It's increadible what the internet plus smart people can do sometimes. I almost can't believe that such a rich content is totally free and with so much quality and value. Big thanks Rob!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@Perfect Hair Health thanks for this valuable information. I have quick question, could you just take 0.0912 mg orally to get the same effects as the topical formula(0.005% 2 ml)?
@@PerfectHairHealth Rob You don't specify all the variations like the composition of 5% minoxidil and 0.1% finasteride how many ml to put in a day I take the combination with 5% minoxidil and 0.1% finasteride (plus Latanoprost) 2X1ml (twice a day from 1ml) and I am thinking of reducing it to 1ml a day, (ie once a day 1ml) to reduce side effects! Do you think my hair will start falling out?
This is an incredibly detailed video that actually breaks down the science. Mostly everywhere I have looked and even when talking directly with specialists they at most give anecdotal evidence and suggestions. I really wish more people in the hair loss community were taking this detailed approach - it feels like we would be so much further along. Thanks Rob!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
After my hair transplant, I faced hair loss and my case was diffused pattern hair loss. I tried topical finasteride .1% and it gave me bad side effects. I tried using it twice also only per week and that too gave me side effects. I finally tried 0.005% with your finasteride calculator to make a topical finasteride in my home. Right now in just 25-30 days, I can see my hair fall has reduced to a significant margin and I am also experiencing new hair growth near my non-transplanted hair. This information is Gold
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
It's interesting how we've had the knowledge of a good dose for many years and yet the most commonly prescribed and used dose is much higher than necessary. Fantastic and very informative video, btw.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
I’ve watched hundreds of videos related to androgenic Alopecia and am fascinated with the topic. It’s safe to say I’ve been down the rabbit hole. These videos from Perfect Hair Health are by far the best out there bar none. Thank you Rob!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
The information in this video is fantastic. I am a pharmacist and I was confused about what dose would be optimal . The manufacturers of topical finasteride use sprays which doesn't tell us how much is applied. I love how you clarify this. Keep up the great content!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation. That's why !!!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
This video was worth its weight in gold!!! So much quality information, thank you. I am very wary of Finastride as it did not go well with me in the past - it hit me suddenly. So I am very cautious in even trying out the topical version, so this video was extremely beneficial.
@@winnersmakenoexcuses2360 no, I was taking it for a while but suddenly I got various symptoms, sure effects and I couldn't figure out what was going on. It lowers your libido, reduces your blood flow and fogs your brain.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
🎯 Key Takeaways for quick navigation: 00:00 📊 Topical finasteride sold at high dilutions is unnecessary. 03:38 🧪 Use topical finasteride to reduce scalp DHT and avoid systemic side effects. 05:43 💡 Optimal daily topical finasteride dose: minimize blood DHT impact (0.091 mg daily). 09:10 🧴 Formulation matters; small dose changes affect systemic absorption. 16:33 🩸 Monitor serum DHT levels to adjust topical finasteride dosage. Made with HARPA AI
Really enjoying your “to the point” explanations about currently available studies and their levels of reliability during your meta analysis based presentations. Great work and great information. Thank you.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
First much respect to Rob for making this video. Very tired of seeing other people on RUclips mentioning that Finasteride does not cause side effects. This information will help many guys such as myself, and proves that one does not need to completely nuke DHT levels with outrageous amounts of Fin'. Respect to Rob and his team, and this does seem to work. This, due to my current use of this formulation (my dose is a bit higher).
@@sanktxando First, I am not a doctor, and any information given is not intended to treat or cure any medical condition. I crush a quarter piece of finasteride into a bottle of liquid minoxidil. If you use 2 drop fulls of minoxidil a day, then multiply the percentage to be used (0.02%) by 30. In my case I use (4 )1 ML drop fulls for total scalp coverage. If only 2 drop fulls then crush half a fin' tab into the minoxidil.
0:06: 📚 Topical finasteride dosage for maximizing hair gains while minimizing side effects. 3:51: 🧪 Topical finasteride may reduce or eliminate side effects, but the dose-dependent effect poses a problem. 8:20: 📊 Topical finasteride can effectively lower blood levels of DHT. 11:16: 💡 Careful application of topical finasteride is crucial for effective results. 14:51: 💉 The lowest cost option for DHT testing is Merrick Health, and it is recommended to do the test before starting topical finasteride. Recap by Tammy AI
Careful with the dht blood tests. You might see a difference of 30% just taking the test on different days. You would need to take several tests to get an average of your typical dht before you can know what effect finasteride had.
@@jimandrews8768 He says so in the video. The tests are not inaccurate per se, rather there are natural fluctuations of 20-40% in serum DHT levels depending on many natural factors like sleep and time of day, etc.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@@HejskakajHdhdhsjs you can take vitamins but the absolute last thing you want to do is take a potent 5ar inhibitor like finasteride and dutasteride. These will change your manhood and life especially as you are growing. If your genetics are set for balding you may want to start accepting masculinity and you will NEVER be able to fight what your genes are programmed to do. Go look at the guys with post finasteride syndrome and every single one of them all day they'd rather have been bald than to deal with the lifelong detrimental neurological and physical side effects. It's NOT worth it. Enjoy your life and keep your hair cut very short and allow your body and brain to become what it is capable of because you will not have that opportunity if you take finasteride or dutasteride. Best of luck to you
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@@madelainemelberg996@madelainemelberg996 absolutely yes 100% . It's finasteride and in any amounts of going to cause issues. When are people going to learn ?; Hate to break it to you but yes topical at the lowest concentration will cause detrimental neurological side effects it's just the nature of the nature of the medication. The only one who benefits is the pharmaceutical companies and hims and keeps.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
I was using 1 mg everyday for many years. I switched last year to 0.1% finasteride mixed with 5% minoxidil twice daily, and 1 mg orally 3 times a week,and got waaayyyy less side effects with a better result on hairline.
My biggest concern with using any form of Finasteride is it's possible link to infertility in men. I've read that some men do have trouble in conceiving when they are on Finasteride, but that it "usually" normalizes after you stop using it. My biggest fear is that it doesn't return to normal.
I've never seen any big company claim zero sides, if topical. But it stands to reason, as with any drug, not taking oral and going through liver, is a good thing and reduces possibility of sides and more site specific.
Great information! However, I believe you should also compare scalp DHT levels. Like, how much Scalp DHT reduces by applying 0.005%, 2ml topical Fin as compared to applying 0.25%, 1ml. This thing will give us the more clearer view.
exacty makes what he is saying completely obsolete, what the point of less systemic reduction if scalp is not being reduced sufficiently enough. The best thing is to stick with oral, most people dont get sides.
the point he is saying is, even with 0.01 top fin there is significant hair growth with out altering serum dht level which mean is even if your lab test shows no diff in SDHT there is a significant hair growth, so what else do u want?
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
An online company called Walk in lab has the DHT test for only $99 if not less depending on any current sales they have at the time of purchase. It’s an online lab order that you print out and take to your local lab, I believe Labcorp and Quest diagnostic is the only two lab companies they offer to choose from though.
@@Mark1Mach2 You want to be careful as there is a cheaper, and less precise measurement of DHT as well as the more expensive more precise version (Liquid chromatography-mass spectrometry LC/MS).
Minor point here, but at 7:14, the red line highlights the wrong graph. It should be the next line down, i.e., third from the top, 2nd from the bottom. Absolutely wonderful video! Thanks so much for posting this comprehensive information!
Robs a genius and straight up genuine guy because he could be capitalising hugely from this subject but chooses not to. Hair loss is such a destroyer in men. Thank you so much Rob for your work. You provide men with hope 🙌🏻
just curious-- are you a real account? i have opened 4 accounts praising this guys research and all 4 accounts have zero subscriptions or content of any kind. looks like you are a bot account and in the world of pharmaceuticals we need to be wary of such tomfoolery... especially so with a drug that has such questionable side effects.
Great Video and very informational however it is missing something important. As you mentioned, companies like Hims and others that openly provide topical solutions that are way too high in finasteride concentration (also expensive) nor do they cater to specific individuals, where and how does one find a topical finasteride solution that works best?
@Rob - Thank you! You are saving lives! Cannot tell you how much I appreciate your hard work in compiling all this research and providing the findings with us.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation. That's the opposite of saving lives !!
Within the first 7 days of having topical Finasteride and Minoxidil via Hims, I definitely overdosed. It's so difficult to put the recommended dosage of product onto my head because I have a lot of hair. Using the provided sprayer is way to much product so I got myself a 1ml dropper. I was putting 1 - 1.5ml on my head per day. On day 5 I got a screaming headache that wouldn't go away and I rarely get a headache. I need to get a smaller dropper and I'm going to try putting .25ml on my head, maybe every other day. I'm planning on waiting for this headache to go away before I resume usage at a dramatically reduced volume & frequency. Great video!!
I've figured out how the papers done their calculations at 8:08. The daily application (mg) based on % w/v of finasteride and volume used is calculated using this equation: w/v% * mL used * 9.1 (a constant value) - you can verify the correctness of this formula by checking the graph at 8:08. this means for those who have 0.2% w/v finasteride and want minimal systemic absorption (i.e., daily dose of 0.091 mg) you should use a total daily volume = 0.2/9.1 = 0.02 mL (this is less than ONE drop of a dropper [1 drop = 0.05 mL] which is impractical...) So I've decided to settle for a ~25% DHT serum reduction by using 0.2 mL (4 drops using a dropper ; you can purchase "marked" droppers online for an accurate dose of 0.2 mL) of my 0.2% w/v finasteride solution which corresponds to 0.2*0.2*9.1 = 0.3648 mg of a daily dose finasteride that relates to a roughly 25% reduction in DHT levels. Well, for comparison, a 0.2mg oral finasteride pill decreases ur DHT serum levels by 69%! This will probably significantly lower my probability of developing any unwanted side effects (gynecomastia, high-grade prostate cancer, decreased libido, harder to achieve erections, breast cancer) whoever reading this, I hope you've a great day and I've somewhat solved your concerns about using topical finasteride. Ive read about 50 papers in the last week about finasteride and thank god my (1st class honours) degree in chemistry (from NUS) did help quite a bit understanding these papers 😄
@@curtin-hammett I started 0.125 mg (approximately) mixed in 0.7 ml minoxidil yesterday. Will also update 👍🏻 Btw I'm aiming for a maximum decrease in blood plasma DHT by about 35-40 %.
This is a thoughtful video, but this study was over 25 years ago with only 52 patients in which only 36 completed it and self-scored themselves with some improvement while the rest dropped out because of lack of any improvement in the status of the scalp hair. There were no stats given on serum testosterone measurements at baseline and throughout, and only a statement that no one reported any side effects. It would be nice to have something more concrete in modern times to support this recommendation with support that it works. Some comments below, and even a search on this study in other very popular hair loss forums, say this protocol either still brought on side effects for them or didn’t do anything at all. Any attempts to get updates on, “is this working with no side effects?”, usually go unanswered in those forums and those threads are short-lived. Are there any hard data or concrete experience testimonials that this protocol works without the side effects of the higher dosage? I would like to try this after an unpleasant run with full-dose oral Finasteride but I just don't see any other compelling proof anywhere that this is worth the trouble?
I had side effects from oral i tried topical at 0.005% at first everything was good no side effects not even a week on the stuff gave me chest tingling and a new lump developed under my nipples
@@kristianadamsaric1998 Oral (1mg 3 times a week only) started out with testicular ache and increased libido for the first few weeks. Then quick onset of anorgasmia followed by total erectile dysfunction, complete loss of libido, and tingling pain in testicles, urethra, and prostate area that was constant. I also just did not feel well at all. I stopped because these were intolerable. I returned to normal, but it took 8-12 weeks for that to happen fully.
A few questions: 1. Shouldn't we also be considering the surface area of the head where we are applying the topical? I mean intuitively shouldn't 1ml topical finasteride over a certain surface area have the same effect as 2ml topical finasteride on a surface area that's 2 times bigger if the topical is distributed equally in both examples? If you zoom in with a microscope wouldn't you see the same amount of topical on each part of the skin meaning that each part has the same probability of it leaking to the bloodstream? 2. You showed the difference of how much DHT is reduced systemically based on the amount of topical application but was there a part in the video where you alao compared their effectiveness? You mentioned that the 0.005% dose study showed that it still had results but I don't think I saw any mention of how significant those results were compared to other doses or to different amounts of oral finasteride. If for instance the highest amount of topical use that doesn't heavily affect systematic DHT is only half as effective as normally prescribed oral use, that's also an important factor to consider. 3. Why is it that in the chart at 7:50 the two 0.25%, 0.2ml have such different levels of systemic DHT reduction? Was it bad testing by the researchers by not properly accounting for how DHT fluctuates during the day like you described at the end of the video or is there some other factor at play that the 2 research groups differed on that also has a significant role in DHT reduction other than just the total topical exposure or another reason? 4. How do we account for the point you mentioned at 13:13? What are best ways to keep and apply the topical to make sure we are getting the expected amount? 5. How do we get a 0.005% dilution of finasteride? Does it work if we add a certain amount of the 0.3% product to 60 times its volume of water?
good questions, Rob mentioned the ideal topical dosage, but most certainly will not have the same effect as higher solutions. So maybe what he recommends is best for those who are not thinning agressively and just want to keep their hair as it is. I doubt it would do too much with more agressive balding. The solution he provides must be prepared by a chemist, no one can do it at home. What I find interesting is that , there seems to be no difference between topical and oral when it comes to sides. If the same amount of topical can cause the same sides as the oral, then there is no point in using topical. This is completely different when using minoxidil, when high percentage solutions are much safer than the oral tablets. I think that more research should be done how topical can be made less systemic, like applying a gel which would stop finasteride to trickle down into the bloodstream. I know some companies made this, but they just come up with finasteride percentages that are huge. No one really makes this experiment, I bet there is an ideal dose that would help hair growth, eliminate sides with some extra gel applied.
Mention a point that I don't get though, which is that if topical does indeed lower DHT by similar amounts to oral, in at least the dosages that are widely available, then why do so many people actually report a lower incidence of side effects? Could it be placebo?
Reading so many people who are experiencing detrimental neurological side effects from finasteride even the topical. Such a negative change of trajectory in people's lives from a hair loss medication. So disturbing.
Interesting. I just started taking Saw Palmetto because I heard that there were studies showing that it decreased DHT and improved hair without side effects. I also started using a shampoo with Rosemary that supposedly lowers DHT. I've started using Minoxidil on top of that but only about half a milliliter (maybe less) twice a day since I'm only experiencing recession of the temples. So far no side effects. Hopefully this helps prevent further hairloss
There's some support for saw palmetto! Though that support isn't necessarily of the highest quality. See this article: perfecthairhealth.com/saw-palmetto-for-hair-growth/ If SP doesn't work to improve things within 6-8 months, low-dose topical finasteride is a great stepping stone for anyone looking to therapeutically lower DHT levels in the scalp while also minimizing drug exposure elsewhere. I hope you see success!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
I am shocked at the quality here. Really fantastic job and analysis, but one question: chart at 7:00 suggests 1mL application reduces serum DHT by 25%, but chart at 8:10 suggests the same dose reduces it by ~50%? Isn't this conflicting data or am I misinterpreting either chart?
I am quite stunned that for such a detailed video you did not mention the single most important variable when using topical finasteride which is avoiding first liver pass.
@@887levi Topical administration allows finasteride to reach hair follicles without first passing through the digestive system and liver. It also prevents the creation of several metabolites which are the root cause of side effects.
Love your channel. Big Fan. Could you do a part on why those (men and women) with hypothyroidism lose hair if they work out for 1 hour (strenuous exercises, cross circuit and weights training)? I know you mentioned it in one of your videos in one sentence. Also, if you could discuss does that hair thinning in hypothyroidism get reversed and the timing and what steps to take will be great!
Hi Rob. Yet another great video. Quick couple of questions based on everything covered in this video. Many years ago I was taking Finasteride in pill form and I did suffer a little with side effects. I was only on it for about a year before deciding what o come off of it. I do have fairly advanced hairloss and have tried many options. However, I am on the hims regime now and have been for about 4 months. This is their combined topical Finasteride and Minoxidil solution, with the Finasteride dose at 0.5ml. I’m in the UK and they work on the principle of topically administrating this 0.5ml dose twice a day. However, I have only been applying a single dose of 0.5ml once a day in the morning. So although I’m not ideally using it to the company’s directive, it has had an effect thus far. I am also derma rolling once a week, so maybe that’s helping too. So based on your video info here, I feel that I may stick to the single daily dose rather than squeeze in a 2nd each day. It helps with cost of course, but with the percentages you mention, the single dose may well be the better balance for me, especially as the pill all those years ago did obviously have an effect on my overall DHT. Do you agree on that basis Rob, or do you think I should try and apply twice a day? Thank you in advance Rob. Kind Regards, Simon. UK.
@@Mark1Mach2 hi there. I certainly haven’t had any side effects whatsoever with the topical finasteride/minoxidil combo. However, I’ve been using the solution for around 9 months now and I haven’t really had any positive results, which is a shame. I suppose I must be one of the 10% that it doesn’t work for. Maybe you’ll have more success.
You'd have to have it compounded at a pharmacy, generally, which is usually a bit expensive. Personally I consider the easiest way to obtain low-dose topical fin (cheaply) is by crushing 5mg of Finasteride pill(s) into a powder, and adding it to 60ml of Minoxidil, which will bring the dose very nearly to the one recommended in the video (it would actually be slightly weaker, at around 0.0833% per 1ml, which I consider acceptable since I combine the mixture with a small amount of tretinoin cream to increase absorption.
@@SavageArms357how’s the regime going? Also I was wondering if you are only applying 1ml of fin/minox a day at 0.0833% or if you are applying the 1ml twice daily?
@@chriscorbartUnfortunately, I was not a very strong responder to finasteride, and ultimately decided to cease using it and rock the shaved head look instead. When I was taking it, I would use it once a day, usually at night before bed. I generally used a little bit more than 1ml, sometimes 2ml to ensure full coverage, since I figured the dose was low enough not to matter much. I never experienced any side effects in the year and a half I used it, and I did get *some* regrowth, just not enough to really justify the effort, at least in my case. I ended up using Minoxidil foam on my face instead to promote beard growth, along with a small amount of tretinoin and microneedling, and that had a *significant* effect.
While this video was informative, it didnt mention about the amount of hair growth with shown low doses. Which kinda makes it pointless. Like, okay, you used topical at a low dose and your blood dht didnt drop as much, but how much hair growth you had this way? This is what the video lacked. For exaggeration, %1 of hair growth could be called "it still stimulates hair growth" but it would be pointless.
I decided to start fin 1mg 3 times a week orally. After the first pill, i had all the side effects (ED, chest pain , mood swings, itchy balls). I stopped it immediately, amd After 10 days of stopping the drug every thing went back to normal. Now i decided to restart it topically, i am using 0.2 mg per day (0.02% , 1ml per day) and i have zero sides. I hope my hair responds well to this topical dose.
That's great to hear! Congrats on taking the time to troubleshoot this and finding a dose that works with your body. For what it's worth, the study on 0.005% topical finasteride at 2 mL daily showed positive hair outcomes over 16 months. That suggests your dose (provided you're using 0.5-2 mL daily) should also help.
You can make your own using finasteride tablets steeped in an alcohol based solution (such as minoxidil or a mix of alcohol and PG etc). 0.005% is 5mg per 100mL.
It doesn't make sense why the side effects wouldn't be the same with oral or topical. They're both still getting in your bloodstream and flowing throughout your whole body either way
Fantastic vid! Have been considering going topical but you drew attention to factors I haven't considered. I take 0.31mg of oral twice a week as I believe myself to have combination hair loss (genetically lucky towards AA but with a very sensitive scalp that causes excess shedding). I find it has really worked with a daily loss down from 150+ to 40 approx. Question is...does this still cause sufficient issues systemically iyo? And does such sparse staggering of fin (mon morning and thurs night) create their own set of problems due to the potentially unstable fluctuations of hormones of such irregular doses? Thanks Rob
Excellent video and backed up with facts! I went looking for a topical solution and they are few and far between. I stumbled over a site that suggested crushing Finasteride tablets and adding them to Minoxidil solution. What are your thoughts on this?
But wait there's more!! Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
So if you're making it yourself in a bottle of 60ml Kirkland Minoxidil, you're using 0.0912 mg per 2mL that's 0.0456 mg per 1ml, and then 0.0456 x 60 is 2.73mg per bottle of 60mL of minoxidil. Is that math right?
Excellent video. The thing no one talks about is how much to put on your scalp when you have a lot of hair. It’s a lot more difficult to penetrate your scalp. What do you think?? I got a hair transplant back in January with great results. My hair transplant doctor told me if I want to go with the pill form that 1mg oral finasteride is complete over kill. He recommended .25 to at the most .5 mg.
I have been reading that topical Finasteride should be applied separately to minoxidil. Minoxidil is a vasodilator which would increase the chances of topical finasteride going systemic.
Finasteride appears to have a low therapeutic index- basically the difference between a dose that is too small to work & a dose that is toxic or has side effects is very small. This makes it a rather poor consumer lifestyle medication. I wonder if any other DHT blockers have higher therapeutic index?
Hi Rob - Excellent video. You really got me thinking about all of this and I am now encouraged to try it. As I prepare my request to the doctor for an Rx, I have a couple of things I want to make sure I have correct. There are two things to consider: 1. the actual concentration of the topical. 2. The total daily exposure to the drug. So you're saying a concentration of .005% (w/w) will provide enough potency to help with hair loss and a total daily exposure not to exceed .2 mg. Is this correct ? I cannot find the study that shows the effectiveness and DHT effects for the .005% concentration. Can you please provide a link ? If anyone else has thoughts on this, I would appreciate the feedback. Best regards, R
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@@mraayush1881 look at the studies kiddo. Studies don't lie. It's not a matter of IF you will get the detrimental neurological side effects it's just a matter of WHEN! !
Thanks a million, Rob! As expected, topical finasteride is marketed with layman-inducing bloviation. So, the one bit of information that could definitely act as the icing on top is what brand(s) of topical finasteride do you find best hew to the substance of your research by yielding maximum benefits with the lowest risk of side effects? Anything particularly helpful for men with pregnant partners would be greatly appreciated!
I think you can crash 2.75 mg (tablet of 1 mg) on 60 ml of rogaine and you have 0.045mg \ 1 ml. If you drop 1 ml twice a day you exposed your scalp to 0.0916 mg of fina , as the graph on the video. Correct me if im wrong
Thinking the same thing…I think if you combine 1.5mg of finasteride with a bottle of Kirkland minoxidil 60ml and you use 2ml a day that equates to .005%
@@mattiapancin3926 that's the same math I got, if you're using 0.0912 mg per 2mL that's 0.0456 mg per 1ml, and then 0.0456 x 60 is 2.73mg per bottle of 60mL of minoxidil
I’m gonna try this. I’ve been staying away due to the fear of PFS but I believe in you guys and I’m going to put in the work to stay safe. But what happens if you drop your dht too low? Is there a way to raise it back to normal levels? Do you just need the fin to fully leave your body
Hi, Rob, great video, very informative, thanks! What do you thinkg about using retinoic acid along with minoxidil to combat fibrosis, is there any study in this regards?
If you use topical finasteride, you need to cover the whole area of dht sensitive hairs, from the hairline to the vertex, not just on the temples or where you are balding. Use it like minoxidil and just treat problem areas, in 5 years time, you'll discover you were losing hairs behind your hairline and those hairs had been going commando the whole time.
This is what Marek Health says as well. I got some from Strut, here's hoping. I've only had the stuff two weeks or so 1x a day with the tretinoin + minox though. Thing is that's the CHEAPEST I could ever hope to afford something compounded like that and topical. Just wish they'd include the latanoprost with it (the prostaglandin system for my scalp COULD use some work)
*Hey* *Rob* , Based on the chart at 11:48, don't you think it would make more sense to get the second Serum DHT test at 4 weeks--when the decrease stabilizes?
But wait there's more!! Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
What if I dilute the hims .3 with distilled water to get it to 0.01? I just order it and don’t want it to go to waste. Does anyone know how much water to add and sprays that would be? They recommend 4 sprays now at .3 once a day.
I've read that diluting with water isn't the best because it doesn't dissolve and distribute evenly. May also affect absorption. I have heard of people putting 1 ml of Hims 0.3% into a 60ml bottle of generic minoxidil and then using 1ml of the final solution per day. I haven't tried it yet but am interested.
Why isn’t getting results with 0.5mg 3x a week more popular then if it blocks damn near the same % of DHT as 1mg? I hear 1mg 3x a week is pretty standard these days thanks to the recommendation by the “hair loss show” on RUclips
I'm using this formulation- 12mg of finasteride into a 60ml minoxidil bottle. This equates to 0.2 mg per ML or .020% formulation which you would use only once a day. I use minoxidil 2x a day, once with finasteride and once without. I got sides from daily .25 oral finasteride. Mainly brain fog and depression so I discontinued for 2 weeks and felt normal again. This is my anecdotal experience. Not a reccomendation just my opinion. Ill report back in 6 months with results.
I upped it to 15mg and then 19mg per 60ml of minoxidil. Hair is stronger than ever. Didn’t really start to see results till month 5. Head massages and micro needling are extremely important for blood flow. Be consistent.
Great work - eating these videos up. As a physician, I would actually not test or favor testing for DHT in most patients who want to use topical finasteride UNLESS A) a patient just really wanted to know which I have no problem honoring a patient request like (insurance would NEVER pay for that lab test, so they would still have to pay out of pocket), B) if a patient was having side effects with oral and we really needed a laser guided precision strike. This video is awesome and I love personalized and precision based medicine that is driven by good data. Clinically though - finasteride is super safe and most patients do not have side effects and those who do typically know right away - you stop and those side effects go away; some patients have delayed onset of side effects due to the half life of finasteride and it building up over time and again when they stop using finasteride - side effects typically just go away. So unless there is a good clinical reason (i.e. patient concern or adverse outcomes on higher dosses) to run down that rabbit hole, I would advocate and trial by error approach. Most patients are going to do great with standard finasteride (topical or oral) and it is a much less expensive and resource intensive approach - also the difficulty and stress of finding a physician who will work with you to do this might be the hardest part of all sadly. We are also venturing into experimental waters here with DHT testing and then using that to drive treatment decisions for custom made finasteride. I think it is perfectly fine as that falls squarely within the true art of medicine but you really have to take this kind of practice with a large grain of salt and this I would happily keep in my back pocket as a clinician for select cases.
Feedback skews positive! However, the serum DHT test are necessary if you really care about near-complete effect localization. About half of members don’t see an appreciable change in serum DHT; the others do. Also, check out our video on Bryan Johnson for a deeper dive into whether serum DHT is the best proxy for risks of adverse events with topical finasteride.
Great read. For someone who already has weak erections at times, would you still recommend finasteride? Since you said side effects are not permanent, I am eager to try finasteride beforehand to see how it affects my libido
I've heard of people putting 1 ml of Hims 0.3% into a 60ml bottle of generic minoxidil and then using 1ml of the final solution per day. I haven't tried it yet but am interested. Please correct me if I am wrong.
![Natanael Cano - Amor Eterno [Official Video]](http://i.ytimg.com/vi/EO4prCs6WpM/mqdefault.jpg)
It's increadible what the internet plus smart people can do sometimes. I almost can't believe that such a rich content is totally free and with so much quality and value. Big thanks Rob!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@@KropTop12 thanks for sharing. Can you link any study pls?
Is Oral Finasteride the same as the one dissolved in any topical product?
Topical**
@@bene88597 there's no avoiding the detrimental neurological side effects with the mechanism of the 5AR inhibitor
My God!!!...
The amount of details that goes into making these superb videos..
Hats off to Rob and his team..
Great, great work...
Much appreciated..
Thanks!
Wait till you regrow your hair before taking your hat off son
Very detailed. I watched it like 3x.
@Perfect Hair Health thanks for this valuable information. I have quick question, could you just take 0.0912 mg orally to get the same effects as the topical formula(0.005% 2 ml)?
@@PerfectHairHealth Rob You don't specify all the variations like the composition of 5% minoxidil and 0.1% finasteride how many ml to put in a day
I take the combination with 5% minoxidil and 0.1% finasteride (plus Latanoprost) 2X1ml (twice a day from 1ml) and I am thinking of reducing it to 1ml a day, (ie once a day 1ml) to reduce side effects!
Do you think my hair will start falling out?
This is an incredibly detailed video that actually breaks down the science. Mostly everywhere I have looked and even when talking directly with specialists they at most give anecdotal evidence and suggestions. I really wish more people in the hair loss community were taking this detailed approach - it feels like we would be so much further along. Thanks Rob!
Video is a bit too long. 5 minutes should be enough to dumb it down and get to the point
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
After my hair transplant, I faced hair loss and my case was diffused pattern hair loss. I tried topical finasteride .1% and it gave me bad side effects. I tried using it twice also only per week and that too gave me side effects. I finally tried 0.005% with your finasteride calculator to make a topical finasteride in my home. Right now in just 25-30 days, I can see my hair fall has reduced to a significant margin and I am also experiencing new hair growth near my non-transplanted hair.
This information is Gold
Amazing! Really happy for you, and I hope things continue to improve.
@@PerfectHairHealthRob I truly truly told you that you are the best hairloss RUclipsR 🥺
How did you do the calculations?
Can you please explain
What kind of side effects
Dude you go more in depth on finasteride than my dermatologist did lmao. Good content my man.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
It's interesting how we've had the knowledge of a good dose for many years and yet the most commonly prescribed and used dose is much higher than necessary. Fantastic and very informative video, btw.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
Everyone talking about likes and views , no one provide real information.
But ROB you are my favorite RUclipsr 💕
I’ve watched hundreds of videos related to androgenic Alopecia and am fascinated with the topic. It’s safe to say I’ve been down the rabbit hole. These videos from Perfect Hair Health are by far the best out there bar none. Thank you Rob!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
The information in this video is fantastic. I am a pharmacist and I was confused about what dose would be optimal . The manufacturers of topical finasteride use sprays which doesn't tell us how much is applied. I love how you clarify this. Keep up the great content!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
You've surpassed more plates more dates with regards to hairloss mitigation information! Kudos, and many thanks!
What makes you say that just wondering?
How does this dude not have more subs wtf? This is a crazy amount of info.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
That's why !!!
The only channel that goes truly in-depth about this. Great job 👍
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
This is the best hair loss channel I've come across in RUclips. Fantastic content.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
This video was worth its weight in gold!!! So much quality information, thank you.
I am very wary of Finastride as it did not go well with me in the past - it hit me suddenly. So I am very cautious in even trying out the topical version, so this video was extremely beneficial.
Can you please explain what you mean with "it hit me suddenly"? Did it help you growing your hai back?
Please tell what happened?
@@winnersmakenoexcuses2360 no, I was taking it for a while but suddenly I got various symptoms, sure effects and I couldn't figure out what was going on. It lowers your libido, reduces your blood flow and fogs your brain.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
🎯 Key Takeaways for quick navigation:
00:00 📊 Topical finasteride sold at high dilutions is unnecessary.
03:38 🧪 Use topical finasteride to reduce scalp DHT and avoid systemic side effects.
05:43 💡 Optimal daily topical finasteride dose: minimize blood DHT impact (0.091 mg daily).
09:10 🧴 Formulation matters; small dose changes affect systemic absorption.
16:33 🩸 Monitor serum DHT levels to adjust topical finasteride dosage.
Made with HARPA AI
Rob you are by far the best hairloss youtuber, just started dosing with .12mg topical ED mixed in some 5% minoxidil, wish me luck!
Updates?
Update
Updates?
Update?
Update?
Really enjoying your “to the point” explanations about currently available studies and their levels of reliability during your meta analysis based presentations. Great work and great information. Thank you.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@@KropTop12interesting points,,, what’s your source and what are the percentages for each of the aforementioned?
First much respect to Rob for making this video. Very tired of seeing other people on RUclips mentioning that Finasteride does not cause side effects. This information will help many guys such as myself, and proves that one does not need to completely nuke DHT levels with outrageous amounts of Fin'. Respect to Rob and his team, and this does seem to work. This, due to my current use of this formulation (my dose is a bit higher).
What's your dose/formulation?
@@sanktxando First, I am not a doctor, and any information given is not intended to treat or cure any medical condition. I crush a quarter piece of finasteride into a bottle of liquid minoxidil. If you use 2 drop fulls of minoxidil a day, then multiply the percentage to be used (0.02%) by 30. In my case I use (4 )1 ML drop fulls for total scalp coverage. If only 2 drop fulls then crush half a fin' tab into the minoxidil.
@@mikecronin6265could you explain that a little more? I take .25mg of finasteride per day and I use 2 ml of minoxidil per day.
0:06: 📚 Topical finasteride dosage for maximizing hair gains while minimizing side effects.
3:51: 🧪 Topical finasteride may reduce or eliminate side effects, but the dose-dependent effect poses a problem.
8:20: 📊 Topical finasteride can effectively lower blood levels of DHT.
11:16: 💡 Careful application of topical finasteride is crucial for effective results.
14:51: 💉 The lowest cost option for DHT testing is Merrick Health, and it is recommended to do the test before starting topical finasteride.
Recap by Tammy AI
Where can I buy topical finasteride?
Thanks
@@Krillepcrush fin pills in minoxidil
@@totallegend2480how would that be? Crush 1 mg and pour it in and how would you know how much mg is in each spray?
Careful with the dht blood tests. You might see a difference of 30% just taking the test on different days. You would need to take several tests to get an average of your typical dht before you can know what effect finasteride had.
Why are dht tests so inaccurate?
@@jimandrews8768 He says so in the video. The tests are not inaccurate per se, rather there are natural fluctuations of 20-40% in serum DHT levels depending on many natural factors like sleep and time of day, etc.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
What should I do about hairloss at 15? Confirmed hairloss btw
@@HejskakajHdhdhsjs you can take vitamins but the absolute last thing you want to do is take a potent 5ar inhibitor like finasteride and dutasteride. These will change your manhood and life especially as you are growing. If your genetics are set for balding you may want to start accepting masculinity and you will NEVER be able to fight what your genes are programmed to do. Go look at the guys with post finasteride syndrome and every single one of them all day they'd rather have been bald than to deal with the lifelong detrimental neurological and physical side effects. It's NOT worth it. Enjoy your life and keep your hair cut very short and allow your body and brain to become what it is capable of because you will not have that opportunity if you take finasteride or dutasteride. Best of luck to you
@@HejskakajHdhdhsjs what are you doing about your hair-loss?
Stumbled across this vid and it was pure gold! Immediately liked and subbed; thank you so much Perfect Hair Health!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
Just reading your comment alone it is obvious that you are not well
@@KropTop12 are you suggesting it has a negative impact on the CNS in any concentration %?
@@madelainemelberg996@madelainemelberg996 absolutely yes 100% . It's finasteride and in any amounts of going to cause issues. When are people going to learn ?; Hate to break it to you but yes topical at the lowest concentration will cause detrimental neurological side effects it's just the nature of the nature of the medication. The only one who benefits is the pharmaceutical companies and hims and keeps.
The word HEALTH needs to be left completely out of your statement.
Spectacular video. The best I have seen regarding treatment with topical finasteride. Super comprehensive, informative and detailed. Thanks Rob.
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
I was using 1 mg everyday for many years.
I switched last year to 0.1% finasteride mixed with 5% minoxidil twice daily, and 1 mg orally 3 times a week,and got waaayyyy less side effects with a better result on hairline.
How can i mix it? Could you please explain how many tablets you need for 60ML Minoxidil to geht 0.1% finasteride?
@@Excalibur01972 I am not sure I understand you're question properly but there are premixed Minoxidil + Finasteride solution in the market.
@@sushantgambhir Yes i know but the premixed products contain too much Finasteride
Did you take minoxidil before? Because the better results can also come from minoxidil.
@@Excalibur01972 60 x 1mg tablets to make 0.1% solution.
i cant believe this video isnt getting the recognition it deserves
My biggest concern with using any form of Finasteride is it's possible link to infertility in men. I've read that some men do have trouble in conceiving when they are on Finasteride, but that it "usually" normalizes after you stop using it. My biggest fear is that it doesn't return to normal.
I've never seen any big company claim zero sides, if topical. But it stands to reason, as with any drug, not taking oral and going through liver, is a good thing and reduces possibility of sides and more site specific.
Great information!
However, I believe you should also compare scalp DHT levels. Like, how much Scalp DHT reduces by applying 0.005%, 2ml topical Fin as compared to applying 0.25%, 1ml.
This thing will give us the more clearer view.
exacty makes what he is saying completely obsolete, what the point of less systemic reduction if scalp is not being reduced sufficiently enough. The best thing is to stick with oral, most people dont get sides.
DHT level blood tests are incredibly unreliable. More often there are no differences and yet side effects occur.
the point he is saying is, even with 0.01 top fin there is significant hair growth with out altering serum dht level which mean is even if your lab test shows no diff in SDHT there is a significant hair growth, so what else do u want?
Very informative video, switched from 1 mg oral fin daily to low dose topical fin + dut and your recommendations on fin helped a lot!
Me too! What are you on?
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
your video was the reason i started to take 0.2 mg oral a day. and it was the best decision ever.
Like you broke the pill down? Plz help
How do u only take 0.2 ?
@@thanosmenfou2616 yes
@@thanosmenfou2616 I purchased a pill cutter to take one quarter a week
@@jacobmunoz3970 yeah he mostly did that only
After watching a lot videos about hair loss, i can honestly say this is the best one
An online company called Walk in lab has the DHT test for only $99 if not less depending on any current sales they have at the time of purchase. It’s an online lab order that you print out and take to your local lab, I believe Labcorp and Quest diagnostic is the only two lab companies they offer to choose from though.
thanks for that info
@@Mark1Mach2 You want to be careful as there is a cheaper, and less precise measurement of DHT as well as the more expensive more precise version (Liquid chromatography-mass spectrometry LC/MS).
Wow this was the exact info I needed. Do you have an idea on where you can get a topical solution like that made?
Minor point here, but at 7:14, the red line highlights the wrong graph. It should be the next line down, i.e., third from the top, 2nd from the bottom.
Absolutely wonderful video! Thanks so much for posting this comprehensive information!
This is fantastic content team - bloody well done
Robs a genius and straight up genuine guy because he could be capitalising hugely from this subject but chooses not to. Hair loss is such a destroyer in men. Thank you so much Rob for your work. You provide men with hope 🙌🏻
just curious-- are you a real account? i have opened 4 accounts praising this guys research and all 4 accounts have zero subscriptions or content of any kind. looks like you are a bot account and in the world of pharmaceuticals we need to be wary of such tomfoolery... especially so with a drug that has such questionable side effects.
@@strange_ranger1considering he joined RUclips 8 years ago, no he is not a bot
Great Video and very informational however it is missing something important. As you mentioned, companies like Hims and others that openly provide topical solutions that are way too high in finasteride concentration (also expensive) nor do they cater to specific individuals, where and how does one find a topical finasteride solution that works best?
You have to make it yourself.
Perfectly informative - my goodness! Thanks so much for this video
@Rob - Thank you! You are saving lives! Cannot tell you how much I appreciate your hard work in compiling all this research and providing the findings with us.
Agreed!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
That's the opposite of saving lives !!
Excellent video! I’ve been doing .25% at 1ML twice daily. No doubt it’s gone systemic. I should probably just switch to the oral.
Perfect beard health
Within the first 7 days of having topical Finasteride and Minoxidil via Hims, I definitely overdosed. It's so difficult to put the recommended dosage of product onto my head because I have a lot of hair. Using the provided sprayer is way to much product so I got myself a 1ml dropper. I was putting 1 - 1.5ml on my head per day. On day 5 I got a screaming headache that wouldn't go away and I rarely get a headache. I need to get a smaller dropper and I'm going to try putting .25ml on my head, maybe every other day. I'm planning on waiting for this headache to go away before I resume usage at a dramatically reduced volume & frequency. Great video!!
Thanks for info. That product appeals to me because it seems super convenient, but I will proceed with caution.
@@jimcrookston2776stop using it now. Or you will ruin life
I've figured out how the papers done their calculations at 8:08. The daily application (mg) based on % w/v of finasteride and volume used is calculated using this equation: w/v% * mL used * 9.1 (a constant value) - you can verify the correctness of this formula by checking the graph at 8:08.
this means for those who have 0.2% w/v finasteride and want minimal systemic absorption (i.e., daily dose of 0.091 mg) you should use a total daily volume = 0.2/9.1 = 0.02 mL (this is less than ONE drop of a dropper [1 drop = 0.05 mL] which is impractical...)
So I've decided to settle for a ~25% DHT serum reduction by using 0.2 mL (4 drops using a dropper ; you can purchase "marked" droppers online for an accurate dose of 0.2 mL) of my 0.2% w/v finasteride solution which corresponds to 0.2*0.2*9.1 = 0.3648 mg of a daily dose finasteride that relates to a roughly 25% reduction in DHT levels. Well, for comparison, a 0.2mg oral finasteride pill decreases ur DHT serum levels by 69%! This will probably significantly lower my probability of developing any unwanted side effects (gynecomastia, high-grade prostate cancer, decreased libido, harder to achieve erections, breast cancer)
whoever reading this, I hope you've a great day and I've somewhat solved your concerns about using topical finasteride. Ive read about 50 papers in the last week about finasteride and thank god my (1st class honours) degree in chemistry (from NUS) did help quite a bit understanding these papers 😄
Thanks
Update?
@@ugglanvu takes about 3-4 months to see results w finasteride! Will keep the post updated
are you using minioxidil with it.?
@@curtin-hammett I started 0.125 mg (approximately) mixed in 0.7 ml minoxidil yesterday. Will also update 👍🏻
Btw I'm aiming for a maximum decrease in blood plasma DHT by about 35-40 %.
Excellent video rob, very informative. Hope to see more videos from you and your team. Subscribed.
This is a thoughtful video, but this study was over 25 years ago with only 52 patients in which only 36 completed it and self-scored themselves with some improvement while the rest dropped out because of lack of any improvement in the status of the scalp hair. There were no stats given on serum testosterone measurements at baseline and throughout, and only a statement that no one reported any side effects. It would be nice to have something more concrete in modern times to support this recommendation with support that it works. Some comments below, and even a search on this study in other very popular hair loss forums, say this protocol either still brought on side effects for them or didn’t do anything at all. Any attempts to get updates on, “is this working with no side effects?”, usually go unanswered in those forums and those threads are short-lived. Are there any hard data or concrete experience testimonials that this protocol works without the side effects of the higher dosage? I would like to try this after an unpleasant run with full-dose oral Finasteride but I just don't see any other compelling proof anywhere that this is worth the trouble?
Hi Ben! You mentioned it was an unpleasent run with oral finasteride, which side effects have you experienced?
I had side effects from oral i tried topical at 0.005% at first everything was good no side effects not even a week on the stuff gave me chest tingling and a new lump developed under my nipples
@@sponsponm1 You are probably allergic. That’s not normal
@@kristianadamsaric1998 Oral (1mg 3 times a week only) started out with testicular ache and increased libido for the first few weeks. Then quick onset of anorgasmia followed by total erectile dysfunction, complete loss of libido, and tingling pain in testicles, urethra, and prostate area that was constant. I also just did not feel well at all. I stopped because these were intolerable. I returned to normal, but it took 8-12 weeks for that to happen fully.
@@sponsponm1 where did you get your 0.005% or how did you make it?
You are something big brother ❤. Thanks for the diamond info.
A few questions:
1. Shouldn't we also be considering the surface area of the head where we are applying the topical?
I mean intuitively shouldn't 1ml topical finasteride over a certain surface area have the same effect as 2ml topical finasteride on a surface area that's 2 times bigger if the topical is distributed equally in both examples? If you zoom in with a microscope wouldn't you see the same amount of topical on each part of the skin meaning that each part has the same probability of it leaking to the bloodstream?
2. You showed the difference of how much DHT is reduced systemically based on the amount of topical application but was there a part in the video where you alao compared their effectiveness? You mentioned that the 0.005% dose study showed that it still had results but I don't think I saw any mention of how significant those results were compared to other doses or to different amounts of oral finasteride. If for instance the highest amount of topical use that doesn't heavily affect systematic DHT is only half as effective as normally prescribed oral use, that's also an important factor to consider.
3. Why is it that in the chart at 7:50 the two 0.25%, 0.2ml have such different levels of systemic DHT reduction? Was it bad testing by the researchers by not properly accounting for how DHT fluctuates during the day like you described at the end of the video or is there some other factor at play that the 2 research groups differed on that also has a significant role in DHT reduction other than just the total topical exposure or another reason?
4. How do we account for the point you mentioned at 13:13? What are best ways to keep and apply the topical to make sure we are getting the expected amount?
5. How do we get a 0.005% dilution of finasteride? Does it work if we add a certain amount of the 0.3% product to 60 times its volume of water?
good questions, Rob mentioned the ideal topical dosage, but most certainly will not have the same effect as higher solutions. So maybe what he recommends is best for those who are not thinning agressively and just want to keep their hair as it is. I doubt it would do too much with more agressive balding. The solution he provides must be prepared by a chemist, no one can do it at home. What I find interesting is that , there seems to be no difference between topical and oral when it comes to sides. If the same amount of topical can cause the same sides as the oral, then there is no point in using topical. This is completely different when using minoxidil, when high percentage solutions are much safer than the oral tablets. I think that more research should be done how topical can be made less systemic, like applying a gel which would stop finasteride to trickle down into the bloodstream. I know some companies made this, but they just come up with finasteride percentages that are huge. No one really makes this experiment, I bet there is an ideal dose that would help hair growth, eliminate sides with some extra gel applied.
Mention a point that I don't get though, which is that if topical does indeed lower DHT by similar amounts to oral, in at least the dosages that are widely available, then why do so many people actually report a lower incidence of side effects? Could it be placebo?
Reading so many people who are experiencing detrimental neurological side effects from finasteride even the topical. Such a negative change of trajectory in people's lives from a hair loss medication. So disturbing.
Interesting. I just started taking Saw Palmetto because I heard that there were studies showing that it decreased DHT and improved hair without side effects. I also started using a shampoo with Rosemary that supposedly lowers DHT. I've started using Minoxidil on top of that but only about half a milliliter (maybe less) twice a day since I'm only experiencing recession of the temples. So far no side effects. Hopefully this helps prevent further hairloss
There's some support for saw palmetto! Though that support isn't necessarily of the highest quality. See this article:
perfecthairhealth.com/saw-palmetto-for-hair-growth/
If SP doesn't work to improve things within 6-8 months, low-dose topical finasteride is a great stepping stone for anyone looking to therapeutically lower DHT levels in the scalp while also minimizing drug exposure elsewhere. I hope you see success!
Any progress with your hair? It’s been 3 months
@TheLAexplorer Any updates?
Great video Rob
I appreciate your work bro ❤
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
So how do you get topical finasteride in specific dosages?
Thank you so much for the great advice , guide, and information ❤
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
I am shocked at the quality here. Really fantastic job and analysis, but one question: chart at 7:00 suggests 1mL application reduces serum DHT by 25%, but chart at 8:10 suggests the same dose reduces it by ~50%? Isn't this conflicting data or am I misinterpreting either chart?
Hi @Rob, do you know the answer to this?
First chart is single application
I am quite stunned that for such a detailed video you did not mention the single most important variable when using topical finasteride which is avoiding first liver pass.
Could you expand, please...
@@887levi Topical administration allows finasteride to reach hair follicles without first passing through the digestive system and liver. It also prevents the creation of several metabolites which are the root cause of side effects.
What is the importance of bypassing the liver?
This is an excellent video. No wonder so many people get sides!!
Love your channel. Big Fan. Could you do a part on why those (men and women) with hypothyroidism lose hair if they work out for 1 hour (strenuous exercises, cross circuit and weights training)? I know you mentioned it in one of your videos in one sentence. Also, if you could discuss does that hair thinning in hypothyroidism get reversed and the timing and what steps to take will be great!
Thanks! Check out our video on telogen effluvium - it should help explain things in better details. ruclips.net/video/UGBamyyJLOk/видео.html
OMG ROB. I LOVE YOUR BEARD. PLEASE KEEP IT LONGER AND LONGER. X
Hi Rob. Yet another great video. Quick couple of questions based on everything covered in this video. Many years ago I was taking Finasteride in pill form and I did suffer a little with side effects. I was only on it for about a year before deciding what o come off of it. I do have fairly advanced hairloss and have tried many options. However, I am on the hims regime now and have been for about 4 months. This is their combined topical Finasteride and Minoxidil solution, with the Finasteride dose at 0.5ml. I’m in the UK and they work on the principle of topically administrating this 0.5ml dose twice a day. However, I have only been applying a single dose of 0.5ml once a day in the morning. So although I’m not ideally using it to the company’s directive, it has had an effect thus far. I am also derma rolling once a week, so maybe that’s helping too. So based on your video info here, I feel that I may stick to the single daily dose rather than squeeze in a 2nd each day. It helps with cost of course, but with the percentages you mention, the single dose may well be the better balance for me, especially as the pill all those years ago did obviously have an effect on my overall DHT. Do you agree on that basis Rob, or do you think I should try and apply twice a day? Thank you in advance Rob. Kind Regards, Simon. UK.
have you got any improvement after using combined topical Finasteride and Minoxidil solution
Yepp I'm also interested in knowing if hims topical solution even once has helped you without the side effects? Thanks.
@@Mark1Mach2 hi there. I certainly haven’t had any side effects whatsoever with the topical finasteride/minoxidil combo. However, I’ve been using the solution for around 9 months now and I haven’t really had any positive results, which is a shame. I suppose I must be one of the 10% that it doesn’t work for. Maybe you’ll have more success.
@@simonrussell6372 hey how is it going ?
Please make more such informative video filled with authentic information from researchs done.
This is an amazingly well done video. Where in the world can I find .01% topical finasteride though?
You'd have to have it compounded at a pharmacy, generally, which is usually a bit expensive. Personally I consider the easiest way to obtain low-dose topical fin (cheaply) is by crushing 5mg of Finasteride pill(s) into a powder, and adding it to 60ml of Minoxidil, which will bring the dose very nearly to the one recommended in the video (it would actually be slightly weaker, at around 0.0833% per 1ml, which I consider acceptable since I combine the mixture with a small amount of tretinoin cream to increase absorption.
@@SavageArms357 1.5mg fin into 60ml minoxidil you will get 0.025%
@@SavageArms357how’s the regime going? Also I was wondering if you are only applying 1ml of fin/minox a day at 0.0833% or if you are applying the 1ml twice daily?
@@chriscorbartUnfortunately, I was not a very strong responder to finasteride, and ultimately decided to cease using it and rock the shaved head look instead.
When I was taking it, I would use it once a day, usually at night before bed. I generally used a little bit more than 1ml, sometimes 2ml to ensure full coverage, since I figured the dose was low enough not to matter much. I never experienced any side effects in the year and a half I used it, and I did get *some* regrowth, just not enough to really justify the effort, at least in my case.
I ended up using Minoxidil foam on my face instead to promote beard growth, along with a small amount of tretinoin and microneedling, and that had a *significant* effect.
Excellent straightforward advice.
While this video was informative, it didnt mention about the amount of hair growth with shown low doses. Which kinda makes it pointless.
Like, okay, you used topical at a low dose and your blood dht didnt drop as much, but how much hair growth you had this way? This is what the video lacked.
For exaggeration, %1 of hair growth could be called "it still stimulates hair growth" but it would be pointless.
Excellent video. Sorely needed
Nice Video! Do you have any tips or a guide on making the formulation by yourself at home?
Yea would like to know that aswell
I use Avodart at .5mg. Have for 15 years and works great. No side effects that I know of and prostate looks good as well.
I decided to start fin 1mg 3 times a week orally.
After the first pill, i had all the side effects (ED, chest pain , mood swings, itchy balls). I stopped it immediately, amd After 10 days of stopping the drug every thing went back to normal.
Now i decided to restart it topically, i am using 0.2 mg per day (0.02% , 1ml per day) and i have zero sides. I hope my hair responds well to this topical dose.
That's great to hear! Congrats on taking the time to troubleshoot this and finding a dose that works with your body. For what it's worth, the study on 0.005% topical finasteride at 2 mL daily showed positive hair outcomes over 16 months. That suggests your dose (provided you're using 0.5-2 mL daily) should also help.
Which company provided the topical fin ? Thanks
@@PerfectHairHealth i hope that... waiting for the results!
@@prabshiro it's 1mg Fin called " Prohair "
@@hasysn do you have a website link ? Is that a pharmacy Italian?
Very good scientific analysis
Really nice video mate! But how can i get 0.005% Finasterid? 😁 If you could a tutorial that would be great, cheers!
Just got mine from hemiacosmetics
@@richestate4902 really because i looked on there website the lowest dose they provide is 0.025mg which equals 0.25 mg per 1ml of topical
You can make your own using finasteride tablets steeped in an alcohol based solution (such as minoxidil or a mix of alcohol and PG etc). 0.005% is 5mg per 100mL.
@@sponsponm1 message them they'll tell you to put the percentage you want in the code box as you check out
@@SetTheCurve So 3mg finasteride + 60ml Minoxidil = 0.005%?
It doesn't make sense why the side effects wouldn't be the same with oral or topical. They're both still getting in your bloodstream and flowing throughout your whole body either way
Fantastic vid! Have been considering going topical but you drew attention to factors I haven't considered. I take 0.31mg of oral twice a week as I believe myself to have combination hair loss (genetically lucky towards AA but with a very sensitive scalp that causes excess shedding). I find it has really worked with a daily loss down from 150+ to 40 approx. Question is...does this still cause sufficient issues systemically iyo? And does such sparse staggering of fin (mon morning and thurs night) create their own set of problems due to the potentially unstable fluctuations of hormones of such irregular doses? Thanks Rob
Excellent video and backed up with facts! I went looking for a topical solution and they are few and far between. I stumbled over a site that suggested crushing Finasteride tablets and adding them to Minoxidil solution. What are your thoughts on this?
Great content.
But wait there's more!!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
So if you're making it yourself in a bottle of 60ml Kirkland Minoxidil, you're using 0.0912 mg per 2mL that's 0.0456 mg per 1ml, and then 0.0456 x 60 is 2.73mg per bottle of 60mL of minoxidil. Is that math right?
Great video! Is there a way to dilute a higher dosage?
Excellent video. The thing no one talks about is how much to put on your scalp when you have a lot of hair. It’s a lot more difficult to penetrate your scalp. What do you think?? I got a hair transplant back in January with great results. My hair transplant doctor told me if I want to go with the pill form that 1mg oral finasteride is complete over kill. He recommended .25 to at the most .5 mg.
I have been reading that topical Finasteride should be applied separately to minoxidil. Minoxidil is a vasodilator which would increase the chances of topical finasteride going systemic.
Finasteride appears to have a low therapeutic index- basically the difference between a dose that is too small to work & a dose that is toxic or has side effects is very small. This makes it a rather poor consumer lifestyle medication.
I wonder if any other DHT blockers have higher therapeutic index?
What are the pros and cons on combining micro needling and topical finasteride?
Tons of info without any demo on how to make or where to get
Perhaps you could use your own brain and Google rather than expecting someone to spoon feed you
Hi Rob - Excellent video. You really got me thinking about all of this and I am now encouraged to try it. As I prepare my request to the doctor for an Rx, I have a couple of things I want to make sure I have correct. There are two things to consider:
1. the actual concentration of the topical.
2. The total daily exposure to the drug.
So you're saying a concentration of .005% (w/w) will provide enough potency to help with hair loss and a total daily exposure not to exceed .2 mg. Is this correct ?
I cannot find the study that shows the effectiveness and DHT effects for the .005% concentration. Can you please provide a link ?
If anyone else has thoughts on this, I would appreciate the feedback.
Best regards,
R
How is it going ? doesnit work ?
Really amazing…best video i have seen on topical finasteride
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
@@KropTop12 If so, then why this drug is FDA approved?
@@mraayush1881 look at the studies kiddo. Studies don't lie. It's not a matter of IF you will get the detrimental neurological side effects it's just a matter of WHEN! !
Rob, with facial hair👌
Thanks a million, Rob! As expected, topical finasteride is marketed with layman-inducing bloviation. So, the one bit of information that could definitely act as the icing on top is what brand(s) of topical finasteride do you find best hew to the substance of your research by yielding maximum benefits with the lowest risk of side effects? Anything particularly helpful for men with pregnant partners would be greatly appreciated!
Hey Rob. Where can one get a prescription for 0.005% Finasteride at 2ml? Seems like no companies offer this strength.
I think you can crash 2.75 mg (tablet of 1 mg) on 60 ml of rogaine and you have 0.045mg \ 1 ml. If you drop 1 ml twice a day you exposed your scalp to 0.0916 mg of fina , as the graph on the video. Correct me if im wrong
Thinking the same thing…I think if you combine 1.5mg of finasteride with a bottle of Kirkland minoxidil 60ml and you use 2ml a day that equates to .005%
@@ClownAztec whats the equation? I thought Its necessary 2.75 mg of fin on 60 ml for 0.005% solution
@@mattiapancin3926 that's the same math I got, if you're using 0.0912 mg per 2mL that's 0.0456 mg per 1ml, and then 0.0456 x 60 is 2.73mg per bottle of 60mL of minoxidil
@@Alfi0s1 Yes thanks, i think that this formulation can be safely used
Taking hims. What about just spraying it every other day? Great content btw
I’m gonna try this. I’ve been staying away due to the fear of PFS but I believe in you guys and I’m going to put in the work to stay safe. But what happens if you drop your dht too low? Is there a way to raise it back to normal levels? Do you just need the fin to fully leave your body
Any updates bro?
Updates?
Thanks so much for this video, it's really useful and insightful!
Hi, Rob, great video, very informative, thanks!
What do you thinkg about using retinoic acid along with minoxidil to combat fibrosis, is there any study in this regards?
If you use topical finasteride, you need to cover the whole area of dht sensitive hairs, from the hairline to the vertex, not just on the temples or where you are balding. Use it like minoxidil and just treat problem areas, in 5 years time, you'll discover you were losing hairs behind your hairline and those hairs had been going commando the whole time.
What are your thoughts on topical dutasteride? Rumor is that it's less likely to go systemic because of its higher molecular weight.
This is what Marek Health says as well.
I got some from Strut, here's hoping. I've only had the stuff two weeks or so 1x a day with the tretinoin + minox though.
Thing is that's the CHEAPEST I could ever hope to afford something compounded like that and topical.
Just wish they'd include the latanoprost with it (the prostaglandin system for my scalp COULD use some work)
@@nunyabeezwax6758Updates? Did it work? Did the topical dustride work.
Watch out for side effects when taking taking finasteride. There are some tragic tales.
like what?
*Hey* *Rob* , Based on the chart at 11:48, don't you think it would make more sense to get the second Serum DHT test at 4 weeks--when the decrease stabilizes?
Wow, thanks for sharing some great information here!
But wait there's more!!
Finasteride treatment impairs biosynthesis and function of neurosteroids, which are critical regulators of central (CNS) as well as peripheral nervous system functions and modulate a host of neurotransmitter receptors, such as gamma amino butyric acid receptors. Thus, finasteride-induced neuroendocrine disruption of biosynthesis of critical signaling molecules results in pathophysiological states, which contribute to inhibition of biochemical pathways responsible for a host of physiological functions, ranging from sexual activity, mood, and cognition. In addition, finasteride-induced epigenetic changes in gene expression, including upregulation of androgen receptors (AR), increased histone acetylation, and methylation results in undesirable biological outcomes such as impairment of dopaminergic signaling and modulation of other neurotransmitter receptors, may be the underlying mechanism causing persistent or permanent adverse effects, manifested in anxiety, depression, and suicidal ideation.
What if I dilute the hims .3 with distilled water to get it to 0.01? I just order it and don’t want it to go to waste. Does anyone know how much water to add and sprays that would be? They recommend 4 sprays now at .3 once a day.
I've read that diluting with water isn't the best because it doesn't dissolve and distribute evenly. May also affect absorption. I have heard of people putting 1 ml of Hims 0.3% into a 60ml bottle of generic minoxidil and then using 1ml of the final solution per day. I haven't tried it yet but am interested.
Why isn’t getting results with 0.5mg 3x a week more popular then if it blocks damn near the same % of DHT as 1mg? I hear 1mg 3x a week is pretty standard these days thanks to the recommendation by the “hair loss show” on RUclips
I'm using this formulation- 12mg of finasteride into a 60ml minoxidil bottle. This equates to 0.2 mg per ML or .020% formulation which you would use only once a day. I use minoxidil 2x a day, once with finasteride and once without. I got sides from daily .25 oral finasteride. Mainly brain fog and depression so I discontinued for 2 weeks and felt normal again. This is my anecdotal experience. Not a reccomendation just my opinion. Ill report back in 6 months with results.
its been 6 months ...updates?
They never report back
I upped it to 15mg and then 19mg per 60ml of minoxidil. Hair is stronger than ever. Didn’t really start to see results till month 5. Head massages and micro needling are extremely important for blood flow. Be consistent.
@@bryangarciafilms You are puting pills into minoxidil?
Great work - eating these videos up. As a physician, I would actually not test or favor testing for DHT in most patients who want to use topical finasteride UNLESS A) a patient just really wanted to know which I have no problem honoring a patient request like (insurance would NEVER pay for that lab test, so they would still have to pay out of pocket), B) if a patient was having side effects with oral and we really needed a laser guided precision strike.
This video is awesome and I love personalized and precision based medicine that is driven by good data.
Clinically though - finasteride is super safe and most patients do not have side effects and those who do typically know right away - you stop and those side effects go away; some patients have delayed onset of side effects due to the half life of finasteride and it building up over time and again when they stop using finasteride - side effects typically just go away. So unless there is a good clinical reason (i.e. patient concern or adverse outcomes on higher dosses) to run down that rabbit hole, I would advocate and trial by error approach.
Most patients are going to do great with standard finasteride (topical or oral) and it is a much less expensive and resource intensive approach - also the difficulty and stress of finding a physician who will work with you to do this might be the hardest part of all sadly. We are also venturing into experimental waters here with DHT testing and then using that to drive treatment decisions for custom made finasteride. I think it is perfectly fine as that falls squarely within the true art of medicine but you really have to take this kind of practice with a large grain of salt and this I would happily keep in my back pocket as a clinician for select cases.
Really great comment. I think your perspectives are spot on here.
@@PerfectHairHealthrob how are your members finding this concentration?
Feedback skews positive! However, the serum DHT test are necessary if you really care about near-complete effect localization. About half of members don’t see an appreciable change in serum DHT; the others do. Also, check out our video on Bryan Johnson for a deeper dive into whether serum DHT is the best proxy for risks of adverse events with topical finasteride.
Great read. For someone who already has weak erections at times, would you still recommend finasteride?
Since you said side effects are not permanent, I am eager to try finasteride beforehand to see how it affects my libido
can you do a video on topical dutasteride?
I love this channel!
Do you know of anywhere we can get a formulation close to the .005% concentration? I’ve never seen it being sold for even close to that dilute
It's pretty impossible, not to mention getting a doctor to prescribe it.
Would be around 3.5mg of fin in 60ml of minoxidil to get to around 0.005%
I've heard of people putting 1 ml of Hims 0.3% into a 60ml bottle of generic minoxidil and then using 1ml of the final solution per day. I haven't tried it yet but am interested. Please correct me if I am wrong.
@@rft2001 what fin solution does this result in?
@@idunnoo26 0.005% I believe