Histone acetylation and methylation
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- Опубликовано: 31 май 2015
- This epigenetics lecture explains about the Histone acetylation and methylation. Histone acetylation and deacetylation are the approaches in which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene law.
Histone acetylation and deacetylation are most important components of gene regulation. These reactions are normally catalysed through enzymes with "histone acetyltransferase" (HAT) or "histone deacetylase" (HDAC) endeavor. Acetylation is the approach the place an acetyl sensible crew is transferred from one molecule (on this case, Acetyl-Coenzyme A) to an extra. Deacetylation is readily the reverse response the place an acetyl staff is removed from a molecule.
Acetylated histones, octameric proteins that organize chromatin into nucleosomes and finally better order constructions, symbolize a sort of epigenetic marker inside chromatin. Acetylation removes the positive charge on the histones, thereby reducing the interaction of the N termini of histones with the negatively charged phosphate companies of DNA. As a consequence, the condensed chromatin is modified into a more comfortable constitution that's related to higher levels of gene transcription. This leisure can also be reversed by way of HDAC pastime. Comfortable, transcriptionally active DNA is known as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation will also be brought on via techniques together with deacetylation and methylation; the action of methylation is oblique and has no outcomes upon charge.
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Thanks a lot, Somu. You explained the acetylation of histone very clearly .
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Histone H3 Lys 4 is the active histone mark... and histone N terminal domain, instead of C- is the modification hotspot.
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Regulation of the chromatin structure .
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Thank you so much sir for the awesome explanation.....
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In the histones video you said n-terminal tails are more suited for chemical modifications. Here,you talked about c-terminal. Can you clarify this. Brilliant content over all and thanks a lot.
I also wondered about this. I can confirm from reading the literature that acetylation modifications primarily occur on the n-terminals. Reference - www.ncbi.nlm.nih.gov/pmc/articles/PMC3193420/
Itz n terminal babe ......dnt confuse
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It's N terminal . He said it by mistake may be...don't confuse
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histone modifications actually occurs on the N-terminal tail of histones
Yes they occur at the N terminal
if it's on n tail... y u said c termn
Please add note in the video or record it again, this is going to mislead everybody watching this.
This somu always makes such mistakes....please learn properly before you teach!
@@Abeliever000 mistakes to sb se hoti hain and he is also a human being so instead of degrading appreciate his efforts he made for the students🙂sorry if you mind..
Amazing brother your lecture are awesome
Tha
My interest is physics but I find your uploads very interesting . Thanks
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Great video! Although, I think you meant methylation of Lys 4 for transcriptional activation of gene promoters. Rather than Lys 3? Would you please clarify this?
This is so helpful! Thank you :)!
+Ann Behanan glad to hear that
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Well explained !
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sir how r u,, ur lectures help me a lot,,,and most of the time I used to see ur lecture,,do u have any lecture on epigenetices and diseases, and epigentices and environmental effect
sir........... realy ur notes are very helpful................thanku very much..............
Thank you so much. All the best. Keep watching.
Sir, great video. The only improvement that I could suggest is that you slow down when you speak. You are a little hard to understand at some points. But other then that great video!
Or you can try to adapt to his teaching style rather than him to you.
You can modify the speed of the video in the settings.
Make it on 0.75x
extraordinary explanation thank u so much somu sir
Glad dyou liked it
thank u so much... i completed my max syllabus by u.. thank u.. nucleosome soliniod model is my need.. plz do a clasa..
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Very Nice good job thank you very much
Very good lecture
thank u sir for making this video
Sir really really help full video thanks a lot sir
Sir from this video I get the common prosedure of modification but what actually happened there ... I mean process off ..
Sir please make a another video on It please sir
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Absolutely great...!!
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This video is very helpful! Just one thing: lysine is K not L (as he wrote in the top right of the board)
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thank you so much , high content
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Best explanation ❤
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Hi Shomu, loved the video, just one question. If a histone has been methylated and the DNA is tightly wound around the histone, is it possible acetylate the DNA to unwind it?
Histone modification
Great explanation sir
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Welcome sir
what is histone code hypothesis?
Wonderful !
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oh wonderful. thanku :)
Very nice video.
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Sir, Good video but you mentioned methylation or any modifications occured in N-terminals of Histones in previous video but you completely explained those on C-Terminal. Please dont confuse the viewers.
N terminal is correct
very very concept full vedio.
nice tutorial
Is it true if the dna is unpacked the genes are activated and when packed the genes are inhibited ? Videos online say the opposite but my lecture tells me this
Thank you very much. Is it possible that permanent high or
too low “cortisol level” leads to gene methylation? Your answer is appreciated.
Sincere effort. U r a good teacher
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one word , genius.
Sorry sir and thanks ...
I found the videos of the histone modification in your channel in details thank u ...sir ...
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thankyou so much sir 😊🙏
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Acetylation and methylation of h3 occurs on which terminals c or n?
Nice sir, but what about H1 protein
Sir Is Modification occur in both the terminal c and n because in histone video you mentioned the n terminal for modi..?
N terminal
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Great video, but I think it's 4th position of lysine for transcription activation
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Can I write histone acetylation and methylation brief in chromatin remodeling..
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AFTER 4 DAYS I SHALL PRESENT ROLE OF HISTONE IN GENE REGULATION PLZ SIR I WANT TO CLEAR MY CONCEPTS FROM U
hi Mr. Suman
the acetyl group will bind to the C-Terminal or to the N - tail ?
because you said in the previous video that histones have N - tails , but here you said C - Terminal.
Regard
There is both N and C terminal tail but histone modifications occur mostly (not 100%) on N-terminal tail.
Dear Shomu, I believe that you meant methylation of Lysine 4 on H3 to induce an activation, not Lysine 3...
He explained methylation of lysine3 in the H3 subunit helps to unwrapp DNA for replication or transcription
That is not true it is Methylation on lysine reside 4 i.e H3 K4 which causes activation ....not on 3 as he said
Sir which is the correct ans....residue 3/4?
Sir one confusion how HAT and hdac activated
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Thanks
nice video but i forget many things related to your viedos something are clearly understood but some are not...likr role of enzymes in DNA packaging
I love this teacher aha.
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Sir I have doubt ... Is methylation occur in both lysins and arginine or only in lysine . I hope you will reply fastly because Monday I have exam
sir, i have a doubt the modification of histone occurs in c terminal or in n terminal?
+surya prasad n terminal
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sir i have little bit confused ..in the previous video you said N-terminal is very important, now you saying c-terminal plz sir correct it, which one is correct
Yes he corrected in one of his comment that modification is at n terminal
thank you
0.75x speed is perfect to those who find him too fast.