Vit C and E dosages would be useful to know, of course every body is different. Those of us with MCAS seem to absorb nutrients differently so would be really helpful to get some guidelines as we tinker around with the minimum doses us sensitive MCASers can handle without becoming allergic.
Thank u soooooo much -when first startedcsupplementing (to halt Rheumatoid arthritis thru diet and supplements -i was successful) was told you could only take glutathione precursors (there were no liposomal preps avail) dr perricone used it w success on aids patients to improve their health-i knew vit c a co factor but always struggle to get complete info such as can i take all at same time (some things cancel out benefits so need to separate dose) now i can take at same time w confidence -i do liquids now so much easier all in one glass as i hate taking pills and often would go off regimen-please continue to give such advice on cofactors and what to take together w other supplements -as a megasupplementer i seek to understand bioavailability/absorption issues (linus pauling still the man now you stand beside him)
Lengthy list -as i said need to be concerned with bio-availability/absorption which leads to checking supplement forms such dr anderson discussed w glutathione preferred as liposomal or reduced form s-acetyl - i mega supplement as rheum arth and then long haul covid really hurt me-for rhem arth i started w approach what are your inflammatory events/causes w most blood sugar spike being number one so reduce carbs/sugars more plant based diet-2-increase protein i learned by body weight i was severely deficient needed 70 grm day 3- boost immune system w foods check out youtube dr william li OMG he is incredible and add in immune boosting supplements-why glutathione of interest as it is the bodys biggest antiflammatory agent -4- upped calcium like fulvic acid cal mag blend by VitalEarth minerals 5- zinc necessary 6-niacin or niacinamide - 7- and huge Vit C need a constant circulating blood supply so now you can take liposomal and take it once a day i take 3,000 mg you cantake much more as a water soluble vit and virtually no toxicity level u just excrete it much info on hi dose benefits out there including dr anderson -halted rheum arthr which had already started to curl fingers and night pain in joints awfuland even reversed effects so all but one of my fingers straightend back out@@boomerang0101
Doc I’m taking 6-9g of glycine… one of three glutathione building blocks. MagGly is about 100 to 1. I’m sure I would be taking 100g of mag per gram of glycine. What ratio of mag to glutathione are you suggesting
Had bought some Glutathione liquid. It was supposed to be a nano technology now they sell that same thing it’s called Swash . This is the first time watching Dr. Paul Anderson so very interesting I like his details and it’s in depth so I’m going to watch some other videos and see if I have time to add him to , better mental health videos this video Rated 5*S video from me. I heard on this video that glutathione can’t be prescribed by Dr. that’s interesting. I showed my doctor at the VA he didn’t say anything about it. I feel a lot better with taking glutathione
i have this coondition called visual snow syndrome also my scans show subtle cortical thinckening in the brain suspecitng focal corticl dyslapsia.. will gluathion be beneficial for me?
NAC is not a food supplement; it's a drug design for short term usage. There is no data for long term consumption. Any cell with a nucleus must maintain a balance between oxidation and reduction (redox), one of the functions of glutathione is to be an intracellular antioxidant. The proponents of NAC ignore the fact that not knowing how much antioxidant action is required, most probably NAC end up being a PRO-oxidant!!, which is equally BAD, i.e., not achieving a balance but tilting the balance in the opposite direction... The natural mechanism for the production of glutathione is to provide any cell with the precursors of glutathione so the cell decides how much glutathione to synthesize. The precursors are: glycine, glutamate, and cysteine. Cysteine must be in the form of CYSTINE which is a "dysulfide" amino acid containing two cysteine molecules connected by their sulfur atoms. These natural precursors are available in any mammalian (mother's) milk. This milk should be UNPASTEURIZED, otherwise the dysulfide bond is broken. A quick query to PERPLEXITY at PERPLEXITY.AI QUERY: in a REDOX environment, what happens when antioxidants increase too much. ANSWER: In a redox (reduction-oxidation) environment, an excessive increase in antioxidants can lead to a phenomenon known as reductive stress, which can be as harmful as oxidative stress. This imbalance can have several negative consequences on cellular functions and overall health. Reductive Stress When antioxidants are present in excessive amounts, they can disrupt the delicate balance between oxidation and reduction in cellular environments. This leads to a state of reductive stress, where the cellular environment becomes overly reduced. Reductive stress can be just as detrimental as oxidative stress, and has been linked to various health issues, including: 1)Cancer 2)Cardiomyopathy 3)Disruption of normal cellular functions Prooxidant Activity Paradoxically, high concentrations of antioxidants can cause them to act as prooxidants, promoting oxidative stress rather than alleviating it3. This occurs because: Antioxidants may react with transition metals, generating more reactive species They can interfere with the body's natural antioxidant defense systems. At high concentrations, some antioxidants can undergo autoxidation, producing reactive oxygen species (ROS). Disruption of Cellular Signaling Free radicals, in moderate amounts, play essential roles in cellular signaling and function. An overabundance of antioxidants can interfere with these processes by: 1)Neutralizing beneficial concentrations of ROS required for optimal cellular functioning 2)Disrupting cell-to-cell communication 3)Interfering with the metabolism and breakdown of drugs Impaired Adaptive Responses Excessive antioxidant intake can hinder the body's natural adaptive responses, particularly in the context of exercise: 1)It can prevent the activation of Nrf2, a key transcription factor involved in antioxidant defense. 2)High doses of antioxidants may impair exercise-induced adaptations, such as improvements in cardiorespiratory function. 3)Supplementation can interfere with mitochondrial biogenesis and muscle hypertrophy Increased Oxidative Damage Counterintuitively, high doses of antioxidants can sometimes lead to increased oxidative damage: 1)Studies have shown that vitamin E supplementation can increase lipid peroxidation following high-intensity resistance training 2)In some cases, antioxidant supplementation has been associated with increased plasma protein oxidation and lipid peroxidation in well-trained athletes. In conclusion, while antioxidants are essential for maintaining redox balance, excessive amounts can lead to reductive stress, prooxidant activity, disrupted cellular signaling, impaired adaptive responses, and even increased oxidative damage. This underscores the importance of maintaining a balanced redox environment and obtaining antioxidants primarily through a varied, nutrient-rich diet rather than high-dose supplements.
Vit C and E dosages would be useful to know, of course every body is different. Those of us with MCAS seem to absorb nutrients differently so would be really helpful to get some guidelines as we tinker around with the minimum doses us sensitive MCASers can handle without becoming allergic.
This is so helpful. Dr Oz promoted glutathione but didn't explain the process so I wasted a lot of money apparently.
I had a few times IV Meyers cocktail, and after that IV push Gluthatione... It was great!
Thank you so much for this detailed education on glutathione absorbtion and cycling process..
deeply appreciated
much gratitude.
I've started taking 250mg of S Acetyl L Glutathione + Shilajot for minerals + magneium glycinate + a high dose bioavailable b complex.
Well youtube wont let me tell you what i did to halt rheum arth -any other way to comm?
@@Bacchus57 discord?
@@Bacchus57 I have RA and need help. Already taking many of the supplements. But any suggestions?
@@Bacchus57 APOPHYSIS!! SAYING IT BY APPEARING NOT TO!
@@Bacchus57 Please tell us..
Chelation. Indeed add vitamines.
Thank you, this one is of great value. 🙏
support the bodys own making with NAC.
And add glycine...and v.C.
So thinking GLYNAC is the best versus a liposomal glut yes?
Thank u soooooo much -when first startedcsupplementing (to halt Rheumatoid arthritis thru diet and supplements -i was successful) was told you could only take glutathione precursors (there were no liposomal preps avail) dr perricone used it w success on aids patients to improve their health-i knew vit c a co factor but always struggle to get complete info such as can i take all at same time (some things cancel out benefits so need to separate dose) now i can take at same time w confidence -i do liquids now so much easier all in one glass as i hate taking pills and often would go off regimen-please continue to give such advice on cofactors and what to take together w other supplements -as a megasupplementer i seek to understand bioavailability/absorption issues (linus pauling still the man now you stand beside him)
could you please tell us what you take?
Lengthy list -as i said need to be concerned with bio-availability/absorption which leads to checking supplement forms such dr anderson discussed w glutathione preferred as liposomal or reduced form s-acetyl - i mega supplement as rheum arth and then long haul covid really hurt me-for rhem arth i started w approach what are your inflammatory events/causes w most blood sugar spike being number one so reduce carbs/sugars more plant based diet-2-increase protein i learned by body weight i was severely deficient needed 70 grm day 3- boost immune system w foods check out youtube dr william li OMG he is incredible and add in immune boosting supplements-why glutathione of interest as it is the bodys biggest antiflammatory agent -4- upped calcium like fulvic acid cal mag blend by VitalEarth minerals 5- zinc necessary 6-niacin or niacinamide - 7- and huge Vit C need a constant circulating blood supply so now you can take liposomal and take it once a day i take 3,000 mg you cantake much more as a water soluble vit and virtually no toxicity level u just excrete it much info on hi dose benefits out there including dr anderson -halted rheum arthr which had already started to curl fingers and night pain in joints awfuland even reversed effects so all but one of my fingers straightend back out@@boomerang0101
@@Bacchus57 thanks but I tried high dose vit C (3g acerola extract powder) back in 2022 and after six months got a kidney stone (calcium oxalate).
In the list of "Secondary" things for glutathione cycling, which form of magnesium is best for this? Thanks 👍
Can this be done long term for diabetics to help with neuropathy?
What is your opinion on the intramuscular Glutathione modality? Is it as bioavailable as IV?
We'll be coming out with a video on this soon, stay tuned - Team Dr. A
You should take gamma-glutamylcysteine (glyteine) to raise intracellular glutathione
Thank you! It is so helpful to learn about a nutrient and what/how it works AND what it needs to be flanked with to be effective.
Doc I’m taking 6-9g of glycine… one of three glutathione building blocks. MagGly is about 100 to 1. I’m sure I would be taking 100g of mag per gram of glycine.
What ratio of mag to glutathione are you suggesting
Does anyone know, does taking the vitamin E as tocotrienols vs tocopherols pose an issue?
Can you specify dosages of cofactors in regard to glutathione dosage?
Had bought some Glutathione liquid. It was supposed to be a nano technology now they sell that same thing it’s called Swash . This is the first time watching Dr. Paul Anderson so very interesting I like his details and it’s in depth so I’m going to watch some other videos and see if I have time to add him to , better mental health videos this video Rated 5*S video from me. I heard on this video that glutathione can’t be prescribed by Dr. that’s interesting. I showed my doctor at the VA he didn’t say anything about it. I feel a lot better with taking glutathione
Thank you, dr. A!
Thank you, Dr. Anderson. Would long-term supplemental glutathione negatively impact endogenous production?
Excellent question. Pulse and titrate dosing off and on is best.
Does NAC + Glycine produce glutathione? How do you take b vitamin / vitamin C full empty stomach?
i have this coondition called visual snow syndrome also my scans show subtle cortical thinckening in the brain suspecitng focal corticl dyslapsia.. will gluathion be beneficial for me?
I'm well served with 2x500mg NAC instead of Gluthadion, and Taurrine...🤩
whats NAC
@@masonmartin1464 an aminoacid and precursor for gluthadion, liver detox named n'acetylcystein...😊
Hi! I’m taking toniiq glutathione and it says 98% (reduced form). Is that sufficient? Also instead of taking selenium, can I eat Brazil nuts?
Brazil nuts do provide selenium, I will put the reduced glutathione form question into the line-up! - Team Dr. A
@@DrA-Online thank you!
I wonder that is why my son has worse behaviors I only gave him B1 and glutathione
😊
Appalachian Homestead with Patara YT channel everyone. Prep prep prep
NAC is not a food supplement; it's a drug design for short term usage. There is no data for long term consumption.
Any cell with a nucleus must maintain a balance between oxidation and reduction (redox), one of the functions of glutathione is to be an intracellular antioxidant. The proponents of NAC ignore the fact that not knowing how much antioxidant action is required, most probably NAC end up being a PRO-oxidant!!, which is equally BAD, i.e., not achieving a balance but tilting the balance in the opposite direction...
The natural mechanism for the production of glutathione is to provide any cell with the precursors of glutathione so the cell decides how much glutathione to synthesize. The precursors are: glycine, glutamate, and cysteine. Cysteine must be in the form of CYSTINE which is a "dysulfide" amino acid containing two cysteine molecules connected by their sulfur atoms. These natural precursors are available in any mammalian (mother's) milk. This milk should be UNPASTEURIZED, otherwise the dysulfide bond is broken.
A quick query to PERPLEXITY at PERPLEXITY.AI
QUERY: in a REDOX environment, what happens when antioxidants increase too much.
ANSWER:
In a redox (reduction-oxidation) environment, an excessive increase in antioxidants can lead to a phenomenon known as reductive stress, which can be as harmful as oxidative stress. This imbalance can have several negative consequences on cellular functions and overall health.
Reductive Stress
When antioxidants are present in excessive amounts, they can disrupt the delicate balance between oxidation and reduction in cellular environments. This leads to a state of reductive stress, where the cellular environment becomes overly reduced. Reductive stress can be just as detrimental as oxidative stress, and has been linked to various health issues, including:
1)Cancer
2)Cardiomyopathy
3)Disruption of normal cellular functions
Prooxidant Activity
Paradoxically, high concentrations of antioxidants can cause them to act as prooxidants, promoting oxidative stress rather than alleviating it3. This occurs because:
Antioxidants may react with transition metals, generating more reactive species
They can interfere with the body's natural antioxidant defense systems.
At high concentrations, some antioxidants can undergo autoxidation, producing reactive oxygen species (ROS).
Disruption of Cellular Signaling
Free radicals, in moderate amounts, play essential roles in cellular signaling and function. An overabundance of antioxidants can interfere with these processes by:
1)Neutralizing beneficial concentrations of ROS required for optimal cellular functioning
2)Disrupting cell-to-cell communication
3)Interfering with the metabolism and breakdown of drugs
Impaired Adaptive Responses
Excessive antioxidant intake can hinder the body's natural adaptive responses, particularly in the context of exercise:
1)It can prevent the activation of Nrf2, a key transcription factor involved in antioxidant defense.
2)High doses of antioxidants may impair exercise-induced adaptations, such as improvements in cardiorespiratory function.
3)Supplementation can interfere with mitochondrial biogenesis and muscle hypertrophy
Increased Oxidative Damage
Counterintuitively, high doses of antioxidants can sometimes lead to increased oxidative damage:
1)Studies have shown that vitamin E supplementation can increase lipid peroxidation following high-intensity resistance training
2)In some cases, antioxidant supplementation has been associated with increased plasma protein oxidation and lipid peroxidation in well-trained athletes.
In conclusion, while antioxidants are essential for maintaining redox balance, excessive amounts can lead to reductive stress, prooxidant activity, disrupted cellular signaling, impaired adaptive responses, and even increased oxidative damage. This underscores the importance of maintaining a balanced redox environment and obtaining antioxidants primarily through a varied, nutrient-rich diet rather than high-dose supplements.