How often should you take finasteride or dutasteride for hair loss?
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- Опубликовано: 8 сен 2024
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Sources:
1. Gormley GJ, Stoner E, Bruskewitz RC, et al. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia. New England Journal of Medicine. 1992;327(17):1185-1191. doi:10.1056/NEJM199210223271701
2. Faller B, Farley D, Nick H. Finasteride: a slow-binding 5 alpha-reductase inhibitor. Biochemistry. 1993;32(21):5705-5710. doi:10.1021/bi00072a028
3. Steiner JF. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride: Clinical Pharmacokinetics. 1996;30(1):16-27. doi:10.2165/00003088-199630010-00002
4. Drake L, Hordinsky M, Fiedler V, et al. The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol. 1999;41(4):550-554.
5. Gisleskog PO, Hermann D, Hammarlund-Udenaes M, Karlsson MO. The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination. Br J Clin Pharmacol. 1999;47(1):53-58. doi:10.1046/j.1365-2125.1999.00843.x
6. Steckelbroeck S, Watzka M, Reichelt R, et al. Characterization of the 5α-Reductase-3α-Hydroxysteroid Dehydrogenase Complex in the Human Brain1. The Journal of Clinical Endocrinology & Metabolism. 2001;86(3):1324-1331. doi:10.1210/jcem.86.3.7325
7. Sullivan MJ, Geller J. The effectiveness of reducing the daily dose of finasteride in men with benign prostatic hyperplasia. BMC Urology. 2002;2(1):2. doi:10.1186/1471-2490-2-2
8. Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor. The Journal of Clinical Endocrinology & Metabolism. 2004;89(5):2179-2184. doi:10.1210/jc.2003-030330
9. Tartagni M, Schonauer MM, Cicinelli E, et al. Intermittent low-dose finasteride is as effective as daily administration for the treatment of hirsute women. Fertility and Sterility. 2004;82(3):752-755. doi:10.1016/j.fertnstert.2004.02.118
10. DHT rebound minimal after missed 5-ARI doses. Published September 1, 2004. Accessed January 3, 2024. www.urologytim...
11. Olsen EA, Hordinsky M, Whiting D, et al. The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride. Journal of the American Academy of Dermatology. 2006;55(6):1014-1023. doi:10.1016/j.jaad.2006.05.007
12. Drury JE, Costanzo LD, Penning TM, Christianson DW. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex *. Journal of Biological Chemistry. 2009;284(30):19786-19790. doi:10.1074/jbc.C109.016931
13. Pohlman GD, Pohlman EA, Crawford ED. Dutasteride: A Review of its Use in the Management of Prostate Disorders. Clinical Medicine Insights: Therapeutics. 2011;3:CMT.S1956. doi:10.4137/CMT.S1956
14. Kim KH, Park SM, Lee YJ, Sim WY, Lew BL. 16799 Similar efficacy of maintenance treatment of finasteride 1 mg every other month compared with finasteride 1 mg daily in Korean men with androgenetic alopecia after taking finasteride 1 mg daily for 1 year. Journal of the American Academy of Dermatology. 2020;83(6):AB185. doi:10.1016/j.jaad.2020.06.828
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Kevin I hope this comment finds you. You have no idea how you have saved my life. I was balding, and was very depressed. Your encouragement to take finasteride, you sense of humor helped me to get through that difficult time
Your passion for video games too helped me get back into gaming
That means a lot to me, choom. Thanks! I am glad to have you here.
@@haircafekevin You are my inspiration, white father. 😸 My Asian father wasn't this cool. 😊
@@ytsux9259 like for real, Kevin here selflessly saving all men, unlike my father 😂
@@user-jq5xl1yq2wMy Asian father whipped me when I stepped out of line. Kevin is my white father who always caresses me. 😸😆🤣
@@user-jq5xl1yq2w Yeah, my Asian father whipped me when I stepped out of line. God rests his soul! 😊 Now Kevin is my white father. 😸😆
The difference in the number of subscribers between haircafe and baldcafe shows that only few people in life are proactive enough to take charge of their life
Exactly doing nothing about hair loss and going bald is the easy way out. We're ready to fight like Hell. Warrior spirit honestly.
@@God-hs4hc
We are like the Underground resistance against the Norwood repaer’s army while the Baldcafe subs decided to Submit and Surrender. 🤭
dropped a like without even watching
Only case of simping that I support
Always.
Huge and Based
Lmao fr
I just take Finasteride and Dutasteride. I want the baldcells and DHT to know that I’m not joking. Happy new Hair Kev and everyone!
why 2?
@@raphaelfernandes5195 fin is so cheap that Why not? I know dut is enough.
How did you get a prescription for Dutasteride?
@@user-jq5xl1yq2w If you're in the US, look at "medical wellness center"
@@user-jq5xl1yq2w I just ask for
I've always had a receding hairline since my teenage years, and my father and all my cousins on my fathers side have hair loss. So it was inevitable I would also be exposed to this. When I was 23 my cousin pointed out that my crown was thinning. I took a picture of it and saw this was true. This was the final straw for me. I did my due diligence watching the Hair Loss show and Haircafe and I was rid of the Finasteride fear mongering. I then two months later started 1mg every other day of Finasteride. I am happy that now at almost 26 my hair is pretty much no different, maybe even slightly improved. Im so glad i caught it early.
Lol
Finasteride onlt suppresses 40% of DHt.
60% was still ravaging your follicles, but your body’s natural healing managed to counter it
If you used dutasteride, you would have had a bit of regrowth.
You saved me from the bludflow theory. Watched what I learned and thought I can save my hair with head massages, now I'm working to get some finasteride.
I have to thank What I've Learned. A lot of people found my channel because of his terrible video.
@@haircafekevin
What i’ve -learned- blindly believed after reading
Same here...bluud flow guided me here😂@@haircafekevin
BLUD FLO!
Choom, I just gotta say your content is completely unrivaled in the hair loss community. Love knowing that every time I watch a vid I'm becoming more informed without having to worry about ulterior motives. Thanks for everything you're doing!!
I wish we had a Kevin mann to distill the research on other subjects of interest too lol.
@@maalikserebryakov absolutely. me too
Kevin you‘re a legend! Watching your videos is giving me a lot of courage to start fin and save my hair as I‘m still „only“ a NW2. Also thanks for caring about your community so much! Literally see you answering questions on new comments on 3 year old videos and here you also answer everything! Thanks choom🙏🏼
Happy to have you here choom!
Taking it less often isn’t about the side effect concern, it’s also about saving money.
Good point.
proscar is budget 5ar2 inhibition
You are such a beautiful person for helping spread empirical data in cutting through all of the BS sales tactics of so many snake oil fraudsters! Plus you are also beautiful on the outside 🥂
I got my hair back because of you,funny enough I found your channel through Perfect hair health’s videos lol. I tried finasteride and minoxidil with tretinoin. I got so much hair back its insane my friends and family could not believe it , I even grew back my hairline. For some reason my eye lashes and eye brows are growing longer and thicker. I got best case scenario all growth and no sides, if it wasn’t for your channel I would have been a slap head right now, so thank you from the bottom of my heart ❤
Do u apply tret before minox or do you just mix them together into chemicsl soup
@@maalikserebryakovI mix them together
I mix them together into a chemical soup
@@mrazoz5538how did it takes you to see différence are you still using it please ?
@@mrazoz5538 0.1% tret?
Anyone here who's just starting to bald, you have no idea how lucky you are to be here and have Kevin on your side! I'm turning 40 next year and got a prescription for Finasteride at 26, but of course I got swayed to tried natural treatments, there goes another 2-3 years of my life and my hair only got way worse, then I did only Minoxidil because of the fear mongering, and only in my 30s started Finasteride. I did also try RU/Dut at some point but that's another story. I wish I had someone like Kevin to tell me to take my finasteride when I just started balding and MOVE ON WITH MY LIFE. If there comes a point where Fin isn't enough anymore then sure get back on the drawing board.
I only have a major gripe with Minoxidil, after a decade on it, I'm sick of applying it daily. Wish I wouldn't have to worry about minoxidil first drying and not touching my hair and then face etc..
I'll probably need 2 hair transplants to have a some what reasonable hair for my age.
You can take minoxidil orally
what else should we take besides oral fin?
@@WeanerBeaner69Been there, done that, for 2 years. Experimented up to 10mg. I'm 39 and I simply don't see oral monoxidil as a viable solution for me. I'm very viable to headaches, I had more often on oral, plus I was a bit more bloated (I know my body very well, I maintain visible abs year round), and last thing I can't be %100 sure about, but I think it didn't do any good to my skin. I regret not taking progressive skin pictures to assess if it was monoxidil or just my imagination/natural aging.
@@user-de6ld7jp2c Right now just topical monoxidil.
If I could have started very young I would have never touched monoxidil, I hate applying topicals on the scalp. And later on assess the situation of the balding progresses severely.
I love the fact you’re super educational yet you manage to be a comedian at the same time
Kevin your hair loss videos are the highest quality. We need you to give us other lifestyle advice, you have lots of wisdom. I'm thinking diet advice, how to be confident, etc. I really enjoyed your video games of the year review. Thanks again!
Thanks! And I will cover some other topics down the road. The game of the year video was very fun to make, glad you enjoyed it.
Hi Kevin. You have a female audience too! Thanks for covering a study involving women. If you want to do a video on finasteride dosage / frequency for women with androgenic alopecia, that would be welcome.
Thanks! Research is definitely more limited when it comes to women but there is still some high quality data out there. I have made some videos on it.
ruclips.net/video/5Tq5zt_46Bk/видео.html
ruclips.net/video/74zQFT4ZmxU/видео.html
Interestingly enough, it seems 5 MG per day is the sweet spot for women who want to take finasteride.
How have I just found out about this chad? Instantly subscribed.
Thanks, choom! Glad to have you here.
Hi Kevin!
Just got my fin prescription today.
I am 20 years old and have no signs of MBP, yet….
All of the males on both sides of my family however are thinning/bald.
I am taking no risks here. I’m turning 21 in about 1 month.
The plan is the day I turn 21 I Will start fin. And just keep on taking it until I die.
Thanks for making me the only person in the family with hair!
Same here, I am 25. And not even sure if im hair loss but signs may be. There..
No chance taken, started Finasteride.
@@akashlimbu1987at 25 I had a slight receding hairline nothing terrible it still looked good. At age 26 I was ok then in half a year it all changed. Wish I took it at that age. Im 28 now
@@MyWifesSon69and did it helped you to keep existing hair any side effects etc how's your hair now ?
Very helpful information. Thank you. I'll definitely share this to people just starting out finasteride that have questions like how often to take.
A great refresher for those new to the channel. Haven been on fin almost 7 years now and last year added in dutasteride twice pw. Next year I plan on adding both daily. Thanks Choom
I asked the Mann some months prior about stacking both simultaneously, he informed me that it’s unnecessary since they dont stack together. I was let down a little bit because I wanted the added protection but knowing whats what is more comforting in the end imo, hope you feel the same
So I have been advised by Gillett Health that they DO stack together@@bobbybigballs4038
is taking both Fin + Dut a thing now?
what else is essential besides oral Fin?
@@user-de6ld7jp2c it most certainly is!
I guess a better question wouldve been does it make sense to have both an oral and topical anti-androgen? especially for people like who were to scared to try oral Fin for yrs so I was using things like RU and now would like to stop and just use oral fin but I'm wondering if my scalp is addicted to topical anti-androgen? I have heard some people say to use both topical and oral of some sort.
I had 2 dermatologists advise me to use 1.25mg fin everyday because thats what the clinical studies showed, i really want to switch to eod for peace of mind. Glad i saw this video, fingers crossed its just as effective.
Take daily bro, trust me you won’t have side effects, I was afraid too, but nothing happened.
@@user-jq5xl1yq2wfor how long you're using it please and did it helped you to keep existing hair and regrow some new ?
results?
Thanks a lot man!! I wanted to do something to stop my MPB progression and knew that fin was the solution, but I was hesitant to start because I read too much about the side effects. I've been watching your videos for a few days now, and they gave me the confidence to finally go for it. started this week with 1mg every MWF dosage.
Again, thanks a lot!! your vids are informative as well as entertaining.
After over a year of daily 1mg Fin I cut to every other day and still have the slap head curse under control. Even if no side effects seems better to take any drug less if you can. This channel is awesome. Should have way more subs.
Binged your vids for the last month and a half my brother in choom. Just started my finasteride 1mg treatment yesterday and I’ll keep ya updated! I have mild anxiety, though your videos keep it under control and keep me confident! I’m in great physical shape and have no reason to worry, but ya know how it is. Thank you for the videos man!!!!
I also had anxiety when I first started out. But nothing bad happened in the end and I simply ended up with good hair
@@isnortCGproductshow do you take fin like every other day or daily n what dose ?
Update?
@@STUNNEDCREATOR Well my crown filled in pretty much all the way, and I have a lotttttt of new hairs on my temple/hairline that are about half the length of the rest of my hair. No sides whatsoever with either medication, aside from maybe a slight test increase at the very beginning of the Finasteride. Everything except my hairline, can't even tell I was ever thinning. I think the reason the hair line is taking a while, I started doing my whole scalp instead of only trouble spots about 3 months in and I believe it started a separate shed.
I hope ur channel blow to 1 million man!
you a witcher, i have no doubt. had this topic on my mind the past few weeks. thank you so much! greetings from europe
Hi, just recently found out about you and really want to say that you’re a great entertainer and content creator. Top notch. Kudos
Thank you for that! Glad to have you here.
Finally started taking Finasteride(mainly after watching your channel) after a couple years stalling because of hearing about all the negative side effects. I am about 3.5 months in and no side effects yet(hopefully never). I am also taking it for another side benefit for prostate health, not only for BPH, but because of the recent PCPT trial showing a 25% reduced risk in prostate cancer when taking Finasteride.
I think people taking it for hair loss under-appreciate the benefits for prostate health. Good strategy!
@@haircafekevin Hey Kevin. 1 question I wanted to ask is about Finasteride and hair shedding. I had a hair transplant about a year and half ago. I am 3.5 months in taking Finasteride and have noticed that transplanted area being thinner now. I am assuming this is normal though? How long will this last due to the shedding aspect of Finasteride?
As normal as it gets. Give it a few more months to stabilize.
@@haircafekevinhey Kevin do you have any other socials like instagram?
The crazy part about your hair channel is that you looked really good with your buzzed after the transplant
Thanks. I don't mind the buzzed look, I just like having the freedom to choose how my hair looks, and sometimes I enjoy changing things up.
Kevin I need some encouraging words from you. I finally gathered the courage to go ask a dermatologist here in Germany to prescribe Fin, but he said I have to warn you about the sexual side effects, although they're rare, but some people also experience PFS.
I mean why did he even mentioned PFS, he did say it was rare twice, but still, he could've left at sexual sides. This was a nasty blow, it literally took me 1 year to even gather enough courage to go there.
You're a here, I'm re-going over all of your videos about sides and PFS!!
Doctors in Germany are very old-fashioned and uneducated. Try using an online service like doktoronline instead as those will prescribe anything given you pass the idiot test when ordering. PFS is not a real condition because as Kevin has indicated in this video, finasteride does not last in your tissues for more than a few weeks. ED occurs "naturally" in men the older they get and many like to blame their issues on finasteride or other drugs such as ssris. But the fact is, no clinical trial to date has ever shown a single patient who did not resolve side effects upon cessation of finasteride or through continued use.
Bro PFS gibts nicht xd sagt er doch auch. Nimm einfach dein Finasterid. Ich nehms auch und hab null Nebenwirkung
Geht mir genauso. Auch keine Nebenwirkungen 👍
Ganz ehrlich grade jetzt nach dem video...lass es dir verschreiben und fang einfach mit ner ganz niedrigen dosis an...nur für die psyche...0,25 3mal die woche und dann alle 1-2 monate dosis steigern...0,5 3mal die woche...und naja dabei kannst du es ja auch einfach belassen...hab ich auch so gemacht...hatte auch angst trotz den ganzen videos von kevin....jetzt seit 3 jahren auf fin und 0,0 nebenwirkungen
Danke, brothers!
Eure Hilfe war echt super! Haare behalten ist jetzt das Wichtigste
my bro science take is if side effects and hormone changes are acute/temporary (which for me they definitely were) then it would be ideal to stick to daily as the consistency would allow for the body to adapt quicker and easier.
I started with a low dose side effects came and went then upped the does alot and never got sides by a larger dose, it's like my body adapted by using a small dose for 6 months.
You saved many people, including myself. The way you talk backed up by science I feel like it’s an older brother giving his younger brother advice. 1g Monday/Wednesday/Friday is working fine for me for the last 2 years.
1g is a helluva dose
2 years ago you did write that you experienced side effects with 1mg 3times a week and that you would try again but reduce the dose... So you mean that you did not reduce it, and you have gone again through 1mg 3times a week and hopefully since then no more side effects ?
@@WezaBeatz yes, your body adapts. Some times I’ll go a week without taking it and just take it. If you also view the “hair loss show” they say it’s a 30 day cycle. Just keep topping up whenever you can within the 30 days. That’s the way I think about it these days.
@@WatchuGoneDo thank you for such details, I still think I would rather go bald anyway, because everyone has different response and I doubt mine will be as good as yours
The doctor on the Hair Loss Show suggests 1mg, 3 x week as a suitable dose for most people. Another doctor on RUclips said 1mg/daily is necessary for people with transplants but allows variable dosing for others.
I think it ultimately depends on the individual. I was able to drop my dosage from 1 mg daily to 4 mg a week without any loss of efficacy. However someone with more severe hair loss may need to stick to the standard 1 mg daily dose.
My girlfriend overheard the “but Kevin!”part and started laughing 😂😂
Kevin, these thumbnails are ace! 😂
It’s truly amazing to see this man’s channel continue to grow. All fully deserved
I’m on Fin for 3 yrs now. Also using minoxidil foam and derm pen. Lemme tell you, 1+1+1= 4 with this combo. Be consistent and be patient. Do not miss days until we’ll after results appear. I have reduce Fin to 5 days per week with hair holding strong. I try to use days I don’t workout as a day I don’t tak Fin assuming there is less Testosterone in my blood.
actually fin increases test label in your blood
How do you use the derma pen / minoxidil. Derma pen frequency cleaning and everything.
Thank you for another informative video, choom. I think it'll be easier now to convince my doc that I at least know the "risks" of fin and what the product does when I talk to him about a script next month.
Just in time, too. I'm starting to see a bit of temporal recession on my right, and a bit of thinning on my left. You've literally saved me my hairline. My new years was preem; Spent all night gaming lol. Hopefully you had a good new year and Christmas, too.
Also I nearly crapped myself seeing you comment on that debate between Shawn Baker and The Nutrivore, where Nick tried to argue that we need to eradicate all life because existence is problematic.
Was a super unexpected cameo lol; That guy needs help.
Thanks, choom! That sounds glorious! I platinumed Alan Wake II on New Years.
And yeah that debate was a train wreck. So I guess the Nutrivore's take is that without life there will be no suffering? That sounds like the motivation of a villain in some cheesy JRPG.
Please make a video on insulin resistance/T2D and T1D and how each condition might affect hair loss, thank you for your content
i used finasteride for 3 years 1mg a day. but i dont think im losing any hair anymore so for the last year i have just been using 2-3 times a week so 2-3mg so this video helped. im considering stopping finasteride alltogether and save the fin i have left for a potential testosterone cycle or if i need it again. maybe i just stick with a topical anti androgen will see
good video as always
I take dutasteride .5 mg, every other day has been working great, no side effects at all
Please make a video about what differentiates hair loss causes in scalp biopsies. Would be very helpful for someone like me who is considering if one is worth it.
thank you Patrick Bateman
I don´t care about the side effects I just wanna save money. good video
Just shave itthrn
Then u can brag abour how much money you save on shampoo
Hahahah
Thank you for everything you do, Kevin.
You’re the reason I have faith in fighting the good fight ❤
Your best video so far. Keep up the good work, slayer of DHT.
I know this is anecdotal but I personally found that switching from 1mg every other day to 1.25 daily actually reduced my side effects - I felt so much better and still do 2 years later.
Advice for someone who has been balding since 17 . Im on dut and min. Current age 19. Still losing some hair and want to have some more defence against hair loss but pyraludamide has lost hope so no other option left.
You could consider maxing out the dut at 2.5 mg daily. But maybe you just need to give it more time, especially if you have been on treatment less than 2 years.
Just what I was looking for thanks
Suggestion for next video: topical finasteride, dosege in percentage and frequency (for men and women, your opinion) and what do you think about a study that says that two daily applications are worse than one. Thank you for your work and help.
There's a hair transplant surgeon I've seen on RUclips who's recommending to use Dutasteride 3 days a week, but only in blocks of three days. So not with days in between. He claims it to be safer then taking Finasteride every day and should be as or maybe more effective...🧐 Anyways, After many years 1mg fin/day, I've switched to 1x 0,5mg Dutasteride a week and 6x 0,5 Finasteride a week and that seems to work very good! Almost a year on this regimen, at almost 43yo. 😊 PS: Thanks kevin, for being a hair-loss warrior and saving as many guys as you can from a dreadful hairless life !! 👍👍👍
I’am about to take after this video yo, keep up the good works buddy! 😂
wow Kevin... great job !
Kevin. Thanks for your analytical approach. When you have an opportunity, I am sure many are interested in your take on the merits/potential for topical sult1a1 enzymes to enhance response to topical minoxidil. Rida and Daniel Alain have products that purport to deliver this enzyme to scalp follicles to enable minox to work. The Daniel Alain product ingredients seems to mimic the formulation in the 25 patient study done with a minox +/- a sult1a1 topical enzyme Thanks again.
You bet! That is definitely on my agenda.
Thanks Kevin. I’ve been on minox 35yrs, finasteride 26. Thinking about a switch to dut as even though finasteride has worked, I have slowly lost a bit of ground over the years. But still trying understand the long term safety of inhibiting type ar1 in the liver (potential for fatty liver, insulin resistance). I don’t think this has been studied enough.
There's the drug itself and there's the drug's EFFECTS. The half life of finasteride itself in your serum is 6-8hrs, but the half life of finasteride's effects is 30 days. That is a catastrophic difference. Similar to an antibiotic. An antibiotic can pass through your gut in hours or days, but the effects it leaves on your microbiome can last for weeks or months.
It's not catastrophic. And the biochemical data I presented suggests the biological effect lasts more like 2 weeks than 30 days. The fact that there is a prolonged effect just means low doses and intermittent dosing can be used. The 5AR blockade is reversible, so it all goes away if you need to stop the drug, but it does take about 2 weeks for that to happen despite the short half-life.
Thumbnail lvl: 1000
I did not expect that photo ever being a thumbnail on this channel lol
Thanks Big Choom.
I have great head of hair because of you bro
When did you started how long you are using finasteride etc ?
I started January 2020 so it’s been 4 years that I started fin. I def grew some hair back, strengthened and held what I did have. Last year I started minoxidil on my corners and it brought a lot of my hair back. I’m glad I started when I did.
@@RobMurillo-si3bi thanks for answering 👍🏼👍🏼👍🏼
Hey Kevin, I've watched your videos for years now (from back in the days when you did vegan videos as well, which influenced me to go plant based : -) ). Thank you for all the effort you put in.
Wanted to request for you to go a bit deeper into the allegations that dutasteride, through its inhibition of the type 1 5ar enzyme (which as you said is the predominent one in the brain), impacts the production of certain neurosteroids, such as allopregnanolone.
I'd love some more attention for dutasteride, as I am one of those individuals who has sadly still been receding while taking 1,25 mg of finasteride daily.
Would be nice to get a clearer picture of if, and if so to which extend, this impacts certain apsects such as mood, memory, anxiety etc.
Thanks in advance and I hope you had pleasant holidays, best wishes
PS: Could you remember me why you stopped taking dut? I remember you mentioning this a long while ago, but I forgot.
It might be worth doing a whole video on this, but I'll just summarize the reasoning that I've presented in some of my videos. First, there is debate whether dutasteride crosses the blood-brain barrier. It is a larger molecule than finasteride. Some researcher say it does, some say it doesn't. Maybe it does, but poorly. That would limit its type 1 effect on brain neurosteroids.
Second, 0.5 mg of dutasteride didn't even affect peripheral neurosteroid levels in this study, pubmed.ncbi.nlm.nih.gov/26272051/ . However 2.5 mg did have an effect. Keep in mind though that even though dutasteride is 100 times stronger at blocking the type 1 5ar enzyme, it is still is a weaker blockade than its blockade of the type 2 5ar enzyme. So it takes a lot of dut to have an effect on the type 1 isoenzyme. Also, peripheral neurosteroids don't correlate with brain neurosteroids.
Finally, depression hasn't even been added to the package insert as a side effect for dutasteride, even though it was for finasteride (inappropriatedly), because despite its type 1 5ar blocking effects, there's no evidence for neuro sides occurring because of dut. If the type 1 blocking effect was affecting brain neurosteroids, you'd think there would be a lot of complaints of neuro sides.
The reasons I stopped taking dut are because fin was working well enough and I didn't notice any additional improvements with dut. I also didn't like how dutsteride was a soft gel, being a vegan.
The Hair Messiah!
Legend!
Awesome man.
Gorgeous video.
That thumbnail is hilarious lmao. Can’t believe Vaush claims to be 6’2 and still agreed to have that picture taken.
Yeah, Tim Pool is 4'10 so no way Vaush is 6'2
As one who ventured into the abyss of baldness and returned, I can attest that there's scarcely a more profound, life-altering experience for a man enamored by the fairer sex. For they loathe the specter of baldness.
Hey Kev, ive used fin for 2 years now, and it has done wonders! You helped me take the leap. I was wondering, how long does fin work?
Glad to hear it, choom! It works indefinitely so congrats on getting into the game when you did.
ruclips.net/video/LsF9MwIM_AM/видео.html
Excellent video sir. I always believed that less is best with any drug or supplement.
I've been on 0.5 Avodart daily for a month now, nothing to report except detailed whacky dreams. Each nights a roller coaster.
Been on it daily for a year. Hairline strong, 0 sides.
16:45
Timestamp for Dutasteride Master Race
Dude u always make a super hilarious thumbnails😂
Hey Kev, happy new year! 🎉
You too, choom! Thanks.
Nice one Kevin. Cheers mate
“DHT is a trash hormone” should be a mandatory motto of all countries
Trash for adults… not teens and kids
Happy new year Kev
Thanks choom! You as well.
IN KEVIN WE TRUST
Kevin I have joined the dutasteride master race. Unfortunately finasteride did not stop the hair loss at my crown that has been going on since my late teens.
Get to Turkey my man 🇹🇷 under 2k sorted amd keep on the fin you will be fine. That’s what I did 43 and never happier
Thumbnail on point 😂
Happy New Years @Haircafe
Here’s to a year full of BlūudFlö in 2024 🎉
HI Kevin, my treatment was going great until catching Covid again 2 weeks ago, now I am experiencing bad shedding, I really hope it's reversible. (11 months Fin user)
Not sure if you've heard but Hims recently launched some all-in-one fin (1.1 mg) + min (3 mg; yup ridiculous) + random supplement blend chews. Wonder what your thoughts are on that. Great video, man. Keep it up
Don't like the oral minoxidil aspect, or the random supplement additives.
oral minoxidil works amazing for hair growth but has some serious, life threatening side effects if taken long term
can cause age sking?@@Crosswizz
Seems like finasteride would work great with a week long loading phase then a less frequent maintenance phase to reduce sides
Hey Kevin I know you're health conscious but with the current trend of TRT being more prevalent in society and main stream I'm curious why you haven't hopped on TRT? Keep up the vids.
Just don't feel like I need to, at least not yet. My strength and virility feel fine.
Also, gaming channel would be sick. Id watch. Youre a rly good orator, man. Enjoy your content a lot.
My doctor prescribed dutasteride from Monday to Friday, I take it from Monday to Sunday.
Use the weekend to give your liver a rest
I take dut over 10 years 3 times per week and it works fine for me never had hairloss since
Why 3x pr week did your doctor prescribe you this protocol?
@@markalejandrox I dont know why he prescribed, but it works perfectly fine for me
1mg Fin daily 6x per week.
0.5mg Dut every Monday.
2 months in. Went from NW1.5 to NW3. Devastating but I'm hoping things will not get worse and return to NW2 before summer. No chance I'm stopping treatment.
only two months and gone from 1.5 to 3? god damn lmfao
@@e47kz it's very very aggressive but what can i do
@@antonisprotopapas you could keep increasing dutasteride dosage, although it’s probably way too early to know/see if your current regiment isn’t enough
why did u put dut bro, if fin was fine???@@antonisprotopapas
You might just be shedding man, hold out for a year and reassess.
But Kevin, if all these doses of Finasteride have the same effect, then how come people have to take 5mg a day for treating prostate enlargement, but only 1mg a day for hairloss, that doesn't make any sense bro
Could you do a possible video into topical finasteride and the dosage for that? As I've seen companies sell even 3mg per 1ml as their recommended dosage which would be counter intuitive if the whole selling point of topical fin is to reduce side effects. I use topical finasteride about 0.25-0.5mg a day but I believe the oral form would have been more effective, I'm still yet to see how much topical fin is needed for systematic absorption
use both
@ibeseal2515 im thinking of using both but trying to figure out what's the best + most affordable topical Fin?
I was using Minoxidilmax but that stuffs kills my scalp, I like the Gel based prescription finasteride but it's very expensive almost 100$ a month here in Canada at essential (apparently the cheapest place)
i’m convinced this guy is saul goodman
Kevin, with all this knowledge and speaking qualities, what do you do for a living?
Thanks! I work in sales, for medical equipment like pacemakers.
Kevin I got a question based on the evidence presented, if finasteride was being used to prevent hirsutism in women, wouldn't that also apply to men trying to grow a beard? I have a full beard and have been using dutasteride for over 4 months and I noticed mild thinning but im worried over a decade I might fully recede facially. I have already seen your video on testosterone for beard density and DHT for speed of growth. Were the researchers just trying to slow down the growth of those womens hair? Thanks again I trust you 100%.
In men, after adolescence, testosterone are high enough to maintain beard hair. In women, testosterone levels are low, and increased DHT or testosterone will increase body hair, so cutting down the DHT level helps. Lowering testosterone would have helped too.
@@haircafekevin
Interesting, but the skin is 5ar1 not 5ar2 so finasteride probably won’t stop beard hair growth.
It boggles the mind why nature decided to make the Androgen receptors of the beard react well with dht but the scalp ones react poorly.
Great stuff
3 absolute dorks in the thumbnail. Love it
i like how Kevin change to his batman voice to address those writing comment😂
3 years on finasteride 2 days ago. I think I have missed only one day in this time. It still feels like I shed weak hairs this far into treatment.
but it worked for you?
@@edigas_1 Yes it definitely works. But what I meant was that I still shed those weak hairs that has been affected by androgenic alopecia and I think that means that I still haven't reached the full effect of the medicine. Because I talked to someone on reddit that got all his hair back past the 3 year mark. Before those 3 years his hair looked bad and then it regrew quite fast at the 3 year mark. I hope that that is the case for me as well and it feels like it is. So there is never a reason to to think that you have reached the full effect at only 1 year of treatment. I'm also on Dutasteride and in may I have reached 3 years on that as well.
Hey Kevin, greetings from Germany! Today I found your channel and nearly every video sounds super interesting to me. Really like to positivity towards Finasteride. I'am 22 years old and I love my natural light blond hair a lot. I got into surfing last year and my hair really fits in with that. Of course I want to keep my hair as long as possible. Taking a look on my dad (he is half bald) concerned me about my future hair. Currently, I don't think I have severe hair loss, but I can feel a difference between the DHT-sensitive part of my head (thinner hair) and the non-sensitive part. My plan is to take Finasteride more as an preventative measure (+ to thicken my hair). Therefore, I plan to start with 4 x 0.25mg per week (taken on Monday, Wednesday, Friday and Sunday). Do you think that's enough for beeing an preventive measure? With increasing age I would then switch to 0.25mg every singe day etc.
Awesome video! Hey can you make one of minoxidil both topical and oral.
Right now I use only topical
1x daily
Thanks Kevin. You're the reason I started taking finasteride one year ago, but I'm now switching to Dutasteride due to poor results/aggressive thinning. I think you have seen the research showing that Dutasteride was more effective than Finasteride at blocking DHT in the follicle, and 2.5mg worked even better than 0.5mg. What do you thik about that? It sounds like taking more Dutasteride is the way to go.
The major drawback in the studies you cited is that they don't measure scalp DHT which is the only important thing. Scalp and serum DHT levels are not linearly connected. 0.5 mg and 2.5 mg of dut suppress the same amount of serum dht but very different amount in the scalp. I guess the same apply for the frequency.I personally take 10mg of dut every 2-3 weeks for the last year and it works just fine. I've heard that 5ar receptors renew every month or so so 2 weeks should be optimal.
Since the drugs accumulate in tissues like the scalp, and since the 5AR blocking effect is prolonged throughout the body, I think we can assume the scalp DHT suppression lasts a long time too. Just not 2 months! I think it's possible every 2 week dosing might work, but no one has bothered to study it.
Awesome vid Kevin! Quick question: I have been on finasteride for about a year and two months. I experienced an intense shed in the beginning and then my hair came back stronger than before. However, in the past couple of months I feel as if my hair loss may have progressed and am also shedding much more than I have for the last year. Is this the seasonal shed people talk about? I may also be noticing more shedding as I have let my hair grow longer so it may be more noticeable than shorter hair shedding. Thanks!
It's probably a seasonal shed. I'd give it more time to resolve, maybe another couple months before I'd consider doing anything different. If it looks like you are really losing ground you could consider adding dutasteride 0.5 mg once or twice a week to your regimen, but like I said, I'd hold off for now.
How it's going now any improvement did the shadding stopped how's your hair looking now ?