What Causes Aging? - with Dr. David Sinclair | The Empowering Neurologist EP. 109
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- Опубликовано: 5 сен 2024
- Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we've seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called "free radicals,” changes in the function of our mitochondria, and so many others.
Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state.
David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan - Why We Age and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together.
In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.
In closing, I really need to say that Lifespan (amzn.to/3sSoCNS) ranks as one of the most influential books I have ever read. Please enjoy today’s interview.
To stay current on Dr. Sinclair, follow him on Twitter ( / davidasinclair ) and Instagram ( / davidsinclairphd )
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My wife and I really appreciate Dr. Sinclair, he inspired us for our biological age is possibly can be reversed. Next year, I'll be 60. We started our NMN & Resveratrol journey a year ago and got more than we expected result. We are feeling much younger, more energetic, have motivation to learn all sorts of things. we reversed our biological age sucessfully last year. We are very grateful to reconfirm that "It's Never too late" indeed is true. Thank you!
Where do we get these supplements I live in Sydney Australia? Thanks I’m advance
Were these 2 all that you were taken? I thought it is necessary to include TMG? I am really happy that Dr Sinclair is giving a scientific knowledge about role of exercise and fasting which helps turn on these longeviity genes.
@@agelessfree329 Yes, We are also taking TMG and some dried parsley as well for inhibit CD38.
How did you test that you "reversed your biological age"?
“The end of biological aging would not mean the end of death in any way. It’s more like a Summer evening when you were a kid, and your mom called you inside. You just wanted to keep playing, have a little more fun during sunset before you went to sleep. It’s not about playing forever, just a little longer, until we feel tired.” That is the most beautiful way of describing the want to prolong life I’ve ever heard. So it's just like that. We only live once, and life is something we can never restore once it's already gone. This urged me to slow down my age process, and so much grateful of Dr. Sinclair's podcasts about NMN supplement's benefits in our body as we age. I have been taking NMN by Vitruvin Nutrition for over a year now, and just like what they say in their reviews online, it resulted to me an impressive benefits. My energy levels are through the roof, no more fatigue, no more medical issues.
Really liked the part where you praised him for giving credit and space in his book to his coleagues in the lab
This is not a solo journey, so important to recognize the contributions others make.
It stands out in David Sinclair's book. He directs praise to the person in his lab who did the work. It is nice to see his concern for others acknowledge.
Sinclair always dropping knowledge 🧠
I see Dr. Sinclair, I click.
Same 😂😂
I click, I see Dr. Sinclair.
I click Sinclair I see click
Good rule of thumb
Indeed we are fearfully and wonderfully made! Praise God! (Psalm 139:14)
love dr Perlmutter.... what a beautiful guy, speaker, writer (and dr Sinclair of course! )
One of the best RUclips videos I’ve ever seen on this topic and I’ve watched dozens and read the book. Excellent interview and interviewing.
An honor to get that feedback!
I love this interview. I have seen Sinclair in other interviews struggeling to have a proper conversation on his level. He seems uneasy in explaining and conveying it to individuals that are not on his level of knowlegde and expertise.
But here he seems sharp as a knive and you kept him this sharp throughout the interview. Very well done.
Thank you very much Mr. David PerlmutterMD for asking the right questions of Sinclair which I haven't heard asked of him elsewhere. Thoroughly interesting, please keep the updates coming, I've subscribed to your channel.
Glad to know you found this so valuable!
I’m a huge fan of both your work. We are very lucky to have direct exposure and so fortunate your both willing to give your time to educate, and personally hugely appreciative.
I think this is the most comprehensive interview with Dr. David Sinclair so far. Thank you Dr. David Perlmutter. Cheers (Red Wine of course:)
Honored to know you think so. Thanks!
Thank's to Dr Sinclair! We are big funs of your work! ✌❤
I hope he also honored all the mice who are giving their very lives for this research!!
High quality content from both doctors 💙 and as fellow Aussie so proud of dr Sinclair’s passion for making a difference today and tomorrow👌😇
Thanks for watching Lynn!
Honestly, I just don't want to be a wrinkly grey-haired useless woman who can’t remember stuff in my ripe age. If I can get older and be able to sustain my body slowing down aging or even biologically reverse aging to my prime, that is ideal. Obviously, nobody can live forever, but I feel like we can live a lot longer, so why not slow our age rather than age slowing us down? This is why I am constantly taking Dr. Sinclair’s NMN, a NAD booster and indeed a health provider. With NMN Vitruvin Nutrition (500mg) a day every morning with protein drink and Greek yogurt, it has radically changed everything. All sorts of problems have disappeared. Now, age is just a number.
Gotta love Dr. Sinclair.
Agreed!
Jerry tennant in his book, (healing is voltage )explains why the newt grows it limbs back.
It's all to do with voltage. I thought you may have heard about him. Cheers great interview by the way
Fasciniating discussion. I am 69yo and obviously find such chats so relevant to my life. But I am probably not alone in wondering how successful research that extends life 10-20 years, will effect population numbers.
Phenomenal Dr Perlmutter
Great podcast, thanks so much for doing this! I'm excited for more content of this type. I've newly subscribed!
Welcome to the community!
The idea of combining these protocols with those of Dr. Dale Bredesen for brain neurogenesis is so exciting!!! I am a Brain Health Coach and am going to immediately start incorporating some of these with my clients. Thank you so much for all you do!!!
Wow. Thank you🙏.
Thank you for this fantastic interview.
Thanks for watching!
Wonderful, thank you 🙏🏻💖🌷
Anyone know where can buy NMN and RESV best company name ?
👏👏👏🇧🇷🙏LOVE YOU 2!!!!! Have both books 📚!!!!!!
Parabéns para você também! É ótimo ver brasileiros interessados em saúde de verdade
Yaaay! And really enjoyed the higher level of discussion for us laymen.
Did Dr. Sinclair talk about his daily routine in this video? I'm trying to find a new list if there is any, I remember he talks about it in one other video
He mentioned that he has started taking oleic acid (or olive oil). I think he said it has benefits similar to the effects of taking resveratrol.
I would like to start taking resveratrol and NMN but am fearful about possibly activating cancer. Breast cancer -DCIS- 20 years ago. Is this a valid concern?
Dr. Sinclair has said somewhere that NMN is probably not for anyone who has cancer. Research is needed before we will really know but the danger is it could invigorate the tumor. If you’re in remission... well probably all we can say is that further research is needed. I don’t know if resveratrol has any similar risks.
No one has done as much for young mice with their optic nerves crushed by David Sinclair than David Sinclair has.
Lol. Accuracy in praise.
Can anyone recommend any brands I can look into when purchasing NMN supplements?
Several companies make/ sell it....uniformly made.
Jump in and gift yourself, we deserve higher quality of life after retiring....I'm 68!!
Its definitely working with ME!
I began a very low Carb eating pattern about 15 years ago.
Lost 200 pounds but this supplement is KING of staying younger.
Donotage supplements
DoNotAge...great company sells quality NMN❤️
All the NMN in the market is of unknown quality imported from China, including donotage, alive by science, etc. by the way. Get Nicotinamide Riboside instead (Tru Niagen), it is certified as safe (GRAS) from FDA and similar regulatory entities in other countries.
One question would be the paper on mnm intake helped cancer cell growth ...
That was nothing suprising considering it boost NAD+ which powers cellular growth implying ANY cell. So you can see NAD+ as a booster to any NAD+ process, including cancer cells. So one thing you could do before NMN is take a full body scan to clear you off cancer in general so you know you aren't boosting a tumor growing.
Other things we can do is make sure our diet is clean and we are doing everything right in order to stimulate authophagy and combatting the removal of senesent cells first and stimulating the removal of mutated cells. After doing this for a while you will see major health improvements and from that point on you can top if off with NMN.
@@unholyquail4560 how can you make sure there is no wrong mutation? It just so random event and can happen anytime without knowing/ detection... i mean sure, healthy diet/ life style, intermittent fasting and so on helps but there is more to that
Would like to see Dr. Sinclair weigh in on the NAD+ salvage pathway and the influence of food components. I looked at the studies discussed by Nichola Conlon, PhD, and they indicate that substances like EGCG, quercetin, and apigenin have significant positive effects on the salvage pathway, which might preclude use of NR and NMN, especially when combined with exercise and some form of fasting. Also, one study indicates that within the tested range there is an inverse relationship between protein consumption and NAD+
The worst thing for ageing is thinking about it, celebrating birthdays annually, telling yourself your another year older..
So everyday tell yourself your a day younger, and don't use phrases like how Old are you ask the age not how old are you, Stop using the negatives... I'm a year younger next year.. I'm a day younger tomorrow.
Talking about the sun and it’s properties for causing cancer, so which is it, get some sun for vitamin D, or stay out of the sun?
He takes vitamin D supplement.
Get some sun it's from GOD !!!
Am I the only person to notice that Dr Sinclair looks younger in this video than those from 7 years ago. He hasn’t aged a bit at the very least. Look up his old videos and compare for yourselves.
Maybe the model works!
Facial work done... it's obvious
When did this interview take place?
I can't recall when exactly we sat for this but likely November or December of last year.
En idioma español..gracias
Que quieres decir?
Every living thing ages
NMN need more time to get better results on human
52 years old, looks 30. Yea, I trust him.
And you only want to know so you can mess with it
Dangers of Metformin: numerous, including vit B 12 and vit K interference. Vit MK7 is the wonder vitamin IMO. Taking Metformin for “health” is crazy.
Always have my dose of resveratrol in my half glass of red wine diluted with water 50/50 and dark chocolate every evening ☺
one need waay more than 200 glasses of red wine for a therapeutic dose.
That's great, however as Sinclair once said "Resveratrol is like brake dust". It doesn't dissolve easy and it needs to be taken with a fat such as yogurt or olive oil, not wine.
@@a72Stang Correct
@@a72Stang drink with meal of full fat cheeses like brie de meaux, nuts and olive oil ☺
@@ethimself5064 ok but look at the real world Italians on the med diet aren't exactly dying young, they drink alot of wine
So why not just take NAD sold at health food stores? Any help for this?
Research shows that NAD taken as an oral supplement does not make it through the digestive tract intact, therefore will not raise levels in the blood or cells. NR and MNM are precursors which can raise NAD levels in the body
@@seslews Can NAD be used successfully if it bypasses the stomach? On an empty stomach?
@@seslews NMN
@@chrisfrankford8899 Is there not contervcy on that?
Well the scientific reason for the ineffectiveness of taking NAD+ is that it is too big of a molecule to enter the cell. There is no known mammalian transporter. However, NMN enters the cell via the SLC12A8 transporter and then directly converts into NAD+
Aging is not inevitable? Are you Zeus? Insane.
Two Capricorn Davids interested in biohacking
L
⁰and p0p
David you dyed your hair too dark. It is obvious fom watching previous videos. You need to be consistent with the dye and make sure it is the right color...
Interesting, If we go back in time to the original First pair of humans,according to the bible we were never Originally created to die, We could have lived forever if We humans didn’t decide that we knew better than God and we went our own way of doing things . But the good thing is that Everlasting live on a paradise earth is still open to us, because God is going to make all things new, and those words are faithful and truth. The more we learn the more we realise the bible is true.this following Verse in the Bible came to my mind it’s in Romans chapter 5 verse 12
That is why Through one man (Adam)sin entered the world, and death through sin, and so death spread to all men
You started out well, then went off the rails quickly...
Brenda, you left out the best part of that story. “But God demonstrates his own love for us in that while we were yet sinners, Christ died for us.” Romans 5:8.
I don’t see anything in the Bible as precluding Christians from working to alleviate or prevent human suffering, do you? The founders of most of the first universities and hospitals seemed to think it was a great idea.
@@larrykraft2743 : I’m sure you’re a nice and honest guy Larry (applying the benefit of the doubt), and the old saying, “Nature needs stupid too.”
@@ecr-9341 Thanks for the encouraging words. Be well.
@@larrykraft2743 : You bet Larry. You got some reading to do. But, fortunately we live in the free-est nation with access to more data than one could contemplate in a lifetime. There’s more books than that ‘one.’ Step outta the box. It won’t hurt and your eyes will be opened and you will see...
Oh, and be well to you too..