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Normal Skin Histology - Explained by a Dermatopathologist
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- Опубликовано: 14 авг 2016
- A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)
Topics discussed:
Epidermis:
Layers of epidermis: 0:10
Melanocytes vs Keratinocytes: 5:16
Langerhans cells: 10:10 & 33:30 & 57:30
Dermis:
Papillary and reticular dermis: 11:50
Three types of white empty spaces on a slide: vessels, glands/ducts/cysts, or artifact: 15:25
Blood vessels & nerves: 18:24 & 48:50 & 58:59
Arrector pili & other dermal smooth muscle: 20:00
Adnexal:
Sebaceous gland: 21:10
Hair follicle 23:14
Eccrine sweat glands and ducts 24:45 & 50:00
Gland/duct vs blood vessel 27:20 & 48:50
Apocrine glands: this video kikoxp.com/posts/7837 (at 12:30)
Acrosyringium: this video kikoxp.com/posts/7837 (at 10:00)
Three types of pink bundles: smooth muscle, nerve, dense connective tissue: 27:50
Acral skin (palm sole) with contact dermatitis 29:37
Parakeratosis 30:00
Perivascular lymphocytes 30:40
Eosinophils vs neutrophils 31:20
Spongiosis with desmosome keratinocyte spines 32:10
Spongiotic vesicles with Langerhans cells 33:30
Normal acral skin (palm & sole) with stratum lucidum 34:20
Normal glomus body/apparatus (canal of Sucquet-Hoyer) 35:40
Nerve 36:46 & 51:50
Adipose tissue (white fat cells) in subcutis with Lochkern 37:55
Normal scalp skin with large anagen hair follicles: 39:30
Hair follicle anatomy (bulb/matrix, inner root sheath, outer root sheath, hair shaft, isthmus, infundibulum): 40:55 (labeled images):
kikoxp.com/posts/3661 & kikoxp.com/posts/7899
Pacinian corpuscle 50:40
Meissner corpuscle 1:02:28
Dense regular connective tissue (Fascia/Tendon/Ligament) vs Smooth Muscle 53:00
Basic Normal Skin Immunohistochemistry:
-cytokeratin in epidermis: 55:33
-S100 in melanocytes and Langerhans cells and adipocytes: 57:30
-Desmin in smooth muscle (arrector pili and blood vessels): 58:59
-CD31 in endothelial cells of blood vessels: 59:33
-SOX-10 in melanocytes: 1:00:40
Digit/Finger/Toe histology (amputation for subungual acral melanoma) 1:04:10 & 1:08:30
-bone 1:05:40
-glomus body 1:05:15
-tendon/ligament 1:06:10
-artery 1:06:58
-fingernail/toenail 1:08:54
-acrosyringium 1:10:45
Solar elastosis (what wrinkles look like microscopically!) 1:11:50
Other videos you might like:
Tendon vs Nerve Histology Made Simple with the Ramen Noodle Sign (of Fulton) video: kikoxp.com/posts/4466
Melanocytes vs Keratinocytes made easy video: kikoxp.com/posts/3802
Blood Vessel vs Gland vs Artifact Made Easy video: kikoxp.com/posts/4808
The basic normal structures of the skin discussed and described by a dermatopathologist. This material is intended for use by medical students, junior pathology or dermatology residents, or for anyone else studying normal human histology. Special thanks to two of my medical students at UAMS for helping make this video possible. Miki Lindsey convinced me that I really needed to sit down and record this video. Akash Patel took time to edit the video and make it ready for RUclips. My sincere thanks to both of them for helping me overcome procrastination.
Huge thanks to Abigail Cline, a medical student at Medical College of Georgia, for volunteering to type a transcript of this ENTIRE video (over 14,000 words!) so that I could provide closed caption subtitles for those with hearing impairments and for those who may need assistance in understanding spoken English (particularly given how quickly I speak!). You can access a text version of her transcript of my video here: kikoxp.com/posts/5390
Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions.
Also, in the past I used "keratinocyte" and "squamous cell" interchangeably (this is because in dermatopathology, we see and talk about squamous cell carcinomas all the time, and those tumors are composed of keratinocytes). But technically, in normal skin histology, "squamous cell" refers only to the flattened keratinocytes in the superficial epidermis. Thankfully, a histology PhD colleague pointed this out to me and corrected my lazy nomenclature!
Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: bit.ly/2Te2haB
This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.
Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.
Follow me on:
Snapchat: JMGardnerMD
Twitter: @JMGardnerMD
Instagram: @JMGardnerMD
Facebook: / jmgardnermd
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Also, Correction - I made a mistake in the video. I said that sebaceous gland secretions are turned into smelly substances by bacteria and that this makes body odor. That is incorrect. That is actually true of APOCRINE gland secretions not sebaceous secretions. Sorry about that!
Jerad Gardner, MD yes I thought so too thanks for correcting.. u usually keep the arrow to point out minor structures plz keep arrows pointing on each structure to make it more clear.sometimes the arrow is lost..thanks so much for wonderful videos
Спасибо за ваш труд (Thank you for your work.)
Thank you so much!!
Hey, Doctor Jerad. How are you? I'm from Brasil and I have a channel on youtube. Could I use this video, without the audio, to explain the skin? I mean, I just want the images of the tissues, I will take off your voice and I will explain this all in my voice. I'll put the creditis down bellow the video and a link for your channel and this video. What do you say?
Dude, you displayed a shit ton of notions/informations, how are we supposed to judge you from this small mistake? XD
I'm a medical student in Portugal and I could not be more grateful for your effort. It enabled me not just to learn some concepts that will be essential for my studies, but also allowed me to start liking this. It is amazing to learn all this material by listening to your explanations rather than reading a book and finding all this boring, when it is great fun. Thanks, Sir. 😊
I am a professor of pathology in Brazil. I always watch your videos, because it is a mirror where I can try to level myself. You have a didactic talent, showing in a simple and direct way how it works and how our body is attacked. Congratulations.
🙏🏻🙏🏻🙏🏻
Dermatology Resident here, OMG I want to thank you so much for recording and uploading these videos. Better than my teachers, for sure :P
So glad you enjoy them!
I am a pathology resident and your videos really helped me. Thank you for the great lessons!
I'm a layman with nerdy hobbies like Microscopy. I have a Lomo Research Microscope circa 1960
that I've used to examine many tissue slides over the years and I loved your video.
I'm 76 years old and I just subscribed to your channel and watch more of your videos
in an effort to continue my education.
Thank you.
Nerdy hobbies are the best! Glad you enjoy the videos!
wish i had the ability to spot a monocyte amidst all that mess, it's a talent
Same 😄👍
is there any chance you will make more videos like this? you are a natural gifted teacher. we would definitely appreciate videos in pathology ...
thanks for this one!
Thanks for the kind words. More videos in the works soon.
A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology)
Thank you for making this video. It's what a proper histology lesson should look like.
Thank you so much for making these videos. I appreciate it so much!!!!! I am a dermatology resident in Germany and this is so much better than most clinics teach their residents. I love these videos and will hopefully get through all of them step by step. Greetings from Germany
This is absolutely wonderful. I wish there were great videos like this for every organ and their major diseases. Thank you so much!!!
Thank you! Check out WashingtonDeceipt channel. He has tons of great pathology and histology videos. He's an excellent educator.
Great job Jerad! You don't see glass slides being used for creating videos nowadays! This is old-school histology teaching and it's great to see.
Went through the whole video once again.
It is so packed with "pearls of wisdom" that every time I see it, I get something new out of it.
So thanks once again Dr Jerad Gardner.
Thank you! Also you might find this helpful...A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
I am a Turkish medical student and i want to thank you for bringing this amazing video. Its really better than other videos, showing us whole content in a video directly from microscopic view is truely educational.
Excellent video! Laying the foundations right. Can't wait for more from dermpath.
Mr. Gardner, I am really excited that I can finally attend your video! So happy to find that there are closed subtitles, it was very difficult for me to attend the video without subtitles because of my hearing impairment. Thus, I would like to thank you and the volunteer medical student Abigail Cline for the amazing work. Thank you very much!
My pleasure. More subtitles are in the works currently.
I just started my pathology residency in germany, and your videos are helping me a lot to understand the fundamentals, thank you for your clear and good explanations
Thank you for this. I am a first year pathology trainee and I so appreciate you taking the time to go through what normal looks like. I find a lot of people skip what normal looks like and go straight to the pathology of whatever organ they are teaching on, which makes it difficult to recognise normal down the microscope
I am a dermatology attending in my country and now aspiring to be a pathologist in US. Your videos have taught me alot about dermpath. So thanks for such great teaching🙏
Reviewing and rethinking of normal histology always make me fresh !!
You channel is awesome for any pathologist esp in derm and bone soft tissue pathology.
I no more find it difficult as it used to be for me.
You way of showing no.of cases gives a lot more confidence about the tumors.
Your way of teaching the aproach to see any slide is soo good.
Thank you so much.
This is so good! THANK YOU SO MUCH for your effort! This is awesome. Very highly appreciated. Thank you!!
Thank you for publishing these! I am a beginning A&P student. Histology is brand new to me and I was struggling to find it relevant to put in the time to figure it out. I found your videos on synovial sarcoma. My cousin (same age) passed over 10 years ago from synovial sarcoma so that video anchored my learning to something that I care about, but many concepts went over my head (which is great since you made me curious). Then I found this video which is really bringing alive the concepts I am learning in class. THANK YOU!
Top notch lesson, really what I was looking for. Thank you!!
Hello from Argentina. Great video! It helps understand skin histology clearly! Thank you !
great video o dermal histology, laying the foundation right. waiting for more........
I’ve never seen better histology video and explanation than this one . Thank you very much ... I will wait for some new videos )
Dear Professor Gardner, I have learned numerous things from this video. Thanks for sharing your experiences.
Thank you very much for your excellent videos. I am a senior dermatologist living in Italy and recently happened to read your book “survival guide to dermatopathology” that is in my opinion the very best introduction to this subject I had ever seen out there. I appreciate your teaching skill. You make a difficult subject easy to understand. Sincerely yours, Riccardo
Thank you! Can I ask a small favor? Since you liked my #dermpath survival guide book, could you please rate it & write a short honest review on Amazon? Thank you! 🙏🏻 buff.ly/366R7va
I love this video. I hope that in the future you might make a video on the normal hair follicle anatomy, stages, how to differentiate different types of alopecia... I love your book too!Thanks for all you do
Thank you! And I’m so glad you like the book. Hair follicle Histology I could do, but alopecia is still so complicated for me. Maybe once I get a better grasp of it can make a video! What I should do is partner up with Len Sperling or one of the other alopecia gurus to make a video. That would be pretty awesome. If I get a chance to make that happen, I will go for it.
Holy smokes, Doc. Do you have podcast? You will make an exceptional podcast speaker for sure! Thank you for this, Doc. I'm a first year medical student and our exams this dec 17. Understanding the concepts will surely boost my memory retention.
I'm very keen on skin pathology and I am going to train to become a pathologist, so I find this extremely helpful! Thank you!
YOU ARE THE CUTEST PATHOLOGIST I'VE EVER SEEN!!! So well explained presentation and it really helped me a lot w understanding the content!!!
Extremely clear!! Keep on doing this!
That's a real amazing video to start learning dermatopathology. Thank you!
EXCELLENT! You are such a wonderful teacher. Thank you so much!
Blessed to see these videos. Heartful thanks to awesome teacher
Amazing video,you are a gifted teacher.
Very helpful and a very simple language,so we understand very easily.
Thanks indeed
Excellent videos, so educative indeed, your effort is highly appreciated and please keep it up
I am so grateful to find your video. You did amazing job. You have natural yalent to make people understand. Hope you stay healthy and well. Cheers😊
you are such an amazing educator. i love these. residents, please look at these!!
Thank you for the kind compliment, carnol10!
Thank you very much dear Dr Gardner!I am now a faithful fans of you.Your teaching is so excellent and you try your best to share what you know,to help people who want to learn dermpath and those lovely petients.Your English is so beautiful and perfect for us non-English-speaking doctors to learn professional English.Wait for your subsequent update.May god bless you.Take care!
Thank you for the video! It was incredibly informative and helpful. I appreciate your expertise and the effort you put into explaining concepts.
Thank you so much for your lessons. I am a pathology resident and i think i would not have known the subject as i do now had not seen your videos. Honestly, cannot thank you enough. May Allah bless you. Love your work.
Thank you Jerad! Really helpful for a dermatology resident starting out :)
No words can describe my gratitude! I'm sure those lectures will help not only students but dermatologists all over the world. Thanks a million!
Excellent!...waiting for more
Sir actually I had a lot of doubts in histology spotters, but most of doubts got clarified to me after watching this video. Please continue to make more videos like this. Thank u soooooooo much sir.
You’re an amazing teacher. Please make more!
im a first year dentistry student at wits university and this is my first time encountering this content and i already feel like i mastered it. that you Dr Gardner.
Hi Dr. Gardner! I am a sophomore in High School where I was selected to be in the Advanced Science Research Program. Over this course of this upcoming summer I will be conducting my own graduate-level dermatology research which will transpire to the next 3 years of my high school career. Your videos have taught me so much and vastly increased my background knowledge on dermatology which will surely help assist me through my research path. I have such a passion for dermatology and hope you keep making these videos!
That is awesome! Bravo on being selected for such an ambitious research program at such a young age. You are way ahead of where I was at your age! I’m so glad my videos helped you. Thanks so much for giving me that feedback. Knowing that I can help even a few high school students as they pursue a STEM career is so meaningful to me. If you need any other help along the way, just let me know and I’ll do my best. Best of luck!
It’s been 2 yrs how’s the research going
More more more! Great for veterinary pathologists too!
just Amazing ! A BIG THANK YOU SIR ..
Just spectacular! Thank you a million times sir
WHAT A LECTURE! WOW! I've studied histology in biology school, for 2 years now in medical school, and never have i ever seen the skin explained so thoroughly and so well. I'm currently studying the histology of skin carcinomas and i thought I'd go back a little and refresh my memory on what normal looks like and found your video. man, it's the basics! and i didn't know that i didn't know shit about the basics. NOW I know the basics, thanks to you! so grateful! and so wowed! thank you!
So glad you found it helpful. Thanks for the kind words! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Very helpful, thank you Dr. Gardner for your efforts.
really great talk. I I wish every teacher was like that. Thank you.
Thanks Jerad. I really appreciate your work a lot. I am a pathologist in Nicaragua.
I have seen many of your videos and for me they are truly invaluable for colleagues, Pathology residents and Medical students.
Gracias, amigo!
Gracias a ti. Un día quizás logremos conectar para un evento de Patología en Nicaragua. Tienes un don maravilloso. Sigue brillando
Thank you so much for the explanation!! You´re the best. This help me a lot.
Appreciate the informal chatting style very much
Amazing video. I believe this video will be also very useful for veterinary dermatology residents. Thank you so much!
thank you so much doctor! keep uploading videos!
Great thanks doctor.
I watched the video with my eyes open wide
Wonderful presentation
Bless you !!
💐💐💐💐🙏🙏🙏🙏
Thank you SO MUCH for the video sir. I have never understood histology and pathology so well! 🎉 Now I like this science. Immediately subscribed to your channel ☑️
Thank you a lot for your great video. It' s very helpful for young dermatopathologist.
Thanks for the walk through. Really interesting and made me wish I had some slides of my own to explore.
Really very helpful. Please continue the teaching
Thanks prof. Such a comprehensive video
Really very helpful, thanx a lot for ur effort and time explaining this in a simply way
You r making me fall in love with pathology
thank you ! this was a great video, extremely helpful.
Thank you! Much appreciation for this perfect explanation!!
This video is really GREAT! I'm a dermatology resident and really learnt a lot from this video. Thank you!
Awesome thanks! Be sure to check out this one also. 100 classic Dermpath entities are covered. ruclips.net/video/Q88yDU-Pyis/видео.html
Thank you professor for this highly informative lecture
thanks a lot! You are an inspiring and passionate teacher !
Fantastic! Learned a bunch
This is very helpful, Thank you!
Thank you so so much for this incredible video. I am a Derm Resident in South Africa and this is so so helpful!
Glad you like it! Have you seen this one too? ruclips.net/video/Q88yDU-Pyis/видео.html
This is awesome thank you so much for this!!
thank you so much Jerad. Thanks to you I could understand thing that were impossible to me onky by reading
Great video, thank you so much!
This helped me clear the concepts of normal skin histology
Can you please do a video on skin reaction patterns
Thank you for your videos. I really enjoy pathology
Perfect video! Congrats!!
Such a lucid and excellent video
Excellent video, I really enjoyed watching the whole videos at once, you have an amazing teaching skills
Thank you for the great video.
Too too good! Thanks for the video.
Thank you so much for this video! It helps a lot! You are pretty didactic! Please, don't stop doing these videos
Glad you enjoyed it! A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: kikoxp.com/posts/5084 (dermpath) & kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).
Such a great video! thank you
Great lecture! Very helpful! Thank you
Im in my 2dn year of Dermatology and you have really helped me a lot, thank you
Thank you !!! Your lectures are awesome
Excellent review of normal histology.
This was amazing! Thanks a lot
Very helpful. Thank you so much !
Awesome work. Thank you.
Absolutely fantastic.
Thank you alot Dr. Gerard very useful videos
just a great video really helpful for pathology resident
Wow. Perfect! Thanks
Great lecture.
Learnt many things in spite of having been in Pathology for over 25 years.
Thank you! I'm so happy to know it is useful to learners at all experience levels!
Lo and behold! Now our entire department is hooked to your videos.
Stay blessed and keep posting please.
really excellent video