David Sinclair Is Extending Human Lifespan | Rich Roll Podcast
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- Опубликовано: 24 авг 2024
- David Sinclair PhD is a biologist and Professor of Genetics at Harvard Medical School, co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging and author of the forthcoming book "Lifespan: The Revolutionary Science of Why We Age -- and Why We Don't Have To".
This conversation is about the science behind aging and David's research on the biology of lifespan extension, treating diseases of aging and extending human lifespan.
Note - this is AUDIO ONLY (we didn't film this podcast)
Enjoy!
✌🏼🌱 - Rich
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Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist at large. But mainly I'm a dad of four. If you want to know more, the NY Times wrote some nice things.
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I am 86 , retired, healthy also have some aches and pains, mostly from a bad auto accident .I am finding out that I am tired of being retired, it is boring, I want to start a new adventure , a new carrier, I am starting to do what Dr. Sinclair is talking about , I think there are a lot of people out there who would be bored and want to help to make the world a better place , to feel useful again, if they could reverse their aging and be young again.
Do you take any NMN or Resveratrol?
@Wuotans Krieger oooh what a prick
@Wuotans Krieger Ironic that a useless amoeba like you says that. I contribute more to society in a single month than you will in a lifetime. Judging by the fact that you spend time trolling people instead of trying to make discussion, you are a loser and a nobody.
Dale Kirkendall best wishes in your pursuit!! 😘👏
Set a goal and make it happen. Our elders are invaluable.
David, God Bless you and your kind heart, Keep up the great work. Thank you! I am 86 and I have always planned to live past 150, I am watching your podcasts everyday, and starting to do what you talk about.
It seems you did not listen to the podcast. People have the tendency of having fewer children as population grows so no overpopulation will happen
4:45 why Sinclair went into anti-aging field
12:30 university and M.I.T. with Leonard Guarante
20:00 longevity sirtuin genes in the 1990s
25:00 the epigenome
32:23 NAD+ and NMN
39:53 what are Sinclair's anti-aging drugs goals?
45:23 NMN's effects on old mice and humans, blood flow
49:23 effects of boosting on the mitochondria
55:05 resveratrol
1:03:20 going out to 100
1:05:05 intermittent fasting and exercise
1:18:54 mtor and rapamycin
1:21:05 mimicking exercise
1:35:30 people will be living into their 100s
1:53:00 how humanity might change with 150+ year lifespans
2:01:50 Sinclair's advice for better health; NR and NMN supplements that raise NAD+
,
Jzja
Thanks for the list!
Great job bro. Well done x
yamishogun Enormous thank you 🙏
I've seen dozens of interviews with David Sinclair and this is by far the best one. Virtually every question I have got asked and answered in the interview. Bravo Rich!!!!
The Area of how inflammation effects longevity was not discussed enough.
@@dcole7092 also, would be great to know which Resveratrol to buy...
I am 70 and have practiced only eating when your hungry missing meals drinking apple cider vinegar etc I am also a long time meditator so I look in my 50s that’s others perception. So it works!
For information of readers -- ONLY drink apple cider vinegar AFTER you dilute heavily with water.
@@StarCoded Yes!!! I thought you were supposed to drink it straight and it burns your lungs lol.
Really interesting from 1hr 30 onwards when you got onto challenges around the philosophical and practical challenges of population increase and so on. David Sinclair more impresses with his fully rounded perspective on the work he is doing and likely impact.
This is such an interesting and intelligent conversation. Thank you so much!
I have been watching Dr. Sinclair's interview and this is the best so far. Very informative conversation. His book is also very educative. I love that book. In there, there's no point increasing lifespan without healthspan. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. I hate aging and the illnesses it brings over time. This is why I am now taking NMN supplement by Vitruvin constantly.
I'm happy to come across to a Vitruvin user like you... I hope to hear the same results in the long run. 😇
Im listening to all the podcasts with dr Sinclair. Now I think Ive become addicted to his soothing voice apart from being fascinated with his work :)
Next 10 years is going to be amazing 😀
Liberty309 I doubt it. Probably 25 years before age reversal is available to the masses if we are lucky. Ill be 77 😖.
@@kevn99 Eat healthy, and exercise and we'll make it. 😆😆😆
Kevin that’s cutting it close , good luck man
I'll be 65....hmmm...
We'll first start to see weirdly young-looking billionaires that just seem to keep going.
It will be amazing. because its already amazing. .
just listened to it because you recommend it in your recent part 2 podcast and I learned so much. Thank you! Gonna read his book for sure
No matter how long you live it's trained mindfulness which really makes each moment come alive and more enjoyable. For that Thich Nhat Hanh is the master to learn from.
My takeaway is to up my lvl of exercise and to keep improving my 8-year experience with a healthy and fresh, highly varied plant based diet. Other than that I will try to get more hungry more often. I will keep going with my cold showers and my intermittent fasting regimen and will try more regular sauna.
Imagine your parents are still around, or your grand parents. How amazing would it be to have four generations healthy and around. That maybe in the very near future.
As long as those relatives are decent people, it would be fantastic. If they are a bunch of abusive narcissists, it’ll be a nightmare.
@@albertmarble like the dreaded mother in law!!
@fortnite4201 x
😂😂
yes! lots more people around to fight and argue ;-)
Oh Jesus ... my dad will have time to start his 4th set of children. My children will have their own children plus baby aunts and uncles.
I love every interview of Dr. David ever since he started discussing longevity. I have also acquired his book "Why We Age and Why We Don't Have To." That book is eye-opening and educative. In there, there's no point increasing lifespan without health span. The goal should be to live longer while staying young and healthy. Sinclair believes that in the foreseeable future, it's possible for humans to live beyond 120 or even 150, without the frailty, diseases and disability we now associate with old age. This is when I found my NMN supplement, Vitruvin Nutrition 500mg/day. I want the world to know that we only live once, let's live a little longer.
Doing hard PHYSICAL work(I'm 65, a window cleaner), not playing with a computer mousse all day, I believe helps too.
I have been on NMN and Resp. with vegan diet and B12, D3, PQQ supplementation for about 15 months. I cut out alcohol for that 15 months and exercise a lot. My wife and I did the Dr. Longo fast once back in April 2019. Last year was the best year of my life for training and general health. All my markers are good for a 60 year old. I went off everything for one month (Dec 2019) after completing Ironman Cozumel and felt like (I used to). Now back on the program and look forward to getting back to training.
What’s nmn and resp
You were going to leave some information about Resveratrol in the show notes but I can't see it. Interested to know what brand and source for what you are taking. Thanks
Yeah! Me also!
Thanx for mentioning, still don't know which is the best one...
Still waiting for the link!
Thorne Research Labs has one of the better resveratol supplements available. It's very pure. Third party tested and noticeable in its effects after a couple weeks of taking it. It's also combined with the Quercetin that Dr. Sinclair also praised. I'm not sure if he backs this company or not but it's a very reputable company backed by other brilliant minds su h as Dr. Rhonda Patrick who's also been on RR multiple times.
Maybe I am 3 years to late listening to this. Maybe not. As I have said before to those who will listen and learn... It's never to late with life as we know it until you are in your grave. Love Words of Wisdom
This podcast is my only food, I'm gonna life for ever !
There you have it people.
Right from the pioneer of aging reversal.
What you put in your mouth and getting active is key to longevity.
Take personal accountability and make your life all it can be.
Omit high fructose corn syrup...
A great start ......
Thank you for your life long dedication to helping our children Mr. Sinclair....
Cheers
Eat clean, exercise regularly and supplement what you can't get from whole food.
I remember asking my parents at age elleven, about why are we going to die? It scared me.. im now 59 and about to turn 60 September 7th 2019..wow I cant believe it..
Time waits for no Man! Do you feel 60?
Death is an illusion don't worry
@Papaya Tasty wow that was such a synchroncity , i was literally thinkng about reincarnation then i saw this message
Youve probbaly been born and been young and then grown old hundreds of times and youll be young again , give 15-20 years- reincarnation
Happy birthday
In Huxley's Brave New World they talked about about shortening the disease phase at the end of Life, something like people don't wilt with old age they snap and die quickly when the time comes
In Huxley's "After many a summer dies the swan" a millionaire travels to England to meet a nobleman who figured out how to extend life. When he finds him, the nobleman had turned into an ape.
Thank you for taking the time to meet with David Sinclair and sharing it with the world too.
I am 74 no ache and pain but with asthma under control. My mom is also an ashmatic but her asthma disappeared 98 yesrs old
Great work Dr. Sinclair! I was very interested to hear you are working on iPSCs like the Belmonte group. If selling a house were not so expensive I would apply to the PhD program there and come help! My MS in biochem. is pretty rusty (1988) but I've been thinking of helping out on the aging/health-span work as my 5th career (20 yrs. USAF/pilot, taught chemistry/biology many years) before I hit age 76 next summer! I'm 6 hrs. SW in Reading, Pa. w/ no comparable school in the area.
I love the optimistic vision you discuss in the end of this very interesting podcast. I am deeply convinced that people with a vision Will continue to be active and that wisdom can change the Way we understand and interprete life and possibilities 🎵🍀🎶💚🦋🙏
Great talk! Thanks for uploading.
What an amazing interview, thank you, Rich,, thank you, Dr. David Sinclair, you rock! xx
Are they using sound frequencies to turn it off and on? 🤨
Fascinating research & fascinating discussion. Good job Rich!
A. We'll have to forget about retiring at 65. Maybe 140.
B. Our old age security fund is going to run out of money.
C. I'm going to get a lot more motorcycle riding than I had figured.
A. We'll retire earlier due to AI & automation.
B. We'll get the UBI.
C. You can ride your bike as much as you want.
B will be saved by less health care need
Who needs an old age security fund when you got wheels and years!
C. You can ride on an automated motorcycle longer than you thought...
related?
What a FANTASTIC interview and discussion! I always thought it was ludicrous that we get to an age where we are wise and experienced, and then body starts to fall apart. Crazy! I had no idea that an aging drugs and research were so close at hand. I'm 64 and looking forward to the drugs, as long as they are safe. Meanwhile I should eat less and exercise more.
Also I see that pet lifespan will also be increased, making dog owning a lot less stressful!
Maybe when we know we can live a couple hundred years we will be much more careful about preserving and healing
our beautiful Earth environment. And also be much more responsible about procreating.
The supplements NMN, NAD+ and Resveratrol are now on the market, check out Joe Rogan #1234 where David Sinclair talks about how he takes it.
A wonderful podcast with a wonderful man.
A great subject to cover.
Just unfortunate that he mentions eating a steak is the worst thing you could do..ONLY on a vegans podcast. He never mentioned it on Joe Rogan's podcast or others I have heard even when he is specifically asked what they should do to stay looking young.
Thanks for your time Mr Sinclair - very informative - also a nice job by the host Rich
David is a lovely man, and what he is trying to do for humanity is just amazing 👏
If you think doling out misinformation is helpful, then you need to raise your bar.
So good! Loved this.
Brilliant Ideas; God Bless You Dr. David Sinclair
I wish my mother lived little longer
I am so heart broken.
Me too.
Sara singh Sending you love 💖
Sara singh I'm so sorry!! 😘❤️😍
Sorry 🌷
Thank you sir david you are awesome, atleast somehow my worries of getting old diminish abit, iam 49 years old
I hope and pray for your success,specially on longevity matter.😊😊
this was a fascinating podcast. thanks!
AGING IS A DISEASE 🙃
Adam in the bible died at the age of 930 years old and his descendants died at the age of 800 to 700 to 600, etc and Joseph died at the age of 110 years old. We will be lucky to have Dr. Sinclair help us live up to 200 years old with this poluted and processed food world.
r/longevity is a great place to discuss this topic for anyone interested
Great tip! Thank you.
I'll check it out, thanks.
Thank you good man .🇦🇺
Wow ! Such an awesome conversation ! Dr. David Sinclair and Rich Roll you are the best interviewer --- thanks for asking the " layman's" question and " translating " for peeps like me the highly complex scientific terminology --- breakinf it down to practical lay person's language.
So at this point the question is: How do we determine the levels of "healthy" stress (hormesis). If we overdo this, we will do more bad than good.
It is a vital question. To use the example he discussed, fasting decreases fertility in women because hormones that regulate ovulation and probably other functions are incredibly sensitive to energy intake. On the other hand, NMN that is activated by exercise or fasting also has the effect of erasing symptoms of menopause and restoring regular monthly cycles, potentially making it possible for older women to become pregnant again. All we can do for the time being is regular blood testing to track biomarkers that may be thrown out of range by any of these techniques or supplements.
@@Elayman1 well how confusing...can a super skinny person with little muscle fast do you think?
betzi b yes, I do. As long as you ingest healthy fats and nutrition when you do eat, then you should be fine.
Thank Dr David Sinclair ALL THE INFORMATION ABOUT THE NMN IS PERFECT BUT IT 'S VERY IMPORTANT TO KNOW HOW AND WHERE WE COULD BUY THE NMN .
PLEASE DR SINCLAIR SEND US INFORMACIÓN ABOUT IT.
THANKS.
How is it changing your life?
Diane Williams what brand of nmn did you purchase from Amazon? I was looking at them tonight and not sure which to try. Thank you!
I'm 38 and depressed. When I was happy, this research inspired me. Now I don't care and I don't expect to live very old.
halneufmille aw😚
Concentrate on getting over ur depression. Theres alot of research on the net . Good luck
Yet somehow through gods grace you ended up here. Coincidence- I think yes ❤
My mom lived to be 93 years old. For the last two or three years she would sometimes say "We're living too long." She was in a fair amount of pain and discomfort most of the time from arthritis and allergies.
If I could live to two hundred I would have gone back to college to study neurology and bioinformatics. Being 65 that kind of investment of time and money is just not feasible.
Not if you can live to 120, then u would be middle aged.
I had a 65 year old high school principle in my registered nurse college class...he graduated and intended on helping his parents live better and longer....
You can even now live until 200... in vegetative state.
Never say never!
Think of how great a Neurologist with a hundred and seventy-five years experience would be!!!!!
great interview, fantastic topic!
so enriching thanks a lot
I have pretty much lived this way for the last 35 years without really knowing it. Vegetarian, relative caloric restriction with a lot of aerobic exercise in extreme temperatures etc....Id be curious to be tested by Dr. Sinclair to see what if anything this has done for my health.....
Do you look young for your age?
People always think I am considerably younger than I am.
@@andreasmaher8749 thats great :) am just 23 but my boyfriend keeps saying I look really old and could u give me some tips maybe ?
There is really no secret as far as what Ive done over the years. I run and cycle up to two hours total most days, sometimes more sometimes less. I typically only eat two meals a day other than say a lowfat yogurt and maybe a piece of fruit for "lunch". Im not vegan, I do have milk products on occasion but never any meat, fish, poultry etc...My breakfast is invariably a large bowl of oatmeal with maybe a few walnuts, some blueberries and brown sugar made with water. Dinner is usually some sort of vegetable concoction and maybe some bread of some sort. I do have a bit of a sweet tooth so I indulge in desert in the evenings. I burn a lot of calories through endurance training so I think the sweets help to fuel that. Not that it makes a difference but Im not a caffeine person so little if any coffee, tea or the like. Mostly only drink mineral water. As Ive gotten older I do take a multivitamin as a precaution.
@@andreasmaher8749 thnk you :) I'll follow it from tomorrow
Wonderful and informative as always!
Judging by the state of this earth with climate change, more political instability, the race to produce more and better weapons, the depletion of wildlife areas the question should be "is it advisable that we extend human lifespan?"
Ascending to infinite enthalpy and energy, perfect balance of energy . Or perfectly controlled imbalance. Or perfectly observed imbalances. Or no observer and just flow
So these supplements he’s mentioning needs to be taken everyday? Or every other day?
Special interview
I would like to live as long as possible so i can make the world a better place
I want to experience life beyond this computer and the internet
At a Starbucks in Calabasas, I met Rich, nice guy!
An excellent (and I believe, superior) counterpoint to Sinclair's work can be found by typing "Ray Peat" and resveratrol .
Thanks
Resveratrol is old news look up something current
@@brianhickey666 David Sinclair is talking about resveratrol in this video, dumb dumb.
@@wmp3346 You're welcome.
Ray peat
I think about it almost everyday at 30
Great podcast!
Iterates the “one disease, one cure” theory of health and disease
One interesting thing a friend of mine mentioned when i told him about all that stuff in relations to not only expanding the life-span but the health-span as well is: All the years of struggle we currently have to go through, the period of morbidity, getting hit by one desease after another, getting weaker and weaker and so on actually prepare us for death. At some point we just die out of resignation, no longer able and or willing to keep up the fight and we actually feel relieved of letting go and saying goodbye, knowing its for the best, its time, its all good.
As David mentioned, by pushing the tail end of the vitality curve as far out as possible and when you are 130 you get sick for 1 week and you die would most likely result in people not getting confronted with their own mortality that much at all, clinging to life and their vitality and actually getting surprised of things ending so sudden. Not being able to make their peace with it.
Our life-span increased by a lot and i guess its fair to say that our health-span couldn't keep up and therefor increased the period of morbidity. So shortening it would be surely a good thing. But shrinking it down to a week seems a bit too much and would result in other problems, as mentioned.
Most people are probably going to want relief from their own restlessness and vitality after 130 years -- but telling them to just go kill themselves when they have had enough is not going to be an acceptable answer either.
its very true ,im 60+ and think like a 20 year old and find i prefer to talk to young people over older as older people mostly are so negative and behave old.
45:54 "Is this cool?" LOL. I love it!
big, big business coming...and Dr.Sinclair pitches the concept.
I can appreciate this discussion, but the whole pharma route makes me uncomfortable. I can only imagine what this treatment would cost. Maybe he is right, in time it may be cheaper just like air travel.
I understand he is doing a good thing for science. Such a huge topic for me to synthesize...living to 150.
It's cheap. Amazon
The drug (NAD) is a molecule that's already in your body.
YOu can order Nmn+nr, on amazon. Its cost you about 30 Dollars every 4-8 Weeks.
Pharma - yes, for sure. I totally get it. But identifying substances in the body that decline with age then augmenting health directly with those substances - makes me hopeful.
NMN is expensive, but prices are coming down slowly, supplements should be just that; supplement what you can't get from whole food and quality exercise.
Dr. Sinclair, you are on the right track as it is the will of our Wonderful Creator to appreciate Creation and His awesomeness.
Sir, evolution is NOT scientific, and we ate not animals; that is why we are conscious of death. Medical Science has it's root firmly established in Genesis chapter 2 of the Holy Bible. Our Wonderful Creator put Adam into a deep sleep, opened him up, took a rib to form a woman, Eve, for a wife. Hence, marriage between man and a woman is the foundation for a family!!! I respect the fact that some people feel/prefer to be different.
DNA is a complete and the most complex form of program. It contains diverse forms of human beings in accordance with their environmental needs, which is adaptation. Adaptation is NOT evolution! DNA has the ability to repair itself.
At 46 got my first batch of NMN and Resveratrol last week, and 6 months of exercise at gym. so far so great!
Manonsilvermountain what company did you go with for nmn?
@@jasonlovin3442 I got it from alivebynature dot com
@@jasonlovin3442 I've been taking Genex NMN sold on amazon
How about this: Aging is not a disease but a state of enhanced disease processes. Even if we live to 200, we're still going to die. I like the idea of thinking in terms of delaying disease processes rather than seeing aging as a disease and death as its outcome. We're still going to die, even if we double our lifespan tomorrow.
Maybe. But we could still have a few millennia to decide. The anti aging field is barely 25 years old and Dr. Sinclair is already talking about living to 1000.
@@Elayman1 Of course I'd prefer a thousand years to mull it over to 90. If that means "classifying" aging as a disease then I'm fine with that, but I find a philosophical discussion of what aging actually is more interesting and was thinking there may be a way to merge the two.
I don't know but it is an interesting question. If the human lifespan is indeed unlimited are people that aren't treated going to be thought of as fundamentally sick or diseased ?
I believe aging is classed as a disease because it happens to everyone, we will all die, but I want to be a fit and healthy as possible right up until the day I die, at whatever age; I don't want the last few years to be just existing!
So i would imagine that Cryotherapy and Infrared Saunas on a regular basis would shock the DNA repair mechanism into action.
I believe that about the infrared sauna... I used that on a regular basis for a while... it was great for me
2:20:13 "what I do to sleep better"
filter blue light at night and get heathy sunlight, all cells work on clocks.
Lol too good
I'm very interested in David Sinclair's actual diet. I know he doesn't eat a lot, if any, red meat.... Curious if he's more plant based as he states do not eat to much protein... Anyone out there able to answer this question? TY!!
If you are interested in plant based go check out nutritionfacts dot org. A great resource of knowledge based on numerous studies
Does the resveratrol powder have to be white???
Can't agree about forgetting about death from 6 onward. As your brain develops as a teen I certainly started to think about all kinds of questions like if there's a god and what happens after you die. Many people just accept there is a heaven which then allows them to stop thinking about death and get on with living which has it's advantages. Now we can hope that we can live an extremely long time and not worry about dying in that way and get on with our lives (although of course doing all the things required to increase your probability of long life, but these things should be habit, not conscious acts)
the idea that epigenetic marks are lost upon DNA repair is excellent and the research looks great. One simple way to think about it all is that it's all about dynamic genomic integrity, and who needs NMN (or NR)?? -> if you can get B vitamins (niacin, remember is B3), have enough Magnesium (just the simple salt is fine) and anti-oxidants, and move a bit... just imho! ageing well for all is a great goal (not just looking for new things to market to the masses)! Take care!
I want to live forever. I stopped smoking, limit sugar to less than 6G per day, consume NO bread or grains. Lots of nuts, fish, collagen and vit d paired with two miles of walk/run every morning. I just started resveritrol and started exercising in the cold. I'm noticing some anti aging already. That stubborn fat below the jaw is going away along with wrincles. I think my knee is also rebuilding itself 5 years after my ACL replacement surgery. I was able to RUN down a wet mountain trail the other day and I felt like a kid. No pain or soreness at all. I wish I could make people feel what it's like to approach their genetic potential (which is always greater than you would expect).
1. No to low sugar
2. No bread period
3. Intermittent fasting
4. Eat oily fish like sardines
and stay away from strachy veg and legumes. (They cause bloating and inflammation)
5. Walk/run every day within an hr of waking for at least 30min.
6. Take good supplements
I think The term 30 is The new 20, 40 is The new 30 will have a relevant meaning pretty soon
Life will be wonderful if u can also preserve ur equanimity.
Loved this conversation.
I’ve not yet come across this question .. Has David Sinclair tested himself daily to monitor his level of NAD when using metformin, Resveratrol, and NMN? It would be good to know if one dosage kept his levels up for just only the day or a few days.. obviously everyone’s chemistry is different but it would still be a good measure to know. Thanks!!
From watching previous and newer videos with Dr. Sinclair, he's been taking NR or NMN for ten years now and his 23 and Me test revealed that he biological age was in his late 30's or so if I recall correctly. The $64K dollar question is, how old are those mice now? How long did they live? Especially the treadmill mice!
They touch on testosterone around the 1:23 mark and I am curious to hear more. He says increasing your testosterone could have a negative affect on longevity. As we age our testosterone levels go down, but with NMN he says his blood chemistry shows he is decades younger. Does the blood chemistry showing he is younger include elevated levels of testosterone? The studies in mice show that with NMN older mice can have the strength of younger mice. What accounts for this increased strength, are their muscles larger, more efficient, less fatigue?
Perhaps it is increasing ATP in cells , so more energy is available. My great uncle, was a tall lean guy, with baseballs for biceps. He was not big, but wiry , he was an active logger well into his late 60"s and he was ripped.
The process basically starts with the etabolism of fatty acids and glucose which requires NAD+ which is in turn necessary for the production of skeletal muscle to enable posture, breathing, and locomotion etc. So it is a major player in skeletal muscle development, regeneration, aging, and disease. I'm not exactly sure how testosterone augments strength in the beginning but comes back to bite later but the vast majority of studies indicate that lower NAD+ levels are harmful for muscle health and higher NAD+ levels increase muscle health.
Rich you do great podcasts but this one really matters don't you agree? I mean this really IS a game changer in so many ways..
If you enjoyed it, you should check out David on Rogan as well.
It will happen, regardless of how much resistance. Evolution inertia. So let’s prepare for it.
Make eternal youth happen to both humans and animals!
Wonder what Sinclair's stand on adjusting hormones to optimal levels such as human growth hormone & testosterone to help slow or reverse aging.
Can someone please share their summary of the podcast?)
There's never been a better time to be an elderly mouse.
@@scottalias8245 It's been a year since your reply, I'm going to be getting a laugh throughout this year! That's how clever and FUNNY your reply is! 🤣 Touche!
Fun fun fun. Thanks for enlightening and uplifting podcast .
Sounds like great stuff. Lots of risk. Don't know if David is all he says he is or knows all he says he knows or how much of it is true but it seems to all line up with my own superficial look-see over the past few years. Again, giving I don't know him, I like his attitude and his humility. A little worried he is a little presumptuous. In this case it may be warranted :-) Usually isn't though. For example maybe some people would prefer to live to 60 with lots of muscles than to a hundred without them. Might even be the best thing for them...
In this case - in a unique case like this - it seems that philosophical implications can affect humanity not unlike hard science discoveries, and so must be identified and then weighed carefully. Presumption eventually leads down blind paths.
He was on Joe rogan and that podcast I believe he explains his background in the science far better then this.
Second I agree him explaining the benefit/cost of certain diets and supplements is just opening an avenue for people to choice how they want there life to grow.
I imagine a society where many will live longer as this data is harnessed into better information, then they will live longer but we all be different as a species.
I think Aubrey De Grey has a better plan for ending aging actually, but David Sinclair is a much better salesman. That is why the masses listen more to David than Aubrey.
People it still hasn't been PROVEN that human life has been extended , David is still in the process to prove that , it has worked to some exstence in a mouse that had younger physical abilities but didn't show a comparison life span , NO facts that life is extended IN HUMANS BUT TIME WILL Tell !
I don’t see the link for resveritrol mis spelled or brand ??????
I ordered The NAD and I started taking it twice a day.
What brand name and where do you order it?
Mick Nikolas I ordered it, the NAD, on Amazon.com, and I also ordered the NMN. And both are sublingual for better absorption.
Maria, do you feel any benefits?
How fascinating, and exciting! With Uranus in Taurus for the next approximately 7 years , we will see many many breakthroughs in the field of regenerative health. I think we are on the brink of discovering and understanding many secrets of human life. Hopefully we will make the best of it and use our energy to expand our consciousness and develop the virtues of peace and love as a society.
Whilst it is interesting to think about living longer physically we need to think about the emotional and structure of society when will what David Sinclair is doing and how we design the future going to come together so that mankind can cope with potentail consequences. Science as all to often come up with answers to problems before mankind has known what question to ask.
Sign me up for the human trials.
Hello Good Sir,
What is the relationship between NMN and Nitric Oxide?
Cheers
Daniel
Scientists use jargon when it is not necessary to discuss simple terms all too often. Essentially niacin (B3) can convert to NAD and positively influence a bit of juvenescence in the cells. As I understand it, tryptophan can also convert a bit into NAD.
By the way, niacin improves blood pressure and cholesterol. Do your own research.
That's really interesting!!! Thanks 👍
I don't recall Dr. Sinclair ever criticizing Niacin and it may be an original NAD+ precursor but it doesn't have a longevity effect he is looking for (at least in mice). There should be more in his book but there are real differences that aren't a matter of terminology.
@@Elayman1 Hi there. I was not suggesting that he criticized Niacin. He simply never used the term, when in some instances it can be interchangeable. I can attest to seeing an effect with Niacin in a less clinical manner. Some other research has highlighted its benefits. I combine its use with three other natural products. I was born in 1967. Melanin is not always a factor. Lifestyle is.
Were these your questions or questions he told you to ask? You asked great questions, and gave good analogies. So far 1hr it's an awesome interview. I'm hoping there r a bunch of action steps coming. Thanks 🤙😎🤙
@Mike Haydon Yes, I will be scooping it up for sure. I'm always down to support positive people like this guy! Not to mention, there's gotta be some golden nuggets in it.
My naturopath suggested I do NAD iv once a month ... still trying to wrap my head around this stuff ... but if anyone is interested in that... they charge $300 for that ... one round... slow drip ... I may switch to oral supplementation, but will likely do another three or four iv’s at least ... it is more expensive than the other iv treatments which usually run around 175... or less ... I did it once so far ... I was unwell at the time, fatigued, recovering from a gallbladder attack, I’m anemic, super low on D and have a large benign tumor... all I can say is that NAD iv revived me.
you dont have to spend that kind of money. my company is putting out an NAD supplement next month
Cassandra Decosta while I don’t know how much more advantageous it is to do the iv version, and it may not be all that more advantageous... but, often iv’s are superior, probably not always though... and yes, the cost of the iv is quite prohibitive... I have considered going with supplementation ... I still feel like I need to understand more... and like I said, I will probably only do the iv for a short time... my ND recommended it once a month for now... I did not ask him how long... but I can manage the cost right now, so I will probably do the iv another 3 to 5 times and do plan to switch to a supplement strategy from there
Please tell us what you ingest or drink on the days of no food....
What does he think about the carnivore diet? I heard him say too much protein ages us.
@Chew Chew Train but the carnivore diet helped so much when I was having major stomach issues and so many people have amazing results on it so I'm perplexed. I cant eat lectins or anti-nutrients from plants.
@Chew Chew Train yea I was thinking about going back to basic diet of eggs sauerkraut and olives and avo. That seems to really tame down the symptoms too.
@Chew Chew Train right! My stomach loves that and kimchi👌🏼
Studies have proven that high carnivore diet is linked with more cancer. I believe Dr's Longo and Fung recommend plant based with small amounts of fish (best) a couple of times a week. More protein if you are a senior
Good discussion. One clarification in your Dad's Story on the reason his employment services were requested for so long. It is not because Anchorage or Alaska has an enormous Native population and they value wisdom of elders. Both are true however Alaskans value anyone who has many year experience working in the Alaskan Environment, particularly Engineering and construction. I know first hand. My Grandparents came to Alaska in 52 when it was a Territory. They both African American lived to 99 and 97 as well as all there siblings into there 90s and mother 100. All worked into there 90s. A good friend of the family owned a construction company and buildt perhaps 10% of the city. He is 86 and still is called for advice and work by non native Alaskans who are the majority of the population. I have lived all my life in the state, while travelling to 33 countries and working few years abroad. My family's key to long life. Work, have a purpose and eat clean nothing processed nor excessively.