What do you mean at the acetylation part? It stated that when acetylation takes place, it reduces the positive charge of histone tail hence, repels the DNA negative charge. How can that be? Isn't it unlikely to repel if it less positive? And ain't repulsion of the negative charge DNA strand only happen when the positive charge is stronger? Any clarification on this? Thanks in advance.
Excellent presentation. Thanks. But I ask. Are we meant to believe this breathtakingly sophisticated system evolved over millions of years!!?? How does the epigenome mutate? And a beneficial mutation in the genome must be simultaneously accompanied by its epigenetic equivalent for the magic to occur. Sounds very deus ex machina to me.
I too am troubled by this. Despite the standard and valid refrain that we simply can't conceive of large numbers, such as in trying to imagine a progression of changes over hundreds of millions of years, it all seems so wildly improbable. But then here we are. So, WTF is going on? Sorry but, nobody knows or ever will, deal with that.
Those stick diagrams contains billions of atoms and they all interact perfectly with one another. Seems like intelligent design to me; designed by God.
This is the clearest explanation of epigenetics I've seen yet! Thanks for making it
Thank you for this wonderful animation. It makes the concept of gene expression or suppression much beter to understand.
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Excellent, didactic presentation! Thank you
Excellent stuff
Very helpful. Well done.
Nice
Thank You
Very well described. Thanks alot.
Hey if you want to have bleach and put it in your dna say which dna
perfect!
Thank you!! This tutorial has benefited me greatly.
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Delicious...
Does anybody know where the second part to this video is?
Really well explained. I just wanted to ask, if acetylation positively charges and DNA is negatively charged, shouldn't the structure become tighter?
it was really helpfull😍👌
God is so big without him no one would be here or live including everything He made.
Please! the histone methylation and DNA methylation occur together or separately in epigenetics?
What do you mean at the acetylation part? It stated that when acetylation takes place, it reduces the positive charge of histone tail hence, repels the DNA negative charge. How can that be? Isn't it unlikely to repel if it less positive? And ain't repulsion of the negative charge DNA strand only happen when the positive charge is stronger? Any clarification on this? Thanks in advance.
Less positive also means that it becomes more negative, leading it to repel the negative charge of DNA (as negative + negative = repellence).
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I never understood what gene is expressed instead of a gene that's turned off. It can't be nothing...
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Evolution did it 😀
Excellent presentation. Thanks. But I ask. Are we meant to believe this breathtakingly sophisticated system evolved over millions of years!!?? How does the epigenome mutate? And a beneficial mutation in the genome must be simultaneously accompanied by its epigenetic equivalent for the magic to occur. Sounds very deus ex machina to me.
I too am troubled by this. Despite the standard and valid refrain that we simply can't conceive of large numbers, such as in trying to imagine a progression of changes over hundreds of millions of years, it all seems so wildly improbable. But then here we are. So, WTF is going on? Sorry but, nobody knows or ever will, deal with that.
the nucleosomes depicted here have a right handed DNA turn, and it should be left-handed turn.
Those stick diagrams contains billions of atoms and they all interact perfectly with one another. Seems like intelligent design to me; designed by God.
Ohio man
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