status
my hero
Another great video as always!!
hi, your video is so awesome.
I have question. Where does our body can get the Fatty acid CoA?
Can our body synthesizes it ? or should we take it externally?
Fatty acid synthesis + acetyl coa (could be from pyruvate, from carbohydrates, lipids, amino acids)
Thank you. It really helped a lot!!!
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Thank you
Thanx sir for ur best explanation
We love you thanks a million just keep going
firstly thanks a lot for your great explanation you and the team works with you to create such an amazing stuff like this
I have a question 🙋 can adipose tissue contain a glycerol or not.
I know it only get the glycerol 3- phosphate from the glycolysis because it's doesn't have glycerol kinase but I think you said in this videos the glycerol come from the adipose tissue when it breakdown or something like that ....... explain it to me please.
thanks a lot
The video is amazing. But regarding the glycerol 3-P wasn't it supposed to be PO3 2- and not PO4 3- ?
Thanks
very good