Ironically, I was fortunate enough to get sucked into a Twitter argument about lifting the shelter in place here in the US because someone posted this video in support of their position. I have been trying to avoid the drama while keeping informed across the available sources of information and I usually move on from those types of things in search of more useful information. This video was buried pretty deep in the theead so I was very fortunate, but I digress. I wanted to thank you for the manner in which you presented this information and in the comments below. It reflects a tremendous amount of respect and gratitude to the family of this patient that words alone could not. Also, please accept my gratitude for the information provided. A lifetime ago, I was in school to become a nurse paralegal to render opinions in medical malpractice cases, but life had other plans for me and I never finished the process. It's speaks to your teaching skills, however, that I was instantly transported back in time and could follow along quite easily! My sister and I are caregivers of our elderly parents and I have 2 autoimmune diseases. The mainstream media repeatedly reports that the elderly and immunocompromised are the most at risk, but hasn't broken down with any specificity as to what we should be doing to protect our parents as well as myself being that we fall into these categories. Therefore, the information you provided here has really helped me understand what exactly these patients are going through which in turn helps me to better understand what steps should be taken for the wellbeing of my family. Again, words fall short most of the time when trying to convey feelings, but deepest thanks and well wishes to you and yours for the time and effort taken to seek out a willing family and to put together this presentation. Stay well!!
Thank you for the honest feedback and compliments. I'm glad you were able to find this presentation useful. Do take care of yourself, and your parents. Right now the best thing you can do is self quarantine until the infection rates in your local area drop significantly.
Thank you so much for your work! What do you think it's the cause of anosmia in patients with covid-19? Have you tried studying the nasal mucosa or perhaps the nervous tissue?
I'm so glad you liked the video. We did not examine the brain so I do not have microscopics of the olfactory tracts. Encephalitis has been reported in other corona viruses so it is probable that the novel corona virus affects that CNS in some way. Some have hypothesized that impairment of the medullary respiratory centers contribute to the respiratory failure in some patients. It is difficult to know for sure with so few pathology reports. Hopefully, as we continue to gather more data, we will soon know more about the pathogenesis of the COVID-19 virus.
I effin knew it!!! i've only done a single postmortem study of a suspected covid patient back in january and it was filled with those viral citopathic cells. Im in colombia and back at that time we did not had any laboratory test for covid, but the clinical and pathological findings where those of a typical viral pneumonia.
Thank you very much! I do only know the "healthy/ physiological histology" (I don't know how you call this in english) of most tissues. So these videos are a great enrichment for me.
Most organs have very limited ways in which they can react to injury, so the anatomic findings for both viruses are similar. I do not believe SARS caused a prothrombotic state or hypokinesis/arrhythmias, as the novel coronavirus seems to do.
@@AdventuresinNeuropathology Thanks. I am RT in LA, just interested what postmortem findings in the lungs of virus patients. Looks like some chronic abnormalities developed into acute irreversible process because of coronavirus. Wish you can cut lungs of virus survivals:)
We just published a paper with the findings in this case. You could probably use a translation tool to translate the content into Russian. www.archivesofpathology.org/doi/pdf/10.5858/arpa.2020-0217-SA
It would be helpful to look at other cofactors such as History of vaccines especially flu shots in last 5 years as well proximity to high wifi technology Especially four and five g near her home and or work.
I am not sure about her prior vaccinations. Regarding wifi - I do not believe that would have any impact on how a virus infects and affects human tissues.
Ironically, I was fortunate enough to get sucked into a Twitter argument about lifting the shelter in place here in the US because someone posted this video in support of their position. I have been trying to avoid the drama while keeping informed across the available sources of information and I usually move on from those types of things in search of more useful information. This video was buried pretty deep in the theead so I was very fortunate, but I digress. I wanted to thank you for the manner in which you presented this information and in the comments below. It reflects a tremendous amount of respect and gratitude to the family of this patient that words alone could not. Also, please accept my gratitude for the information provided. A lifetime ago, I was in school to become a nurse paralegal to render opinions in medical malpractice cases, but life had other plans for me and I never finished the process. It's speaks to your teaching skills, however, that I was instantly transported back in time and could follow along quite easily! My sister and I are caregivers of our elderly parents and I have 2 autoimmune diseases. The mainstream media repeatedly reports that the elderly and immunocompromised are the most at risk, but hasn't broken down with any specificity as to what we should be doing to protect our parents as well as myself being that we fall into these categories. Therefore, the information you provided here has really helped me understand what exactly these patients are going through which in turn helps me to better understand what steps should be taken for the wellbeing of my family. Again, words fall short most of the time when trying to convey feelings, but deepest thanks and well wishes to you and yours for the time and effort taken to seek out a willing family and to put together this presentation. Stay well!!
Thank you for the honest feedback and compliments. I'm glad you were able to find this presentation useful. Do take care of yourself, and your parents. Right now the best thing you can do is self quarantine until the infection rates in your local area drop significantly.
Thank you so much for your work! What do you think it's the cause of anosmia in patients with covid-19? Have you tried studying the nasal mucosa or perhaps the nervous tissue?
I'm so glad you liked the video. We did not examine the brain so I do not have microscopics of the olfactory tracts. Encephalitis has been reported in other corona viruses so it is probable that the novel corona virus affects that CNS in some way. Some have hypothesized that impairment of the medullary respiratory centers contribute to the respiratory failure in some patients. It is difficult to know for sure with so few pathology reports. Hopefully, as we continue to gather more data, we will soon know more about the pathogenesis of the COVID-19 virus.
Thank you for all your work
I effin knew it!!! i've only done a single postmortem study of a suspected covid patient back in january and it was filled with those viral citopathic cells. Im in colombia and back at that time we did not had any laboratory test for covid, but the clinical and pathological findings where those of a typical viral pneumonia.
Thank you very much!
I do only know the "healthy/ physiological histology" (I don't know how you call this in english) of most tissues. So these videos are a great enrichment for me.
The shown sections of the slices look very good btw.
Thank you Luca. I'm glad you found this helpful.
Could the peripheral leukocytes be damaged through CD147 mediated viral endocytosis?
Very helpful and comprehensive review!
Glad it was helpful. Thank you for watching!
What pathological differences with old sars (2005?)/ From autopsy point of view.
Most organs have very limited ways in which they can react to injury, so the anatomic findings for both viruses are similar. I do not believe SARS caused a prothrombotic state or hypokinesis/arrhythmias, as the novel coronavirus seems to do.
@@AdventuresinNeuropathology Thanks. I am RT in LA, just interested what postmortem findings in the lungs of virus patients. Looks like some chronic abnormalities developed into acute irreversible process because of coronavirus. Wish you can cut lungs of virus survivals:)
@@andreychizov8201 you can cut the lungs of survivors, but it's called murder. Unless the subject of a lung transplant.
Excellent presentation!
Thank you kindly!
hi.thank you! where can i read it ? the problem is that I need to translate the information in russian language for my father!)
We just published a paper with the findings in this case. You could probably use a translation tool to translate the content into Russian. www.archivesofpathology.org/doi/pdf/10.5858/arpa.2020-0217-SA
@@AdventuresinNeuropathology wow!!!!!!! YOU ARE THE GREATEST!!!!!!! THANK YOU SO MUCH!😍😍😍😍😍😍😍😍😍
Oh and i dont think it was bronchial epithelium desquamating, necrotizing bronquitis tend to slodge off pieces of bronchial epithelium like that
Very interesting. There are now immunostains for detecting SARS-CoV-2 virus in formation fixed tissue, so that should help moving forward.
Thank you💖🙏✌🏻.
Thank you Maysam. Stay safe and well.
@@AdventuresinNeuropathology I wish and I am trying to ✨🌈 be a great human being like you. I must pay back all of angles priceless help.💖✌🏻.
It would be helpful to look at other cofactors such as History of vaccines especially flu shots in last 5 years as well proximity to high wifi technology Especially four and five g near her home and or work.
I am not sure about her prior vaccinations. Regarding wifi - I do not believe that would have any impact on how a virus infects and affects human tissues.