How CRISPR lets you edit DNA - Andrea M. Henle
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- Опубликовано: 28 июл 2024
- Explore the science of the groundbreaking technology for editing genes, called CRISPR- Cas9, and how the tool could be used to cure diseases.
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From the smallest single-celled organism to the largest creatures on Earth, every living thing is defined by its genes. With recent advancements, scientists can change an organism’s fundamental features in record time using gene editing tools such as CRISPR. But where did this medical marvel come from and how does it work? Andrea M. Henle examines the science behind this new technology.
Lesson by Andrea M. Henle, directed by Adam Wells.
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View full lesson: ed.ted.com/lessons/how-crispr...
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Wow just 70 year ago we discovered DNA and now we can change the genome of an organism!
25 / 7 but we still can’t cure cancer
It was actualy Made in 2015 so yea
It's 2019 y'all! You'll see people flying with wings soon!
Cin scientifically speaking, human with wings is very impractical. The wings have to be so huge to lift our body and it will be exhausting to fly. And plus the fur can bring so many diseases and will be so hard to maintain. Iron suits for me please.
@@akes9793 as an electrical engineering student, I'll work hard for your request sir!
Cas9: Tries to defend its bacteria
Humans: Reverse engineer Cas9 to defeat viruses and bacteria
Cas9: Well, I guess I am working with them now.
time to make inmune papayas and spider goats
@@gasparg643 already existing flying spiders in Brazil: *laughs*
If you can't beat um’, join um’.
thats fair lol
@Redawesomeoby Oy vey. Sadly I don't trust all humans. Some genius will either goof up terribly if they're not as smart as they think, or do something awful intentionally if they are as smart as they think.
I love that as a now former Sickle Cell patient, I have benefitted from this research. Just 5 years later
Yay! Makes me so happy.
"Every living thing is defined by its jeans."-TED Ed 2019
genes*
@@Melecie r/woOosh
Manas Gujral what if i told you
you just got woooshed, not me, that post was supposed to be a wooosh
@@Melecie You just got double woooshed xd. And I got that you don't know the correct and crispy meaning of woooosh. ;)
@@Melecie you're hit on reddit 🔥😂
We're literally just hacking into ourselves at this point. I'm in.
Very soon we will hack the very nature of reality
@@FedJimSmith Yes, I would like to discover the cheat codes for everything
Mambodog 532 what’s the money cheat code?
@@thechimp8045 That's why I would like to discover them.
U guys should watch Ted ed's BIOHACKING vedio
I had to watch this twice because I was completely transfixed on how absolutely amazing the animation is and didn't hear a single word of the actual lesson.
I demand a lesson on animation now, Ted.
Crisper is literally revolutionary 🤨
ikrrr
The animation is amazing....
This video makes it so simple. But really it's very complex
yeas it is
I have Sickle-Cell Anemia and just heard about the UK approving of a new genetic therapy that engineers the bone-marrow to stop it from producing Sickled Cells. I didn’t understand how that was possible but what do you know, my favorite educational channel already made a video about it 4 years ago! Love this video and thank you for enlightening me❤
You can get through this ❤❤
I too was wondering about genetic modifications a few days ago and here I'm thanks to yt feed
Hello, I am currently participating in a conference called Speak Up, its located in Sarajevo and has been organised by my school. Im in the committee for designer babies, especially crispr. Could you possibly share your experience while getting medical treatment? it would really help my committee defend our topic in the debate that will be held at the end of the conference.
It just works
Justin Y.
Ah, always Justin time.
That's how CRISPR works!
lvl 1 RNA
lvl 100 DNA
Hello Justin
Did you know Araki drew the cover art for Cell magazine once? Not kidding, look it up
Did you even sleep?
00:07 Why did the single cell look like a Dictator ?
LuMbAgO
Ogulcan U lmaoo
pareidolia is at play in your head bruh
Cells are Aryans
Someone said it
I admire Ted ed lessons a lot
Thx
@@tedchirvasiu are you ted edx?
So, In some decades, we can probably customize ourselves like the sims?
Hopefully. Gotta rid of my f-ing gigantic nose. Or elongate my tiny banana.
@@jeromealday614 *Nice, just... nice.*
@marios gianopoulos yesssss, that's what I want the world to be like.
So I wonder if it can change any ones race?
Y is the comments section in RUclips always memes and jokes?😂
"what makes you, you?"
"my genes"
"so if i change your genes, are you still you?"
Damn, deep. But I feel that apart from our genes, our experiences and memories make us too. So changing our genes but retaining past memories would still make us, us, right?
Or is it?
@@averageillegalmemesdealer
I thought the exact same thing. So, yes, that's right.
There's a video on epigenetics if you want to know more on this question and then better answer it for yourself.
Hey vsauce
I'm excited for the future of genetic medicine.
amazingly explained and animated!
Hello, thank you for this video. I have been looking at other videos to grasp the concept of CRISPR but felt difficult. I believe your narrative approach paired with the visual representation helped.
Thank you so much. I am not good at molecular biology and you helped me put so many of these pieces together to help me understand the process
Thank you Ted-Ed for such a vivid and beautiful animation.I understood everything!
Mark my words: The first superhero/supervillian will be made via CRISPR.
It's actually kinda possible in the not so far future... it's fun to teorize eheh
I am expecting super soldiers like Captain America...
Whatever we will have mutants.
I want to be the first test subject for superpowers. I don't care if I'm a hero or a villain.
Gates already exists
then stan lee would be ahead of his time
Some of the most beautifull animation on this channel yet! Great job
2:20
CAS9: OMAE WA MOU SHINDIERU
bacteria: NANI!!!!?!
You know that omae wa mou shindieru means I’m already dead
*Rice Krispies wants to know your location*
LMAOOOOO
LOLOLOLOL
The animation is so soothing...
Finally, a video with easiest yet most comprehensive approach towards explanation the CRISPR- Cas9 technology. Thank you !
The video is brilliant! Beautifully shot and edited, captivating the viewers attention throughout the video. Kudos to the TED-ED team😁
Intellia therapeutics could also be successful
Wonderful illustrations and to the point explanation. Thank you.
I’m glad I watched this video, I’m doing a last minute paper on this subject and I’d have a very hard time understanding the much more complex science articles if I didn’t have this good overview
one of my favourite topics in uni, made me so inspired :)
Yes, me too. I m thinking of pursuing research.
Yet another awesome and educational video! Keep up the great work!
i was waiting for a ted-ed video on this matter, well explained!!!
The best content on RUclips! Thanks TedED!
This helped me so much with my year 12 biology assignment on genetic technologies.
It is future. I too have it in syllabi.
Can it fix my parent’s marriage
Pardon
I'm sorry son
You mean you? It probably could
I would type F now, but this is actually making me sad
Oof
Thank you so much Ted ed for making a video on this topic 👍😀
Absolutely well done and definitely keep it up!!! 👍👍👍👍👍
Who controls this, has more power than anybody in history ever had..
This is really interesting and may help many people with genetic disorders. Thanks for sharing, TED-Ed.
Excellent. Thank you! Education with curiosity and pleasure.
The animation is brilliant as always.
Nice work Ted ed.
First video where I finally understood this. Thank you. But it does go against what the mainstream media has been touting which is that this is cheap, fast and super accurate. I believe you rather than them
Perfect background music and soothing animation.. thank you for that
background music name?
Thank you for making it so simple.
Honestly could've mentioned the first CRISPR-edited human babies born in PRC, Lulu and Nana.
So many great possibilities with this stuff! I am super excited for the next few decades of genetic modification research!
Superb Imagination used to make video ...😍👍thank you so much TED X
breathtaking. thanks Ted!
Crispr is to human progress what the Manhattan Project was to clean energy.
Genetically changing a person so they're healthier sounds like an amazing goal but I fear that is not what this technology will ultimately be used for.
This all will lead to a Brave New World future. Transhumanism, genetic engineering, etc etc. Things can and will go wrong eventually.
You're right. If I had the time and money I'd let certain qualified individuals take as much time as they need turning me into a human capacitor.
More videos like this please... great explanation... thanks ted :)
very nice explanation! thank you so much
This is a good introduction, but you can really make 2-3 more videos on the topic and discuss about the biochemical aspects of CRISPR, and how homology directed repair works, and another one using a specific example from an experiment.
Your animations are amazing! I hope you get a sponsor from someone big!
They don't do the animation. Someone does it for them and it varies in every video. They need funds to pay the animators and make the videos.
I know, but these videos belong to them.
TED-Ed is someone big by itself, there not some channel run by one guy, it's an official company channel
Ted ed IS someone big
And finally, I have understood what CRISPR is really about !!!
i love this style of animation so much
fantastic communication of this concept!!!
One step closer to being immortal.
fr
@Rustydingomingo unless we discover the multiverse so we can jump from universe to universe forever…although, forever sounds like such long time is kind of scary.
Terrific graphics! Great job communicating the essence of CRISPR to a general audience. Must have been a lot of fun work to produce. Just one point that may be misleading -- unless I am misunderstanding. Shouldn't the RNA and guide RNA be depicted as single-stranded molecules?
beautiful explaination and illustration
the best explaned video about CRISPR!
Although the video is interesting I feel that the details on how the 'repair' is controlled would have improved it. I feel it's still unclear, but simply stated that it's done.
Oh and by the way, a Chinese scientist has already genetically modified a human fetus
That's because they're less concerned about ethics
Tsonima
That’s how the western world is getting behind china
@@fitrianhidayat he's in jail for 3 years and etchics is a social construct,it's what you make it to be
lol source??
It wonderful to see that Ted Ed makes these videos on current scientific affairs
Thx ted Ed I was hopping for this vid
Concern: Can a DNA be patented? If so then this would indicate that someone can legally own this DNA? What are the implications of this?
To be honest we don't really own our DNA, it's 50/50 from our parents, and it came from their parent's parents and so on.
I don't know a lot of legalities and protocols around gene editing, so this is just my opinion, but I would assume that the process to create it might get patented, and the specific drug they administer to create it might be, but I wouldn't thin the DNA segment in itself would be patented. However, if a company were to create a specific gene that was completely new and non-existent in anyone, patent it, and someone suddenly by some crazy chance has their genes mutate to produce that, I doubt there would be legal complications around their ownership since they aren't trying to commercialize it.
I think it should be made that anything that can help people must be illegal to patent.
I wish to be a doctor and help the word to find new cures with It.
Finding new cures? Maybe you should get into research instead
Yeah you should study biomedical sciences! I studie them in the netherlands and it is the most amazing study ever!
A lot of people become doctors to save lives.. I feel people don't realize how many lives scientists actually save
Get into research instead buddy.
I completed my medical degree then took molecular biophysics to do research because doctors just dictate what already has been invented or discovered.
I am not saying being a doctor is not exciting and fascinating but being a researcher is way more interesting and gives you that freedom to cure all diseases, and reverse aging and what all.
Papa Franku the medical industry is corrupt. They already have cures but pharmacist earn lots of money prescribing drugs and kemo is expensive. Sadly some people care more about money than about saving lives.
awesome video! thank you so much
Incredible animation and info😁❤
The question is...
*Can it **_fix_** my **_broken heart?_*
It depends on wether your heart is literally hacked into pieces or is just hurting from a breakup or something lol
Yes just release some dopamine.
I just hope this doesn’t get too out of hand. Like everyone is tall, blonde hair, blue eyed. Differences make humans humans.
“When everyone is super, no one is” -syndrome
But I do like that this can help in the medical field.
And yes, I did credit the villain from incredibles. what about it?
I don't care if someone's super, or special. Those are human made-up terms. But you are right that if everyone was the same it'd be bad. You're just right for the wrong reason. :)
Scientifically, this is bad because diversity is the key to survival. There is no perfect genome because genomes are context-sensitive. This is why eugenics leads to extinction.
However, what if the technology was used to add more diversity, instead of removing existing diversity?
As the number of genomes in a population approaches infinite, the number of possible extinction events that population can survive approaches infinite.
It might seem scary, but that could lead to an extinction-proof human species-complex, or as close to extinction-proof as is logistically possible.
Added bonus, we could actually colonize other worlds instead of just talking about it. Just send variants already suited to that world. Cost would be about 1/1,000,000,000,000'th the cost of terraforming.
zpardus whatever we do should be done with caution and moderation, manipulating the natural order of things has caused climate change and the extinction of many animals on our behalf. I just hope we don’t become reckless. With CRISPR and iPS we could change everything for the better or lose ourselves in the process.
That depends who's asking?
(Your name)
We could cure cancer
@Augusto Jose
Go back to mexico
We already know what CRISPR is (From this video and many other articles like it). Could you guys make a video of some ongoing studies or treatments which uses the technology?
That was a good one ! Loved the TYPO thing ! :P
The reason why i love biology is because i love my life and i want to understand it well....
I'm very early here!!
hats off the the animator , veryyyy smooth and clean looking animation
Her voice is soooo relaxing♥️♥️
I just want to save my genetic code from my 20s, and use it to replace the new bad copies from time to time. Ya know... so I can live forever. How much is that going to cost.
A lot and i mean A LOT but in the future it should go down
So what you’re saying is in the future we can have real life Catgirls? I’m in.
But there is one dark side to the ability to make catgirls...
The ability to make furries
Mambodog 532 It’s worth the risk
Before we do that, we should first strike every furry down to the grave.
Can we make Jesus?
@@blookirby2076 i've got my shotgun
Thank you so much! This is my dream job!
Great demonstration ❤️
Cris. P bacon
Chris. P. Bacon.
I have pretty much enjoyed all of the TED videos but I find this especially straight forward. I only wish that they spoke more about the ethical dilemma instead of just sort of casually mentioning it near the end. Of course it may be discussed further in a talk that I haven't yet experienced.
Finally a vid on Crispr
very good video, with interesting infromation.
This sounds like some serious fuel for conspiracy theorists
Anything is fuel if you look for conspiracy.
Jesus Christ, that's the most accurate thing I've heard all week
This is not a conspiracy. It’s a very real possibility
@Jort Kuiper They are doing it through THE vaccine.
@@celesteforslund4186 yes exactly what they are doing! Don’t take it!
So many great possibilities with this. So many horrible ones as well. Amazing and terrifying.
Stay +
You make amazing animations every video
What an amazing video!!
*At an interview
Interviewer: "So what programming languages you know?"
Me: "Assembly, C++, CRISPR, Python..."
Interviewer: "May you repeat yourself?"
Me: "I said Python"
now having a literal bugs on your code is possible
Can a muggle become a wizard by using CRISPR
Yes
Fantastic animations and music as always :)
Background music name?
tysm!! im doing A level biology and my exam's in a few days, this really helps me visualise things
Well, it says in 2:40 that it is precise, it is not. the number of unexpected alterations to the genome being modified it's actually pretty high, but for some reason, it is almost never brought up.
Actually you have it the wrong way around. The older methods are what caused unexpected alterations. The entire reason CRISPER is so special is that it is incredibly precise.
@@SG-bp4lg yeah, but in order to be precise you have to make longer chains so it doesnt get mixed with other similar sections of the dna
PS: i'm on the phone and my corrector its set to spanish cause' it's my first languaje, i hope it gets throuh
@@SG-bp4lg also, i'm aware that the defect from the older metods have been reduced but not totally corrected, update me if i'm wrong
So does this mean I can finally be half fish now?
Just did a presentation on CRISPR for Hunter College, well done video!
THE ANIMATION IS AMAZING
So that means I can turn my eyes blue?!!!
Your offsprings,
100% your offsprings probably yours
Anti-GMO apologetics are hindering technological progress.
They will never stop it from being used.
Nope, I'm witnessing 2-legged GMO walking all around me due to the vaccine
The animation is stunning
Awesome, This is great