Generation and action of siRNAs and miRNAs

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  • Опубликовано: 14 окт 2024
  • In this animation, we discuss how siRNAs and miRNAs are generated and how they act to mediate gene silencing.
    ukcatalogue.oup...

Комментарии • 51

  • @PeLuRu4586
    @PeLuRu4586 9 лет назад +157

    Agreed with what most people here suggested, the narrator should speak a bit clearer and louder. But the content itself is very excellent. Thank you very much!

    • @hunglikehuang
      @hunglikehuang 6 лет назад +3

      Turn on the captioning. It's essential when there are dense jargon being thrown around.

  • @Randymanrockssocks
    @Randymanrockssocks 6 лет назад +60

    Thanks prof. Snape! I totally get it now!

  • @prakritirds
    @prakritirds 6 лет назад +8

    Nice animation and excellent explanation. For those who is getting problem with sound I suggest to use headphones, it is quite a clear sound.

  • @rickyroko1
    @rickyroko1 9 лет назад +10

    The accent might make it hard to grasp the informations, but to the video has an excellent quality. Thank you very much.

  • @abm4952
    @abm4952 7 лет назад +4

    great review and animation. Need to have a basic knowledge of miRNAs and siRNAs to be able to fully appreciate this.

  • @musicfanman94
    @musicfanman94 9 лет назад +22

    Awesome information! Broken down in detail and animation is great! I just could not understand the narrator from time to time!

  • @BrokenTwistedPrince
    @BrokenTwistedPrince 6 лет назад +15

    Noteworthy: 100% homologous complementarity between the passenger miRISC* and target mRNA will result in endonuclease activity and mRNA cleavage, whereas asymmetrical RISC assembly with partial match will result in translational repression of mature mRNA.

  • @ylhuang6144
    @ylhuang6144 7 лет назад +9

    i like this video! it solved my problem perfectly! open the subtitles would be helpful.

  • @ds862
    @ds862 9 лет назад +15

    Beautiful animation, but in a completely silent room with my computer volume up to max, I can still only hear and make out 2/3 words that the narrator is saying. I unfortunately won't be able to show it to my AP Biology class with any great success. The narrator needs to speak louder into the microphone (and perhaps a bit slower, but the clarity will probably be helped if the volume of the video sound is increased.

    • @ds862
      @ds862 8 лет назад +3

      +violinsheets Last year I had students curious about siRNA and miRNA as they were mentioned in their AP Biology textbook. This would have been appropriate to help explain that section of their text for interested students. You're correct, though, in that it's not a standard focus point of the AP Biology curriculum. I don't think I have to be "high" to want to offer a little more detail for students who REQUEST IT and who will be entering into selective premed programs next year.

    • @violinsheetmusicblog
      @violinsheetmusicblog 8 лет назад +1

      Deanna Schnepp I was going to say... I thought you were making them memorize the proteins and complexes. Some of these things were only recently discovered like 10 years ago

    • @BigManJay69
      @BigManJay69 8 лет назад

      +violinsheets memorising all these would be a bit harsh yeh

    • @violinsheetmusicblog
      @violinsheetmusicblog 8 лет назад

      BigManJay69 welp I had to do it for my molecular biology course I was taking. so glad that torture is over

    • @BigManJay69
      @BigManJay69 8 лет назад

      spent so much time learning and memorising this whole procedure and NONE OF IT CAME UP IN MY EXAM TODAY! that is annoying, i had it down so fuckin well

  • @chunkilabhutia6721
    @chunkilabhutia6721 9 лет назад +30

    I can't understand...if the voice was clear it could be more interesting..!

  • @TanoMac73
    @TanoMac73 8 лет назад +8

    Narrators voice is not easy tun understand at times. Audio could be reworked for actual academic use.

  • @Juicyvale14
    @Juicyvale14 7 лет назад +3

    very informative but why does his voice sound like Kevin Malone from The Office

  • @BigManJay69
    @BigManJay69 8 лет назад +14

    This is actually very very good. If you don't understand it i recommend watching the simpler more basic videos on mi and siRNA's first. Then this will make more sense :)

  • @madelynnowak-roddy5121
    @madelynnowak-roddy5121 8 лет назад +2

    this actually helped loads, thanks so much :)

  • @frankgomez7579
    @frankgomez7579 6 лет назад +1

    This is awesomme

  • @ericabaker5295
    @ericabaker5295 7 лет назад +1

    beautiful video!

  • @CompBioQuest
    @CompBioQuest 6 лет назад +1

    Love the animational, beautiful!

  • @moocowbaasheep
    @moocowbaasheep 8 лет назад +1

    People complaining about the voice but it seems perfectly clear to me and my Spanish friend.

  • @CellRus
    @CellRus 10 лет назад +18

    the video is very nice but the voice of the demonstrator is not very clear, i guess its the accent, so it makes non-native speaker like me hard to listen to! If you can choose a person with a better voice, it would be a very good and clear video.

  • @carolinejaqueline1727
    @carolinejaqueline1727 6 лет назад +4

    how the fuck am I supposed to remember all this

  • @georgem.7539
    @georgem.7539 9 лет назад +8

    The narrator is not speaking clearly enough and he is like he is whispering.

  • @JOCELIOSANTOS_JTS
    @JOCELIOSANTOS_JTS 5 лет назад

    Please, enable the video to allow translation

  • @tiaanwest4905
    @tiaanwest4905 6 лет назад

    Thank you very much!!!

  • @nilanjandas3575
    @nilanjandas3575 5 лет назад +1

    Thank you infinitely for it.

  • @patrickdv1727
    @patrickdv1727 8 лет назад

    ps. and there are thousands of possibilities of different multible underfunctions include a proteine changer

  • @naadirahismail5797
    @naadirahismail5797 9 лет назад +10

    i can hear him clearly and im sitting in a library

  • @drcal7282
    @drcal7282 8 лет назад +1

    GREAT animation! #GRINDTIME

    • @mmaking8664
      @mmaking8664 7 лет назад

      Put that work in man and have self belief. U can do anything u want in life with #hardwork and #selfbelief and #discipline

  • @rubine24
    @rubine24 9 лет назад +2

    good video but too quiet......

  • @patrickdv1727
    @patrickdv1727 8 лет назад

    Inbuilding of a rso gain complex of a cannabinoid structure will change everything....think about it ;-)

  • @keanureaves2228
    @keanureaves2228 8 лет назад +1

    almost forgot to watch this today

  • @boaz411133
    @boaz411133 8 лет назад

    thank you!

  • @BalaBiologyWorld
    @BalaBiologyWorld 8 лет назад

    thanks sir......

  • @nanangs1077
    @nanangs1077 6 лет назад

    The narrator accent should be appropriate with this very nice video. Every body does not alway catch the voices. So please the voices of narrator should be clearer so easy to hear, if it intends to share this for learning or education. Anyway,Thanks.

  • @MoeMerkin
    @MoeMerkin 7 лет назад +2

    DAT VOICE THOUGH

  • @beanage85
    @beanage85 7 лет назад +1

    The narrator sounds like Greg Davies...

  • @pipeyto7
    @pipeyto7 7 лет назад +5

    peanut butter mouth

  • @alissonrocha4836
    @alissonrocha4836 7 лет назад

    almost I dont understand this is video.

  • @mirnaresendiz959
    @mirnaresendiz959 9 лет назад

    hi

  • @sobster123
    @sobster123 8 лет назад +2

    three words, too fekin complex!

  • @robertaannibale1522
    @robertaannibale1522 7 лет назад

    ;)