RNAi: Slicing, dicing and serving your cells - Alex Dainis
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- Опубликовано: 5 окт 2024
- View full lesson: ed.ted.com/less...
RNA, the genetic messenger, makes sure the DNA recipe gives your cells exactly what they ordered. But sometimes that means inhibiting some other RNA that got the recipe wrong. This process is called RNA interference (RNAi), and it acts as a self-correcting system within the complicated genetic kitchen of your body. Alex Dainis explains the importance -- and exciting potential -- of RNAi.
Lesson by Alex Dainis, animation by Cinematic Sweden.
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I couldn't understand RNAi well, but this lecture is very clever and help my study so much! Thanks!!!
Before then, I was a little confused by technical terms of this phenomenon.
The cooking metaphor sorta makes it a bit more confusing for me
The quality of the animation is sooo good! I'm used to seeing amateurish work in these edutainment animations. This animator actually understands stretch, correct physics, motion blur etc.
secondjoint Great animations, but I do think that the metaphor shown by those animations only manages to confuse the matter instead of clarifying.
Quality of animation is good but the content was not upto mark, ended confusing the topic more than clarifying it.
I wish to contribute myself in creating this kind of educative videos when I grow up. This is so much meaningful.
so, did you?
Great video , best metaphor ever and I like the cute animation
Let me summarize everything in one shot ( actually this is the project that I've been assigned)
So rna interference is basically used to prevent gene expression ( prevention of translation and hence production of proteins )
So to do it artificially we use vectors and introduce the desired dna . Now this dna produces both sense and anti sense strand these being complementary to each other bind together . Dicer proteins sense these and chop them and these thereby approach the m rna and slicer protein comes and chops down the m rna too
So , viola ! We've successfully prevented the gene expression
So in eukaryotes these double stranded rnas are created in response to an attack by viruses???
Wait aren't you supposed to use desired Double Stranded RNA and not DNA for the vector?
@@Sapnakolira no. Sometimes, viruses have genetic material in the form of double stranded RNA, instead of DNA that we have. So, they insert it in cells and manipulate their cell functions, in order to replicate their dsRNA and move to close cells and infect them too.
Moral of the story,
Chop up unsatisfied customers.
This is the best explanation out there. Thanks a bunch! Really appreciate it.
What a classic video. I watched this video when I was studying for my MCAT and now I am in medical school, studying for USMLE Step 1 and came across an RNA question and it reminded me of this. Thank you so much for these videos!
woww........difficult topic explained in very easy way.......thanks a lotttt
That RNA decking the other RNA caught me off guard and had me bustin up!
this video is 4 weeks to late. tried to understand it for an exam, but the information given was too confusing. this video sums it up perfectly :)
Amazing communication of science in this video!
The voice has perfect timing to understanding.
This video is awesome! Its so informative! Good job alex!
too good difficult concept discussed very easily
kirtika Saxena Good evening, Ma'am...
Farhan Ahmed lol
Creepy
Congratulations Alex! What an accomplishment...
Where were you when I was looking all over RUclips to understand rnai for my biology test yesterday 😭😭😭😭😭😭😭😭😭😭😭
This video is absolutely amazing
Ribosome: what can I get for you
Red blood cell: S-Sugar
Ribosome: so glucose?
Red blood cell: S-S-Sugar
Ribosome: I don’t have the full ingredients for that
Red blood cell: rolls on the floor screaming
The animation was awesome
wow Alex! That is way cool. You are certainly making an impact! Thank you!
Wow I didn't know Alex Dainis narrated a Ted-Ed video !
Something along those lines, but NO, no one volunteers. Neuroscientists study patients who already had an accident or a stroke, which lead to damage in certain localities in the brain. During and after preliminary treatment by ER physicians and/or neurosurgeons, scans are done, including MRI, fMRI, CT, PET, etc. which help localize the injured parts. After doing whatever they can, the patients are assessed behaviorally and compared to before the accident, etc., as well as normal brain scans.
what was that at 2:18, wooallaaaa....!! 🤣🤣🤣🤣🤣🤣🤣.
Nice animation and correctly explained with an example of a kitchen.
Pretty helpful for explaining to the students. 👍 👍 👍
Wow! So complex yet so organized and it all happened by chance?...At least that's what some people believe. This is what science must be all about. Things we can observe, study and test.
Nice animation! I liked it a lot
AHHH this is so addictive.
Trying to make it relatable, you guys screwed with the explanation 100 times more!
I read that RNAi is also being used to deal with the varroa destructor mites that are devastating beehives.
there are many kinds of rna, some sends message from dna to the ribosome to create proteins, some are attached to the ribosome used to create protein.
The body is [mostly, I think] reactive not active. Enough material is floating around inside to keep the process going even though the prices don't know where they're going.
Best TED video, ever!
I'm shocked when I saw that this video is 10 years old! I'm currently working as a research physician with a pharma company developing RNAi drug to treat obesity.
Succinctly narrated; wonderfully illustrated :)
Why good videos like this has so little watches?
Alex for the win!
Thanks I'm good at learning this way
this video is so amazing.
Oh man that was impressive I understand everything. ❤thank you
Congrats Alex!
Perfect explanation
I'm sure I'd understand it better without the metaphor lol
dingovory I'm almost sure that you wouldn't. I've tried to understand this for half a hour by biology videos, this video gets the information a lot easier... ;-)
Aline Oliveira yeah no
I'm a bit depressed that the video isn't in german. It would be pretty perfect for my presentation tomorrow, but in fact its in english - most of my course wouldn't understand it directly :(
+Ladiduify There are German subtitles. :)
Best video on this topic...Thanks a lot😊
The animation is hilariously violent!
OMG what a great explanation!
Loved it .....well done Alex
superb..........saw genetic engineering class via kitchen mechanism
Congratulations alex, this is cool!
wonderfully done
Aw well done Alex!
what a cute animation!
very nice and simple
Lovely video. Thank you.
Thank you for the lesson.
superb video !
such a nice video.
imagine ur body housing silent assassins. lol
thank you for making wonderful video
A fantastic video, thank you for this
thank was sooooo amazing people
Thank you
That video was great really love it 😍😍
That is stunning 😍
Thanks a lot 🙏 💓
Hello TEDed. I love your videos. All your videos very interesting but in some case I try to understand without transcript as I'm not native speaker. Can I have this transcript from somewhere. Thanks.
well explained
Was just about to skip this on my sub list. Then I saw the name Alex Dainis. :-)
beautiful. thanks
Wow, gruesome.
Drusome
This is so cool and easy to remember now XD thanks
How does our cells know which RNA is virus RNA vs our own good RNA
Clearly many things chemicals could never do without being directed by a Maker.
THANKS!!!
cool video!
wow! amazing video
узбеккино
узбеки но х
узбеккино
i didnt understand anything u said
+vidmario bros me too
please no more metaphors
perfect!
I like how she said volia
Thx
This was awesomely violent.
i may be wrong by the looks of the direction of this
wow
just wow
+taeyang Same!!! I think people in general need a little bit more of previous knowledge to fully understand the video but it amazing nonetheless
Plz explain this topic liteally
You could have made the pieces of the double stranded RNA look alive like smaller living parts of it :P
중간에 나오는 푸른빛집명나방이 아니라 예쁜꼬마선충(C.elegans)이 맞는거 같은데 ...
I think that Korean subtitles are wrong. lI hear as [예쁜꼬마선충 - C.elegans] , but the Koean subtitle is [푸른빛집명나방Teliphasa elegans ]
영어 고수님들 이거 보시면 제대로된 영문으로 작성좀 해주세요.....ㅋㅋㅋㅋㅋㅋ
perfect
no that would be Bradford, UK
that brutally escalated quick.
Not a lot of views:/ what's wrong with his world?!!?!!! Ashton kutchers video has more views than this informative, useful video. WHY?!!?! :'(
what's the difference of rna and dna?
slice and dice
the animation is so cute
the RNA part was always the most complicated in genetics
Very good:)
How do you manipulate expression in gene expression, is this possible to do within yourself without any external help?
yes like if u starve yourself the genes will express differently in response to lower levels of some proteins in blood to metabolize slower
Yay Alex! :)
Alexxxxx!
Usually, TedEd does well at describing phenomena through metaphors, but here it was just distracting. Not as bad as the one about oil and water not mixing, but still.